公开(公告)号：US4001265A

公开(公告)日：1977-01-04

申请号：US554848

申请日：1975-03-03

申请人： Daniel Tim-Wo Chu ,  David Lyon Garmaise

发明人： Daniel Tim-Wo Chu ,  David Lyon Garmaise

IPC分类号： C07C233/00 ,  C07D413/10 ,  C07D261/16

CPC分类号： C07D413/10 ,  C07C233/00

摘要： A specific anilino derivative of chelocardin having high antibiotic activity is described. This new derivative shows unusually low toxicity and consequently a very high therapeutic index as chemotherapeutic agent against gram-negative organisms.

公开(公告)号：US3963774A

公开(公告)日：1976-06-15

申请号：US554849

申请日：1975-03-03

申请人： Daniel Tim-Wo Chu ,  David Lyon Garmaise

发明人： Daniel Tim-Wo Chu ,  David Lyon Garmaise

IPC分类号： C07C233/00 ,  C07D413/10 ,  C07C97/10 ,  C07C101/48

CPC分类号： C07D413/10 ,  C07C233/00

摘要： A number of specific anilino derivatives of chelocardin having high antibiotic activity are described. These new derivatives show unusually low toxicity and consequently a very high therapeutic index as chemotherapeutic agents against gram-negative organisms.

摘要翻译： 描述了具有高抗生素活性的许多具有较高抗生素活性的特洛西汀的特定苯胺基衍生物。 这些新的衍生物显示异常低的毒性，因此作为抗革兰氏阴性生物体的化学治疗剂具有非常高的治疗指数。

公开(公告)号：US3971849A

公开(公告)日：1976-07-27

申请号：US471940

申请日：1974-05-21

申请人： Raj Nandan Prasad ,  David Lyon Garmaise

发明人： Raj Nandan Prasad ,  David Lyon Garmaise

IPC分类号： C07H19/16

CPC分类号： A61K31/70 ,  C07H19/16

摘要： Esters of 1,N.sup.6 -etheno-5'-adenosine carboxylic acid represented by the formula ##SPC1##Wherein R.sub.1 is loweralkyl, loweralkenyl, loweralkynyl or cycloalkyl; and R.sub.2 and R.sub.3 each are hydrogen or acyl, or R.sub.2 and R.sub. 3 taken together form an isopropylidene or benzylidene moiety; and the pharmaceutically acceptable acid addition salts thereof.The compounds wherein R.sub.2 and R.sub.3 are hydrogen are useful in treating cardiovascular disorders and are particularly useful as anti-anginal and anti-hypertensive agents. Compounds wherein R.sub.2 and R.sub.3 are acyl or when taken together form an isopropylidene or benzylidene moiety are intermediates useful in the preparation of the final products. (R.sub.2 and R.sub.3 = hydrogen). The final products are also useful as intermediates for preparing pharmaceutically active compounds, and, more specifically, for preparing the corresponding 1,N.sup.6 -etheno-5'-adenosine carboxamides.

摘要翻译： 由式WHEREIN R1表示的1，N6-乙烯基-5'-腺苷羧酸的酯是低级烷基，低级烯基，低级炔基或环烷基; 并且R 2和R 3各自为氢或酰基，或者R 2和R 3一起形成异亚丙基或亚苄基部分; 及其药学上可接受的酸加成盐。

公开(公告)号：US3988446A

公开(公告)日：1976-10-26

申请号：US521727

申请日：1974-11-07

申请人： Gerard Yvon Paris ,  David Lyon Garmaise

发明人： Gerard Yvon Paris ,  David Lyon Garmaise

IPC分类号： C07C69/003 ,  A61K31/215 ,  A61K31/225 ,  A61K31/403 ,  A61K31/404 ,  A61K31/405 ,  A61P29/00 ,  C07C67/14 ,  C07C69/00 ,  C07C69/612 ,  C07C69/66 ,  C07D209/26 ,  C07D209/28 ,  C11C3/04 ,  C07D209/04 ,  C07C69/52 ,  C07D207/24 ,  C11C3/02

CPC分类号： C07D209/28 ,  C11C3/04

摘要： Triglycerides carrying the anti-inflammatory drug moiety in the 2-position and hydrocarbon acyl moieties in the 1- and 3-position exhibit excellent anti-inflammatory properties without causing the side effects often associated with the anti-inflammatory drug itself.

摘要翻译： 在2-位上携带抗炎药物部分的甘油三酯和1-和3-位的烃酰基部分表现出优异的抗炎性质，而不引起通常与抗炎药物本身有关的副作用。

公开(公告)号：US3931401A

公开(公告)日：1976-01-06

申请号：US472029

申请日：1974-05-21

申请人： Raj Nandan Prasad ,  David Lyon Garmaise

发明人： Raj Nandan Prasad ,  David Lyon Garmaise

IPC分类号： C07H19/16 ,  A61K31/70

CPC分类号： C07H19/16

摘要： Amides of 1,N.sup.6 -Etheno-5'-adensine carboxylic acid represented by the formula ##SPC1##Wherein R.sub.1 and R.sub.2 each are hydrogen, loweralkyl, loweralkenyl, loweralkynyl or cycloalkyl, and R.sub.3 and R.sub.4 each are hydrogen, acyl, or R.sub.3 and R.sub.4 taken together form an isopropylidene or benzylidene moiety; and the pharmaceutically acceptable acid addition salts thereof.The compounds wherein R.sub.3 and R.sub.4 are hydrogen are useful in treating cardiovascular disorders and are particularly useful as anti-anginal and anti-hypertensive agents. Compounds wherein R.sub.3 and R.sub.4 are acyl or when taken together form an isopropylidene or benzylidene moiety are intermediates useful in the preparation of the final products. (R.sub.3 and R.sub.4 = hydrogen).

摘要翻译： 由式WHEREIN R1和R2表示的1，N6-乙烯基-5'-连接羧酸的酰胺各自为氢，低级烷基，低级烯基，低级炔基或环烷基，R 3和R 4各自为氢，酰基，或者R 3和R 4一起 形成异丙叉或亚苄基部分; 及其药学上可接受的酸加成盐。