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1.
公开(公告)号:US20220089585A1
公开(公告)日:2022-03-24
申请号:US17422642
申请日:2020-01-10
申请人: Dane James CLAUSEN , Joseph A. KOZLOWSKI , Jian LIU , Scott E. WOLKENBERG , Wensheng YU , Merck Sharp & Dohme Corp.
IPC分类号: C07D413/14 , C07D413/12 , A61K45/06 , A61K31/422 , A61K31/4709 , C07D417/14 , A61P31/18
摘要: The present invention relates to Compounds of Formula I and pharmaceutically acceptable salts or prodrug thereof, wherein R1, R2, R3, R4, X and A are as defined herein. The present invention also relates to compositions comprising at least one compound of Formula I, and methods of using the compounds of Formula I for treating or preventing HIV infection in a subject.
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公开(公告)号:US20140206681A1
公开(公告)日:2014-07-24
申请号:US14160587
申请日:2014-01-22
申请人: RONALD M. KIM , Jian Liu , Xiaolei Gao , Sobhana Babu Boga , Deodialsingh Guiadeen , Joseph A. Kozlowski , Wensheng Yu , Rajan Anand , Younong Yu , Oleg B. Selyutin , Ying-Duo Gao , Hao Wu , Shilan Liu , Chundao Yang , Hongjian Wang
发明人: RONALD M. KIM , Jian Liu , Xiaolei Gao , Sobhana Babu Boga , Deodialsingh Guiadeen , Joseph A. Kozlowski , Wensheng Yu , Rajan Anand , Younong Yu , Oleg B. Selyutin , Ying-Duo Gao , Hao Wu , Shilan Liu , Chundao Yang , Hongjian Wang
IPC分类号: C07D471/04 , A61K31/4985 , A61K31/506 , C07D487/04 , A61K31/5383 , A61K31/519 , A61K31/5365 , A61K45/06 , C07D498/04 , C07D455/02
CPC分类号: C07D491/048 , A61K31/497 , A61K31/4985 , A61K31/506 , A61K31/519 , A61K31/5365 , A61K31/5383 , A61K45/06 , C07D455/02 , C07D471/04 , C07D487/04 , C07D498/04 , C07D519/00 , Y02A50/411 , Y02A50/463
摘要: The present invention provides Bruton's Tyrosine Kinase (Btk) inhibitor compounds according to Formula I or a pharmaceutically acceptable salt thereof or to pharmaceutical compositions comprising these compounds and to their use in therapy. In particular, the present invention relates to the use of Btk inhibitor compounds in the treatment of Btk mediated disorders.
摘要翻译: 本发明提供了根据式I的Bruton's酪氨酸激酶(Btk)抑制剂化合物或其药学上可接受的盐或包含这些化合物的药物组合物及其在治疗中的用途。 特别地,本发明涉及Btk抑制剂化合物在治疗Btk介导的病症中的用途。
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公开(公告)号:US10208047B2
公开(公告)日:2019-02-19
申请号:US15538910
申请日:2015-12-17
申请人: Jian Liu , Joseph A. Kozlowski , Brian M. Andresen , Sobhana Babu Boga , Xiaolei Gao , Deodial Guy Guiadeen , Jiaqiang Cai , Shilan Liu , Dahai Wang , Hao Wu , Chundao Yang
发明人: Jian Liu , Joseph A. Kozlowski , Brian M. Andresen , Sobhana Babu Boga , Xiaolei Gao , Deodial Guy Guiadeen , Jiaqiang Cai , Shilan Liu , Dahai Wang , Hao Wu , Chundao Yang
IPC分类号: C07D487/04 , A61K31/4985 , A61K45/06
摘要: The present invention provides Bruton's Tyrosine Kinase (Btk) inhibitor compounds according to Formula I, or pharmaceutically acceptable salts thereof, Formula I or to pharmaceutical compositions comprising these compounds and to their use in therapy. In particular, the present invention relates to the use of Btk inhibitor compounds of Formula I in the treatment of Btk mediated disorders.
