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公开(公告)号:US20200347068A1
公开(公告)日:2020-11-05
申请号:US16933095
申请日:2020-07-20
发明人: Nathanael S. GRAY , Jianming ZHANG , Barun OKRAM , Xianming DENG , Jae Won CHANG , Amy WOJCIECHOWSKI
IPC分类号: C07D487/04 , C07D239/94 , A61P9/00 , A61P35/02 , A61P19/00 , A61P35/00 , A61P17/00 , C07D239/42 , C07D403/04 , C07D403/06 , C07D403/12 , C07D417/04 , C07D473/34 , C07D495/04 , A61K31/517 , A61K31/519 , A61K31/52 , A61K31/5377 , A61K31/7076 , A61K45/06 , C07D471/04 , C07H19/16
摘要: The present disclosure provides novel heteroaryl compounds of formula (IV). Such compounds are useful for the treatment of cancers.
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公开(公告)号:US20170349595A1
公开(公告)日:2017-12-07
申请号:US15582004
申请日:2017-04-28
发明人: Nathanael S. GRAY , Jianming ZHANG , Barun OKRAM , Xianming DENG , Jae Won CHANG , Amy WOJCIECHOWSKI
IPC分类号: C07D487/04 , A61K31/517 , C07D473/34 , C07D471/04 , C07D417/04 , C07D403/12 , C07D403/06 , C07D403/04 , C07D239/94 , C07D239/42 , A61K45/06 , A61K31/7076 , A61K31/5377 , A61K31/52 , A61K31/519 , C07D495/04 , C07H19/16
CPC分类号: C07D487/04 , A61K31/517 , A61K31/519 , A61K31/52 , A61K31/5377 , A61K31/7076 , A61K45/06 , A61P9/00 , A61P17/00 , A61P19/00 , A61P35/00 , A61P35/02 , C07D239/42 , C07D239/94 , C07D403/04 , C07D403/06 , C07D403/12 , C07D417/04 , C07D471/04 , C07D473/34 , C07D495/04 , C07H19/16 , Y02A50/401
摘要: The present invention provides novel heteroaryl compounds of formula (I) having a pyrimidine-containing core that is linked to a 4-trifluoromethoxyphenyl group via an amine linker. Such compounds are useful for the treatment of cancers.
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公开(公告)号:US20220135573A1
公开(公告)日:2022-05-05
申请号:US17574132
申请日:2022-01-12
发明人: Nathanael S. GRAY , Jianming ZHANG , Barun OKRAM , Xianming DENG , Jae Won CHANG , Amy WOJCIECHOWSKI
IPC分类号: C07D487/04 , A61K31/517 , C07D471/04 , C07D239/42 , C07D403/06 , A61K31/519 , A61P35/02 , C07D473/34 , C07D495/04 , A61P35/00 , A61K45/06 , A61P17/00 , A61K31/7076 , C07D403/12 , C07D239/94 , C07D403/04 , A61P19/00 , A61K31/52 , A61K31/5377 , C07H19/16 , A61P9/00 , C07D417/04
摘要: The present disclosure provides novel heteroaryl compounds of formula (VII). Such compounds are useful for the treatment of cancers.
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公开(公告)号:US20200270223A1
公开(公告)日:2020-08-27
申请号:US16717813
申请日:2019-12-17
发明人: Justin S. CISAR , Cheryl A. GRICE , Todd K. JONES , Micah J. NIPHAKIS , Jae Won CHANG , Kenneth M. LUM , Benjamin F. CRAVATT
IPC分类号: C07D295/205 , C07C271/12 , C07D317/46 , C07D317/58 , C07D231/12 , C07D231/16 , C07D231/56 , C07D241/04 , C07D471/04 , C07D471/10 , C07D261/08 , C07D487/04 , C07D263/32 , C07D205/04 , C07D491/107 , C07D207/14 , C07D271/06 , C07D307/79 , C07D405/14 , C07D215/42 , C07D213/40 , C07D295/26 , C07D213/55 , C07D401/04 , C07D407/06 , C07D413/06 , C07C271/10 , C07D207/09 , C07D213/38 , C07D215/46 , C07D401/10 , C07D403/10 , C07D413/10
摘要: This disclosure provides compounds and compositions which may be modulators of MAGL and/or ABHD6 and their use as medicinal agents, processes for their preparation, and pharmaceutical compositions that include disclosed compounds as at least one active agent. The disclosure also provides for method of treating a patient in need thereof, where the patient is suffering from indications such as pain, solid tumor cancer and/or obesity comprising administering a disclosed compound or composition.
