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公开(公告)号:US5169961A
公开(公告)日:1992-12-08
申请号:US796298
申请日:1991-11-22
IPC分类号: C07C313/08 , C07C319/14 , C07C319/24 , C07C323/22 , C07D333/56 , C07D497/08
CPC分类号: C07D497/08 , C07C313/08 , C07C319/14 , C07C319/24 , C07D333/56
摘要: A process for the production in high yield of 2-acetylbenzo[.beta.]thiophene and its alkyl and alkoxy substituted derivatives by converting a 2-halobenzaldehyde to a 2,2'-dithiobis(benzaldehyde) intermediate and reacting that intermediate successively with 2,4-pentanedione and chloroacetone in the presence of base.
摘要翻译: 通过将2-卤代苯甲醛转化为2,2'-二硫代双(苯甲醛)中间体并使该中间体依次与2,4和2二硫代双 戊二酮和氯丙酮。
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2.Process for the preparation of N-4-[(substituted phenyl)alkylheterocyclic]- N 失效
标题翻译: 制备N-4 - [(取代苯基)烷基杂环基] -N-羟基脲化合物的方法公开(公告)号:US5580989A
公开(公告)日:1996-12-03
申请号:US472448
申请日:1995-06-07
申请人: James D. Ratajczyk , Juliette K. Busse , Sanjay R. Chemburkar , Daniel A. Dickman , Yi-Yin Ku , Hemantkumar H. Patel , Ramesh R. Patel , David P. Sawick , John N. Starr , Bhadra Shelat , Harry O. Spiwek
发明人: James D. Ratajczyk , Juliette K. Busse , Sanjay R. Chemburkar , Daniel A. Dickman , Yi-Yin Ku , Hemantkumar H. Patel , Ramesh R. Patel , David P. Sawick , John N. Starr , Bhadra Shelat , Harry O. Spiwek
IPC分类号: A61K31/38 , A61K31/381 , A61P29/00 , A61P37/08 , A61P43/00 , B01J27/13 , B01J31/22 , C07D307/52 , C07D333/20 , C07D333/22 , C07D307/36
CPC分类号: C07D333/20 , C07D307/52
摘要: A process for preparing a compound of the structure I ##STR1## where A is oxygen and sulfur and R.sup.1 is selected from the group consisting of hydrogen, halogen, alkyl of one to six carbon atoms, alkoxy of one to six carbon atoms, and trifluoromethyl, and R.sup.2 is alkyl of one to four carbon atoms, comprising coupling a compound of formula II: ##STR2## where X is bromine or iodine, with an N-hydroxyurea compound of formula III: ##STR3## in the presence of a palladium catalyst followed by reaction of the product thus formed with an alkali metal isocyante.The compounds of formula I are inhibitors of the enzyme 5-lipoxygenase and are thus useful as therapeutic agents for the treatment of allergic and inflammatory disease conditions.
摘要翻译: 制备结构I I的化合物的方法,其中A是氧和硫,R 1选自氢,卤素,1至6个碳原子的烷基,1至6个碳原子的烷氧基,以及 三氟甲基,R 2为1-4个碳原子的烷基,其中包括式I化合物:其中X为溴或碘的式II化合物与式III的N-羟基脲化合物: 钯催化剂,随后将由此形成的产物与碱金属异氰酸酯反应。 式I化合物是5-脂氧合酶的抑制剂,因此可用作治疗过敏性和炎性疾病病症的治疗剂。
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公开(公告)号:US07932245B2
公开(公告)日:2011-04-26
申请号:US10691095
申请日:2003-10-22
申请人: Youssef L. Bennani , William H. Bunnelle , Sou-Jen Chang , Sanjay R. Chemburkar , Jinhua Chen , Michael J. Dart , Dilinie P. Fernando , Yi-Yin Ku , Mark Lockwood , Lei Wang
发明人: Youssef L. Bennani , William H. Bunnelle , Sou-Jen Chang , Sanjay R. Chemburkar , Jinhua Chen , Michael J. Dart , Dilinie P. Fernando , Yi-Yin Ku , Mark Lockwood , Lei Wang
IPC分类号: A61K31/397 , A61K31/535 , A61K31/4965 , A61K31/445
CPC分类号: C07C233/58 , A61K31/397 , A61K31/445 , A61K31/537 , A61K31/54 , C07C2602/50
摘要: The present invention relates to the use of compounds of formula (I) for the treatment of epilepsy, bipolar disorder, psychiatric disorders, migraine, pain, or movement disorders, and to provide neuroprotection.
