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    Intravesical infuser
    1.
    发明授权
    Intravesical infuser 失效
    内窥镜注射器

    公开(公告)号：US06171298B2

    公开(公告)日：2001-01-09

    申请号：US09041475

    申请日：1998-03-11

    申请人： David G. Matsuura ,  Walter Dean Gillespie ,  John Patrick Greelis ,  Charles Lowell Parsons ,  Mikxay Sirivong ,  Paul F. Zupkas

    发明人： David G. Matsuura ,  Walter Dean Gillespie ,  John Patrick Greelis ,  Charles Lowell Parsons ,  Mikxay Sirivong ,  Paul F. Zupkas

    IPC分类号： A61K922

    CPC分类号： A61M31/002 ,  A61L17/145 ,  A61L27/34 ,  A61L31/10 ,  A61L33/0011 ,  A61L33/0094 ,  A61L33/08 ,  A61M5/152 ,  A61M31/00 ,  A61M2210/1085 ,  C08L5/00

    摘要： A drug-infusing device is implanted into a body cavity such as a bladder. The device is implanted in an uninflated, low profile state. After insertion into the body cavity, the device is filled with a substance, such as a drug, and assumes an increased profile. After the device is filled, it is allowed to float freely within the body cavity. Alternatively, the device can be tethered to a wall of the body cavity. The device delivers the drug at a controlled rate over an extended period of time. In order to deliver the drug at a controlled rate, the device preferably has a pressure-responsive valving member. The flow resistance of the valving member is responsive to the pressure at which the drug is stored within the infusing device. The resistance of the valving member decreases as the pressure within the infusing device decreases, thereby providing a resultant controlled flow rate.

    摘要翻译： 将药物注入装置植入诸如膀胱的体腔内。 该器件植入未膨胀的低调状态。 在插入体腔后，装置中填充有诸如药物的物质，并呈现增加的外形。 装置装满后，允许在体腔内自由浮动。 或者，该装置可以系在体腔的壁上。 该设备在长时间内以受控的速率递送药物。 为了以受控的速率递送药物，该装置优选地具有压力响应阀构件。 阀构件的流动阻力响应于药物在输注装置内储存的压力。 当输液装置内的压力降低时，阀构件的阻力减小，从而提供合成的受控流量。

    Method for delivering a medication
    2.
    发明授权
    Method for delivering a medication 失效
    递送药物的方法

    公开(公告)号：US06183461B2

    公开(公告)日：2001-02-06

    申请号：US09395415

    申请日：1999-09-14

    申请人： David G. Matsuura ,  Walter Dean Gillespie ,  John Patrick Greelis ,  Charles Lowell Parsons ,  Mikxay Sirivong ,  Paul F. Zupkas

    发明人： David G. Matsuura ,  Walter Dean Gillespie ,  John Patrick Greelis ,  Charles Lowell Parsons ,  Mikxay Sirivong ,  Paul F. Zupkas

    IPC分类号： A61M3100

    CPC分类号： A61M31/002 ,  A61M5/152 ,  A61M31/00 ,  A61M2210/1085

    摘要： A drug-infusing device is implanted into a body cavity such as a bladder. The device is implanted in an uninflated, low profile state. After insertion into the body cavity, the device is filled with a substance, such as a drug, and assumes an increased profile. After the device is filled, it is allowed to float freely within the body cavity. Alternatively, the device can be tethered to a wall of the body cavity. The device delivers the drug at a controlled rate over an extended period of time. In order to deliver the drug at a controlled rate, the device preferably has a pressure-responsive valving member. The flow resistance of the valving member is responsive to the pressure at which the drug is stored within the infusing device. The resistance of the valving member decreases as the pressure within the infusing device decreases, thereby providing a resultant controlled flow rate.

    摘要翻译： 将药物注入装置植入诸如膀胱的体腔内。 该器件植入未膨胀的低调状态。 在插入体腔后，装置中填充有诸如药物的物质，并呈现增加的外形。 装置装满后，允许在体腔内自由浮动。 或者，该装置可以系在体腔的壁上。 该设备在长时间内以受控的速率递送药物。 为了以受控的速率递送药物，该装置优选地具有压力响应阀构件。 阀构件的流动阻力响应于药物在输注装置内储存的压力。 当输液装置内的压力降低时，阀构件的阻力减小，从而提供合成的受控流量。

    Method and apparatus for placement and activation of a medical device within a body cavity
    3.
    发明授权
    Method and apparatus for placement and activation of a medical device within a body cavity 失效
    用于在体腔内放置和激活医疗装置的方法和装置

