公开(公告)号：US08394742B2

公开(公告)日：2013-03-12

申请号：US11910591

申请日：2006-04-14

申请人： Daniel D. Von Hoff ,  Haiyong Han ,  Hong Wang ,  Gary A. Flynn

发明人： Daniel D. Von Hoff ,  Haiyong Han ,  Hong Wang ,  Gary A. Flynn

IPC分类号： C40B30/06 ,  C12N15/11

CPC分类号： C07C235/84 ,  C07D231/54 ,  C07D233/64 ,  C07D263/32 ,  C07D277/48 ,  C07D413/04 ,  C07D413/12 ,  C07D417/04 ,  C12Q1/6886 ,  C12Q2600/136 ,  C12Q2600/158 ,  G01N33/5011

摘要： This invention is directed to methods for screening and identification of compounds capable of selectively eliminating cancer cells with specific loss-of-function alterations, including but not limited to mutations, deletions, hypermethylations, and other types of gene silencing. This invention is also directed to novel compounds that selectively eliminate cancer cells with specific loss-of-function alterations. Furthermore, this invention is directed to methods for production and therapeutic use of compounds that selectively eliminate cancer cells with specific loss-of-function alterations.

摘要翻译： 本发明涉及用于筛选和鉴定能够以特定功能丧失功能改变选择性地除去癌细胞的化合物的方法，包括但不限于突变，缺失，高甲基化和其他类型的基因沉默。 本发明还涉及以特定的功能丧失改变选择性地消除癌细胞的新型化合物。 此外，本发明涉及用于特异性功能丧失改变选择性地消除癌细胞的化合物的生产和治疗用途的方法。

公开(公告)号：US20090137420A1

公开(公告)日：2009-05-28

申请号：US11910591

申请日：2006-04-14

申请人： Daniel D. Von Hoff ,  Haiyong Han ,  Hong Wang ,  Gary A. Flynn

发明人： Daniel D. Von Hoff ,  Haiyong Han ,  Hong Wang ,  Gary A. Flynn

IPC分类号： C40B30/06 ,  C07C233/77 ,  C07D263/32 ,  C07D231/54 ,  C07D277/46

CPC分类号： C07C235/84 ,  C07D231/54 ,  C07D233/64 ,  C07D263/32 ,  C07D277/48 ,  C07D413/04 ,  C07D413/12 ,  C07D417/04 ,  C12Q1/6886 ,  C12Q2600/136 ,  C12Q2600/158 ,  G01N33/5011

摘要： This invention is directed to methods for screening and identification of compounds capable of selectively eliminating cancer cells with specific loss-of-function alterations, including but not limited to mutations, deletions, hypermethylations, and other types of gene silencing. This invention is also directed to novel compounds that selectively eliminate cancer cells with specific loss-of-function alterations. Furthermore, this invention is directed to methods for production and therapeutic use of compounds that selectively eliminate cancer cells with specific loss-of-function alterations.

摘要翻译： 本发明涉及用于筛选和鉴定能够以特定功能丧失功能改变选择性地除去癌细胞的化合物的方法，包括但不限于突变，缺失，高甲基化和其他类型的基因沉默。 本发明还涉及以特定的功能丧失改变选择性地消除癌细胞的新型化合物。 此外，本发明涉及用于特异性功能丧失改变选择性地消除癌细胞的化合物的生产和治疗用途的方法。

公开(公告)号：US10420166B2

公开(公告)日：2019-09-17

申请号：US13542247

申请日：2012-07-05

申请人： Lixiang Xu ,  Hong Wang ,  Huarui Liang

发明人： Lixiang Xu ,  Hong Wang ,  Huarui Liang

IPC分类号： H04W76/30 ,  H04W8/08 ,  H04W36/00

摘要： Methods for avoiding handover failure are provided. The method includes determining, by a source Base Station (BS), to perform a handover of a User Equipment (UE); determining, by the source BS, whether a target BS connects with a user plane node serving the UE at the source BS; and releasing resources, when the target BS does not connect with the user plane node serving the UE at the source BS.

公开(公告)号：US10089263B2

公开(公告)日：2018-10-02

申请号：US15118501

申请日：2014-03-24

申请人： INTEL CORPORATION ,  Thiam Wah Loh ,  Gautham N. Chinya ,  Per Hammarlund ,  Reza Fortas ,  Hong Wang ,  Huajin Sun

发明人： Thiam Wah Loh ,  Gautham N. Chinya ,  Per Hammarlund ,  Reza Fortas ,  Hong Wang ,  Huajin Sun

IPC分类号： G06F13/24

摘要： A processor is disclosed and includes at least one core including a first core, and interrupt delay logic. The interrupt delay logic is to receive a first interrupt at a first time and delay the first interrupt from being processed by a first time delay that begins at the first time, unless the first interrupt is pending at a second time when a second interrupt is processed by the first core. If the first interrupt is pending at the second time, the interrupt delay logic is to indicate to the first core to begin to process the first interrupt prior to completion of the first time delay. Other embodiments are disclosed and claimed.

