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公开(公告)号:US5275950A
公开(公告)日:1994-01-04
申请号:US15873
申请日:1993-02-10
申请人: Daniel A. Dickman , Bruce W. Horrom , Chi-Nung W. Hsiao , M. Robert Leanna , Hormoz Mazdiyasni , Howard E. Morton , Thomas M. Zydowsky , William R. Baker , Stephen L. Condon
发明人: Daniel A. Dickman , Bruce W. Horrom , Chi-Nung W. Hsiao , M. Robert Leanna , Hormoz Mazdiyasni , Howard E. Morton , Thomas M. Zydowsky , William R. Baker , Stephen L. Condon
IPC分类号: A61K38/00 , C07D277/28 , C07D277/46 , C07D295/26 , C07K5/065 , C12P13/04 , C07D241/04 , C12P11/00 , C12P17/12
CPC分类号: C07D277/28 , C07D295/26 , C07K5/06078 , A61K38/00
摘要: Intermediates and a process for their preparation are disclosed which are useful for the preparation of a renin inhibiting compound of the formula: ##STR1## wherein R is a nitrogen-containing heterocycle which is bonded via a nitrogen atom to the sulfonyl group, R.sub.6 is hydrogen, alkoxy, halogen or loweralkyl, R.sub.7 is loweralkyl having 2 to 7 carbon atoms, and R.sub.8 is loweralkyl, cycloalkyl, or aryl or a pharmaceutically acceptable acid addition salt thereof.
摘要翻译: 公开了中间体及其制备方法,其可用于制备下式的肾素抑制化合物:(*化学结构*)(I)其中R是通过氮原子与氮原子键合的含氮杂环 磺酰基,R6是氢,烷氧基,卤素或低级烷基,R7是具有2-7个碳原子的低级烷基,R8是低级烷基,环烷基或芳基或其药学上可接受的酸加成盐。
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2.
公开(公告)号:US5693813A
公开(公告)日:1997-12-02
申请号:US806806
申请日:1997-02-26
IPC分类号: C07D455/02
CPC分类号: C07D455/02
摘要: A process for the preparation of a compound having the formula: ##STR1## wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, and R.sup.5 are defined, from an enamine by chain expansion and ring closure followed by additional derivatization, treatment with a 3-alkoxyl-acryloyl compound, another ring closure, and converting a hydroxyl group to a leaving group.
摘要翻译: 制备具有下式的化合物的方法:其中R 1,R 2,R 3,R 4和R 5定义为烯胺,通过链扩链和闭环,随后进一步衍生化,用3-烷氧基 - 丙烯酰基化合物,另一个闭环,并将羟基转化成离去基团。
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公开(公告)号:US4963568A
公开(公告)日:1990-10-16
申请号:US359448
申请日:1989-05-31
申请人: Robert W. Schoenleber , John W. Kebabian , Yvonne C. Martin , Michael P. DeNinno , Richard J. Perner , David M. Stout , Chi-Nung W. Hsiao , Stanley DiDomenico, Jr. , John F. DeBernardis , Fatima Z. Basha , Michael D. Meyer , Biswanath De
发明人: Robert W. Schoenleber , John W. Kebabian , Yvonne C. Martin , Michael P. DeNinno , Richard J. Perner , David M. Stout , Chi-Nung W. Hsiao , Stanley DiDomenico, Jr. , John F. DeBernardis , Fatima Z. Basha , Michael D. Meyer , Biswanath De
IPC分类号: A61K31/13 , A61K31/135 , A61K31/16 , A61K31/335 , A61K31/40 , A61K31/403 , A61K31/404 , A61K38/00 , A61P9/00 , A61P25/00 , A61P25/18 , A61P25/30 , C07C41/02 , C07C215/48 , C07C215/64 , C07C217/56 , C07C217/74 , C07C219/28 , C07C233/18 , C07C237/08 , C07C271/16 , C07C271/44 , C07C309/65 , C07C323/60 , C07D207/08 , C07D209/08 , C07D209/62 , C07D221/06 , C07D221/10 , C07D221/20 , C07D311/76 , C07D311/78 , C07D311/96 , C07D313/08 , C07D405/04 , C07D405/06 , C07D405/12 , C07D407/04 , C07D407/12 , C07D493/10 , C07K5/06
CPC分类号: C07D207/08 , C07C215/64 , C07C217/74 , C07C219/28 , C07C233/18 , C07C237/08 , C07C271/16 , C07C271/44 , C07C309/65 , C07C323/60 , C07D209/62 , C07D221/10 , C07D221/20 , C07D311/76 , C07D311/78 , C07D311/96 , C07D313/08 , C07D405/04 , C07D405/06 , C07D405/12 , C07D407/04 , C07D407/12 , C07D493/10 , C07K5/06026 , A61K38/00 , C07C2101/14 , C07C2102/10 , C07C2102/28 , C07C2103/28 , C07C2103/74 , C07C2103/93
摘要: Novel compounds which are selective dopamine agonists are useful for treating disorders characterized by abnormal dopamine levels, such as Parkinson's Disease, as well as cardiovascular disorders.
摘要翻译: 作为选择性多巴胺激动剂的新型化合物可用于治疗以异常多巴胺水平为特征的疾病,例如帕金森病,以及心血管疾病。
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