摘要翻译: 本发明涉及式(I)化合物用于治疗癫痫,双相情感障碍,精神障碍,偏头痛,疼痛或运动障碍的用途,并提供神经保护作用。
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公开(公告)号:US20100144804A1
公开(公告)日:2010-06-10
申请号:US12644439
申请日:2009-12-22
申请人: John F. Bauer , Azita Saleki-Gerhardt , Bikshandarkoil A. Narayanan , Sanjay R. Chemburkar , Ketan M. Patel , Harry O. Spiwek , Philip E. Bauer , Kimberly A. Allen
发明人: John F. Bauer , Azita Saleki-Gerhardt , Bikshandarkoil A. Narayanan , Sanjay R. Chemburkar , Ketan M. Patel , Harry O. Spiwek , Philip E. Bauer , Kimberly A. Allen
IPC分类号: A61K31/427 , A61P31/18
CPC分类号: C07D417/12 , C07D277/28
摘要: A new crystalline polymorph of ritonavir and methods for its use and preparation are disclosed.
摘要翻译: 公开了利托那韦的新结晶多晶型物及其使用和制备方法。
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公开(公告)号:US20110201060A1
公开(公告)日:2011-08-18
申请号:US13026749
申请日:2011-02-14
申请人: Rajarathnam E. Reddy , Sanjay R. Chemburkar , Douglas R. Spaulding , Yi Pan , Lei Cao , Jose A. Restituyo , Richard Lorenzini , Michael DeMarco
发明人: Rajarathnam E. Reddy , Sanjay R. Chemburkar , Douglas R. Spaulding , Yi Pan , Lei Cao , Jose A. Restituyo , Richard Lorenzini , Michael DeMarco
IPC分类号: C12P19/02
CPC分类号: C12P7/18 , C07B2200/07 , C07C29/12 , C07C2601/14 , C07H3/02 , C07C35/16
摘要: This invention pertains to a process for manufacturing scyllo-Inositol. Specifically, the current invention pertains to a process for converting myo-Inositol to scyllo-Inositol using a bioconversion process.
摘要翻译: 本发明涉及制备鲨肌醇的方法。 具体地,本发明涉及使用生物转化过程将肌醇转化为鲨肌醇的方法。
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6.PROCESS FOR THE SYNTHESIS OF (2S,3AR,7AS)-OCTAHYDRO-1H-INDOLE CARBOXYLIC ACID AS AN INTERMEDIATE FOR TRANDOLAPRIL 失效
标题翻译: (2S,3AR,7AS)-OCTAHYDRO-1H-吲哚羧酸合成方法作为中间体用于沙丁胺醇公开(公告)号:US20110065930A1
公开(公告)日:2011-03-17
申请号:US12837686
申请日:2010-07-16
申请人: Sanjay R. Chemburkar , Rajarathnam E. Reddy , Douglas M. Reamer , John T. Pavlina , Stephen S. Ulrey , Brian J. Kotecki
发明人: Sanjay R. Chemburkar , Rajarathnam E. Reddy , Douglas M. Reamer , John T. Pavlina , Stephen S. Ulrey , Brian J. Kotecki
IPC分类号: C07D209/42
CPC分类号: C07D209/42
摘要: A process for the preparation of (2S,3aR,7aS)-octahydro-1H-indole-20carboxylic acid hydrochloride.