公开(公告)号：US20180225118A1

公开(公告)日：2018-08-09

申请号：US15943614

申请日：2018-04-02

申请人： Ed Grochowski ,  Hong Wang ,  John P. Shen ,  Perry H. Wang ,  Jamison D. Collins ,  James Held ,  Partha Kundu ,  Raya Leviathan ,  Tin-Fook Ngai

发明人： Ed Grochowski ,  Hong Wang ,  John P. Shen ,  Perry H. Wang ,  Jamison D. Collins ,  James Held ,  Partha Kundu ,  Raya Leviathan ,  Tin-Fook Ngai

IPC分类号： G06F9/30 ,  G06F9/38

CPC分类号： G06F9/30003 ,  G06F9/30087 ,  G06F9/3009 ,  G06F9/30101 ,  G06F9/3013 ,  G06F9/384 ,  G06F9/3851

摘要： A method and system to provide user-level multithreading are disclosed. The method according to the present techniques comprises receiving programming instructions to execute one or more shared resource threads (shreds) via an instruction set architecture (ISA). One or more instruction pointers are configured via the ISA; and the one or more shreds are executed simultaneously with a microprocessor, wherein the microprocessor includes multiple instruction sequencers.

公开(公告)号：US09867157B2

公开(公告)日：2018-01-09

申请号：US12527328

申请日：2008-02-13

申请人： Bing Bu ,  Xiaoqiang Li ,  Chunying Sun ,  Hong Wang ,  Lixiang Xu ,  Yanmin Zhu

发明人： Bing Bu ,  Xiaoqiang Li ,  Chunying Sun ,  Hong Wang ,  Lixiang Xu ,  Yanmin Zhu

IPC分类号： H04W60/06 ,  H04W76/06

CPC分类号： H04W60/06 ,  H04W76/32

摘要： A method for detachment of a mobile set within the equivalent route area moving between the communication systems comprising steps of: during the detachment process is implemented between a mobile set and a service node in one communication system, the service node generates one or more messages and transmits it to the service nodes in one or more communication system within the ERA. If the message is transmitted to the service node within the ERA of only one communication system, this service node transmits this message or the message generated according to this message to the service nodes within the ERA of the other communication system. With the method proposed in present invention, when a mobile is detached from two or more communication systems which share the same ERA, the service nodes in all communication systems within the ERA can still correctly manage the relevant information on this mobile set.

公开(公告)号：US20170020717A1

公开(公告)日：2017-01-26

申请号：US15273117

申请日：2016-09-22

申请人： Hong Wang

发明人： Hong Wang

IPC分类号： A61F6/04

CPC分类号： A61F6/04

摘要： A condom of embodiments of the disclosed technology has a tip and base with cords connecting the two, creating portals where the urethra is exposed and fully capable of feeling abrasion with other objects. The base ring is oppositely disposed from the tip and an extreme other end of the condom. The base ring also extends circumferentially and in parallel to a largest circumference of the solid tip, when the cord extends perpendicularly to the largest circumference of the solid tip and the base ring. The largest circumference of the circle referred to herein, in embodiments of the disclosed technology, is a portion of the tip which is closest to the base ring.

摘要翻译： 所公开技术的实施例的避孕套具有尖端和底部，其具有连接两者的线，创建出口的位置，其中尿道被暴露并且完全能够感受到与其它物体的磨损。 基座环从尖端和避孕套的极端另一端相对设置。 当绳索垂直于固体末端和基环的最大圆周延伸时，基环也周向地并且平行于固体末端的最大圆周延伸。 在所公开的技术的实施例中，这里提到的圆的最大圆周是尖端的最靠近基环的部分。

公开(公告)号：US09198891B2

公开(公告)日：2015-12-01

申请号：US13111769

申请日：2011-05-19

申请人： Timothy Cardozo ,  Hong Wang ,  David Ron

发明人： Timothy Cardozo ,  Hong Wang ,  David Ron

IPC分类号： A61K49/00 ,  A61K31/225 ,  A61K31/24 ,  A61K31/4166 ,  A61K31/4245 ,  A61K31/428 ,  A61K31/433 ,  A61K31/496 ,  A61K31/519 ,  A61K31/536 ,  C07D207/416 ,  C07D239/42 ,  C07D249/12 ,  C07D265/22 ,  C07D277/44 ,  C07D277/54 ,  C07D277/66 ,  C07D307/54 ,  C07D317/60 ,  C07D403/04 ,  C07D403/06 ,  C07D403/12 ,  C07D409/12 ,  C07D417/14 ,  C07D487/04 ,  C12Q1/48 ,  G06F19/00 ,  G06F19/16

CPC分类号： A61K31/225 ,  A61K31/24 ,  A61K31/4166 ,  A61K31/4245 ,  A61K31/428 ,  A61K31/433 ,  A61K31/496 ,  A61K31/519 ,  A61K31/536 ,  C07D207/416 ,  C07D239/42 ,  C07D249/12 ,  C07D265/22 ,  C07D277/44 ,  C07D277/54 ,  C07D277/66 ,  C07D307/54 ,  C07D317/60 ,  C07D403/04 ,  C07D403/06 ,  C07D403/12 ,  C07D409/12 ,  C07D417/14 ,  C07D487/04 ,  C12Q1/485 ,  G06F19/16 ,  G06F19/706

