公开(公告)号：US08382796B2

公开(公告)日：2013-02-26

申请号：US12626175

申请日：2009-11-25

申请人： David J. Blaeser ,  Jerome K. Grudem, Jr. ,  Scott A. Olson ,  Mark R. Christianson ,  Scott M. Hanson ,  Edward J. Anderson ,  Patrick P. Russo ,  Dennis W. Wahr

发明人： David J. Blaeser ,  Jerome K. Grudem, Jr. ,  Scott A. Olson ,  Mark R. Christianson ,  Scott M. Hanson ,  Edward J. Anderson ,  Patrick P. Russo ,  Dennis W. Wahr

IPC分类号： A61B17/04

CPC分类号： A61B17/0057 ,  A61B90/39 ,  A61B2017/00575 ,  A61B2017/00592 ,  A61B2017/00606 ,  A61B2017/00619 ,  A61B2017/00623

摘要： A device for sealing a patent foramen ovale (PFO) in the heart is provided. The device includes a left atrial anchor adapted to be placed in a left atrium of the heart, a right atrial anchor adapted to be placed in a right atrium of the heart, and an elongate member adapted to extend through the passageway and connect the left and right atrial anchors. The right atrial anchor preferably includes a plurality of arms and a cover attached to the arms. The left atrial anchor preferably also includes a plurality of arms and preferably does not include a cover. Preferably, the elongate member has a first end fixedly connected to the left atrial anchor and a portion, proximal to the first end, passing through the right atrial anchor. Preferably, the elongate member is flexible.

摘要翻译： 提供了一种用于密封心脏中卵圆孔（PFO）的装置。 该装置包括适于放置在心脏的左心房的左心房锚，适于放置在心脏右心房的右心房锚，以及适于延伸通过该通道并连接左心室和/ 右心房锚 右心房锚优选地包括多个臂和附接到臂的盖。 左心房锚固件优选地还包括多个臂，并且优选地不包括盖。 优选地，细长构件具有固定地连接到左心房锚的第一端和靠近第一端的部分，穿过右心房锚。 优选地，细长构件是柔性的。

公开(公告)号：US08574264B2

公开(公告)日：2013-11-05

申请号：US11522158

申请日：2006-09-16

申请人： David J. Blaeser ,  Jerome K. Grudem, Jr. ,  Scott A. Olson ,  Mark R. Christianson ,  Scott M. Hanson ,  Edward J. Anderson ,  Patrick P. Russo ,  Dennis W. Wahr

发明人： David J. Blaeser ,  Jerome K. Grudem, Jr. ,  Scott A. Olson ,  Mark R. Christianson ,  Scott M. Hanson ,  Edward J. Anderson ,  Patrick P. Russo ,  Dennis W. Wahr

IPC分类号： A61B17/04

CPC分类号： A61B17/0057 ,  A61B90/39 ,  A61B2017/00575 ,  A61B2017/00592 ,  A61B2017/00606 ,  A61B2017/00619 ,  A61B2017/00623

摘要： A closure device for sealing a patent foramen ovale (PFO) in the heart includes a left atrial anchor adapted to be placed in a left atrium of the heart, a tether fixedly connected to the left atrial anchor and adapted to extend through the passageway of the PFO, a right atrial anchor adapted to be placed in a right atrium of the heart and moved along the tether, and a lock for securing the position of the right atrial anchor along the tether. The left and right atrial anchors preferably include a plurality of arms formed as loops and may include means for securing each arm in case of fracture in the loop. After the closure device is positioned, a cutting tool may sever the portion of the tether proximal of the right atrial anchor. The closure device can be retrieved during delivery, including by use of a snare catheter.

摘要翻译： 用于密封心脏中的卵孔卵泡（PFO）的闭合装置包括适于放置在心脏左心房的左心房锚，与左心房锚连接的系绳，并适于延伸穿过心房的通道 PFO，右心房锚，其适于放置在心脏的右心房并沿着系绳移动，以及用于沿着系绳固定右心房锚的位置的锁。 左心房和右心房锚固件优选地包括形成为环的多个臂，并且可以包括用于在环中断裂的情况下固定每个臂的装置。 在闭合装置定位之后，切割工具可以切断右心房锚的近端的部分。 闭合装置可以在输送期间被收回，包括使用圈套导管。

