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公开(公告)号：US5359046A
公开(公告)日：1994-10-25
申请号：US988194
申请日：1992-12-09
IPC分类号： A61K39/395 , C07K14/00 , C07K14/705 , C07K14/725 , C07K14/73 , C07K14/735 , C07K16/00 , C07K19/00 , C12N5/10 , C12N15/09 , C12Q1/68 , C07H17/00 , A61K35/14 , C07K3/00 , C12P21/00
CPC分类号： C07K14/70535 , C07K14/7051 , C07K14/70514 , C07K2319/00 , C07K2319/02 , C07K2319/32
摘要： Chimeric proteins and DNA sequence encoding chimeric proteins are provided, where the chimeric proteins are characterized by an extracellular domain capable of binding to a ligand in a non-MHC restricted manner, a transmembrane domain and a cytoplasmic domain capable of activating a signaling pathway. The extracellular domain and cytoplasmic domain are not naturally found together. Binding of ligand to the extracellular domain results in transduction of a signal and activation of a signaling pathway in the cell, whereby the cell may be induced to carry out various functions relating to the signalling pathway. A wide variety of extracellular domains may be employed as receptors, where such domains may be naturally occurring or synthetic. The chimeric DNA sequences may be used to modify lymphocytes as well as hematopoietic stem cells as precursors to a number of important cell types.
摘要翻译： 提供嵌合蛋白和编码嵌合蛋白的DNA序列，其中嵌合蛋白的特征在于能够以非MHC限制性方式结合配体的细胞外结构域，能够激活信号通路的跨膜结构域和胞质结构域。 细胞外结构域和细胞质结构域不是天生地共同发现的。 配体与细胞外结构域的结合导致信号的转导和信号通路在细胞中的激活，由此可诱导细胞进行与信号通路相关的各种功能。 可以使用多种细胞外结构域作为受体，其中这些结构域可以是天然存在的或合成的。 嵌合DNA序列可用于修饰淋巴细胞以及造血干细胞，作为许多重要细胞类型的前体。
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公开(公告)号：US06319494B1
公开(公告)日：2001-11-20
申请号：US08479737
申请日：1995-06-07
IPC分类号： C12N1500
CPC分类号： C07K14/70514 , C07K14/7051 , C07K14/70535 , C07K2319/00
摘要： Chimeric proteins and DNA encoding chimeric proteins are provided, where the chimeric proteins are characterized by an extracellular domain capable of binding to a ligand in a non-MHC restricted manner, a transmembrane domain and a cytoplasmic domain capable of activating a signaling pathway. The extracellular domain and cytoplasmic domain are not naturally found together. Binding of ligand to the extracellular domain results in transduction of a signal and activation of a signaling pathway in the cell, whereby the cell may be induced to carry out various functions relating to the signalling pathway. A wide variety of extracellular domains may be employed as receptors, where such domains may be naturally occurring or synthetic. The chimeric DNA may be used to modify lymphocytes as well as hematopoietic stem cells as precursors to a number of important cell types.
摘要翻译： 提供嵌合蛋白和编码嵌合蛋白的DNA，其中嵌合蛋白的特征在于能够以非MHC限制性方式结合配体的细胞外结构域，能够激活信号通路的跨膜结构域和胞质结构域。 细胞外结构域和细胞质结构域不是天生地共同发现的。 配体与细胞外结构域的结合导致信号的转导和信号通路在细胞中的激活，由此可诱导细胞进行与信号通路相关的各种功能。 可以使用多种细胞外结构域作为受体，其中这些结构域可以是天然存在的或合成的。 嵌合DNA可用于修饰淋巴细胞以及造血干细胞作为许多重要细胞类型的前体。
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公开(公告)号：US06407221B1
公开(公告)日：2002-06-18
申请号：US08475442
申请日：1995-06-07
IPC分类号： C07H2104
CPC分类号： C07K14/70514 , C07K14/7051 , C07K14/70535 , C07K2319/00
摘要： Chimeric proteins and DNA encoding chimeric proteins are provided, where the chimeric proteins are characterized by an extracellular domain capable of binding to a ligand in a non-MHC restricted manner, a transmembrane domain and a cytoplasmic domain capable of activating a signaling pathway. The extracellular domain and cytoplasmic domain are not naturally found together. Binding of ligand to the extracellular domain results in transduction of a signal and activation of a signaling pathway in the cell, whereby the cell may be induced to carry out various functions relating to the signalling pathway. A wide variety of extracellular domains may be employed as receptors, where such domains may be naturally occurring or synthetic. The chimeric DNA may be used to modify lymphocytes as well as hematopoietic stem cells as precursors to a number of important cell types.
