-
1.发明授权Catheter devices and methods for their use in the treatment of calcified vascular occlusions 有权导管装置及其用于治疗钙化血管闭塞的方法公开(公告)号：US06730063B2
公开(公告)日：2004-05-04
申请号：US09911529
申请日：2001-07-23
IPC分类号： A61M300
CPC分类号： A61B5/14539 , A61B17/22 , A61B2017/22084 , A61M29/02 , A61M2025/0004 , A61M2025/0034 , A61M2025/1052 , A61M2025/1093 , A61M2025/1095
摘要： Catheter devices and methods for their use in enhancing fluid flow through a vascular site occupied by a vascular occlusion are provided. The subject catheter devices include at least a first, second and third lumen, where: (a) the first lumen is used for delivery of an acidic dissolution solution to the vascular site; (b) the second lumen is used for delivery of a buffer solution to the vascular site; and (c) the third lumen is used for removal of fluid from the vascular site. In many preferred embodiments, the first, second and third lumens are coaxial. In practicing the subject methods, the vascular site is flushed simultaneously with an acidic dissolution fluid and a buffer solution, where flushing is carried out in a manner such that only a surface of the vascular occlusion is contacted with the acidic dissolution fluid and the remainder of the vascular site is not contacted with fluid having a pH that is lower than about 4. Flushing is carried out in this manner for a period of time sufficient for fluid flow through the vascular site to be enhanced, e.g. increased or established. The subject catheter devices and methods find use in the treatment of a variety of different vascular diseases characterized by the presence of calcified vascular occlusions, including peripheral and coronary vascular diseases.
摘要翻译： 提供了用于增强通过血管闭塞占据的血管部位的流体流动的导管装置和方法。 主题导管装置包括至少第一，第二和第三腔，其中：（a）第一腔用于将酸性溶解溶液递送至血管部位; （b）第二管腔用于将缓冲溶液递送至血管部位; 和（c）第三腔用于从血管部位去除流体。 在许多优选实施例中，第一，第二和第三管腔是同轴的。 在实施本发明的方法中，血管部位与酸性溶解液和缓冲溶液同时冲洗，其中以如下方式进行冲洗，使得只有血管闭塞的表面与酸性溶解液接触，其余部分 血管部位不与pH低于约4的液体接触。以这种方式进行冲洗足以使液体流过血管部位以增强的时间，例如 增加或建立 主题导管装置和方法可用于治疗各种不同血管疾病，其特征在于存在钙化血管闭塞，包括外周和冠状动脉血管疾病。
-
2.发明授权Catheter devices and methods for their use in the treatment of calcified vascular occlusions 有权导管装置及其用于治疗钙化血管闭塞的方法公开(公告)号：US06290689B1
公开(公告)日：2001-09-18
申请号：US09425826
申请日：1999-10-22
IPC分类号： A61M3100
CPC分类号： A61B5/14539 , A61B17/22 , A61B2017/22084 , A61M29/02 , A61M2025/0004 , A61M2025/0034 , A61M2025/1052 , A61M2025/1093 , A61M2025/1095
摘要： Catheter devices and methods for their use in enhancing fluid flow through a vascular site occupied by a vascular occlusion are provided. The subject catheter devices include at least a first, second and third lumen, where: (a) the first lumen is used for delivery of an acidic dissolution solution to the vascular site; (b) the second lumen is used for delivery of a buffer solution to the vascular site; and (c) the third lumen is used for removal of fluid from the vascular site. In many preferred embodiments, the first, second and third lumens are coaxial. In practicing the subject methods, the vascular site is flushed simultaneously with an acidic dissolution fluid and a buffer solution, where flushing is carried out in a manner such that only a surface of the vascular occlusion is contacted with the acidic dissolution fluid and the remainder of the vascular site is not contacted with fluid having a pH that is lower than about 4. Flushing is carried out in this manner for a period of time sufficient for fluid flow through the vascular site to be enhanced, e.g. increased or established. The subject catheter devices and methods find use in the treatment of a variety of different vascular diseases characterized by the presence of calcified vascular occlusions, including peripheral and coronary vascular diseases.