摘要翻译: (2S,3aR,7aS) - 八氢-1H-吲哚-20羧酸盐酸盐的制备方法。
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公开(公告)号:US20130190514A1
公开(公告)日:2013-07-25
申请号:US13813082
申请日:2011-07-25
申请人: Rebecca Taub , Tilmann Brotz , John Franc , Larry Cohen , Hemantkumar H. Patel , Sanjay R. Chemburkar , David P. Sawick
发明人: Rebecca Taub , Tilmann Brotz , John Franc , Larry Cohen , Hemantkumar H. Patel , Sanjay R. Chemburkar , David P. Sawick
IPC分类号: C07D333/20
CPC分类号: C07D333/20
摘要: The method of treating patients by administering N-[3-[5-[(4-fluorophenyl)methyl]-2-thienyl]-1-methyl-2-propynyl]-N-hydroxyurea for treatment of leukotriene related pathologies, and compositions for this use.
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8.Process for the synthesis of (2S,3AR,7AS)-octahydro-1H-indole carboxylic acid as an intermediate for trandolapril 失效
标题翻译: 用于合成(2S,3AR,7AS) - 八氢-1H-吲哚羧酸作为中度剂的方法公开(公告)号:US08288565B2
公开(公告)日:2012-10-16
申请号:US12837686
申请日:2010-07-16
申请人: Sanjay R. Chemburkar , Rajarathnam E. Reddy , Douglas M. Reamer , John T. Pavlina , Stephen S. Ulrey , Brian J. Kotecki
发明人: Sanjay R. Chemburkar , Rajarathnam E. Reddy , Douglas M. Reamer , John T. Pavlina , Stephen S. Ulrey , Brian J. Kotecki
IPC分类号: C07D209/04
CPC分类号: C07D209/42
摘要: A process for the preparation of (2S,3aR,7aS)-octahydro-1H-indole-20carboxylic acid hydrochloride.
摘要翻译: (2S,3aR,7aS) - 八氢-1H-吲哚-20羧酸盐酸盐的制备方法。
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9.PHENYLALKYL N-HYDROXYUREAS FOR TREATING LEUKOTRIENE RELATED PATHOLOGIES 审中-公开
标题翻译: 用于治疗白介素相关病理学的苯丙氨酸N-羟基公开(公告)号:US20120029048A1
公开(公告)日:2012-02-02
申请号:US13025106
申请日:2011-02-10
申请人: Rebecca Taub , Tilmann Brotz , John Franc , Larry Cohen , Hemantkumar H. Patel , Sanjay R. Chemburkar , David P. Sawick
发明人: Rebecca Taub , Tilmann Brotz , John Franc , Larry Cohen , Hemantkumar H. Patel , Sanjay R. Chemburkar , David P. Sawick
IPC分类号: A61K31/381 , A61P9/10 , A61P25/28 , A61P19/02 , A61P11/06 , A61P1/00 , C07D333/20 , A61P11/00
CPC分类号: A61K31/381 , A61K9/4858
摘要: The method of treating patients by administering N-[3-[5-[(4-fluorophenyl)methyl]-2-thienyl]-1-methyl-2-propynyl]-N-hydroxyurea for treatment of leukotriene related pathologies and compositions for this use.
摘要翻译: 通过给予N- [3- [5 - [(4-氟苯基)甲基] -2-噻吩基] -1-甲基-2-丙炔基] -N-羟基脲来治疗患者的方法,用于治疗白三烯相关病理学和组合物 这个用法。
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公开(公告)号:US07659405B2
公开(公告)日:2010-02-09
申请号:US11524972
申请日:2006-09-21
申请人: John F. Bauer , Azita Saleki-Gerhardt , Bikshandarkoil A. Narayanan , Sanjay R. Chemburkar , Ketan M. Patel , Harry O. Spiwek , Philip E. Bauer , Kimberly A. Allen
发明人: John F. Bauer , Azita Saleki-Gerhardt , Bikshandarkoil A. Narayanan , Sanjay R. Chemburkar , Ketan M. Patel , Harry O. Spiwek , Philip E. Bauer , Kimberly A. Allen
IPC分类号: C07D417/12
CPC分类号: C07D417/12 , C07D277/28
摘要: A new crystalline polymorph of ritonavir and methods for its use and preparation are disclosed.
摘要翻译: 公开了利托那韦的新结晶多晶型物及其使用和制备方法。
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