公开(公告)号：US08672830B2

公开(公告)日：2014-03-18

申请号：US12562310

申请日：2009-09-18

申请人： Daniel F. Dlugos, Jr. ,  Thomas E. Adams ,  Randal T. Byrum ,  Toralf Bork ,  Christine H. Chen ,  Sean P. Conlon ,  Rocco Crivelli ,  Dean L. Garner ,  Alec J. Ginggen ,  David T. Krumanaker ,  Amy L. Marcotte ,  Anil K. Nalagatla ,  Bret W. Smith ,  Jeffrey S. Swayze ,  Richard W. Timm

发明人： Daniel F. Dlugos, Jr. ,  Thomas E. Adams ,  Randal T. Byrum ,  Toralf Bork ,  Christine H. Chen ,  Sean P. Conlon ,  Rocco Crivelli ,  Dean L. Garner ,  Alec J. Ginggen ,  David T. Krumanaker ,  Amy L. Marcotte ,  Anil K. Nalagatla ,  Bret W. Smith ,  Jeffrey S. Swayze ,  Richard W. Timm

IPC分类号： A61F2/00 ,  A61F13/00

CPC分类号： A61F5/003 ,  A61F2/0036 ,  A61F5/0053 ,  A61F5/0056 ,  A61F5/0059

摘要： An apparatus for regulating the functioning of a patient's organ or duct includes an elongated member having a first end and a second end. A fastener is disposed on the first end of the elongated member. The fastener is configured to engage the second end of the elongated member so that the elongated member forms a loop around the organ or duct. A tension element is disposed for movement within the elongated member. A drive element is associated with and engaging the tension element for causing the tension element to control the tension applied by the elongated member against a patient's body organ or duct. A release mechanism is provided for the tension element.

摘要翻译： 用于调节患者器官或管道的功能的装置包括具有第一端和第二端的细长构件。 紧固件设置在细长构件的第一端上。 紧固件构造成接合细长构件的第二端，使得细长构件围绕器官或管道形成环。 张力元件设置成在细长构件内移动。 驱动元件与张力元件相关联并与其接合，用于使张紧元件控制由细长构件施加的抵抗患者身体器官或管道的张力。 为张力元件提供释放机构。

公开(公告)号：US20110071341A1

公开(公告)日：2011-03-24

申请号：US12562310

申请日：2009-09-18

申请人： Daniel F. Dlugos, JR. ,  Thomas E. Adams ,  Randal T. Byrum ,  Toralf Bork ,  Christine H. Chen ,  Sean P. Conlon ,  Rocco Crivelli ,  Dean L. Garner ,  Alec J. Ginggen ,  David T. Krumanaker ,  Amy L. Marcotte ,  Anil K. Nalagatla ,  Bret W. Smith ,  Jeffrey S. Swayze ,  Richard W. Timm

发明人： Daniel F. Dlugos, JR. ,  Thomas E. Adams ,  Randal T. Byrum ,  Toralf Bork ,  Christine H. Chen ,  Sean P. Conlon ,  Rocco Crivelli ,  Dean L. Garner ,  Alec J. Ginggen ,  David T. Krumanaker ,  Amy L. Marcotte ,  Anil K. Nalagatla ,  Bret W. Smith ,  Jeffrey S. Swayze ,  Richard W. Timm

IPC分类号： A61F2/00

CPC分类号： A61F5/003 ,  A61F2/0036 ,  A61F5/0053 ,  A61F5/0056 ,  A61F5/0059

摘要： An apparatus for regulating the functioning of a patient's organ or duct includes an elongated member having a first end and a second end. A fastener is disposed on the first end of the elongated member. The fastener is configured to engage the second end of the elongated member so that the elongated member forms a loop around the organ or duct. A tension element is disposed for movement within the elongated member. A drive element is associated with and engaging the tension element for causing the tension element to control the tension applied by the elongated member against a patient's body organ or duct. A release mechanism is provided for the tension element.

