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公开(公告)号：US5538739A
公开(公告)日：1996-07-23
申请号：US643880
申请日：1991-01-18
申请人： David Bodmer , Jones W. Fong , Thomas Kissel , Hawkins V. Maulding, Jr. , Oskar Nagele , Jane E. Pearson
发明人： David Bodmer , Jones W. Fong , Thomas Kissel , Hawkins V. Maulding, Jr. , Oskar Nagele , Jane E. Pearson
CPC分类号： A61K38/31 , A61K9/1647 , A61K9/5031 , C08G63/08
摘要： The invention discloses microparticles comprising a polypeptide, preferably somatostatin or an analog or derivative thereof, more preferably octreotide, in a polymeric matrix, preferably poly(lactide-co-glycolide) glucose. The invention also discloses sustained release formulations containing said microparticles and the use of said formulations in treating acromegaly and breast cancer.
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公开(公告)号：US5876761A
公开(公告)日：1999-03-02
申请号：US470907
申请日：1995-06-06
申请人： David Bodmer , Jones W. Fong , Thomas Kissel , Hawkins V. Maulding , Oskar Nagele , Jane E. Pearson
发明人： David Bodmer , Jones W. Fong , Thomas Kissel , Hawkins V. Maulding , Oskar Nagele , Jane E. Pearson
CPC分类号： A61K9/1647 , A61K38/31 , A61K9/5031
摘要： The invention discloses microparticles comprising a polypeptide, preferably somatostatin or an analog or derivative thereof, more preferably octreotide, in a polymeric matrix, preferably poly(lactide-co-glycolide) glucose. The invention also discloses sustained release formulations containing said microparticles and the use of said formulations in treating acromegaly and breast cancer.
摘要翻译： 本发明公开了在聚合物基质，优选聚（丙交酯 - 共 - 乙交酯）葡萄糖中包含多肽，优选生长抑素或其类似物或衍生物，更优选奥曲肽的微粒。 本发明还公开了含有所述微粒的缓释制剂和所述制剂在治疗肢端肥大症和乳腺癌中的用途。
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公开(公告)号：US5688530A
公开(公告)日：1997-11-18
申请号：US470909
申请日：1995-06-06
申请人： David Bodmer , Jones W. Fong , Thomas Kissel , Hawkins V. Maulding , Oskar Nagele , Jane E. Pearson
发明人： David Bodmer , Jones W. Fong , Thomas Kissel , Hawkins V. Maulding , Oskar Nagele , Jane E. Pearson
CPC分类号： A61K38/31 , A61K9/1647 , A61K9/5031 , C08G63/08
摘要： The invention discloses microparticles comprising a polypeptide, preferably somatostatin or an analog or derivative thereof, more preferably octreotide, in a polymeric matrix, preferably poly(lactide-co-glycolide) glucose. The invention also discloses sustained release formulations containing said microparticles and the use of said formulations in treating acromegaly and breast cancer.
摘要翻译： 本发明公开了在聚合物基质，优选聚（丙交酯 - 共 - 乙交酯）葡萄糖中包含多肽，优选生长抑素或其类似物或衍生物，更优选奥曲肽的微粒。 本发明还公开了含有所述微粒的缓释制剂和所述制剂在治疗肢端肥大症和乳腺癌中的用途。
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公开(公告)号：US5639480A
公开(公告)日：1997-06-17
申请号：US470072
申请日：1995-06-06
申请人： David Bodmer , Jones W. Fong , Thomas Kissel , Hawkins V. Maulding , Oskar Nagele , Jane E. Pearson
发明人： David Bodmer , Jones W. Fong , Thomas Kissel , Hawkins V. Maulding , Oskar Nagele , Jane E. Pearson
CPC分类号： A61K9/1647 , A61K38/31 , A61K9/5031
摘要： The invention discloses microparticles comprising a polypeptide, preferably somatostatin or an analog or derivative thereof, more preferably octreotide, in a polymeric matrix, preferably poly(lactide-co-glycolide)glucose. The invention also discloses sustained release formulations containing said microparticles and the use of said formulations in treating acromegaly and breast cancer.
