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1.发明授权公开(公告)号：US12135969B2
公开(公告)日：2024-11-05
申请号：US17261811
申请日：2019-07-19
Applicant: DH TECHNOLOGIES DEVELOPMENT PTE. LTD.
Inventor： Don W. Arnold , Thomas R. Covey , Chang Liu , Stanislaw Potyrala , Alex Tsipirovich
Abstract: Electromagnetic systems and corresponding methods for assembling the electromagnetic systems are described. The electromagnetic systems can be used in fluid processing systems that include a plurality of fluid containers, each configured to define a fluid chamber that receives a fluid and a plurality of magnetic particles, and a plurality of electromagnets configured to generate a magnetic field within at least one of the plurality of the fluid containers. The fluid processing system can also include a PCB board that supplies the electromagnets with electrical current by establishing an electrical connection between electrical contact terminals included on the PCB board and spring loaded connections included on each electromagnet. A control component controls the electromagnetic field generated by each electromagnet to generate a plurality of magnetic field gradients within the at least one fluid container sufficient to magnetically influence the plurality of magnetic particles within the fluid in each fluid container.
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公开(公告)号：US11817302B2
公开(公告)日：2023-11-14
申请号：US18046986
申请日：2022-10-17
Applicant: DH Technologies Development Pte. Ltd.
Inventor： Don W. Arnold , Thomas R. Covey , Chang Liu
CPC classification number: H01J49/0495 , G01N1/405 , H01J49/0404 , H01J49/165 , G01N2030/009
Abstract: Methods and systems for delivering a liquid sample to an ion source for the generation of ions and subsequent analysis by mass spectrometry are provided herein. In accordance with various aspects of the present teachings, MS-based systems and methods are provided in which the flow of desorption solvent within a sampling probe fluidly coupled to an ion source can be selectively controlled such that one or more analyte species can be desorbed from a sample substrate inserted within the sampling probe within a decreased volume of desorption solvent for subsequently delivery to the ion source. In various aspects, sensitivity can be increased due to higher desorption efficiency (e.g., due to increased desorption time) and/or decreased dilution of the desorbed analytes. The methods and systems described herein can additionally or alternatively provide for the selective control of the flow rate of the desorption solvent within the sampling interface so as to enable additional processing steps to occur within the sampling probe (e.g., multiple samplings, reactions).
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3.发明公开
公开(公告)号：US20230349858A1
公开(公告)日：2023-11-02
申请号：US17753921
申请日：2020-09-29
Applicant: DH TECHNOLOGIES DEVELOPMENT PTE. LTD.
Inventor： Thomas R. Covey , Chang Liu
IPC: G01N27/623 , H01J49/04 , G01N27/624
CPC classification number: G01N27/623 , H01J49/0459 , G01N27/624
Abstract: MS-based methods and systems are provided herein in which a desorption solvent desorbs one or more analyte species from an SPME device within a sampling interface that is fluidly coupled to an ion source for subsequent mass spectrometric analysis. In accordance with various aspects of the applicants teachings, the sampling interface includes an internal sampling conduit that provides increased interaction between the desorption solvent and the sampling substrate, thereby improving mass transfer (e.g., increased extraction or desorption speed).
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公开(公告)号：US20230207298A1
公开(公告)日：2023-06-29
申请号：US17999637
申请日：2021-05-21
Applicant: DH TECHNOLOGIES DEVELOPMENT PTE. LTD.
Inventor： Chang Liu , Thomas R. Covey
CPC classification number: H01J49/0454 , H01J49/165
Abstract: An optimal value is calculated for at least one parameter of an ADE device, an OPI, or an ion source device. For each value of a plurality of parameter values for at least one parameter of the ADE device, the OPI, or the ion source device, three steps are performed using a processor. First, the at least one parameter is set to the value. Second, the ADE device, the OPI, the ion source device, and a mass spectrometer are instructed to produce one or more intensity versus time mass peaks for a sample. Third, a feature value is calculated for at least one feature of the one or more intensity versus time mass peaks. A plurality of feature values corresponding to the plurality of parameter values is produced. An optimal value is calculated for the at least one parameter from the plurality of feature values.
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公开(公告)号：US11664210B2
公开(公告)日：2023-05-30
申请号：US16971436
申请日：2019-02-20
Applicant: DH Technologies Development Pte. Ltd.
Inventor： John J. Corr , Thomas R. Covey , Peter Kovarik , Bradley B. Schneider
CPC classification number: H01J49/107 , H01J49/0031 , H01J49/165
Abstract: In one aspect, an ion source for use in a mass spectrometry system is disclosed, which comprises a housing, a first and a second ion probe coupled to said housing, and a first and a second emitter configured for coupling, respectively, to said first and second ion probes. The first ion probe is configured for receiving a sample at a flow rate in nanoflow regime and the second ion probe is configured for receiving a sample at a flow rate above the nanoflow regime. Each of the ion probes includes a discharge end (herein also referred to as the discharge tip) for ionizing at least one constituent of the received sample. In some embodiment, each ion probe receives the sample from a liquid chromatography (LC) column. Further, the ion probes can be interchangeably disposed within the housing.
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6.发明申请
公开(公告)号：US20220139690A1
公开(公告)日：2022-05-05
申请号：US17427428
申请日：2020-02-03
Applicant: DH Technologies Development Pte. Ltd.
