E2F-2, a novel mammalian transcription factor
    6.
    发明授权
    E2F-2, a novel mammalian transcription factor 失效
    E2F-2,一种新型哺乳动物转录因子

    公开(公告)号:US5473056A

    公开(公告)日:1995-12-05

    申请号:US136119

    申请日:1993-10-13

    IPC分类号: A61K38/00 C07K14/47

    摘要: The present invention is directed to a novel protein with E2F-like properties and the cDNA that encodes for that protein. The purified protein exhibits biological activity which is deemed important to medical science in the study of cell cycle regulation in general and the specific study of the Rb rumor suppressor protein and certain viral oncogenes. The protein may be employed in a complex with pRb or other cellular proteins to study inhibitors of biochemical transformations of those proteins, such as for example the phosphorylation of the pRb portion of the complex, therefore aiding in the study of potential pharmaceutical agents useful against certain oncoproteins encoded by DNA tumor viruses.

    摘要翻译: 本发明涉及具有E2F样特性的新蛋白质和编码该蛋白质的cDNA。 纯化的蛋白质表现出生物活性,这在生物活性中被认为对于医学科学在一般的细胞周期调控的研究和Rb肿瘤抑制蛋白和某些病毒致癌基因的具体研究中是重要的。 蛋白质可以用于与pRb或其它细胞蛋白质的复合物中,以研究这些蛋白质的生物化学转化的抑制剂,例如复合物的pRb部分的磷酸化,因此有助于研究对某些有用的潜在药剂 由DNA肿瘤病毒编码的癌蛋白。