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公开(公告)号:US20060094725A1
公开(公告)日:2006-05-04
申请号:US11303665
申请日:2005-12-16
申请人: David Davey , Raju Mohan , Gary Phillips , Guo Ping Wei , Wei Xu
发明人: David Davey , Raju Mohan , Gary Phillips , Guo Ping Wei , Wei Xu
IPC分类号: A61K31/501 , A61K31/454 , A61K31/4178 , C07D403/02
CPC分类号: C07D401/12 , C07D401/14 , C07D405/12 , C07D405/14
摘要: N-Heterocyclic derivatives of the following formula: where m, n, p, A1, R1, R2, R3 and R4 are described herein, as well as other N-heterocyclic derivatives, are useful as inhibitors of nitric oxide synthase. Pharmaceutical compositions containing these compounds, methods of using these compounds as inhibitors of nitric oxide synthase and processes for synthesizing these compounds are also described herein.
摘要翻译: 下式的N-杂环衍生物:其中m,n,p,A 1,R 1,R 2,R 2, 本文描述的3和R 4以及其它N-杂环衍生物可用作一氧化氮合酶的抑制剂。 含有这些化合物的药物组合物,使用这些化合物作为一氧化氮合酶抑制剂的方法以及合成这些化合物的方法也在本文中描述。
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公开(公告)号:US07202263B2
公开(公告)日:2007-04-10
申请号:US11303665
申请日:2005-12-16
申请人: David Davey , Raju Mohan , Gary Phillips , Guo Ping Wei , Wei Xu
发明人: David Davey , Raju Mohan , Gary Phillips , Guo Ping Wei , Wei Xu
IPC分类号: C07D403/02 , C07D403/14 , C07D405/02 , C07D405/14 , C07D401/04 , C07D401/14 , A61K31/4178 , A61P9/04 , A61P19/02
CPC分类号: C07D401/12 , C07D401/14 , C07D405/12 , C07D405/14
摘要: N-Heterocyclic derivatives of the following formula: where m, n, p, A1, R1, R2, R3 and R4 are described herein, as well as other N-heterocyclic derivatives, are useful as inhibitors of nitric oxide synthase. Pharmaceutical compositions containing these compounds, methods of using these compounds as inhibitors of nitric oxide synthase and processes for synthesizing these compounds are also described herein.
摘要翻译: 下式的N-杂环衍生物:
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公开(公告)号:US06995156B2
公开(公告)日:2006-02-07
申请号:US10947635
申请日:2004-09-22
申请人: Judi A. Bryant , Brad O. Buckman , Imadul Islam , Raju Mohan , Michael M. Morrissey , Guo Ping Wei , Wei Xu , Shendong Yuan
发明人: Judi A. Bryant , Brad O. Buckman , Imadul Islam , Raju Mohan , Michael M. Morrissey , Guo Ping Wei , Wei Xu , Shendong Yuan
IPC分类号: A61K31/496 , C07D401/14 , C07D405/14 , C07D413/14 , C07D417/14
CPC分类号: C07D295/205 , C07D215/48 , C07D401/12 , C07D405/12 , C07D413/12 , C07D417/12
摘要: Compounds of the following formula (I): where a, b, R1, R2, R3, R4 and R6 are described herein, are useful as inhibitors of platelet adenosine diphosphate. Pharmaceutical compositions containing these compounds, methods of using these compounds as antithrombotic agents and processes for synthesizing these compounds are also described herein.
摘要翻译: 下式(I)的化合物:化学式id =“CHEM-US-00001”num =“000
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公开(公告)号:US07056923B2
公开(公告)日:2006-06-06
申请号:US10731815
申请日:2003-12-09
申请人: Judi Bryant , Brad Buckman , Imadul Islam , Raju Mohan , Michael Morrissey , Guo Ping Wei , Wei Xu , Shendong Yuan
发明人: Judi Bryant , Brad Buckman , Imadul Islam , Raju Mohan , Michael Morrissey , Guo Ping Wei , Wei Xu , Shendong Yuan
IPC分类号: A61K31/496 , C07D401/12
CPC分类号: C07D405/12 , C07D215/48 , C07D409/12 , C07D413/12 , C07D417/12
摘要: Compounds of the following formula: where m, n, R1, R2, R3, R4 and R6 are described herein, are useful as inhibitors of platelet adenosine diphosphate. Pharmaceutical compositions containing these compounds, methods of using these compounds as antithrombotic agents and processes for synthesizing these compounds are also described herein.
