公开(公告)号：US20160158288A1

公开(公告)日：2016-06-09

申请号：US14903548

申请日：2014-07-14

申请人： Daohong ZHOU ,  Yi LUO ,  Lijian SHAO ,  Wei FENG ,  Jianhui CHANG ,  THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ARKANSAS

发明人： Daohong Zhou ,  Yi Luo ,  Lijian Shao ,  Wei Feng ,  Jianhui Chang

IPC分类号： A61K35/28 ,  C12N5/0789

CPC分类号： A61K35/28 ,  A61K35/15 ,  A61K2035/124 ,  C12N5/0647 ,  C12N2501/2304 ,  C12N2502/1157 ,  A61K2300/00

摘要： The invention generally features compositions and methods for expanding long term hematopoietic stem cells (HSCs) in a population of cells. In particular, the invention relates to a method of expanding long term HSCs by culturing an initial population of HSCs with macrophages that promote self-renewal of long term HSCs. The expanded cell population provides a source of cells for therapeutic treatments utilizing HSC transplantation.

摘要翻译： 本发明一般具有在细胞群中扩展长期造血干细胞（HSCs）的组合物和方法。 特别地，本发明涉及通过培养具有促进长期HSC的自我更新的巨噬细胞的初始HSC群体来扩展长期HSC的方法。 扩大的细胞群体提供了使用HSC移植治疗治疗的细胞来源。

公开(公告)号：US10137154B2

公开(公告)日：2018-11-27

申请号：US14903548

申请日：2014-07-14

申请人： THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ARKANSAS ,  Daohong Zhou ,  Yi Luo ,  Lijian Shao ,  Wei Feng ,  Jianhui Chang

发明人： Daohong Zhou ,  Yi Luo ,  Lijian Shao ,  Wei Feng ,  Jianhui Chang

IPC分类号： A61K35/28 ,  C12N5/0789 ,  A61K35/15 ,  A61K35/12

摘要： The invention generally features compositions and methods for expanding long term hematopoietic stem cells (HSCs) in a population of cells. In particular, the invention relates to a method of expanding long term HSCs by culturing an initial population of HSCs with macrophages that promote self-renewal of long term HSCs. The expanded cell population provides a source of cells for therapeutic treatments utilizing HSC transplantation.

公开(公告)号：US20070184021A1

公开(公告)日：2007-08-09

申请号：US10529661

申请日：2003-09-30

申请人： Daohong Zhou ,  Aimin Meng

发明人： Daohong Zhou ,  Aimin Meng

IPC分类号： A61K38/20 ,  A61K48/00 ,  A61K38/17

CPC分类号： G01N33/502 ,  A61K31/00 ,  A61K38/005 ,  A61K38/1761 ,  A61K38/18 ,  A61K38/193 ,  A61K38/20 ,  A61K45/06 ,  G01N33/5008 ,  G01N33/5017 ,  G01N33/5073 ,  G01N33/5094 ,  G01N2333/96466 ,  G01N2510/00 ,  A61K2300/00

摘要： The present invention provides methods for the treatment of radiation-induced injury by providing to a subject a caspase inhibitor. The caspase inhibitor may be provided before or after the radiation injury, and further may be provided in combination with a second caspase inhibitor, an anti-apoptotic molecule, a radioprotectant, a cytokine or a growth factor.

摘要翻译： 本发明提供了通过向受试者提供半胱天冬酶抑制剂来治疗放射线诱导的损伤的方法。 半胱天冬酶抑制剂可以在辐射损伤之前或之后提供，并且还可以与第二胱天蛋白酶抑制剂，抗凋亡分子，放射防护剂，细胞因子或生长因子组合提供。

公开(公告)号：US20070244076A1

公开(公告)日：2007-10-18

申请号：US10575188

申请日：2004-10-08

申请人： G. Meier ,  Aiping Bai ,  Daohong Zhou

发明人： G. Meier ,  Aiping Bai ,  Daohong Zhou

IPC分类号： A61K31/66 ,  A61K31/265 ,  C07F9/06

CPC分类号： C07F9/091

摘要： Compounds that are heteroatom substituted alkyl derivatives of tricyclodecan-9-yl-xanthogenate, and pharmaceutical compositions of these compounds, are disclosed. Methods of treating a disease or disorder in a subject and methods of protecting normal tissues in a subject from toxicity associated ionizing radiation or chemotherapy using compositions comprising these novel compounds are also disclosed. The invention also concerns methods of treating a disease or disorder in a subject using compositions that include these novel compounds while concurrently or consecutively treating the subject with ionizing radiation or a chemotherapeutic agent.

摘要翻译： 公开了作为三环癸基-9-基 - 黄原酸酯的杂原子取代的烷基衍生物的化合物和这些化合物的药物组合物。 还公开了治疗受试者的疾病或病症的方法以及使用包含这些新化合物的组合物来保护受试者中与正常组织相关的电离辐射或化学疗法的组合物的方法。 本发明还涉及使用包括这些新化合物的组合物治疗受试者的疾病或病症的方法，同时或连续地用电离辐射或化学治疗剂治疗受试者。