摘要翻译： 用于调节患者器官或管道的功能的装置包括具有第一端和第二端的细长构件。 紧固件设置在细长构件的第一端上。 紧固件构造成接合细长构件的第二端，使得细长构件围绕器官或管道形成环。 张力元件设置成在细长构件内移动。 驱动元件与张力元件相关联并与其接合，用于使张紧元件控制由细长构件施加的抵抗患者身体器官或管道的张力。 为张力元件提供释放机构。

公开(公告)号：US09750629B2

公开(公告)日：2017-09-05

申请号：US12562267

申请日：2009-09-18

申请人： Daniel F. Dlugos, Jr. ,  Randal T. Byrum ,  Toralf Bork ,  Rocco Crivelli ,  Dean L. Garner ,  Alec J. Ginggen ,  Geoffrey C. Hueil ,  Donna L. Korvick ,  David T. Krumanaker ,  Amy L. Marcotte ,  Jeffrey D. Messerly ,  Kyle P. Moore ,  Daniel J. Mumaw ,  Anil K. Nalagatla ,  Mark S. Ortiz ,  Frederick E. Shelton, IV ,  Bret W. Smith ,  Jeffrey S. Swayze ,  Patrick J. Swindon ,  Richard W. Timm ,  Eric W. Thompson ,  Lauren S. Weaner

发明人： Daniel F. Dlugos, Jr. ,  Randal T. Byrum ,  Toralf Bork ,  Rocco Crivelli ,  Dean L. Garner ,  Alec J. Ginggen ,  Geoffrey C. Hueil ,  Donna L. Korvick ,  David T. Krumanaker ,  Amy L. Marcotte ,  Jeffrey D. Messerly ,  Kyle P. Moore ,  Daniel J. Mumaw ,  Anil K. Nalagatla ,  Mark S. Ortiz ,  Frederick E. Shelton, IV ,  Bret W. Smith ,  Jeffrey S. Swayze ,  Patrick J. Swindon ,  Richard W. Timm ,  Eric W. Thompson ,  Lauren S. Weaner

IPC分类号： A61B17/122 ,  A61F5/00 ,  A61F2/00

CPC分类号： A61F5/0053 ,  A61F2/0036 ,  A61F5/003 ,  A61F5/0056 ,  A61F5/0059

摘要： An apparatus for regulating the functioning of a patient's organ or duct includes an elongated member having a first end and a second end. A fastener is disposed on the first end of the elongated member. The fastener is configured to engage the second end of the elongated member so that the elongated member forms a loop around the organ or duct. A tension element is disposed for movement within the elongated member. A drive element is associated with and engages the tension element for causing the tension element to control the tension applied by the elongated member against a patient's body organ or duct. A tension release mechanism is associated with the tension element.

公开(公告)号：US20110071558A1

公开(公告)日：2011-03-24

申请号：US12562267

申请日：2009-09-18

申请人： Daniel F. Dlugos, JR. ,  Randal T. Byrum ,  Toralf Bork ,  Rocco Crivelli ,  Dean L. Garner ,  Alec J. Ginggen ,  Geoffrey C. Hueil ,  Donna L. Korvick ,  David T. Krumanaker ,  Amy L. Marcotte ,  Jeffrey D. Messerly ,  Kyle P. Moore ,  Daniel J. Mumaw ,  Anil K. Nalagatla ,  Mark S. Ortiz ,  Frederick E. Shelton, IV ,  Bret W. Smith ,  Jeffrey S. Swayze ,  Patrick J. Swindon ,  Richard W. Timm ,  Eric W. Thompson ,  Lauren S. Weaner

发明人： Daniel F. Dlugos, JR. ,  Randal T. Byrum ,  Toralf Bork ,  Rocco Crivelli ,  Dean L. Garner ,  Alec J. Ginggen ,  Geoffrey C. Hueil ,  Donna L. Korvick ,  David T. Krumanaker ,  Amy L. Marcotte ,  Jeffrey D. Messerly ,  Kyle P. Moore ,  Daniel J. Mumaw ,  Anil K. Nalagatla ,  Mark S. Ortiz ,  Frederick E. Shelton, IV ,  Bret W. Smith ,  Jeffrey S. Swayze ,  Patrick J. Swindon ,  Richard W. Timm ,  Eric W. Thompson ,  Lauren S. Weaner

IPC分类号： A61B17/122 ,  A61F2/04

CPC分类号： A61F5/0053 ,  A61F2/0036 ,  A61F5/003 ,  A61F5/0056 ,  A61F5/0059

摘要： An apparatus for regulating the functioning of a patient's organ or duct includes an elongated member having a first end and a second end. A fastener is disposed on the first end of the elongated member. The fastener is configured to engage the second end of the elongated member so that the elongated member forms a loop around the organ or duct. A tension element is disposed for movement within the elongated member. A drive element is associated with and engages the tension element for causing the tension element to control the tension applied by the elongated member against a patient's body organ or duct. A tension release mechanism is associated with the tension element.