Inventor： Thomas R. Covey , Chang Liu , Stephen A Tate
Abstract: A device that produces charged droplets whose composition is optimized for the creation of ions by electro spray composed of: a transport device that is operative to transfer sample components from a liquid sample to a processing chamber, a flowing stream of liquid through the processing chamber into which the samples are deposited, a controller mechanism operative to control the amount of sample transferred, a transport tube through which the flowing liquid containing the sample is directed to an electro spray emitter with a high electric field at the exit, a flow of expanding gas surrounding the electro spray emitter creating a pressure drop at the exit, and, a mass spectrometer for measuring the number of ions produced from the charged droplets emanating from the emitter; wherein the dilution of the sample in the processing chamber and transport fluid is from 100 to 10,000-fold.
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7.发明授权
公开(公告)号：US11067538B2
公开(公告)日：2021-07-20
申请号：US16088103
申请日：2017-03-21
Applicant: DH TECHNOLOGIES DEVELOPMENT PTE. LTD.
Inventor： Bradley B. Schneider , Erkinjon Nazarov , Thomas R. Covey
IPC: G01N27/624 , H01J49/00 , H01J49/16
Abstract: An apparatus includes a first electrode and a second electrode. The second electrode is placed in parallel with the first electrode to provide constant gap distance. The gap between the first electrode and the second electrode is at atmospheric pressure. Ions are introduced into the center of the gap and travel through the apparatus in a direction parallel to the first electrode and the second electrode. The apparatus is configured as a high-field symmetric-waveform apparatus for filtering high mobility ions or for fragmenting ions. The apparatus is also configured for three modes of operation: as a conventional DMS; as a filter high mobility ions; and as fragmentation device. A symmetric electric field is produced in the gap with a maximum density normalized field strength greater than 10 Td to filter high mobility ions and with a maximum density normalized field strength greater than 100 Td to fragment ions.
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8.发明授权
公开(公告)号：US09305762B2
公开(公告)日：2016-04-05
申请号：US13693837
申请日：2012-12-04
Applicant: DH Technologies Development Pte. Ltd.
Inventor： Thomas R. Covey , Bradley B. Schneider
CPC classification number: H01J49/26 , G01N27/624 , H01J49/004 , Y10T436/24
Abstract: A mass analysis system including a low pressure dissociation region and a differential mobility spectrometer. The differential mobility spectrometer including at least one pair of filter electrodes defining an ion flow path where the filter electrodes generate an electric field for passing through a selected portion of the sample ions based on the mobility characteristics of the sample ions. The differential mobility spectrometer also includes a voltage source that provides DC and RF voltages to at least one of the filter electrodes to generate the electric field, an ion inlet that receives sample ions that have passed through the low pressure dissociation region, and an ion outlet that outputs the selected portion of the sample ions. A mass spectrometer receives some or all of the selected portion of the sample ions.
Abstract translation: 质量分析系统，包括低压解离区域和差动迁移谱仪。 差速迁移谱仪包括至少一对限定离子流路的过滤电极对，其中过滤电极基于样品离子的迁移率特性产生用于通过选定部分样品离子的电场。 差分迁移率光谱仪还包括电压源，其向至少一个滤光器电极提供DC和RF电压以产生电场;接收经过低压解离区域的样品离子的离子入口和离子出口 其输出所选择的样本离子部分。 质谱仪接收样品离子的部分或全部选定部分。
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公开(公告)号：US12209989B2
公开(公告)日：2025-01-28
申请号：US17753921
申请日：2020-09-29
Applicant: DH TECHNOLOGIES DEVELOPMENT PTE. LTD.
Inventor： Thomas R. Covey , Chang Liu
IPC: G01N27/62 , G01N27/623 , G01N27/624 , H01J49/04
Abstract: MS-based methods and systems are provided herein in which a desorption solvent desorbs one or more analyte species from an SPME device within a sampling interface that is fluidly coupled to an ion source for subsequent mass spectrometric analysis. In accordance with various aspects of the applicants teachings, the sampling interface includes an internal sampling conduit that provides increased interaction between the desorption solvent and the sampling substrate, thereby improving mass transfer (e.g., increased extraction or desorption speed).
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公开(公告)号：US12138606B2
公开(公告)日：2024-11-12
申请号：US16765854
申请日：2018-11-20
Applicant: DH Technologies Development Pte. Ltd.
Inventor： Don W Arnold , Thomas R. Covey , Chang Liu
IPC: B01F33/451 , B01F23/50 , B01F35/221 , B03C1/01 , B03C1/033 , B03C1/28 , B03C1/30 , G01R33/12 , B01F101/23
Abstract: A fluid processing system that can include a sample container having a sample chamber for containing a fluid and a plurality of magnetic particles and at least one movable magnetic assembly configured to be movably inserted into or out of the sample chamber. The movable magnetic assembly can include a plurality of electromagnets that generate a magnetic field within at least a portion of the sample chamber when the assembly is inserted at least partially into the sample chamber. The fluid processing system can also include a signal generator that applies electrical signals, e.g., AC electrical signals, to the electromagnets of the magnetic assembly and a controller coupled to the signal generator that is configured to control phases of the electrical signals applied to the electromagnets to generate magnetic field gradients within the portion of the sample chamber effective to magnetically influence the plurality of the magnetic particles.
