摘要:
Dual NK2/NK3-antagonists corresponding to formula I: and physiologically compatible salts of such compounds in which X and R1 to R5 have specific defined meanings, pharmaceutical compositions containing such compounds, methods of using such compounds to treat or inhibit disorders mediated by tachykinin receptors, and a process for preparing such compounds.
摘要:
The invention relates to a group of hydronopol derivatives which are agonists on human ORL1 (nociceptin) receptors. The invention also relates to the preparation of these compounds, to pharmaceutical compositions containing a pharmacologically active amount of at least one of these novel hydronopol derivatives as an active ingredient, as well as to the use of these pharmaceutical compositions for the treatment of disorders in which ORL1 receptors are involved. The invention relates to compounds of the general formula (1) wherein the symbols have the meanings as given in the description.
摘要:
The invention relates to a cooling apparatus, especially for cryogenically preserving biological samples, comprising a duct (5) for delivering a coolant (3) to a cooling chamber (1), a heater (6) that has an adjustable first heating performance (P2) for heating the coolant (3) delivered to the cooling chamber (1), a first temperature sensor (8-10) for measuring the temperature (T2-T4) in the cooling chamber (1), a second temperature sensor (7) for measuring the temperature (T1) of the coolant (3) delivered to the cooling chamber (1), and a regulator (11) for regulating the temperature. Said regulator (11) is embodied as a multiple regulator which detects several temperatures (T1-T4) as control variables and/or adjusts several heating performances (P1, P2) as manipulated variables. The invention further relates to a corresponding operating method.
摘要:
The invention relates to a device and method for handling a probe, in particular, for treating, examining, inserting or extracting a cryoprobe. According to the invention, said probe is surrounded by an ambient gas, during handling, and an air-conditioning device (33) cools, dries and/or at least partially replaces the ambient gas by a protective gas, in order to prevent deterioration of the probe by the ambient gas during handling.
摘要:
3-chloropropylsilanes are prepared from hydrogensilanes and allyl chloride, where a stoichiometric excess of allyl chloride is maintained in the condensate of the vapor emitted by the boiling reactant mixture.
摘要:
3-sulfonyl-3,7-diazabicyclo[3,3,1]nonane compounds corresponding to the formula: ##STR1## wherein R.sup.1 is alkyl, cycloalkylalkyl or benzyl,R.sup.2 is hydrogen or lower alkyl,R.sup.3 is hydrogen or lower alkyl orR.sup.2 and R.sup.3 together form an alkylene chain, andR.sup.4 represents lower alkyl, thienyl, halogen substituted thienyl or a --(CH.sub.2).sub.n --R.sup.5 group, wherein n=0-3 andR.sup.5 is an optionally substituted phenyl group.The compounds are pharmacologically active, particularly in influencing the motility of the stomach.
摘要:
To prevent elongation of a covering tape or ribbon (25) extending over an elongated opening (34) in an elongated base body (2) over which a movable element (3) can slide, the tape or ribbon is retained at preferably both of its ends, by a reverse motion, or one-way lock (50,52). In the simplest form, this reverse-motion lock (50,52) is formed by a leaf spring (63) extending at an acute angle with respect to the tape or ribbon; the tape or ribbon is backed up by bridge-like counter element (54) bridging over the elongated opening (34). If the tape or ribbon stretches, for example due to friction upon movement of the movable element (3) heating, or aging, and the movable element pushes the tape or ribbon in form of a bulge towards a terminal position, it can slide beneath the leaf spring and extend over an end portion of the base body; upon reverse motion of the movable element, the elongated end cannot, however, slip because of the one-way locking feature, thus retaining the tape or ribbon (25) taut against the opening (34) and effecting a good seal to prevent egress of operating fluid, as well as ingress of contamination, such as dirt, extraneous oil or the like.
摘要:
3,7-Diazabicyclo[3,3,1]nonane compounds having valuable heart rate-affecting pharmacological properties corresponding to the Formula I: ##STR1## wherein R.sup.1 is alkyl, cycloalkylalkyl or benzyl,R.sup.2 is lower alkyl,R.sup.3 is lower alkyl, orR.sup.2 and R.sup.3 together form an alkylene chain, andR.sup.4 represents a benzhydryl group, optionally substituted by halogen, lower alkoxy, lower alkyl, hydroxy or trifluoromethyl, or a cinnamyl group optionally substituted by halogen, lower alkyl, lower alkoxy, hydroxy, nitro or trifluoromethyl.
摘要:
The invention relates to a cooling apparatus, especially for cryogenically preserving biological samples, comprising a duct (5) for delivering a coolant (3) to a cooling chamber (1), a heater (6) that has an adjustable first heating performance (P2) for heating the coolant (3) delivered to the cooling chamber (1), a first temperature sensor (8-10) for measuring the temperature (T2-T4) in the cooling chamber (1), a second temperature sensor (7) for measuring the temperature (T1) of the coolant (3) delivered to the cooling chamber (1), and a regulator (11) for regulating the temperature. Said regulator (11) is embodied as a multiple regulator which detects several temperatures (T1-T4) as control variables and/or adjusts several heating performances (P1, P2) as manipulated variables. The invention further relates to a corresponding operating method.
摘要:
The invention relates to a trunk of a motor vehicle, having a goods rail (14) which is oriented approximately in the direction of the longitudinal axis (L) of the vehicle and is intended for fixing goods to be transported. In the event of a rear impact, penetration into a seat region arranged in front of the trunk is prevented by reducing the effective of the goods rail (14), by the goods rail (14) being composed of at least two partial rails (15, 16). According to the invention, the separating plane (17) between the partial rails (15, 16) runs in an obliquely inclined manner.