摘要： The present invention relates to a method of identifying compounds useful in inhibiting protein kinase-like endoplasmic reticulum protein kinase (PERK). The method comprises providing a first model comprising PERK active domains, where the said active domains are selected from the group consisting of the peptide spanning from amino acid residue Asp144 to amino acid residue Ser191 of SEQ ID NO: 1 and a peptide comprising the amino acid residue at position 7 of SEQ ID NO: 1, providing one or more candidate compounds, evaluating contact between the candidate compounds and the first model to determine which of the one or more candidate compounds have an ability to bind to and/or fit in the first model, and identifying the compounds which, based on said evaluating, have the ability to bind to and/or fit in the first model as compounds potentially useful for inhibiting PERK. The present invention further relates to compounds that can be used for inhibition of PERK, for example human PERK, and methods related to treatment of PERK-mediated diseases.

摘要翻译： 本发明涉及鉴定可用于抑制蛋白激酶样内质网蛋白激酶（PERK）的化合物的方法。 该方法包括提供包含PERK活性结构域的第一模型，其中所述活性域选自跨越SEQ ID NO：1的氨基酸残基Asp144至氨基酸残基Ser191的肽和包含氨基酸的肽 提供一种或多种候选化合物，评估候选化合物与第一模型之间的接触，以确定一种或多种候选化合物中的哪一种具有结合和/或适合的能力 第一模型，以及鉴定基于所述评估具有结合和/或适合第一模型的能力的化合物，作为潜在地可用于抑制PERK的化合物。 本发明还涉及可用于抑制PERK的化合物，例如人PERK，以及与治疗PERK介导的疾病有关的方法。

公开(公告)号：US20150153329A1

公开(公告)日：2015-06-04

申请号：US14616295

申请日：2015-02-06

申请人： Lidia L. Demchyshyn ,  Hong Wang

发明人： Lidia L. Demchyshyn ,  Hong Wang

IPC分类号： G01N33/50 ,  G01N33/74

CPC分类号： G01N33/5082 ,  G01N33/5088 ,  G01N33/74 ,  G01N2333/605 ,  G01N2333/726 ,  G01N2500/04 ,  G01N2500/10

摘要： Disclosed herein is a method for measuring the contractility of intestinal tissue upon treatment with GLP-2 or a GLP-2 ligand. Also disclosed is an assay which directly measures the activity of GLP-2 or GLP-2 ligands ex vivo and permits the screening of putative GLP-2 ligands in native tissue.

摘要翻译： 本文公开了一种用于在用GLP-2或GLP-2配体处理时测量肠组织的收缩性的方法。 还公开了一种直接测量GLP-2或GLP-2配体活性的测定法，并允许在天然组织中筛选推定的GLP-2配体。

公开(公告)号：US08971290B2

公开(公告)日：2015-03-03

申请号：US13103314

申请日：2011-05-09

申请人： Huarui Liang ,  Hong Wang ,  Lixiang Xu

发明人： Huarui Liang ,  Hong Wang ,  Lixiang Xu

IPC分类号： H04W36/00 ,  H04W76/06 ,  H04W28/04 ,  H04W28/06 ,  H04W36/08 ,  H04W72/00 ,  H04W76/02

CPC分类号： H04W76/064 ,  H04W8/082 ,  H04W28/04 ,  H04W28/06 ,  H04W36/08 ,  H04W48/02 ,  H04W72/00 ,  H04W76/19 ,  H04W76/34

摘要： A handover method for supporting terminal mobility is provided, wherein, before a target core network node updates bearer information, an access control determination procedure is added. According to the access control determination information provided by the target base station, if it is determined that the bearer supporting a SIPTO or LIPA service is permitted to perform the handover, the target core network node updates the bearer information. If it is determined that the bearer supporting the SIPTO or LIPA service is not allowed to perform the handover, the handover failure is notified as per the bearer not performing the handover, and the bearer information is not updated. Alternatively, during or after the handover to the target network, the bearer release or deactivation is performed for the bearer not performing the handover, so that the UE may re-initiate the bearer establishment process with respect to the bearer not performing the handover.

摘要翻译： 提供了一种用于支持终端移动性的切换方法，其中，在目标核心网节点更新承载信息之前，添加访问控制确定过程。 根据目标基站提供的访问控制确定信息，如果确定支持SIPTO或LIPA服务的承载被允许执行切换，则目标核心网节点更新承载信息。 如果确定不支持SIPTO或LIPA服务的承载不允许执行切换，则根据不执行切换的承载来通知切换失败，并且不更新承载信息。 或者，在切换到目标网络期间或之后，对不执行切换的承载执行承载释放或去激活，使得UE可以针对不执行切换的承载重新发起承载建立过程。