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34 条记录 (耗时 0.026 秒)

    Method of treating or inhibiting obesity
    6.
    发明授权
    Method of treating or inhibiting obesity 有权
    治疗或抑制肥胖症的方法

    公开(公告)号：US07238470B2

    公开(公告)日：2007-07-03

    申请号：US10785042

    申请日：2004-02-25

    申请人： Johannes Hebebrand ,  Jochen Antel ,  Ulf Preuschoff ,  Samuel David ,  Holger Sann ,  Michael Weske

    发明人： Johannes Hebebrand ,  Jochen Antel ,  Ulf Preuschoff ,  Samuel David ,  Holger Sann ,  Michael Weske

    IPC分类号： C12Q1/00

    CPC分类号： A61K31/34 ,  C12Q1/527 ,  G01N33/6893 ,  G01N2800/044

    摘要： A method for the discovery of compounds suitable for the treatment and/or prophylaxis of obesity, in which the ability of the test compounds to inhibit de novo lipogenesis in mammals and/or man is determined. The use of compounds which are capable of inhibiting de novo lipogenesis in mammals, and which are substantially free of effects directed towards the CNS, for the preparation of pharmaceutical compositions for the treatment and/or prophylaxis of obesity, as well as for the treatment and/or inhibition of obesity, are also described.

    摘要翻译： 发现适用于治疗和/或预防肥胖症的化合物的方法，其中测定化合物在哺乳动物和/或人中抑制新生脂肪生成的能力。 使用能够在哺乳动物中抑制从头脂肪生成并且基本上没有针对CNS的作用的化合物用于制备用于治疗和/或预防肥胖症的药物组合物，以及用于治疗和/ /或抑制肥胖。

    Method of preparing pharmaceutical compositions
    8.
    发明授权
    Method of preparing pharmaceutical compositions 有权
    制备药物组合物的方法

    公开(公告)号：US07282325B2

    公开(公告)日：2007-10-16

    申请号：US10785043

    申请日：2004-02-25

    申请人： Johannes Hebebrand ,  Jochen Antel ,  Ulf Preuschoff ,  Samuel David ,  Holger Sann ,  Michael Weske

    发明人： Johannes Hebebrand ,  Jochen Antel ,  Ulf Preuschoff ,  Samuel David ,  Holger Sann ,  Michael Weske

    IPC分类号： C12Q1/00

    CPC分类号： A61K31/34 ,  C12Q1/527 ,  G01N33/6893 ,  G01N2800/044

    摘要： A method for the discovery of compounds suitable for the treatment and/or prophylaxis of obesity, in which the ability of the test compounds to inhibit de novo lipogenesis in mammals and/or man is determined. The use of compounds which are capable of inhibiting de novo lipogenesis in mammals, and which are substantially free of effects directed towards the CNS, for the preparation of pharmaceutical compositions for the treatment and/or prophylaxis of obesity, as well as for the treatment and/or inhibition of obesity, are also described.

    摘要翻译： 发现适用于治疗和/或预防肥胖症的化合物的方法，其中测定化合物在哺乳动物和/或人中抑制新生脂肪生成的能力。 使用能够在哺乳动物中抑制从头脂肪生成并且基本上没有针对CNS的作用的化合物用于制备用于治疗和/或预防肥胖症的药物组合物，以及用于治疗和/ /或抑制肥胖。

    7-phenyl-1, 4-diazepane compounds, process for their preparation, and pharmaceutical compositions containing them
    9.
    发明授权
    7-phenyl-1, 4-diazepane compounds, process for their preparation, and pharmaceutical compositions containing them 有权
    7-苯基-1,4-二氮杂环丁烷化合物，其制备方法和含有它们的药物组合物

    公开(公告)号：US6040303A

    公开(公告)日：2000-03-21

    申请号：US141312

    申请日：1998-08-27

    申请人： Samuel David ,  Jochen Antel ,  Reinhard Brueckner ,  Dieter Ziegler ,  Christian Eeckhout ,  Gerhard-Wilhelm Bielenberg ,  Michael Peck

    发明人： Samuel David ,  Jochen Antel ,  Reinhard Brueckner ,  Dieter Ziegler ,  Christian Eeckhout ,  Gerhard-Wilhelm Bielenberg ,  Michael Peck

    IPC分类号： A61K31/55 ,  A61P1/00 ,  A61P43/00 ,  C07D243/08

    CPC分类号： C07D243/08 ,  Y02P20/55

    摘要： Neurokinin-antagonistic compounds corresponding to formula I: ##STR1## in which R.sup.1 is hydrogen or lower alkyl,R.sup.2 is hydrogen, lower alkyl, lower alkoxy, halogen or trifluoromethyl, andR.sup.3 is hydrogen, lower alkyl, lower alkoxy, halogen or trifluoromethyl, orR.sup.2 and R.sup.3 together are alkylenedioxy with 1 to 2 carbon atoms, bonded to adjacent carbon atoms of the phenyl ring,R.sup.4 is hydrogen, lower alkyl, lower alkoxy, halogen or trifluoromethyl, andR.sup.5 is hydrogen, lower alkyl, lower alkoxy, halogen or trifluoromethyl, orR.sup.4 and R.sup.5 together are alkylenedioxy with 1 to 2 carbon atoms, bonded to adjacent carbon atoms of the phenyl ring,R.sup.6 is lower alkyl, halogen or trifluoromethyl,R.sup.7 is lower alkyl, halogen or trifluoromethyl,A is a --(CH.sub.2).sub.n -- group in which n represents an integer from 1 to 3, or an --NH--(CH.sub.2).sub.m -- group in which m represents an integer from 2 to 3, andB is an alkylene chain with 1 to 3 carbon atoms optionally substituted by lower alkyl,and physiologically acceptable salts thereof and processes for the preparation of these compounds.

    摘要翻译： 对应于式I的神经激肽拮抗化合物：其中R1是氢或低级烷基，R2是氢，低级烷基，低级烷氧基，卤素或三氟甲基，R3是氢，低级烷基，低级烷氧基，卤素或三氟甲基，或R2和 R3一起是具有1至2个碳原子的亚烷基二氧基，与苯环的相邻碳原子键合，R4是氢，低级烷基，低级烷氧基，卤素或三氟甲基，R5是氢，低级烷基，低级烷氧基，卤素或三氟甲基， 或R4和R5一起是具有1至2个碳原子的亚烷基二氧基，与苯环的相邻碳原子键合，R6是低级烷基，卤素或三氟甲基，R7是低级烷基，卤素或三氟甲基，A是 - （CH2）n - 其中n表示1至3的整数的基团，或其中m表示2至3的整数的-NH-（CH 2）m - 基团，B是具有1至3个碳原子的亚烷基链，其任选被 低级烷基和其生理上可接受的盐 d制备这些化合物的方法。