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公开(公告)号:US07026323B2
公开(公告)日:2006-04-11
申请号:US10947579
申请日:2004-09-22
申请人: Judi A. Bryant , Brad O. Buckman , Imadul Islam , Raju Mohan , Michael M. Morrissey , Guo Ping Wei , Wei Xu , Shendong Yuan
发明人: Judi A. Bryant , Brad O. Buckman , Imadul Islam , Raju Mohan , Michael M. Morrissey , Guo Ping Wei , Wei Xu , Shendong Yuan
IPC分类号: A61K31/497
CPC分类号: C07D295/205 , C07D215/48 , C07D401/12 , C07D405/12 , C07D413/12 , C07D417/12
摘要: Compounds of the following formula (I): where a, b, R1, R2, R3, R4 and R6 are described herein, are useful as inhibitors of platelet adenosine diphosphate. Pharmaceutical compositions containing these compounds, methods of using these compounds as antithrombotic agents and processes for synthesizing these compounds are also described herein.
摘要翻译: 下式(I)的化合物:其中a,b,R 1,R 2,R 3,R 4, / SUP>和R 6 6在本文中描述,可用作血小板二磷酸腺苷的抑制剂。 本文还描述了含有这些化合物的药物组合物,使用这些化合物作为抗血栓形成剂的方法和合成这些化合物的方法。
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公开(公告)号:US07084142B2
公开(公告)日:2006-08-01
申请号:US11331621
申请日:2006-01-12
申请人: Judi Bryant , Brad Buckman , Imadul Islam , Raju Mohan , Michael Morrissey , Guo Ping Wei , Wei Xu , Shendong Yuan
发明人: Judi Bryant , Brad Buckman , Imadul Islam , Raju Mohan , Michael Morrissey , Guo Ping Wei , Wei Xu , Shendong Yuan
IPC分类号: A61K31/496 , C07D401/12
CPC分类号: C07D405/12 , C07D215/48 , C07D409/12 , C07D413/12 , C07D417/12
摘要: Compounds of the following formula: where m, n, R1, R2, R3, R4 and R6 are described herein, are useful as inhibitors of platelet adenosine diphosphate. Pharmaceutical compositions containing these compounds, methods of using these compounds as antithrombotic agents and processes for synthesizing these compounds are also described herein.
摘要翻译: 下式的化合物:其中m,n,R 1,R 2,R 3,R 4, 和R 6 6在本文中描述,可用作血小板二磷酸腺苷的抑制剂。 本文还描述了含有这些化合物的药物组合物,使用这些化合物作为抗血栓形成剂的方法和合成这些化合物的方法。
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公开(公告)号:US20060135532A1
公开(公告)日:2006-06-22
申请号:US11347768
申请日:2006-02-02
申请人: Judi Bryant , Brad Buckman , Imadul Islam , Raju Mohan , Michael Morrissey , Guo Ping Wei , Wei Xu , Shendong Yuan
发明人: Judi Bryant , Brad Buckman , Imadul Islam , Raju Mohan , Michael Morrissey , Guo Ping Wei , Wei Xu , Shendong Yuan
IPC分类号: C07D241/04 , A61K31/495
CPC分类号: C07D295/205 , C07D215/48 , C07D401/12 , C07D405/12 , C07D413/12 , C07D417/12
摘要: Compounds of the following formula (I): where A, a, b, R1, R2, R3, R4 and R6 are described herein, are useful as inhibitors of platelet adenosine diphosphate. Pharmaceutical compositions containing these compounds, methods of using these compounds as antithrombotic agents and processes for synthesizing these compounds are also described herein.
摘要翻译: 下式(I)的化合物:其中A,a,b,R 1,R 2,R 3,R 3, 4和4本文描述的,可用作血小板二磷酸腺苷的抑制剂。 本文还描述了含有这些化合物的药物组合物,使用这些化合物作为抗血栓形成剂的方法和合成这些化合物的方法。
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公开(公告)号:US06982259B2
公开(公告)日:2006-01-03
申请号:US10422185
申请日:2003-04-23
申请人: David D. Davey , Raju Mohan , Gary B. Phillips , Guo Ping Wei , Wei Xu
发明人: David D. Davey , Raju Mohan , Gary B. Phillips , Guo Ping Wei , Wei Xu
IPC分类号: C07D401/10 , C07D403/10 , A61K31/4164 , A61K31/454 , A61P9/04
CPC分类号: C07D401/12 , C07D401/14 , C07D405/12 , C07D405/14
摘要: N-Heterocyclic derivatives of the following formula: where m, n, p, A1, R1, R2, R3 and R4 are described herein, as well as other N-heterocyclic derivatives, are useful as inhibitors of nitric oxide synthase. Pharmaceutical compositions containing these compounds, methods of using these compounds as inhibitors of nitric oxide synthase and processes for synthesizing these compounds are also described herein.
