公开(公告)号：US06071249A

公开(公告)日：2000-06-06

申请号：US982324

申请日：1997-12-02

申请人： David D. Cunningham ,  Timothy P. Henning ,  Eric B. Shain ,  Douglas F. Young ,  Michael G. Lowery ,  Hugh W. Graham

发明人： David D. Cunningham ,  Timothy P. Henning ,  Eric B. Shain ,  Douglas F. Young ,  Michael G. Lowery ,  Hugh W. Graham

IPC分类号： A61B5/151 ,  A61B5/00 ,  A61B5/145 ,  A61B5/1459 ,  A61B5/1473 ,  A61B5/15 ,  A61B5/154 ,  A61B5/157 ,  G01N33/48 ,  G01N33/66

CPC分类号： A61B5/15186 ,  A61B5/14532 ,  A61B5/1486 ,  A61B5/150022 ,  A61B5/150068 ,  A61B5/150076 ,  A61B5/150099 ,  A61B5/150221 ,  A61B5/150412 ,  A61B5/150503 ,  A61B5/150664 ,  A61B5/15113 ,  A61B5/15125 ,  A61B5/1519 ,  A61B5/15194 ,  A61B5/157 ,  A61B5/411 ,  A61B2562/0295 ,  A61B5/150358

摘要： Method and apparatus for obtaining a sample of blood from a patient for subsequent diagnostic tests, e.g., glucose monitoring. In one aspect of the invention, the method comprises the steps of:(a) forming an unobstructed opening in the area of the skin from which the sample of blood is to be extracted; and(b) extracting the sample of blood from the unobstructed opening in the skin, with the aid of a vacuum and a stretching of the skin.In another aspect of the invention, an apparatus for carrying out the method described previously is provided. The apparatus comprises:(a) a device for forming an unobstructed opening in an area of skin from which said sample is to be extracted, preferably a lancing assembly; and(b) a vacuum pump.Preferably, the apparatus also includes a housing.It has also been discovered that an improved design and construction of the nosepiece can provide enhanced collection of blood from the unobstructed opening in the skin. It has been discovered that by controlling the construction of the interior cavity of the nosepiece, collection of blood can be improved.

摘要翻译： 用于从患者获得血样的方法和装置用于随后的诊断测试，例如葡萄糖监测。 在本发明的一个方面，所述方法包括以下步骤：（a）在要从其中提取血液样本的皮肤区域中形成无障碍的开口; 和（b）借助于真空和皮肤拉伸从皮肤中的无阻塞的开口提取血液样品。 在本发明的另一方面，提供一种用于执行前述方法的装置。 该装置包括：（a）用于在皮肤区域形成无障碍的开口的装置，所述皮肤区域将从所述皮肤区域中提取所述样品，优选为采血组件; 和（b）真空泵。 优选地，该装置还包括壳体。 还已经发现，鼻梁的改进的设计和结构可以提供来自皮肤中无障碍开口的血液的增强的收集。 已经发现，通过控制鼻梁的内腔的构造，可以提高血液的收集。

公开(公告)号：US5441894A

公开(公告)日：1995-08-15

申请号：US056219

申请日：1993-04-30

申请人： Carole L. Coleman ,  Kevin R. Genger ,  Hugh W. Graham ,  Charles F. Hanna ,  Omar S. Khalil ,  David C. Wender

发明人： Carole L. Coleman ,  Kevin R. Genger ,  Hugh W. Graham ,  Charles F. Hanna ,  Omar S. Khalil ,  David C. Wender

IPC分类号： G01N21/64 ,  B01L3/00 ,  G01N21/77 ,  G01N33/543

CPC分类号： G01N33/54366 ,  B01L3/5023 ,  B01L3/50255 ,  B01L2300/0681 ,  B01L2300/069 ,  B01L2300/0829 ,  B01L2400/0406 ,  Y10S435/81 ,  Y10S436/805 ,  Y10S436/809 ,  Y10S436/81

摘要： An improved device is used for performing solid-phase chemiluminescent immunoassays. The device comprises a container having a fibrous matrix and a porous absorbent material. An improvement in the device is the use of light absorbing material as the absorbent material or as a light barrier between the fibrous matrix and the absorbent material. A second improvement comprises a fibrous matrix of binderless fiber matrix, such as glass fiber. The invention improves the direct measurement of the chemiluminescent signal from a solid surface by reducing background signal. The device is disposable and is suitable for manual use or for use with an apparatus having programmed instructions. The device is designed to be employed in a variety of solid-phase diagnostic assays such as sandwich or competitive binding assays. The device is also designed for use with microparticle capture or ion capture methods of separating the immunochemical reaction products.

摘要翻译： 改进的装置用于进行固相化学发光免疫测定。 该装置包括具有纤维基质和多孔吸收材料的容器。 该装置的改进是使用光吸收材料作为吸收材料或作为纤维基质和吸收材料之间的光阻挡层。 第二改进包括无粘合剂纤维基质如玻璃纤维的纤维基质。 本发明通过降低背景信号来改善来自固体表面的化学发光信号的直接测量。 该装置是一次性的并且适用于手动使用或用于具有编程指令的装置。 该设备设计用于各种固相诊断测定，例如三明治或竞争性结合测定。 该装置还设计用于分离免疫化学反应产物的微粒捕获或离子捕获方法。