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公开(公告)号：US09023376B2
公开(公告)日：2015-05-05
申请号：US12492507
申请日：2009-06-26
CPC分类号： A61L31/127 , A61B2090/0816 , A61F2/0063 , A61F2002/009 , A61K9/00 , A61L31/042 , A61L2400/12 , D01D5/0076 , C08L5/02 , C08L67/04
摘要： A nanofiber-reinforced composition suited to applying to a wound site in a human body includes a carrier liquid and nanofibers dispersed therein in the carrier liquid. The viscosity of the composition is such that it is able to be applied through a tube yet adhere proximate the wound site to provide a barrier layer which assists in healing of the wound by spacing it from neighboring organs.
摘要翻译： 适用于人体伤口部位的纳米纤维增强组合物包含分散在载液中的载液和纳米纤维。 组合物的粘度使得其能够通过管施加而附着在伤口部位附近以提供阻挡层，其通过将其与相邻器官隔开来辅助伤口愈合。
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2.发明授权公开(公告)号：US06737447B1
公开(公告)日：2004-05-18
申请号：US09571444
申请日：2000-05-16
IPC分类号： A61L1504
CPC分类号： D01F6/96 , A61L15/26 , A61L15/44 , A61L17/145 , A61L27/34 , A61L27/54 , A61L29/085 , A61L29/16 , A61L31/10 , A61L31/16 , A61L2300/114 , A61L2300/606 , A61L2300/624 , Y10S623/926 , Y10S977/89 , Y10T428/2998 , C08L79/02
摘要： A novel coating for medical devices provides nitric oxide delivery using nanofibers of linear poly(ethylenimine)diazeniumdiolate. Linear poly(ethylenimine)diazeniumdiolate releases nitric oxide (NO) in a controlled manner to tissues and organs to aid the healing process and to prevent injury to tissues at risk of injury. Electrospun nano-fibers of linear poly(ethylenimine) diazeniumdiolate deliver therapeutic levels of NO to the tissues surrounding a medical device while minimizing the alteration of the properties of the device. A nanofiber coating, because of the small size and large surface area per unit mass of the nanofibers, provides a much larger surface area per unit mass while minimizing changes in other properties of the device.
摘要翻译： 用于医疗装置的新型涂层使用线性聚（亚乙基亚胺）二氮烯鎓二醇的纳米纤维提供一氧化氮递送。 线性聚（亚乙基亚胺）二氮烯鎓二硫酸盐以受控的方式将一氧化氮（NO）释放到组织和器官中，以帮助愈合过程并防止损伤组织的损伤。 线性聚（亚乙基亚胺）二氮烯鎓二醇的电纺纳米纤维向医疗装置周围的组织递送治疗水平的NO，同时最小化装置的性质的改变。 由于纳米纤维的每单位质量的小尺寸和大的表面积，纳米纤维涂层提供了更大的每单位质量的表面积，同时使装置的其它性质的变化最小化。
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公开(公告)号：US08240009B2
公开(公告)日：2012-08-14
申请号：US12829976
申请日：2010-07-02
IPC分类号： D01G13/00
CPC分类号： D04H3/16 , A61F13/0206 , A61F13/0209 , A61F13/0223 , A61F13/0226 , A61F13/0253 , A61L15/225 , A61L15/58 , A61L26/0052 , D04H1/728 , Y10T442/608 , Y10T442/642
摘要： In one embodiment, the present invention relates to a non-woven fiber assembly comprising one or more fibers wherein each fiber contains: a hydrophilic component; and an elastomeric component, and wherein the non-woven fiber assembly further comprises an adhesive component. In still another embodiment, the present invention relates to a non-woven fiber assembly comprising one or more fibers wherein each fiber contains: a hydrophilic component; an elastomeric component; and an adhesive component, wherein the hydrophilic component, the elastomeric component and the adhesive component are all contained within each fiber. Also disclosed is a method of making the afore-mentioned non-woven fiber assemblies. Additionally, a medical dressing made from the non-woven fiber assemblies of the present invention is disclosed.
摘要翻译： 在一个实施方案中，本发明涉及包含一种或多种纤维的无纺纤维组合物，其中每种纤维包含：亲水性组分; 和弹性体组分，并且其中所述无纺纤维组合件还包含粘合剂组分。 在另一个实施方案中，本发明涉及一种包含一种或多种纤维的无纺纤维组合物，其中每种纤维包含：亲水组分; 弹性体组分; 和粘合剂组分，其中亲水组分，弹性体组分和粘合剂组分都包含在每个纤维内。 还公开了制造上述无纺纤维组件的方法。 此外，公开了由本发明的无纺纤维组件制成的医用敷料。
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公开(公告)号：US20090075354A1
公开(公告)日：2009-03-19
申请号：US11916294
申请日：2006-06-07
CPC分类号： C12N1/04 , A61K9/70 , C12N9/96 , D04H1/407 , D04H1/4374 , D04H1/728 , Y10T428/298
摘要： The present invention relates generally to nanofiber structures designed to support, entrap, entangle, preserve, and/or retain one or more biological materials. More specifically, the present invention relates to nanofiber matrix structures made from at least two different types of nanofibers that are designed to support, entrap, entangle, preserve, and/or retain one or more biological materials.