摘要翻译： 用于调节患者器官或管道的功能的装置包括具有第一端和第二端的细长构件。 紧固件设置在细长构件的第一端上。 紧固件构造成接合细长构件的第二端，使得细长构件围绕器官或管道形成环。 张力元件设置成在细长构件内移动。 驱动元件与张力元件相关联并与其接合，用于使张力元件控制由细长构件施加的抗张力抵靠患者身体器官或管道的张力。 张力释放机构与张力元件相关联。

公开(公告)号：US20110071557A1

公开(公告)日：2011-03-24

申请号：US12562250

申请日：2009-09-18

申请人： Daniel F. Dlugos, JR. ,  Toralf Bork ,  Christine H. Chen ,  Rocco Crivelli ,  Donna L. Korvick ,  David T. Krumanaker ,  Timothy P. Lessek ,  Amy L. Marcotte ,  Jeffrey D. Messerly ,  Daniel J. Mumaw ,  Anil K. Nalagatla ,  David N. Plescia ,  Frederick E. Shelton, IV ,  Jeffrey S. Swayze ,  Patrick J. Swindon ,  Mark Tsonton ,  Scott A. Woodruff

发明人： Daniel F. Dlugos, JR. ,  Toralf Bork ,  Christine H. Chen ,  Rocco Crivelli ,  Donna L. Korvick ,  David T. Krumanaker ,  Timothy P. Lessek ,  Amy L. Marcotte ,  Jeffrey D. Messerly ,  Daniel J. Mumaw ,  Anil K. Nalagatla ,  David N. Plescia ,  Frederick E. Shelton, IV ,  Jeffrey S. Swayze ,  Patrick J. Swindon ,  Mark Tsonton ,  Scott A. Woodruff

IPC分类号： A61B17/122 ,  A61F2/04

CPC分类号： A61F5/0059 ,  A61B17/12009 ,  A61F2/0036 ,  A61F5/003 ,  A61F5/0053 ,  A61F5/0056 ,  A61F2250/0002

摘要： An apparatus for regulating the functioning of a patient's organ or duct includes an elongated member having a first end and a second end. A fastener is disposed on the first end of the elongated member. The fastener is configured to engage the second end of the elongated member so that the elongated member forms a loop around the organ or duct. A tension element is disposed for movement within the elongated member. A symmetrical drive system including a drive element associated with and engaging the tension element for causing the tension element to control the tension applied by the elongated member against a patient's body organ or duct is further provided. In accordance with an alternate embodiment an apparatus for regulating the functioning of a patient's organ or duct including an elongated member having a first end and a second end. A fastener is disposed on the first end of the elongated member. The fastener is configured to engage the second end of the elongated member so that the elongated member forms a loop around the organ or duct. A tension element is disposed for movement within the elongated member. The tension element is composed of a flexible first member and a flexible second member, wherein the flexible first member is movable relative to the flexible second member. A drive element is associated with and engages the tension element for causing the tension element to control the tension applied by the elongated member against a patient's body organ or duct.

摘要翻译： 用于调节患者器官或管道的功能的装置包括具有第一端和第二端的细长构件。 紧固件设置在细长构件的第一端上。 紧固件构造成接合细长构件的第二端，使得细长构件围绕器官或管道形成环。 张力元件设置成在细长构件内移动。 进一步提供一种对称的驱动系统，其包括与紧张元件相关联并与其接合的驱动元件，用于使张力元件控制细长构件对患者身体器官或管道施加的张力。 根据替代实施例，一种用于调节患者器官或管道的功能的装置，包括具有第一端和第二端的细长构件。 紧固件设置在细长构件的第一端上。 紧固件构造成接合细长构件的第二端，使得细长构件围绕器官或管道形成环。 张力元件设置成在细长构件内移动。 张力元件由柔性第一构件和柔性第二构件构成，其中柔性第一构件可相对于柔性第二构件移动。 驱动元件与张力元件相关联并与其接合，用于使张力元件控制由细长构件施加的抗张力抵靠患者身体器官或管道的张力。

公开(公告)号：US08617049B2

公开(公告)日：2013-12-31

申请号：US12562250

申请日：2009-09-18

申请人： Daniel F. Dlugos, Jr. ,  Toralf Bork ,  Christine H. Chen ,  Rocco Crivelli ,  Donna L. Korvick ,  David T. Krumanaker ,  Timothy P. Lessek ,  Amy L. Marcotte ,  Jeffrey D. Messerly ,  Daniel J. Mumaw ,  Anil K. Nalagatla ,  David N. Plescia ,  Frederick E. Shelton, IV ,  Jeffrey S. Swayze ,  Patrick J. Swindon ,  Mark Tsonton ,  Scott A. Woodruff