摘要翻译： 提供嵌合蛋白和编码嵌合蛋白的DNA，其中嵌合蛋白的特征在于能够以非MHC限制性方式结合配体的细胞外结构域，能够激活信号通路的跨膜结构域和胞质结构域。 细胞外结构域和细胞质结构域不是天生地共同发现的。 配体与细胞外结构域的结合导致信号的转导和信号通路在细胞中的激活，由此可诱导细胞进行与信号通路相关的各种功能。 可以使用多种细胞外结构域作为受体，其中这些结构域可以是天然存在的或合成的。 嵌合DNA可用于修饰淋巴细胞以及造血干细胞作为许多重要细胞类型的前体。
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4.发明申请公开(公告)号：US20100210596A1
公开(公告)日：2010-08-19
申请号：US12161914
申请日：2007-01-29
申请人： Jeffrey A. Bluestone , Arthur Weiss
发明人： Jeffrey A. Bluestone , Arthur Weiss
IPC分类号： A61K31/505 , A61K31/506 , A61K31/675 , A61P37/06
CPC分类号： A61K31/505
摘要： The present invention provides methods of treating immune disorders. The present invention provides methods of treating an autoimmune disorder; methods of reducing the risk of transplant rejection; methods of increasing transplant survival; and methods of treating graft-versus host disease. The methods generally involve administering to an individual in need thereof an effective amount of an aminopyrimidine compound.
摘要翻译： 本发明提供治疗免疫疾病的方法。 本发明提供治疗自身免疫性疾病的方法; 降低移植排斥风险的方法; 增加移植生存的方法; 以及治疗移植物抗宿主病的方法。 所述方法通常涉及向有需要的个体施用有效量的氨基嘧啶化合物。
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5.发明授权Screening assay for the identification ov novel immunosuppressives using cultured T cells 失效使用培养的T细胞鉴定ov新型免疫抑制剂的筛选试验
公开(公告)号：US5474897A
公开(公告)日：1995-12-12
申请号：US152955
申请日：1993-11-15
申请人： Arthur Weiss , James Fraser
发明人： Arthur Weiss , James Fraser
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6897
摘要： A method for identifying compounds capable of inducing immunosuppression by inhibiting the CD28 signal transduction pathway and T cell comprises exposing cultured T cells to one or more test compounds. The T cells are obtained from a T cell line which stably incorporates DNA sequence comprising in reading frame an enhancer region responsive to a CD28-regulated nuclear binding protein and a marker gene. The cells are cultured under conditions which result in activation of both the T cell receptor and the CD28 receptor, resulting in enhanced expression of the marker gene. Test compounds which inhibit expression of the marker gene are considered as candidates for immunosuppressive drugs.
摘要翻译： 通过抑制CD28信号转导途径和T细胞鉴定能够诱导免疫抑制的化合物的方法包括将培养的T细胞暴露于一种或多种测试化合物。 从T细胞系获得T细胞，T细胞系稳定地包含在读框中包含对CD28调节的核结合蛋白和标记基因有响应的增强子区的DNA序列。 在导致T细胞受体和CD28受体活化的条件下培养细胞，导致标记基因的表达增强。 抑制标记基因表达的测试化合物被认为是免疫抑制药物的候选物。
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