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公开(公告)号:US20210188793A1
公开(公告)日:2021-06-24
申请号:US17195351
申请日:2021-03-08
发明人: Justin S. CISAR , Cheryl A. GRICE , Todd K. JONES , Micah J. NIPHAKIS , Jae Won CHANG , Kenneth M. LUM , Benjamin F. CRAVATT
IPC分类号: C07D295/205 , C07C271/12 , C07D317/46 , C07D317/58 , C07D231/12 , C07D231/16 , C07D231/56 , C07D241/04 , C07D471/04 , C07D471/10 , C07D261/08 , C07D487/04 , C07D263/32 , C07D205/04 , C07D491/107 , C07D207/14 , C07D271/06 , C07D307/79 , C07D405/14 , C07D215/42 , C07D213/40 , A61P25/22 , C07D295/26 , C07D213/55 , C07D401/04 , C07D407/06 , C07D413/06 , C07C271/10 , C07D207/09 , C07D213/38 , C07D215/46 , C07D401/10 , C07D403/10 , C07D413/10
摘要: This disclosure provides compounds and compositions which may be modulators of MAGL and/or ABHD6 and their use as medicinal agents, processes for their preparation, and pharmaceutical compositions that include disclosed compounds as at least one active agent. The disclosure also provides for method of treating a patient in need thereof, where the patient is suffering from post-traumatic stress disorder comprising administering a disclosed compound or composition.
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公开(公告)号:US20180208568A1
公开(公告)日:2018-07-26
申请号:US15925517
申请日:2018-03-19
发明人: Justin S. CISAR , Cheryl A. GRICE , Todd K. JONES , Micah J. NIPHAKIS , Jae Won CHANG , Kenneth M. LUM , Benjamin F. CRAVATT
IPC分类号: C07D295/205 , C07D491/107 , C07C271/10 , C07D471/10 , C07D471/04 , C07D413/10 , C07D413/06 , C07D407/06 , C07D405/14 , C07D403/10 , C07D401/10 , C07D401/04 , C07D317/58 , C07D317/46 , C07D307/79 , C07D295/26 , C07D271/06 , C07D263/32 , C07D261/08 , C07D241/04 , C07D231/56 , C07D231/16 , C07D231/12 , C07D215/46 , C07D215/42 , C07D213/55 , C07D213/40 , C07D213/38 , C07D207/14 , C07D207/09 , C07D205/04 , C07C271/12 , C07D487/04
CPC分类号: C07D295/205 , C07C271/10 , C07C271/12 , C07D205/04 , C07D207/09 , C07D207/14 , C07D213/38 , C07D213/40 , C07D213/55 , C07D215/42 , C07D215/46 , C07D231/12 , C07D231/16 , C07D231/56 , C07D241/04 , C07D261/08 , C07D263/32 , C07D271/06 , C07D295/26 , C07D307/79 , C07D317/46 , C07D317/58 , C07D401/04 , C07D401/10 , C07D403/10 , C07D405/14 , C07D407/06 , C07D413/06 , C07D413/10 , C07D471/04 , C07D471/10 , C07D487/04 , C07D491/107
摘要: This disclosure provides compounds and compositions which may be modulators of MAGL and/or ABHD6 and their use as medicinal agents, processes for their preparation, and pharmaceutical compositions that include disclosed compounds as at least one active agent. The disclosure also provides for method of treating a patient in need thereof, where the patient is suffering from indications such as pain, solid tumor cancer and/or obesity comprising administering a disclosed compound or composition.
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