发明人： Daniel F. Dlugos, Jr. ,  Toralf Bork ,  Christine H. Chen ,  Rocco Crivelli ,  Donna L. Korvick ,  David T. Krumanaker ,  Timothy P. Lessek ,  Amy L. Marcotte ,  Jeffrey D. Messerly ,  Daniel J. Mumaw ,  Anil K. Nalagatla ,  David N. Plescia ,  Frederick E. Shelton, IV ,  Jeffrey S. Swayze ,  Patrick J. Swindon ,  Mark Tsonton ,  Scott A. Woodruff

IPC分类号： A61F2/00 ,  A61F13/00 ,  A61B17/08

CPC分类号： A61F5/0059 ,  A61B17/12009 ,  A61F2/0036 ,  A61F5/003 ,  A61F5/0053 ,  A61F5/0056 ,  A61F2250/0002

摘要： An apparatus for regulating the functioning of a patient's organ or duct includes an elongated member having a first end and a second end. A fastener is disposed on the first end of the elongated member. The fastener is configured to engage the second end of the elongated member so that the elongated member forms a loop around the organ or duct. A tension element is disposed for movement within the elongated member. A symmetrical drive system including a drive element associated with and engaging the tension element for causing the tension element to control the tension applied by the elongated member against a patient's body organ or duct is further provided. In accordance with an alternate embodiment an apparatus for regulating the functioning of a patient's organ or duct including an elongated member having a first end and a second end. A fastener is disposed on the first end of the elongated member. The fastener is configured to engage the second end of the elongated member so that the elongated member forms a loop around the organ or duct. A tension element is disposed for movement within the elongated member. The tension element is composed of a flexible first member and a flexible second member, wherein the flexible first member is movable relative to the flexible second member. A drive element is associated with and engages the tension element for causing the tension element to control the tension applied by the elongated member against a patient's body organ or duct.

摘要翻译： 用于调节患者器官或管道的功能的装置包括具有第一端和第二端的细长构件。 紧固件设置在细长构件的第一端上。 紧固件构造成接合细长构件的第二端，使得细长构件围绕器官或管道形成环。 张力元件设置成在细长构件内移动。 进一步提供一种对称的驱动系统，其包括与紧张元件相关联并与其接合的驱动元件，用于使张力元件控制细长构件对患者身体器官或管道施加的张力。 根据替代实施例，一种用于调节患者器官或管道的功能的装置，包括具有第一端和第二端的细长构件。 紧固件设置在细长构件的第一端上。 紧固件构造成接合细长构件的第二端，使得细长构件围绕器官或管道形成环。 张力元件设置成在细长构件内移动。 张力元件由柔性第一构件和柔性第二构件构成，其中柔性第一构件可相对于柔性第二构件移动。 驱动元件与张力元件相关联并与其接合，用于使张力元件控制由细长构件施加的抗张力抵靠患者身体器官或管道的张力。

公开(公告)号：US20120165794A1

公开(公告)日：2012-06-28

申请号：US12976761

申请日：2010-12-22

申请人： Mark S. Ortiz ,  Christopher J. Hess ,  Jason L. Harris ,  James W. Voegele ,  Mark S. Zeiner ,  Mark D. Overmyer ,  Joseph B. Kraimer ,  Jeff Shimizu ,  Rocco Crivelli ,  Yanik Tardy ,  Thierry Utard ,  Juergen Burger ,  Toralf Bork ,  Martin Pfleiderer ,  Olivier Chossat

发明人： Mark S. Ortiz ,  Christopher J. Hess ,  Jason L. Harris ,  James W. Voegele ,  Mark S. Zeiner ,  Mark D. Overmyer ,  Joseph B. Kraimer ,  Jeff Shimizu ,  Rocco Crivelli ,  Yanik Tardy ,  Thierry Utard ,  Juergen Burger ,  Toralf Bork ,  Martin Pfleiderer ,  Olivier Chossat

IPC分类号： A61M31/00

CPC分类号： A61B1/041 ,  A61B1/00147 ,  A61F5/0013 ,  A61M31/002

摘要： Devices and related methods are provided for the controlled delivery of a therapeutic to a targeted location within a body. More particularly, methods and devices are provided for controlling the rate of passage of an orally administered pill through a body, as well as for controlling the delivery of a therapeutic within the pill at a specific location within the body. Various types of devices, generally referred to herein as “catchers,” are provided that can actively catch a pill as it passes through a body. The catcher can hold the pill at a specific location within the body until a predetermined event occurs, such as partial or complete administration of a therapeutic within the pill. The catcher can then release the pill upon command and/or upon the occurrence of the predetermined event to allow the pill to pass out of the body. In other embodiments, various types of pills are provided that can actively engage a catcher and remain engaged with the catcher until a predetermined event occurs.

