利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

26 条记录 (耗时 0.027 秒)

    Polymers with alkyl- or heteroalkyl -aryl backbone and pharmaceutical compositions incorporating same
    3.
    发明授权
    Polymers with alkyl- or heteroalkyl -aryl backbone and pharmaceutical compositions incorporating same 失效
    具有烷基 - 或杂烷基 - 芳基骨架的聚合物和包含其的药物组合物

    公开(公告)号：US5674482A

    公开(公告)日：1997-10-07

    申请号：US742794

    申请日：1991-08-09

    申请人： John R. Regan ,  Michael N. Chang ,  Jack Newman ,  Schmuel Ben-Sasson

    发明人： John R. Regan ,  Michael N. Chang ,  Jack Newman ,  Schmuel Ben-Sasson

    IPC分类号： A61K31/775 ,  C08G8/04

    CPC分类号： A61K31/775

    摘要： A biologically active polymeric compound comprising an alkylaryl or heteroalkylaryl backbone having about 5 to about 50 repeating aromatic ring-containing units and which, according to the computer program marketed as SYBYL.RTM. version 5.2 running on a DEC VAX.RTM. 11/750 computer, is capable of forming a linear backbone having a helical secondary structure, and wherein the maximum diameter of the helical structure, as measured by the alkylaryl or heteroalkylaryl backbone, is less than 3 times greater than the maximum diameter of the aryl group of the alkylaryl or heteroalkylaryl backbone.

    摘要翻译： 包含具有约5至约50个重复含芳环单元的烷基芳基或杂烷基芳基主链的生物活性聚合物，并且根据在DEC VAX TM 11/750计算机上运行的以SYBYL TM 5.2版为基础的计算机程序，其能够 形成具有螺旋二级结构的线性主链，并且其中通过烷基芳基或杂烷基芳基主链测量的螺旋结构的最大直径小于烷基芳基或杂烷基芳基骨架的芳基的最大直径的3倍 。

    Substituted 2,3,3a,6-tetrahydro-6-oxobenzofuran derivative useful as PAF antagonist
    8.
    发明授权
    Substituted 2,3,3a,6-tetrahydro-6-oxobenzofuran derivative useful as PAF antagonist 失效
    取代的2,3,3a，6-四氢-6-氧代苯并呋喃衍生物可用作PAF拮抗剂

    公开(公告)号：US4704462A

    公开(公告)日：1987-11-03

    申请号：US768009

    申请日：1985-08-22

    申请人： Michael N. Chang ,  San-Bao Hwang ,  Mitree M. Ponpipom ,  Robert L. Bugianesi

    发明人： Michael N. Chang ,  San-Bao Hwang ,  Mitree M. Ponpipom ,  Robert L. Bugianesi

    IPC分类号： C07D307/83

    CPC分类号： C07D307/83

    摘要： Substituted 2,3,3a,6-tetrahydro-6-oxobenzofuran derivatives have been prepared. These neolignans are found to have potent and specific PAF (Platelet-Activating-Factor) antagonistic activities and thereby useful in the treatment of various diseases or disorders mediated by PAF, for example, pain, fever, inflammation, cardiovascular disorder, asthma, lung edema, allergic disorders, skin diseases, psoriasis, toxic shock syndrome and adult respiratory distress syndrome.

    摘要翻译： 已经制备了取代的2,3,3a，6-四氢-6-氧代苯并呋喃衍生物。 发现这些新西兰人具有强效和特异性的PAF（血小板活化因子）拮抗活性，从而可用于治疗PAF介导的各种疾病或病症，例如疼痛，发烧，炎症，心血管疾病，哮喘，肺水肿 过敏性疾病，皮肤疾病，牛皮癣，中毒性休克综合症和成人呼吸窘迫综合征。

    5-(Pyrrol-2-oyl)-1,2-dihydro-3H-pyrrolo [1,2-a]pyrrole derivatives as anti-inflammatory and analgesic agents
    10.
    发明授权
    5-(Pyrrol-2-oyl)-1,2-dihydro-3H-pyrrolo [1,2-a]pyrrole derivatives as anti-inflammatory and analgesic agents 失效
    5-（吡咯-2-基）-1,2-二氢-3H-吡咯并[1,2-a]吡咯衍生物作为抗炎和止痛剂

    公开(公告)号：US4511724A

    公开(公告)日：1985-04-16

    申请号：US449302

    申请日：1982-12-13

    申请人： Michael N. Chang ,  Tesfaye Biftu

    发明人： Michael N. Chang ,  Tesfaye Biftu

    IPC分类号： C07D207/34 ,  C07D207/36 ,  C07D487/04 ,  C07H13/10 ,  C07D487/06 ,  A61K31/40

    CPC分类号： C07D487/04 ,  C07D207/34 ,  C07D207/36 ,  C07H13/10 ,  Y10S514/825

    摘要： Substituted 5-(pyrrol-2-oyl)1,2-dihydropyrrolo[1,2-a]-pyrrole derivatives have been prepared via decarboxylation of the corresponding 1,7-dicarboxylate prepared from condensation of a dialkyl 1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-7-dicarboxylate-7-carboxylic acid with an appropriately substituted 2-pyrroyl chloride, or conversely, an acid chloride of the former bicyclic compounds with a substituted pyrrole. The compounds are analgesic and anti-inflammatory agents of high activities but low ulcerogenic side effects.

    摘要翻译： 已经通过将1,2-二氢 - 吡咯并[1,2-a]吡咯衍生物的缩合制备的相应的1,7-二羧酸酯脱羧制备取代的5-（吡咯-2-基） 3H-吡咯并[1,2-a]吡咯-1,7-二羧酸酯-7-羧酸与适当取代的2-吡咯酰氯反应，前者的双环化合物与取代的吡咯的酰氯。 该化合物是具有高活性但低溃疡性副作用的止痛和抗炎药。