摘要翻译： 提供了用于增强通过血管闭塞占据的血管部位的流体流动的导管装置和方法。 主题导管装置包括至少第一，第二和第三腔，其中：（a）第一腔用于将酸性溶解溶液递送至血管部位; （b）第二管腔用于将缓冲溶液递送至血管部位; 和（c）第三腔用于从血管部位去除流体。 在许多优选实施例中，第一，第二和第三管腔是同轴的。 在实施本发明的方法中，血管部位与酸性溶解液和缓冲溶液同时冲洗，其中以如下方式进行冲洗，使得只有血管闭塞的表面与酸性溶解液接触，其余部分 血管部位不与pH低于约4的液体接触。以这种方式进行冲洗足以使液体流过血管部位以增强的时间，例如 增加或建立 主题导管装置和方法可用于治疗各种不同血管疾病，其特征在于存在钙化血管闭塞，包括外周和冠状动脉血管疾病。
-
3.发明授权Methods for enhancing fluid flow through an obstructed vascular site, and systems and kits for use in practicing the same 有权通过阻塞血管部位增强流体流动的方法，以及用于实施血管部位的系统和试剂盒公开(公告)号：US06488671B1
公开(公告)日：2002-12-03
申请号：US09528576
申请日：2000-03-20
IPC分类号： A61M3100
CPC分类号： A61B17/22 , A61B5/14539 , A61B2017/22084 , A61M29/02 , A61M2025/0004 , A61M2025/0034 , A61M2025/1052 , A61M2025/1093 , A61M2025/1095
摘要： Methods of enhancing fluid flow through a vascular site occupied by a vascular occlusion, as well as systems and kits for use in practicing the same, are provided. In practicing the subject methods, the vascular site is flushed simultaneously with a first dissolution fluid and a second dissolution fluid attenuating fluid, where flushing is carried out in a manner such that only a surface of the vascular occlusion is contacted with the non-attenuated dissolution fluid. Flushing is carried out in this manner for a period of time sufficient for fluid flow through the vascular site to be enhanced, e.g. increased or established. The subject methods, systems and kits for practicing the same find use in the treatment of a variety of different vascular diseases characterized by the presence of vascular occlusions, including both partial and total occlusions.
摘要翻译： 提供了通过血管闭塞所占据的血管部位增强流体流动的方法以及用于实施血管闭塞的系统和试剂盒。 在实施本发明方法时，血管部位与第一溶解流体和第二溶解流体衰减流体同时冲洗，其中冲洗以仅使血管闭塞的表面与非减毒溶解物接触的方式进行 流体。 以这种方式进行冲洗一段足以使流体流过血管部位以增强的时间，例如， 增加或建立 用于实践相同的主题方法，系统和试剂盒可用于治疗各种不同血管疾病，其特征在于存在血管闭塞，包括部分和全部闭塞。
-
公开(公告)号：US06562020B1
公开(公告)日：2003-05-13
申请号：US09483634
申请日：2000-01-14
IPC分类号： A61M2500
CPC分类号： A61M29/02 , A61B17/22 , A61B2017/22084 , A61M2025/0004 , A61M2025/0034 , A61M2025/1052 , A61M2025/1093 , A61M2025/1095
摘要： Kits for use in the treatment of vascular calcified lesions are provided. The subject kits include at least one of: (a) a fluid delivery means for conveying fluid to and from a vascular site; and (b) a dissolution fluid for at least partially dissolving the target lesion. In many embodiments, the kits include both of these components. The subject kits further include instructions for treating vascular calcified lesions with the contents of the kit, where the instructions are typically recorded on a recording medium, e.g. printed on a substrate, such as paper.
摘要翻译： 提供了用于治疗血管钙化病变的试剂盒。 主题套件包括以下中的至少一个：（a）用于将流体输送到血管部位和从血管部位输送流体的流体输送装置; 和（b）用于至少部分溶解靶病变的溶解流体。 在许多实施方案中，试剂盒包括这两种组分。 主题试剂盒还包括用试剂盒内容物治疗血管钙化损伤的说明，其中指令通常记录在记录介质上，例如 印刷在诸如纸的基底上。
-
公开(公告)号：US08771748B2
公开(公告)日：2014-07-08
申请号：US11134051
申请日：2005-05-19
CPC分类号： C04B28/344 , A61K33/42 , C04B2103/12 , C04B2111/00836 , C04B22/16 , C04B24/383 , C04B40/0641
摘要： Methods are provided for producing compositions, e.g. pastes or clays, which rapidly set into high-strength calcium phosphate products. In the subject methods, dry reactants that include calcium and phosphate sources, as well as a monovalent cation dihydrogen phosphate salt, are combined with a setting fluid and the combined reactants are mixed to produce the settable composition. A feature of the invention is that cements rapidly set into high strength product compositions. Also provided are the compositions themselves as well as kits for preparing the same. The subject methods and compositions produced thereby find use in a variety of applications, including hard tissue repair applications.
摘要翻译： 提供了用于制备组合物的方法，例如 糊剂或粘土，迅速成为高强度磷酸钙产品。 在本发明的方法中，包括钙和磷酸盐源的干燥反应物以及一价阳离子磷酸二氢盐与凝固流体混合并将组合的反应物混合以产生可固化组合物。 本发明的特征是水泥迅速地成为高强度的产品组合物。 还提供了组合物本身以及用于制备它们的试剂盒。 由此产生的主题方法和组合物可用于各种应用，包括硬组织修复应用。
-
公开(公告)号：US08062418B2
公开(公告)日：2011-11-22
申请号：US12857289
申请日：2010-08-16
申请人： Brent R. Constantz , Kasra Farsad , Chris Camire , Joshua Patterson , Matthew Ginder-Vogel , Karin Yaccato , John Stagnaro , Martin Devenney , Justin Ries
发明人： Brent R. Constantz , Kasra Farsad , Chris Camire , Joshua Patterson , Matthew Ginder-Vogel , Karin Yaccato , John Stagnaro , Martin Devenney , Justin Ries
CPC分类号： C04B28/04 , B01D53/62 , B01D2251/404 , B01D2257/504 , B01D2258/0233 , C04B14/28 , C04B28/02 , Y02C10/00 , Y02C10/04 , Y10S264/43
摘要： Provided herein are compositions and methods including hydraulic cement, supplementary cementitious material, and/or self-cementing material. Methods for making the compositions and using the compositions are provided.
