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公开(公告)号：US07087243B2
公开(公告)日：2006-08-08
申请号：US10897669
申请日：2004-07-23
申请人： David E. Edgren , Shu Li , Patrick S.-L. Wong , Gurdish Bhatti , Liang-Chang Dong , Si-Hong Yum
发明人： David E. Edgren , Shu Li , Patrick S.-L. Wong , Gurdish Bhatti , Liang-Chang Dong , Si-Hong Yum
CPC分类号： A61K9/2853 , A61K9/0004 , A61K9/282 , A61K9/284 , A61K9/2866
摘要： A composition is disclosed comprising a polymer and a surfactant in a solvent exhibiting a common solubility for the polymer and the surfactant. The composition provides a dosage form for administering a drug over time.
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公开(公告)号：US07060734B1
公开(公告)日：2006-06-13
申请号：US09721111
申请日：2000-11-22
申请人： David E. Edgren , Shu Li , Patrick S.-L. Wong , Gurdish Bhatti , Liang-Chang Dong , Si-Hong Yum
发明人： David E. Edgren , Shu Li , Patrick S.-L. Wong , Gurdish Bhatti , Liang-Chang Dong , Si-Hong Yum
IPC分类号： A01N25/00
CPC分类号： A61K9/0004 , Y10S514/975
摘要： A composition is disclosed comprising a polymer and a surfactant in a solvent exhibiting a common solubility for the polymer and the surfactant. The composition provides a dosage form for administering a drug over time.
摘要翻译： 公开的组合物在溶剂中显示出对聚合物和表面活性剂具有共同的溶解性的聚合物和表面活性剂。 该组合物提供了随时间施用药物的剂型。
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公开(公告)号：US20050003006A1
公开(公告)日：2005-01-06
申请号：US10897669
申请日：2004-07-23
申请人： David Edgren , Shu Li , Patrick Wong , Gurdish Bhatti , Liang-Chang Dong , Si-Hong Yum
发明人： David Edgren , Shu Li , Patrick Wong , Gurdish Bhatti , Liang-Chang Dong , Si-Hong Yum
CPC分类号： A61K9/2853 , A61K9/0004 , A61K9/282 , A61K9/284 , A61K9/2866
摘要： A composition is disclosed comprising a polymer and a surfactant in a solvent exhibiting a common solubility for the polymer and the surfactant. The composition provides a dosage form for administering a drug over time.
摘要翻译： 公开的组合物在溶剂中显示出对聚合物和表面活性剂具有共同的溶解性的聚合物和表面活性剂。 该组合物提供了随时间施用药物的剂型。
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公开(公告)号：US08524277B2
公开(公告)日：2013-09-03
申请号：US11673066
申请日：2007-02-09
CPC分类号： A61K9/0004 , A61K9/2027 , A61K9/2031 , A61K9/2866 , A61K9/2886
摘要： A membrane system comprising an interior wall, a fluid-permeable exterior wall surrounding the interior wall and an internal compartment defined by the membrane system, wherein fluid permeability of the interior wall is responsive to osmolarity of an osmotic core within the internal compartment are disclosed. A controlled release dosage form comprising the membrane system and a process for delivering an osmotically active formulation from an osmotic pump over an extended period of time are also disclosed.
摘要翻译： 公开了一种膜系统，其包括内壁，围绕内壁的流体可渗透的外壁和由膜系统限定的内部隔室，其中内壁的流体渗透性响应于内部隔室内的渗透性芯的渗透压。 还公开了一种包含膜系统的控释剂型，以及用于在延长的时间段内从渗透泵输送渗透活性制剂的方法。
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公开(公告)号：US06245357B1
公开(公告)日：2001-06-12
申请号：US09249700
申请日：1999-02-12
IPC分类号： A61K924
CPC分类号： A61K9/0004 , A61K9/2027 , A61K9/2031 , A61K9/2866 , A61K9/2886
摘要： A dosage form comprising a composition comprising a drug surrounded by an interior and an exterior wall with an exit for administering the drug to a patient; and a method of using the dosage form are disclosed for an indicated therapy.
摘要翻译： 一种剂型，其包含包含由内部和外壁包围的药物的组合物，其具有用于将药物施用于患者的出口; 并且对于指定的治疗公开了使用剂型的方法。
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公开(公告)号：US20110229533A1
公开(公告)日：2011-09-22
申请号：US13149753
申请日：2011-05-31
IPC分类号： A61K9/00 , A61K31/485 , A61K31/60 , A61P29/00
CPC分类号： A61K9/0004 , A61K9/2027 , A61K9/2031 , A61K9/2866 , A61K9/2886
摘要： A membrane system comprising an interior wall, a fluid-permeable exterior wall surrounding the interior wall and an internal compartment defined by the membrane system, wherein fluid permeability of the interior wall is responsive to osmolarity of an osmotic core within the internal compartment are disclosed. A controlled release dosage form comprising the membrane system and a process for delivering an osmotically active formulation from an osmotic pump over an extended period of time are also disclosed.