公开(公告)号：US20120150356A1

公开(公告)日：2012-06-14

申请号：US13400057

申请日：2012-02-18

申请人： Rocco Crivelli ,  Alec Ginggen ,  Toralf Bork

发明人： Rocco Crivelli ,  Alec Ginggen ,  Toralf Bork

IPC分类号： G05D7/06 ,  G05D7/00 ,  F16K31/02

CPC分类号： F16K31/006 ,  A61M5/14276 ,  A61M5/16881 ,  A61M5/172 ,  A61M39/22 ,  A61M2205/0294 ,  A61M2205/70 ,  A61M2205/702 ,  A61M2205/8212 ,  F16K1/34 ,  H01L41/042 ,  Y10T137/86389

摘要： Improving the accuracy of the flow rate of a valve in a fiuidic delivery device in which a desired flow rate may be achieved by varying the duty cycle of the valve. The flow rate of fluid delivery from the valve over its lifetime is stabilized by minimizing the voltage OPENING time of the valve to account for valve and piezoelectric actuator drift. Also, the valve OPENING time of one or more fiuidic parameters that impact on the flow rate delivery by the valve and differ among fiuidic delivery devices is compensated to optimize the flow rate accuracy.

摘要翻译： 提高流体输送装置中阀门的流量精度，其中可以通过改变阀的占空比来实现所需的流速。 通过最小化阀门的电压开启时间来解决阀门和压电致动器漂移，从而使阀门在其寿命期间的流体输送流量得到稳定。 此外，补偿了一个或多个影响阀门流量传递和流体输送装置不同的流体参数的阀门开启时间，以优化流量精度。

公开(公告)号：US08141844B2

公开(公告)日：2012-03-27

申请号：US12255666

申请日：2008-10-22

申请人： Rocco Crivelli ,  Alec Ginggen ,  Toralf Bork

发明人： Rocco Crivelli ,  Alec Ginggen ,  Toralf Bork

IPC分类号： F16K31/02

CPC分类号： F16K31/006 ,  A61M5/14276 ,  A61M5/16881 ,  A61M5/172 ,  A61M39/22 ,  A61M2205/0294 ,  A61M2205/70 ,  A61M2205/702 ,  A61M2205/8212 ,  F16K1/34 ,  H01L41/042 ,  Y10T137/86389

摘要： Improving the accuracy of the flow rate of a valve in a fluidic delivery device in which a desired flow rate may be achieved by varying the duty cycle of the valve. The flow rate of fluid delivery from the valve over its lifetime is stabilized by minimizing the voltage OPENING time of the valve to account for valve and piezoelectric actuator drift. Also, the valve OPENING time of one or more fluidic parameters that impact on the flow rate delivery by the valve and differ among fluidic delivery devices is compensated to optimize the flow rate accuracy.

公开(公告)号：US20090140184A1

公开(公告)日：2009-06-04

申请号：US12255662

申请日：2008-10-21

申请人： Rocco Crivelli ,  Alec Ginggen ,  Toralf Bork

发明人： Rocco Crivelli ,  Alec Ginggen ,  Toralf Bork

IPC分类号： F16K31/02

CPC分类号： A61M5/16881 ,  A61M5/14276 ,  A61M5/172 ,  A61M39/22 ,  A61M2205/0294 ,  A61M2205/70 ,  A61M2205/702 ,  A61M2205/8212 ,  F16K1/34 ,  F16K31/006 ,  H01L41/0933 ,  H02N2/06 ,  H02N2/067

摘要： Improving the accuracy of the flow rate of a valve in a fluidic delivery device in which a desired flow rate may be achieved by varying the duty cycle of the valve. The flow rate of fluid delivery from the valve over its lifetime is stabilized by minimizing the voltage OPENING time of the valve to account for valve and piezoelectric actuator drift. Also, the valve OPENING time of one or more fluidic parameters that impact on the flow rate delivery by the valve and differ among fluidic delivery devices is compensated to optimize the flow rate accuracy.