-
7.发明授权Desalination methods and systems that include carbonate compound precipitation 有权包括碳酸盐化合物沉淀的脱盐方法和系统公开(公告)号：US07931809B2
公开(公告)日：2011-04-26
申请号：US12700129
申请日：2010-02-04
IPC分类号： B01D61/10
CPC分类号： B01D61/025 , B01D2311/04 , B01D2311/06 , C02F1/04 , C02F1/441 , C02F1/5236 , C02F1/66 , C02F2103/08 , Y02A20/128 , Y02A20/131 , Y02W10/33 , Y02W10/37 , B01D2311/26 , B01D2311/103
摘要： Desalination methods that include carbonate compound precipitation are provided. In certain embodiments, feed water is subjected to carbonate compound precipitation conditions prior to desalination. In certain embodiments, desalination waste brine is subjected to carbonate compound precipitation conditions. In yet other embodiments, both feed water and waste brine are subjected to carbonate compound precipitation conditions. Aspects of embodiments of the invention include carbone dioxide sequestration. Embodiments of the invention further employ a precipitate product of the carbonate compound precipitation conditions as a building material, e.g., a cement. Also provided are systems configured for use in methods of the invention.
摘要翻译： 提供了包括碳酸盐化合物沉淀的脱盐方法。 在某些实施方案中，进料水在脱盐之前经受碳酸盐化合物沉淀条件。 在某些实施方案中，脱盐废盐水经受碳酸盐化合物沉淀条件。 在其他实施方案中，给水和废盐水都经受碳酸盐化合物沉淀条件。 本发明的实施方案的方面包括二氧化碳封存。 本发明的实施方案还使用碳酸酯化合物沉淀条件的沉淀产物作为建筑材料，例如水泥。 还提供了配置用于本发明方法的系统。
-
公开(公告)号：US20110067603A1
公开(公告)日：2011-03-24
申请号：US12857267
申请日：2010-08-16
申请人： Brent R. Constantz , Kasra Farsad , Chris Camire , Joshua Patterson , Miguel Fernandez , Karin Yaccato , Ryan Thatcher , John Stagnaro , Irvin Chen , Sidney Omelon , Keith Hodson , Laurence Clodic , Katharine Geramita , Terence C. Holland
发明人： Brent R. Constantz , Kasra Farsad , Chris Camire , Joshua Patterson , Miguel Fernandez , Karin Yaccato , Ryan Thatcher , John Stagnaro , Irvin Chen , Sidney Omelon , Keith Hodson , Laurence Clodic , Katharine Geramita , Terence C. Holland
CPC分类号： C04B28/04 , B01D53/62 , B01D2251/404 , B01D2257/504 , B01D2258/0233 , C04B14/28 , C04B28/02 , Y02C10/00 , Y02C10/04 , Y10S264/43
摘要： Provided herein are compositions and methods including hydraulic cement, supplementary cementitious material, and/or self-cementing material. Methods for making the compositions and using the compositions are provided.
-
公开(公告)号：US20110004219A1
公开(公告)日：2011-01-06
申请号：US12644894
申请日：2009-12-22
申请人： Brent R. Constantz
发明人： Brent R. Constantz
CPC分类号： A61L27/365 , A61L27/12 , A61L27/3608 , A61L27/425
摘要： Aspects of the invention include methods for producing flowable compositions, e.g. pastes, that set into calcium phosphate containing products, where the products include autologous bone. Aspects of the invention further include compositions produced by the methods, as well as kits for preparing the same. The subject methods and compositions produced thereby find use in a variety of applications, including hard tissue repair applications.
摘要翻译： 本发明的方面包括用于生产可流动组合物的方法，例如。 糊剂，其中含有磷酸钙的产品，其中产品包括自体骨。 本发明的方面还包括通过该方法制备的组合物，以及制备该组合物的试剂盒。 由此产生的主题方法和组合物可用于各种应用，包括硬组织修复应用。
-
公开(公告)号：US20100326328A1
公开(公告)日：2010-12-30
申请号：US12826209
申请日：2010-06-29
IPC分类号： C04B14/26
CPC分类号： C04B28/04 , B01D2257/504 , C04B22/10 , C04B28/02 , C04B2103/0086 , C04B2111/00017 , C04B22/106
摘要： CO2-sequestering formed building materials are provided. The building materials of the invention include a composition comprising a carbonate/bicarbonate component. Additional aspects of the invention include methods of making and using the CO2-sequestering formed building material.
-
-
-
-
-
-
-
-
-
搜索结果
114 条记录 (耗时 0.051 秒)