摘要翻译： 公开了一种膜系统，其包括内壁，围绕内壁的流体可渗透的外壁和由膜系统限定的内部隔室，其中内壁的流体渗透性响应于内部隔室内的渗透性芯的渗透压。 还公开了一种包含膜系统的控释剂型，以及用于在延长的时间段内从渗透泵输送渗透活性制剂的方法。
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公开(公告)号：US20070243254A1
公开(公告)日：2007-10-18
申请号：US11737829
申请日：2007-06-28
申请人： David Edgren , Frank Jao , Rhea Kimbel , Padmaja Shivanand , Atul Ayer , Gurdish Bhatti , Andrew Lam , Shu Li , Robert Skluzacek , Winnie To , Patrick Wong , Shaoling Li , Noymi Yam , Sylvia Serofff
发明人： David Edgren , Frank Jao , Rhea Kimbel , Padmaja Shivanand , Atul Ayer , Gurdish Bhatti , Andrew Lam , Shu Li , Robert Skluzacek , Winnie To , Patrick Wong , Shaoling Li , Noymi Yam , Sylvia Serofff
CPC分类号： A61K9/0004
摘要： The present invention is directed to novel drug compositions and dosage forms comprising said drug compositions. The drug compositions of the present invention comprise a pharmaceutical agent and a solubilizing agent. The drug compositions of the present invention are particularly advantageous for use with low solubility and/or low dissolution rate pharmaceutical agents. The present invention is further directed to methods for manufacturing of said drug compositions and dosage forms. The present invention is further directed to methods of treatment comprising administration of said drug compositions and dosage forms.
摘要翻译： 本发明涉及包含所述药物组合物的新型药物组合物和剂型。 本发明的药物组合物包含药剂和增溶剂。 本发明的药物组合物特别适用于低溶解度和/或低溶解速率的药剂。 本发明还涉及制备所述药物组合物和剂型的方法。 本发明进一步涉及包括施用所述药物组合物和剂型的治疗方法。
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公开(公告)号：US20070128279A1
公开(公告)日：2007-06-07
申请号：US11673066
申请日：2007-02-09
申请人： David Edgren , Patrick Wong , Gurdish Bhatti , Shu Li , Robert Skluzacek
发明人： David Edgren , Patrick Wong , Gurdish Bhatti , Shu Li , Robert Skluzacek
IPC分类号： A61K31/485 , A61K9/24 , A61K31/16
CPC分类号： A61K9/0004 , A61K9/2027 , A61K9/2031 , A61K9/2866 , A61K9/2886
摘要： A membrane system comprising an interior wall, a fluid-permeable exterior wall surrounding the interior wall and an internal compartment defined by the membrane system, wherein fluid permeability of the interior wall is responsive to osmolarity of an osmotic core within the internal compartment are disclosed. A controlled release dosage form comprising the membrane system and a process for delivering an osmotically active formulation from an osmotic pump over an extended period of time are also disclosed.
摘要翻译： 公开了一种膜系统，其包括内壁，围绕内壁的流体可渗透的外壁和由膜系统限定的内部隔室，其中内壁的流体渗透性响应于内部隔室内的渗透性芯的渗透压。 还公开了一种包含膜系统的控释剂型，以及用于在延长的时间段内从渗透泵输送渗透活性制剂的方法。
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9.发明申请Osmotic dosage forms comprising semipermeable membranes with polymer blends providing improved properties 审中-公开包含半透膜的渗透剂型与聚合物共混物提供改进的性质公开(公告)号：US20070031496A1
公开(公告)日：2007-02-08
申请号：US11499008
申请日：2006-08-04
申请人： David Edgren , Shu Li , Gurdish Bhatti , Patrick Wong
发明人： David Edgren , Shu Li , Gurdish Bhatti , Patrick Wong
IPC分类号： A61K9/24
CPC分类号： A61K9/0004
摘要： Disclosed are osmotic dosage forms including an osmotic core; a semi-permeable membrane that surrounds the osmotic core and comprises a blend of a cellulose acetate polymer and an acrylate copolymer; and an exit formed through the semi-permeable membrane. Also disclosed are methods of making and administering such dosage forms.
摘要翻译： 公开了渗透剂型，包括渗透核; 围绕渗透芯并包含醋酸纤维素聚合物和丙烯酸酯共聚物的共混物的半透膜; 以及通过半透膜形成的出口。 还公开了制备和施用这种剂型的方法。
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公开(公告)号：US20060165798A1
公开(公告)日：2006-07-27
申请号：US11341251
申请日：2006-01-27
申请人： David Edgren , Gurdish Bhatti , Shu Li , Robert Skluzacek
发明人： David Edgren , Gurdish Bhatti , Shu Li , Robert Skluzacek
IPC分类号： A61K9/24
CPC分类号： A61K9/0004
摘要： Disclosed are oral osmotic dosage forms and methods wherein a semi-permeable membrane of the oral osmotic dosage form includes from about 23 wt % to about 50 wt % of a flux enhancer and from about 0.01 wt % to about 5 wt % of antioxidant, based on the total dry weight of the semi-permeable membrane. Such compositions provide high flux membranes with improved mechanical and transport stability during storage on the shelf.
摘要翻译： 公开了口服渗透剂型和方法，其中口服渗透剂型的半渗透膜包含约23重量％至约50重量％的助熔剂增强剂和约0.01重量％至约5重量％的抗氧化剂，基于 关于半透膜的总干重。 这样的组合物在储存在架子上时具有改善的机械和运输稳定性的高通量膜。
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