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    7-phenyl-1, 4-diazepane compounds, process for their preparation, and pharmaceutical compositions containing them
    4.
    发明授权
    7-phenyl-1, 4-diazepane compounds, process for their preparation, and pharmaceutical compositions containing them 有权
    7-苯基-1,4-二氮杂环丁烷化合物，其制备方法和含有它们的药物组合物

    公开(公告)号：US6040303A

    公开(公告)日：2000-03-21

    申请号：US141312

    申请日：1998-08-27

    申请人： Samuel David ,  Jochen Antel ,  Reinhard Brueckner ,  Dieter Ziegler ,  Christian Eeckhout ,  Gerhard-Wilhelm Bielenberg ,  Michael Peck

    发明人： Samuel David ,  Jochen Antel ,  Reinhard Brueckner ,  Dieter Ziegler ,  Christian Eeckhout ,  Gerhard-Wilhelm Bielenberg ,  Michael Peck

    IPC分类号： A61K31/55 ,  A61P1/00 ,  A61P43/00 ,  C07D243/08

    CPC分类号： C07D243/08 ,  Y02P20/55

    摘要： Neurokinin-antagonistic compounds corresponding to formula I: ##STR1## in which R.sup.1 is hydrogen or lower alkyl,R.sup.2 is hydrogen, lower alkyl, lower alkoxy, halogen or trifluoromethyl, andR.sup.3 is hydrogen, lower alkyl, lower alkoxy, halogen or trifluoromethyl, orR.sup.2 and R.sup.3 together are alkylenedioxy with 1 to 2 carbon atoms, bonded to adjacent carbon atoms of the phenyl ring,R.sup.4 is hydrogen, lower alkyl, lower alkoxy, halogen or trifluoromethyl, andR.sup.5 is hydrogen, lower alkyl, lower alkoxy, halogen or trifluoromethyl, orR.sup.4 and R.sup.5 together are alkylenedioxy with 1 to 2 carbon atoms, bonded to adjacent carbon atoms of the phenyl ring,R.sup.6 is lower alkyl, halogen or trifluoromethyl,R.sup.7 is lower alkyl, halogen or trifluoromethyl,A is a --(CH.sub.2).sub.n -- group in which n represents an integer from 1 to 3, or an --NH--(CH.sub.2).sub.m -- group in which m represents an integer from 2 to 3, andB is an alkylene chain with 1 to 3 carbon atoms optionally substituted by lower alkyl,and physiologically acceptable salts thereof and processes for the preparation of these compounds.

    摘要翻译： 对应于式I的神经激肽拮抗化合物：其中R1是氢或低级烷基，R2是氢，低级烷基，低级烷氧基，卤素或三氟甲基，R3是氢，低级烷基，低级烷氧基，卤素或三氟甲基，或R2和 R3一起是具有1至2个碳原子的亚烷基二氧基，与苯环的相邻碳原子键合，R4是氢，低级烷基，低级烷氧基，卤素或三氟甲基，R5是氢，低级烷基，低级烷氧基，卤素或三氟甲基， 或R4和R5一起是具有1至2个碳原子的亚烷基二氧基，与苯环的相邻碳原子键合，R6是低级烷基，卤素或三氟甲基，R7是低级烷基，卤素或三氟甲基，A是 - （CH2）n - 其中n表示1至3的整数的基团，或其中m表示2至3的整数的-NH-（CH 2）m - 基团，B是具有1至3个碳原子的亚烷基链，其任选被 低级烷基和其生理上可接受的盐 d制备这些化合物的方法。

    Method of treating or inhibiting functional disturbances or illnesses of the lower intestinal tracts, particularly abdominal visceral pain which accompanies them
    9.
    发明授权
    Method of treating or inhibiting functional disturbances or illnesses of the lower intestinal tracts, particularly abdominal visceral pain which accompanies them 有权
    治疗或抑制下肠道功能障碍或疾病的方法，特别是伴随其的腹部内脏痛

    公开(公告)号：US06300336B1

    公开(公告)日：2001-10-09

    申请号：US09525896

    申请日：2000-03-15

    申请人： Christian Eeckhout ,  Holger Sann

    发明人： Christian Eeckhout ,  Holger Sann

    IPC分类号： A61K31505

    CPC分类号： A61K31/506

    摘要： The use of moxonidine or a physiologically compatible acid addition salt thereof for the treatment and/or inhibition of functional gastrointestinal disturbances or illnesses in the region of the lower intestinal tracts, particularly for the treatment and/or inhibition of abdominal visceral pain which accompanies them, and the preparation of pharmaceutical compositions suitable for this treatment are is described. The functional disturbances and illnesses of the lower intestinal tracts which can be treated according to the invention are known in particular as irritable bowel syndrome (IBS) and inflammatory bowel disease (IBD), which generally also include visceral pain as one of their symptoms.

    摘要翻译： 莫西尼定或其生理上相容的酸加成盐用于治疗和/或抑制下肠道区域功能性胃肠道紊乱或疾病，特别是用于治疗和/或抑制伴随其的腹部内脏痛， 并描述了适用于该处理的药物组合物的制备。 根据本发明可以治疗的下肠道的功能紊乱和疾病特别是已知的肠易激综合征（IBS）和炎症性肠病（IBD），其通常还包括作为其症状之一的内脏痛。