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公开(公告)号:US11377438B2
公开(公告)日:2022-07-05
申请号:US16669598
申请日:2019-10-31
发明人: Ashok Arasappan , Ian M. Bell , Michael J. Breslin , Christopher James Bungard , Christopher S. Burgey , Harry R. Chobanian , Jason M. Cox , Anthony T. Ginnetti , Deodial Guy Guiadeen , Kristen L. G. Jones , Mark E. Layton , Hong Liu , Jian Liu , James J. Perkins , Shawn J. Stachel , Linda M. Suen-Lai , Zhe Wu
IPC分类号: C07D401/12 , C07D401/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D491/04 , C07D471/08 , C07D487/04 , C07D491/048 , C07D495/04
摘要: Novel compounds of the structural formula (I), and the pharmaceutically acceptable salts thereof, are inhibitors of Nav1.8 channel activity and may be useful in the treatment, prevention, management, amelioration, control and suppression of diseases mediated by Nav1.8 channel activity. The compounds of the present invention may be useful in the treatment, prevention or management of pain disorders, cough disorders, acute itch disorders, and chronic itch disorders.
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公开(公告)号:US20210069288A1
公开(公告)日:2021-03-11
申请号:US17005686
申请日:2020-08-28
发明人: Hubert Josien , Abbas Walji , Harold B. Wood , Fa-Xiang Ding , Jian Liu , Thomas Joseph Tucker , Michael Man-Chu Lo , Liangqin Guo
摘要: Disclosed are compounds of Formula A, or a pharmaceutically acceptable salt thereof: where A, X, R1, and R2 are as defined herein, which compounds have properties for antagonizing PCSK9. Also described are pharmaceutical formulations comprising the compounds of Formula I or their salts, and methods of treating cardiovascular disease and conditions related to PCSK9 activity, e.g. atherosclerosis, hypercholesterolemia, coronary heart disease, metabolic syndrome, acute coronary syndrome, or related cardiovascular disease and cardiometabolic conditions.
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公开(公告)号:US20190389909A1
公开(公告)日:2019-12-26
申请号:US16446940
申请日:2019-06-20
发明人: Harold B. Wood , Hubert B. Josien , Thomas Joseph Tucker , Angela Dawn Kerekes , Ling Tong , Abbas M. Walji , Anilkumar G. Nair , Fa-Xiang Ding , Elisabetta Bianchi , Danila Branca , Chengwei Wu , Yusheng Xiong , Sookhee Nicole HA , Jian Liu , Sobhana Babu Boga
摘要: Disclosed are compounds of Formula I, or a salt thereof: where A, B, D, X, R1, R2 and R8 are as defined herein, which compounds have properties for antagonizing PCSK9. Also described are pharmaceutical formulations comprising the compounds of Formula I or their salts, and methods of treating cardiovascular disease and conditions related to PCSK9 activity, e.g. atherosclerosis, hypercholesterolemia, coronary heart disease, metabolic syndrome, acute coronary syndrome, or related cardiovascular disease and cardiometabolic conditions.