摘要翻译： 本发明公开了在聚合物基质，优选聚（丙交酯 - 共 - 乙交酯）葡萄糖中包含多肽，优选生长抑素或其类似物或衍生物，更优选奥曲肽的微粒。 本发明还公开了含有所述微粒的缓释制剂和所述制剂在治疗肢端肥大症和乳腺癌中的用途。
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公开(公告)号：US06204308B1
公开(公告)日：2001-03-20
申请号：US09260364
申请日：1999-03-01
申请人： Michael Ausborn , David Bodmer , Oskar Nagele , Laurent Marchal
发明人： Michael Ausborn , David Bodmer , Oskar Nagele , Laurent Marchal
IPC分类号： C08K900
CPC分类号： A61K38/193 , A61K9/5026
摘要： An emulsion-based method of microencapsulating an active agent wherein a water-in-oil emulsion, containing a matrix-forming polymer and an active agent, is dispersed in an aqueous external phase to form a microencapsulated product.
摘要翻译： 一种基于乳液的微囊化活性剂的方法，其中将含有基质形成聚合物和活性剂的油包水乳液分散在水相外相中以形成微囊化产物。
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公开(公告)号：US06623753B1
公开(公告)日：2003-09-23
申请号：US08881216
申请日：1997-06-24
IPC分类号： A61K9127
CPC分类号： A61K31/135 , A61K9/127
摘要： The invention concerns liposomal preparations comprising as the active agent a compound of formula I in free base form or in acid addition salt form. It also concerns a method of preparation of such liposomal preparations by encapsulating a compound of formula I with an appropriate liposome forming material, a corresponding pharmaceutical compositions, and methods of treatment of systemic, topical and pulmonal fungal infections.
摘要翻译： 本发明涉及包含作为活性剂的式I化合物游离碱形式或以酸加成盐形式的脂质体制剂。 它还涉及通过用合适的脂质体形成材料包封式I化合物，相应的药物组合物和治疗全身性，局部和肺部真菌感染的方法来制备这种脂质体制剂的方法。
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公开(公告)号：US20110166320A1
公开(公告)日：2011-07-07
申请号：US13048935
申请日：2011-03-16
申请人： Rainer Albert , Wilfried Bauer , David Bodmer , Christian Bruns , Ivo Felner , Heribert Hellstern , Ian Lewis , Mark Meisenbach , Gisbert Weckbecker , Bernhard Wietfeld
发明人： Rainer Albert , Wilfried Bauer , David Bodmer , Christian Bruns , Ivo Felner , Heribert Hellstern , Ian Lewis , Mark Meisenbach , Gisbert Weckbecker , Bernhard Wietfeld
IPC分类号： C07K7/64
CPC分类号： C07K7/64 , A61K38/00 , C07K14/655 , Y02P20/55
摘要： The invention provides cyclo[{4-(NH2—C2H4—NH—CO—O—)Pro}-Phg-DTrp-Lys-Tyr(4-Benzyl)-Phe], optionally in protected form, or a pharmaceutically acceptable salt or complex thereof, which has interesting pharmaceutical properties.
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公开(公告)号：US07939625B2
公开(公告)日：2011-05-10
申请号：US12265135
申请日：2008-11-05
申请人： Rainer Albert , Wilfried Bauer , David Bodmer , Christian Bruns , Ivo Felner , Heribert Hellstern , Ian Lewis , Mark Meisenbach , Gisbert Weckbecker , Bernhard Wietfeld
发明人： Rainer Albert , Wilfried Bauer , David Bodmer , Christian Bruns , Ivo Felner , Heribert Hellstern , Ian Lewis , Mark Meisenbach , Gisbert Weckbecker , Bernhard Wietfeld
IPC分类号： C07K7/64
CPC分类号： C07K7/64 , A61K38/00 , C07K14/655 , Y02P20/55
摘要： The invention provides cyclo[{4-(NH2—C2H4—NH—CO—O—)Pro}-Phg-DTrp-Lys-Tyr(4-Benzyl)-Phe], optionally in protected form, or a pharmaceutically acceptable salt or complex thereof, which has interesting pharmaceutical properties.