    公开(公告)号：US6139535A

    公开(公告)日：2000-10-31

    申请号：US322131

    申请日：1999-05-27

    申请人： John Patrick Greelis ,  Mikxay Sirivong ,  David G. Matsuura ,  W. Tate Scott ,  Paul F. Zupkas

    发明人： John Patrick Greelis ,  Mikxay Sirivong ,  David G. Matsuura ,  W. Tate Scott ,  Paul F. Zupkas

    IPC分类号： A61M25/00 ,  A61M25/06 ,  A61M5/00

    CPC分类号： A61M25/00 ,  A61M25/0662 ,  A61M2210/1085 ,  A61M2210/1089

    摘要： A delivery device and method for delivering a medical device, such as an infuser, into a body cavity are disclosed. The delivery device includes an ejector tube which slidably extends through a handle. The ejector tube is configured for easy insertion through the urethra into the bladder. A hollow inner tube is located within the ejector tube and includes luer fittings at its distal and proximal ends. The luer fitting at the proximal end of the inner tube is coupled to the handle. Movement of the ejector tube relative to the inner tube causes the distal luer fitting to be withdrawn within the ejector tube and can be used to force an infuser attached to the distal luer fitting from the distal luer fitting. Materials can be transported to the infuser from the proximal luer fitting through the inner tube and out through the distal luer connector.

    摘要翻译： 公开了一种用于将医疗装置（例如输液器）输送到体腔中的输送装置和方法。 输送装置包括可滑动地延伸穿过手柄的喷射器管。 喷射器管被配置为容易地通过尿道插入膀胱。 中空的内管位于喷射管内，并在其远端和近端包括鲁尔接头。 在内管的近端处的鲁尔接头联接到手柄。 喷射器管相对于内管的移动导致远端鲁尔接头在喷射器管内被拉出，并且可用于迫使从远端鲁尔接头连接到远端鲁棒接头的浸入器。 材料可以通过内管从近端鲁尔接头输送到输注器，并通过远端鲁尔连接器输出。

    Medical instrument sheath comprising a flexible ultrasound transducer
    4.
    发明授权
    Medical instrument sheath comprising a flexible ultrasound transducer 失效
    包括柔性超声波换能器的医疗仪器护套

    公开(公告)号：US06582368B2

    公开(公告)日：2003-06-24

    申请号：US09836880

    申请日：2001-04-17

    申请人： Charles R. Holdaway ,  Paul F. Zupkas ,  David G. Matsuura

    发明人： Charles R. Holdaway ,  Paul F. Zupkas ,  David G. Matsuura

    IPC分类号： A61B800

    CPC分类号： A61B5/6848 ,  A61B8/0841 ,  A61B8/12 ,  A61B8/4444 ,  A61B8/4483 ,  A61B2562/164

    摘要： An ultrasound transducer comprises a sheath body constructed from a nonconductive material. The sheath body is configured to be installed over a medical device. A piezoelectric copolymer transducer is held snugly against the medical device by the sheath body when the ultrasound transducer is installed over the medical device. The piezoelectric copolymer transducer transduces incident ultrasound signals into corresponding electric signals. A ground conductor is coupled to a first surface of the piezoelectric copolymer transducer. A signal conductor is coupled to a second surface of the piezoelectric copolymer transducer and conducts the corresponding electric signals to a proximal end of the medical device.

    摘要翻译： 超声换能器包括由非导电材料构成的护套主体。 护套主体构造成安装在医疗装置上。 当超声换能器安装在医疗装置上时，压电共振换能器通过护套主体紧贴地保持在医疗装置上。 压电共振换能器将入射超声波信号转换成相应的电信号。 接地导体耦合到压电共振换能器的第一表面。 信号导体耦合到压电共振换能器的第二表面，并将相应的电信号传导到医疗装置的近端。

    Method and apparatus for determining a measure of tissue manipulation
    5.
    发明授权
    Method and apparatus for determining a measure of tissue manipulation 失效
    用于确定组织操作测量的方法和装置