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公开(公告)号:US09718828B2
公开(公告)日:2017-08-01
申请号:US15250978
申请日:2016-08-30
发明人: Adrianus Petrus Antonius De Man , Jan-Gerard Sterrenburg , Hans C. A. Raaijmakers , Allard Kaptein , Arthur A. Oubrie , Johannes Bernardus Maria Rewinkel , Christiaan Gerardus Johannes Maria Jans , Jacobus C. H. M. Wijkmans , Tjeerd A. Barf , Alan B. Cooper , Ronald M. Kim , Sobhana Babu Boga , Hugh Y. Zhu , Xiaolei Gao , Xin Yao , Rajan Anand , Hao Wu , Shilan Liu , Chundao Yang , Abdul-Basit Alhassan , James Wang , Younong Yu , Jian Liu , Henry M. Vaccaro
IPC分类号: C07D487/04 , C07D497/02 , C07D401/04 , C07D401/14 , C07D403/04 , C07D403/14 , A61K31/437 , A61K31/4985 , A61K31/519 , A61K31/52 , A61K31/53 , A61P19/02 , C07D519/00 , A61K45/06 , A61K31/5377 , A61K31/541 , A61K31/55 , C07D513/04 , C07D471/04
CPC分类号: C07D487/04 , A61K31/4985 , A61K31/53 , A61K31/5377 , A61K31/541 , A61K31/55 , A61K45/06 , C07D471/04 , C07D513/04 , C07D519/00
摘要: Provided are 6-5 membered fused pyridine ring compounds according to Formula (I) or pharmaceutically acceptable salts thereof, pharmaceutical compositions comprising these compounds and their use in therapy. In particular, provided is the use of 6-5 membered fused pyridine ring compounds in the treatment of Bruton's Tyrosine Kinase (Btk) mediated disorders.
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公开(公告)号:US20140378493A1
公开(公告)日:2014-12-25
申请号:US14480202
申请日:2014-09-08
发明人: Pengcheng Patrick Shao , Wanying Sun , Revathi Reddy Katipally , Petr Vachal , Feng Ye , Jian Liu , Deyou Sha
IPC分类号: C07D498/04 , A61K31/4439 , A61K45/06 , A61K31/437 , A61K31/444 , A61K31/424 , A61K31/506
CPC分类号: C07D498/04 , A61K31/424 , A61K31/437 , A61K31/4439 , A61K31/444 , A61K31/506 , A61K45/06
摘要: Compounds having the structure of Formula I, including pharmaceutically acceptable salts of the compounds, are CETP inhibitors and are useful for raising HDL-cholesterol, reducing LDL-cholesterol, and for treating or preventing atherosclerosis.
摘要翻译: 具有式I结构的化合物,包括化合物的药学上可接受的盐,是CETP抑制剂,可用于培养HDL-胆固醇,降低LDL-胆固醇,以及用于治疗或预防动脉粥样硬化。
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9.
公开(公告)号:US20220144837A1
公开(公告)日:2022-05-12
申请号:US17438479
申请日:2020-03-16
发明人: Wensheng Yu , Joseph A. Kozlowski , Dane James Clausen , Jian Liu , James Fells
IPC分类号: C07D471/22 , A61P31/18 , A61K31/4748 , C07D491/18 , C07D498/22 , C07D487/08 , A61K31/438 , A61K31/426 , A61K31/635 , A61K31/4418 , A61K31/506 , A61K31/685 , A61K31/505 , A61K31/4439 , A61K31/52 , A61K31/513
摘要: The present invention relates to Compounds of Formula I and Ia and pharmaceutically acceptable salts or prodrug thereof, wherein R1, R2, X, A and B are as defined herein. The present invention also relates to compositions comprising at least one compound of Formula I or Ia, and methods of using the compounds of Formula I or Ia for treating or preventing HIV infection in a subject.
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10.
公开(公告)号:US20210403479A1
公开(公告)日:2021-12-30
申请号:US17288626
申请日:2019-11-04
发明人: Wensheng Yu , Joseph Kozlowski , Dane James Clausen , Jian Liu , Younong Yu , Ming Wang , Bing Li
IPC分类号: C07D487/10 , C07D403/12 , C07D413/14 , C07D401/14 , C07D401/12 , C07D471/04 , C07D417/14 , C07D498/10 , C07D405/14 , A61K45/06
摘要: The present invention relates to Compounds of Formula I: and pharmaceutically acceptable salts or prodrug thereof, wherein R1, R2, R3, R4 and A are as defined herein. The present invention also relates to compositions comprising at least one compound of Formula I, and methods of using the compounds of Formula I for treating or preventing HIV infection in a subject.
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