摘要翻译： 本发明提供任选以保护形式的环[{4-（NH 2 -C 2 H 4 -NH-CO-O-）Pro} -Phg-DTrp-Lys-Tyr（4-苄基）-Phe]或其药学上可接受的盐或 其复合物，其具有有趣的药物性质。
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公开(公告)号：US06262127B1
公开(公告)日：2001-07-17
申请号：US09357193
申请日：1999-07-20
申请人： Murat Acemoglu , Siegfried Bantle , David Bodmer , Salvatore Cammisuli , Peter Hiestand , Fritz Nimmerfall , Georg Stoll
发明人： Murat Acemoglu , Siegfried Bantle , David Bodmer , Salvatore Cammisuli , Peter Hiestand , Fritz Nimmerfall , Georg Stoll
IPC分类号： A61K914
CPC分类号： C08G64/183 , A61K9/1647 , A61K9/204 , A61K9/5031 , A61K38/2013 , A61K38/204 , A61K38/31 , C08G64/0208 , C08G64/34 , Y02A50/401 , Y10S514/825 , Y10S514/885 , Y10S514/903 , Y10S514/953 , Y10S514/964
摘要： This invention provides pharmaceutical compositions comprising polymeric matrices, especially those comprising IL-6 as an active ingredient. Specific novel poly(ethylene carbomate) polymers are also provided for more general use as matrix materials in sustained release compositions containing pharmacologically active compounds, as are methods of using of IL-6 for treatment of conditions mediated by IL-1 and/or TNF&agr;, e.g., certain autoimmune and inflammatory conditions, as well as septic shock.
摘要翻译： 本发明提供包含聚合物基质，特别是包含IL-6作为活性成分的聚合物基质的药物组合物。 还提供特定的新型聚（亚乙基碳酸酯）聚合物作为含有药理学活性化合物的持续释放组合物中的基质材料的更一般用途，以及使用IL-6用于治疗由IL-1和/或TNFα介导的病症的方法， 例如，某些自身免疫和炎症状况以及败血性休克。
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公开(公告)号：US20150218223A1
公开(公告)日：2015-08-06
申请号：US14681226
申请日：2015-04-08
申请人： Rainer Albert , Wilfried Bauer , David Bodmer , Christian Bruns , Ivo Felner , Heribert Hellstern , Ian Lewis , Mark Meisenbach , Gisbert Weckbecker , Bernhard Wietfeld
发明人： Rainer Albert , Wilfried Bauer , David Bodmer , Christian Bruns , Ivo Felner , Heribert Hellstern , Ian Lewis , Mark Meisenbach , Gisbert Weckbecker , Bernhard Wietfeld
IPC分类号： C07K7/64
CPC分类号： C07K7/64 , A61K38/00 , C07K14/655 , Y02P20/55
摘要： The invention provides cyclo[{4-(NH2—C2H4—NH—CO—O—)Pro}-Phg-DTrp-Lys-Tyr(4-Benzyl)-Phe], optionally in protected form, or a pharmaceutically acceptable salt or complex thereof, which has interesting pharmaceutical properties.
摘要翻译： 本发明提供任选以保护形式的环[{4-（NH 2 -C 2 H 4 -NH-CO-O-）Pro} -Phg-DTrp-Lys-Tyr（4-苄基）-Phe]或其药学上可接受的盐或 其复合物，其具有有趣的药物性质。
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