    公开(公告)号：US6083166A

    公开(公告)日：2000-07-04

    申请号：US982753

    申请日：1997-12-02

    申请人： Charles Holdaway ,  David G. Matsuura ,  Paul F. Zupkas

    发明人： Charles Holdaway ,  David G. Matsuura ,  Paul F. Zupkas

    IPC分类号： A61B8/12 ,  A61B18/00 ,  A61B18/02 ,  A61B17/00

    CPC分类号： B82Y15/00 ,  A61B18/00 ,  A61B18/02 ,  A61B18/0206 ,  A61B18/0218 ,  A61B8/12

    摘要： A surgical device is comprised of a probe adapted for insertion into a patient. The probe has a means for manipulating tissue within a zone of manipulation. The probe also has a first receiver which is disposed within the zone of manipulation. The first receiver responds to receipt of a radiated signal by generation of a first receiver signal indicating a strength at which the radiated signal is received. A means for analyzing the first receiver signal determines a measure of manipulation to the tissue within the zone of manipulation. In one embodiment, the first receiver is disposed at the tip of the probe. In another embodiment, the means for manipulating removes energy from the tissue. In yet another embodiment, the means for manipulating adds energy to the tissue so as to alter the tissue. Optionally, the means for analyzing accumulates a set of values of the first receiver signal over time in order to determine the measure of manipulation. A scanner generates the radiated signal. Optionally, the scanner is an ultrasonic scanner and the radiated signal is an ultrasonic signal.

    摘要翻译： 手术装置由适于插入患者的探针组成。 探针具有在操纵区域内操纵组织的装置。 探头还具有设置在操纵区域内的第一接收器。 第一接收机通过产生指示辐射信号被接收的强度的第一接收机信号来响应接收到辐射信号。 用于分析第一接收器信号的装置确定对操纵区域内的组织的操纵的度量。 在一个实施例中，第一接收器设置在探针的尖端处。 在另一个实施例中，用于操纵的装置从组织中去除能量。 在另一个实施例中，用于操纵的装置向组织增加能量以改变组织。 可选地，用于分析的装置累积随时间推移的第一接收机信号的一组值，以便确定操纵的度量。 扫描仪产生辐射信号。 可选地，扫描器是超声波扫描仪，并且辐射信号是超声波信号。

    Cryosurgical instrument
    6.
    发明授权
    Cryosurgical instrument 失效
    冷冻仪器

    公开(公告)号：US5716353A

    公开(公告)日：1998-02-10

    申请号：US642658

    申请日：1996-05-03

    申请人： David G. Matsuura ,  Paul F. Zupkas

    发明人： David G. Matsuura ,  Paul F. Zupkas

    IPC分类号： A61B18/02 ,  A61B17/38

    CPC分类号： A61B18/02

    摘要： A cryosurgical instrument incorporates a heat transfer zone, which abuts against the portion of the cryosurgical instrument near the input refrigerant entrance, and which receives pure input refrigerant at the coldest temperature for quickly and effectively cooling this portion of the cryosurgical instrument. The cryosurgical instrument includes a shaft portion and a handle portion. The shaft portion includes an outer jacket tube having both an open and closed end. The closed end surrounds the freezing zone for freezing live tissue. A middle tube is disposed within the outer jacket tube. An inner tube is disposed within the middle tube. The inner tube is adapted for routing input cryogenic refrigerant therethrough to the freezing zone. The channel between the inner tube and middle tube forms a cryogenic refrigerant exhaust path for exhausting cryogenic refrigerant from the freezing zone. A heat transfer zone is disposed within the handle portion of the cryosurgical instrument near the entrance of the input refrigerant. The heat transfer zone may take the form of a cooling chamber. The cooling chamber is in fluid communication with the inner tube to receive input cryogenic refrigerant from inlet ports therefrom, and is adapted for circulating input refrigerant within the cooling chamber to induce heat transfer from the walls of the chamber into the refrigerant. The cryosurgical instrument further includes an exhaust chamber disposed within the handle portion adapted for receiving exhaust cryogenic refrigerant from the exhaust path. The exhaust chamber is also adapted for receiving exhaust cryogenic refrigerant from the cooling chamber through outlet ports in the cooling chamber.

    摘要翻译： 冷冻手术仪器包括传热区域，该传热区域邻近输入制冷剂入口处的冷冻手术器械的部分，并且在最冷的温度下接收纯输入制冷剂，以便快速有效地冷却该部分冷冻手术器械。 冷冻手术器械包括轴部和手柄部。 轴部分包括具有打开和关闭端的外护套管。 封闭的端部围绕着冻结区，用于冷冻活组织。 中间管设置在外护套管内。 内管设置在中管内。 内管适于将输入的低温制冷剂路由到冷冻区。 内管和中间管之间的通道形成用于从冷冻区排出低温制冷剂的低温制冷剂排气路径。 传热区设置在输入制冷剂入口附近的冷冻手术器械的手柄部分内。 传热区可以采取冷却室的形式。 冷却室与内管流体连通，以从其入口端口接收输入的低温制冷剂，并且适于使冷却室内的输入制冷剂循环，以引起从室的壁进入制冷剂的热传递。 所述冷冻手术器具还包括布置在所述把手部分内的排气室，其适于从所述排气路径接收排气低温制冷剂。 排气室还适于通过冷却室中的出口从冷却室接收排气低温制冷剂。