公开(公告)号：US20100069954A1

公开(公告)日：2010-03-18

申请号：US12626175

申请日：2009-11-25

申请人： David J. Blaeser ,  Jerome K. Grudem, JR. ,  Scott A. Olson ,  Mark R. Christianson ,  Scott M. Hanson ,  Edward J. Anderson ,  Patrick P. Russo ,  Dennis W. Wahr

发明人： David J. Blaeser ,  Jerome K. Grudem, JR. ,  Scott A. Olson ,  Mark R. Christianson ,  Scott M. Hanson ,  Edward J. Anderson ,  Patrick P. Russo ,  Dennis W. Wahr

IPC分类号： A61B17/08

CPC分类号： A61B17/0057 ,  A61B90/39 ,  A61B2017/00575 ,  A61B2017/00592 ,  A61B2017/00606 ,  A61B2017/00619 ,  A61B2017/00623

摘要： A device for sealing a patent foramen ovale (PFO) in the heart is provided. The device includes a left atrial anchor adapted to be placed in a left atrium of the heart, a right atrial anchor adapted to be placed in a right atrium of the heart, and an elongate member adapted to extend through the passageway and connect the left and right atrial anchors. The right atrial anchor preferably includes a plurality of arms and a cover attached to the arms. The left atrial anchor preferably also includes a plurality of arms and preferably does not include a cover. Preferably, the elongate member has a first end fixedly connected to the left atrial anchor and a portion, proximal to the first end, passing through the right atrial anchor. Preferably, the elongate member is flexible.

摘要翻译： 提供了一种用于密封心脏中卵圆孔（PFO）的装置。 该装置包括适于放置在心脏的左心房的左心房锚，适于放置在心脏右心房的右心房锚，以及适于延伸通过该通道并连接左心室和/ 右心房锚 右心房锚优选地包括多个臂和附接到臂的盖。 左心房锚固件优选地还包括多个臂，并且优选地不包括盖。 优选地，细长构件具有固定地连接到左心房锚的第一端和靠近第一端的部分，穿过右心房锚。 优选地，细长构件是柔性的。

公开(公告)号：US07691128B2

公开(公告)日：2010-04-06

申请号：US11249317

申请日：2005-10-14

申请人： David J. Blaeser ,  Peter T. Keith ,  Jerome K. Grudem, Jr. ,  Scott A. Olson ,  Steven S. Hackett ,  Thomas V. Ressemann ,  Joel D. Phillips ,  Mark R. Christianson ,  Dennis W. Wahr

发明人： David J. Blaeser ,  Peter T. Keith ,  Jerome K. Grudem, Jr. ,  Scott A. Olson ,  Steven S. Hackett ,  Thomas V. Ressemann ,  Joel D. Phillips ,  Mark R. Christianson ,  Dennis W. Wahr

IPC分类号： A61B17/08 ,  A61D1/00

CPC分类号： A61B17/0469 ,  A61B17/00491 ,  A61B17/0057 ,  A61B17/0401 ,  A61B2017/00575 ,  A61B2017/00592 ,  A61B2017/00615 ,  A61B2017/0409 ,  A61B2017/0458 ,  A61B2017/0464 ,  A61B2017/0474 ,  A61B2017/0496 ,  A61B2017/22051

摘要： Devices and methods for sealing a passageway formed by a patent foramen ovale (PFO track) in the heart are provided. One method includes providing an abrading device to the PFO track and abrading the tissue within the PFO track. The abraded tissue forming the PFO track is then held together under pressure, either via lowering right atrial pressure or via applying suction to the septum primum to pull it into apposition against the septum secundum. After a sufficient period of time, the pressure is released and the abraded tissue heals to form a robust seal over the PFO track. Additionally, several devices are provided which can be placed into the PFO track to apply adhesive to the walls of the PFO track. The devices may or may not be left within the PFO track. If the devices are not left within the PFO track, the walls of the PFO track, covered with adhesive, are brought into apposition with one another and adhered together. If the device is left within the PFO track, the device is flattened from an expanded configuration to a flattened configuration, and the walls of the PFO track, adhering to the outer surface of the device, are pulled toward each other as the device flattens. The device may also include interior structure to hold the device in a flattened configuration.