摘要翻译： 本发明一般涉及被设计成支撑，夹带，缠结，保存和/或保留一种或多种生物材料的纳米纤维结构。 更具体地，本发明涉及由至少两种不同类型的纳米纤维制成的纳米纤维基质结构，其被设计成支撑，夹带，缠结，保存和/或保留一种或多种生物材料。
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公开(公告)号：US20120077280A1
公开(公告)日：2012-03-29
申请号：US13222296
申请日：2011-08-31
CPC分类号： B82Y20/00 , B82Y10/00 , C09K11/7706 , H01J2201/30469 , H01L31/02168 , Y02E10/50 , Y10T428/249921 , Y10T428/2918 , Y10T428/294 , Y10T428/2958 , Y10T428/2964
摘要： Nanofibers modified to alter their optical properties in the infrared part of the electromagnetic spectrum, which nanofibers can be used in applications ranging from identification technology to energy conversion devices (e.g., thermophotovoltaics) to stealth technology. The desired optical properties can be obtained by modifying the fibers with rare earth and other materials and then can be incorporated into garments or other composite structures or can be applied as coatings on solid surfaces, to be used in a number of applications that benefit from selective emission properties.
摘要翻译： 纳米纤维被修改以改变其在电磁光谱的红外部分中的光学性质，该纳米纤维可用于从识别技术到能量转换装置（例如，热光伏技术）到隐形技术的应用。 所需的光学性能可以通过用稀土和其它材料改性纤维来获得，然后可以掺入到衣服或其它复合结构中，或者可以作为固体表面上的涂层施用，以用于许多从选择性中受益的应用 发射特性。
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公开(公告)号：US06753454B1
公开(公告)日：2004-06-22
申请号：US09571841
申请日：2000-05-16
申请人： Daniel J. Smith , Darrell H. Reneker , Albert T. McManus , Heidi L. Schreuder-Gibson , Charlene Mello , Michael S. Sennett
发明人： Daniel J. Smith , Darrell H. Reneker , Albert T. McManus , Heidi L. Schreuder-Gibson , Charlene Mello , Michael S. Sennett
IPC分类号： A61F1300
CPC分类号： D01D5/0084 , A61L15/225 , A61L15/42 , D01D5/0076 , D01F1/10 , Y10S977/788 , Y10S977/961
摘要： A novel fiber comprising a substantially homogeneous mixture of a hydrophilic polymer and a polymer which is at least weakly hydrophobic is disclosed. The fiber optionally contains a pH adjusting compound. A method of making the fiber comprises electrospinning fibers of the substantially homogeneous polymer solution. A method of treating a wound or other area of a patient requiring protection from contamination comprises electrospinning the substantially homogeneous polymer solution to form a dressing. An apparatus for electrospinning a wound dressing is discosed.
摘要翻译： 公开了一种包含亲水性聚合物和至少具有弱疏水性的聚合物的基本上均匀的混合物的新型纤维。 纤维任选地含有pH调节化合物。 制造纤维的方法包括基本均匀的聚合物溶液的静电纺丝纤维。 治疗需要保护免受污染的患者的伤口或其他区域的方法包括电纺丝基本均匀的聚合物溶液以形成敷料。 摆放用于静电伤口敷料的装置。
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公开(公告)号：US07765647B2
公开(公告)日：2010-08-03
申请号：US10510457
申请日：2003-04-04
IPC分类号： D01G13/00
CPC分类号： D04H3/16 , A61F13/0206 , A61F13/0209 , A61F13/0223 , A61F13/0226 , A61F13/0253 , A61L15/225 , A61L15/58 , A61L26/0052 , D04H1/728 , Y10T442/608 , Y10T442/642
摘要： In one embodiment, the present invention relates to a non-woven fiber assembly comprising one or more fibers wherein each fiber contains: a hydrophilic component; and an elastomeric component, and wherein the non-woven fiber assembly further comprises an adhesive component. In still another embodiment, the present invention relates to a non-woven fiber assembly comprising one or more fibers wherein each fiber contains: a hydrophilic component; an elastomeric component; and an adhesive component, wherein the hydrophilic component, the elastomeric component and the adhesive component are all contained within each fiber. Also disclosed is a method of making the afore-mentioned non-woven fiber assemblies. Additionally, a medical dressing made from the non-woven fiber assemblies of the present invention is disclosed.