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公开(公告)号:US06861424B2
公开(公告)日:2005-03-01
申请号:US10163742
申请日:2002-06-05
申请人: Judi A. Bryant , Brad O. Buckman , Imadul Islam , Raju Mohan , Michael M. Morrissey , Guo Ping Wei , Wei Xu , Shendong Yuan
发明人: Judi A. Bryant , Brad O. Buckman , Imadul Islam , Raju Mohan , Michael M. Morrissey , Guo Ping Wei , Wei Xu , Shendong Yuan
IPC分类号: C07D295/20 , A61K31/47 , A61K31/4709 , A61K31/495 , A61K31/496 , A61K31/506 , A61K31/5377 , A61P7/02 , A61P43/00 , C07D215/48 , C07D215/54 , C07D215/56 , C07D295/205 , C07D307/33 , C07D401/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D401/14 , C07D405/14 , C07D413/14 , C07D417/14
CPC分类号: C07D295/205 , C07D215/48 , C07D401/12 , C07D405/12 , C07D413/12 , C07D417/12
摘要: Compounds of the following formula (I): where a, b, R1, R2, R3, R4 and R6 are described herein, are useful as inhibitors of platelet adenosine diphosphate. Pharmaceutical compositions containing these compounds, methods of using these compounds as antithrombotic agents and processes for synthesizing these compounds are also described herein.
摘要翻译: 下式(I)的化合物:其中a,b,R 1,R 2,R 3,R 4和R 6如本文所述,可用作血小板二磷酸腺苷的抑制剂 。 本文还描述了含有这些化合物的药物组合物,使用这些化合物作为抗血栓形成剂的方法和合成这些化合物的方法。
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公开(公告)号:US20050101644A1
公开(公告)日:2005-05-12
申请号:US10984430
申请日:2004-11-08
申请人: David Davey , Wheeseong Lee , Shou-Fu Lu , Gary Phillips , Guo Ping Wei , Bin Ye
发明人: David Davey , Wheeseong Lee , Shou-Fu Lu , Gary Phillips , Guo Ping Wei , Bin Ye
IPC分类号: A61K31/135 , A61K31/165 , A61K31/40 , A61K31/435 , C07C217/58 , C07C235/42 , C07C255/54 , C07C275/28 , C07D207/08 , C07D207/12 , C07D207/14 , C07D207/16 , C07D211/14 , C07D211/26 , C07D211/38 , C07D211/42 , C07D211/44 , C07D211/46 , C07D211/48 , C07D211/52 , C07D211/58 , C07D211/62 , C07D211/64 , C07D211/66 , C07D213/20 , C07D213/30 , C07D213/40 , C07D213/53 , C07D213/64 , C07D213/82 , C07D213/89 , C07D217/06 , C07D233/54 , C07D233/88 , C07D235/26 , C07D241/08 , C07D295/13 , C07D295/192 , C07D295/215 , C07D295/26 , C07D319/08 , C07D333/34 , C07D401/06 , C07D401/12 , C07D403/12 , C07D405/12 , C07D471/10 , C07D487/08 , C07D491/10 , A61K31/44 , A61K31/137 , A61K31/138 , A61K31/198
CPC分类号: C07D207/16 , C07C217/58 , C07C235/42 , C07C255/54 , C07C275/28 , C07D207/08 , C07D207/12 , C07D207/14 , C07D211/14 , C07D211/26 , C07D211/44 , C07D211/46 , C07D211/48 , C07D211/52 , C07D211/58 , C07D211/62 , C07D211/64 , C07D211/66 , C07D213/20 , C07D213/30 , C07D213/40 , C07D213/53 , C07D213/64 , C07D213/82 , C07D213/89 , C07D217/06 , C07D233/54 , C07D233/64 , C07D233/88 , C07D235/26 , C07D241/08 , C07D295/13 , C07D295/192 , C07D295/215 , C07D295/26 , C07D319/08 , C07D333/34 , C07D401/06 , C07D403/12 , C07D405/12 , C07D471/10 , C07D487/08 , C07D491/10
摘要: The present invention relates to compounds which are CCR-5 receptor antagonists of the general formula I: wherein R1, R2, R3, R4, Ra, Rb, Rc, Rd, X, m and n are as defined herein. The invention further comprises pharmaeceutical compositions comprising such compounds, as well as the use of such compounds to treat CCR-5 mediated disorders.
摘要翻译: 本发明涉及通式I的CCR-5受体拮抗剂的化合物:其中R 1,R 2,R 3, R 4,R a,R b,R b,R c,R d, X,m和n如本文所定义。 本发明还包括含有这些化合物的药物组合物,以及这些化合物用于治疗CCR-5介导的病症的用途。
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