摘要翻译： 在一个实施方案中，本发明涉及包含一种或多种纤维的无纺纤维组合物，其中每种纤维包含：亲水性组分; 和弹性体组分，并且其中所述无纺纤维组合件还包含粘合剂组分。 在另一个实施方案中，本发明涉及一种包含一种或多种纤维的无纺纤维组合物，其中每种纤维包含：亲水组分; 弹性体组分; 和粘合剂组分，其中亲水组分，弹性体组分和粘合剂组分都包含在每个纤维内。 还公开了制造上述无纺纤维组件的方法。 此外，公开了由本发明的无纺纤维组件制成的医用敷料。
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8.发明授权公开(公告)号：US06855366B2
公开(公告)日：2005-02-15
申请号：US10738582
申请日：2003-12-16
IPC分类号： A61L15/26 , A61L15/44 , A61L17/14 , A61L27/34 , A61L27/54 , A61L29/08 , A61L29/16 , A61L31/10 , A61L31/16 , B05D1/00 , A61F2/00 , A61L15/04
CPC分类号： D01F6/96 , A61L15/26 , A61L15/44 , A61L17/145 , A61L27/34 , A61L27/54 , A61L29/085 , A61L29/16 , A61L31/10 , A61L31/16 , A61L2300/114 , A61L2300/606 , A61L2300/624 , Y10S623/926 , Y10S977/89 , Y10T428/2998 , C08L79/02
摘要： A novel coating for medical devices provides nitric oxide delivery using nanofibers of linear poly(ethylenimine)diazeniumdiolate. Linear poly(ethylenimine)diazeniumdiolate releases nitric oxide (NO) in a controlled manner to tissues and organs to aid the healing process and to prevent injury to tissues at risk of injury. Electrospun nano-fibers of linear poly(ethylenimine) diazeniumdiolate deliver therapeutic levels of NO to the tissues surrounding a medical device while minimizing the alteration of the properties of the device. A nanofiber coating, because of the small size and large surface area per unit mass of the nanofibers, provides a much larger surface area per unit mass while minimizing changes in other properties of the device.
摘要翻译： 用于医疗装置的新型涂层使用线性聚（亚乙基亚胺）二氮烯鎓二醇的纳米纤维提供一氧化氮递送。 线性聚（亚乙基亚胺）二氮烯鎓二硫酸盐以受控的方式将一氧化氮（NO）释放到组织和器官中，以帮助愈合过程并防止损伤组织的损伤。 线性聚（亚乙基亚胺）二氮烯鎓二醇的电纺纳米纤维向医疗装置周围的组织递送治疗水平的NO，同时最小化装置的性质的改变。 由于纳米纤维的每单位质量的小尺寸和大的表面积，纳米纤维涂层提供了更大的每单位质量的表面积，同时使装置的其它性质的变化最小化。
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公开(公告)号：US08568768B2
公开(公告)日：2013-10-29
申请号：US10554191
申请日：2004-04-23
CPC分类号： A61K9/70 , Y10T442/2525
摘要： A fibrous assembly is provided for performing site-specific chemistry. In general the present invention provides a fibrous assembly comprising a first fiber that sequesters a first reactive component; and a second fiber that sequesters a second reactive component, wherein at least the first or second fiber releases its reactive component when the fiber is in the presence of a releasing agent, and wherein when the at least first or second fiber releases its reactive component, the first and second reactive components react with each other to form a reaction product. Related methods of manufacture and use are also provided.
摘要翻译： 提供纤维组件用于进行特定场地的化学。 通常，本发明提供了一种纤维组合件，其包括隔离第一反应组分的第一纤维; 以及隔离第二反应性组分的第二纤维，其中当纤维存在脱模剂时，至少第一或第二纤维释放其反应性组分，并且其中当所述至少第一或第二纤维释放其反应性组分时， 第一和第二反应性组分彼此反应以形成反应产物。 还提供了相关的制造和使用方法。
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公开(公告)号：US08367570B2
公开(公告)日：2013-02-05
申请号：US11435066
申请日：2006-05-16
IPC分类号： D04H1/00
CPC分类号： D04H1/728 , A61F13/53 , A61F13/531 , A61F2013/530299 , A61F2013/53791 , A61L15/225 , A61L26/0052 , B01J20/261 , D01D5/0038 , D01F1/10 , D01F6/88 , D01F6/94 , D04H3/02 , Y10T442/20 , Y10T442/60 , Y10T442/602 , Y10T442/609 , Y10T442/614 , Y10T442/653 , Y10T442/659 , Y10T442/666 , Y10T442/696
摘要： The present invention is generally directed to a liquid entrapping device having the capacity to absorb liquids. More particularly, the present invention is directed to a liquid entrapping device comprising an absorbent component, hydrophilic elastomeric fibrous component in fluid communication therewith, and optionally an adhesive component. The present invention is also directed to a liquid entrapping device having the capacity to absorb liquids while maintaining a suitable degree of mechanical strength. Furthermore, the present invention is generally directed to methods for making and using the foregoing devices and materials.
摘要翻译： 本发明一般涉及具有吸收液体的能力的液体截留装置。 更具体地说，本发明涉及一种液体捕获装置，其包括吸收组分，与其流体连通的亲水弹性体纤维组分和任选的粘合剂组分。 本发明还涉及具有吸收液体的能力同时保持适当程度的机械强度的液体截留装置。 此外，本发明一般涉及制造和使用上述装置和材料的方法。
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