摘要翻译： 提供用于密封由心脏中的卵圆孔卵孔（PFO轨迹）形成的通道的装置和方法。 一种方法包括向PFO轨道提供研磨装置并研磨PFO轨道内的组织。 形成PFO轨道的磨损组织然后在压力下保持在一起，或者通过降低右心房压力或通过向隔膜施加抽吸使其与隔膜隔层相对。 经过足够的时间后，释放压力，磨损的组织愈合，在PFO轨迹上形成牢固的密封。 另外，提供了可以放置到PFO轨道中以将粘合剂施加到PFO轨道的壁上的几个装置。 设备可能会留在PFO轨道中，也可能不会留在PFO轨道中。 如果设备不在PFO轨道内，PFO轨道的墙壁被粘合剂覆盖，彼此并置并粘合在一起。 如果设备留在PFO轨道内，则设备将从扩展配置平坦化到平坦的配置，并且随着设备平坦化，PFO轨道的粘附在设备外表面上的墙壁会相互拉紧。 该装置还可以包括用于将装置保持在扁平结构中的内部结构。

公开(公告)号：US07976564B2

公开(公告)日：2011-07-12

申请号：US10138565

申请日：2002-05-06

申请人： David J. Blaeser ,  Peter T. Keith ,  Jerome K. Grudem, Jr. ,  Scott A. Olson ,  Steven S. Hackett ,  Thomas V. Ressemann ,  Joel D. Phillips ,  Mark R. Christianson ,  Dennis W. Wahr

发明人： David J. Blaeser ,  Peter T. Keith ,  Jerome K. Grudem, Jr. ,  Scott A. Olson ,  Steven S. Hackett ,  Thomas V. Ressemann ,  Joel D. Phillips ,  Mark R. Christianson ,  Dennis W. Wahr

IPC分类号： A61B17/08

CPC分类号： A61B17/0469 ,  A61B17/00491 ,  A61B17/0057 ,  A61B17/0401 ,  A61B2017/00575 ,  A61B2017/00592 ,  A61B2017/00615 ,  A61B2017/0409 ,  A61B2017/0458 ,  A61B2017/0464 ,  A61B2017/0474 ,  A61B2017/0496 ,  A61B2017/22051

摘要： Devices and methods for sealing a passageway formed by a patent foramen ovale (PFO track) in the heart are provided. One method includes providing an abrading device to the PFO track and abrading the tissue within the PFO track. The abraded tissue forming the PFO track is then held together under pressure, either via lowering right atrial pressure or via applying suction to the septum primum to pull it into apposition against the septum secundum. After a sufficient period of time, the pressure is released and the abraded tissue heals to form a robust seal over the PFO track. Additionally, several devices are provided which can be placed into the PFO track to apply adhesive to the walls of the PFO track. The devices may or may not be left within the PFO track. If the devices are not left within the PFO track, the walls of the PFO track, covered with adhesive, are brought into apposition with one another and adhered together. If the device is left within the PFO track, the device is flattened from an expanded configuration to a flattened configuration, and the walls of the PFO track, adhering to the outer surface of the device, are pulled toward each other as the device flattens. The device may also include interior structure to hold the device in a flattened configuration.

摘要翻译： 提供用于密封由心脏中的卵圆孔卵孔（PFO轨迹）形成的通道的装置和方法。 一种方法包括向PFO轨道提供研磨装置并研磨PFO轨道内的组织。 形成PFO轨道的磨损组织然后在压力下保持在一起，或者通过降低右心房压力或通过向隔膜施加抽吸使其与隔膜隔层相对。 经过足够的时间后，释放压力，磨损的组织愈合，在PFO轨迹上形成牢固的密封。 另外，提供了可以放置到PFO轨道中以将粘合剂施加到PFO轨道的壁上的几个装置。 设备可能会留在PFO轨道中，也可能不会留在PFO轨道中。 如果设备不在PFO轨道内，PFO轨道的墙壁被粘合剂覆盖，彼此并置并粘合在一起。 如果设备留在PFO轨道内，则设备将从扩展配置平坦化到平坦的配置，并且随着设备平坦化，PFO轨道的粘附在设备外表面上的墙壁会相互拉紧。 该装置还可以包括用于将装置保持在扁平结构中的内部结构。

公开(公告)号：US20100234881A1

公开(公告)日：2010-09-16

申请号：US12725886

申请日：2010-03-17

申请人： David J. Blaeser ,  Peter T. Keith ,  Jerome K. Grudem, JR. ,  Scott A. Olson ,  Steven S. Hackett ,  Thomas V. Ressemann ,  Joel D. Phillips ,  Mark R. Christianson ,  Dennis W. Wahr

发明人： David J. Blaeser ,  Peter T. Keith ,  Jerome K. Grudem, JR. ,  Scott A. Olson ,  Steven S. Hackett ,  Thomas V. Ressemann ,  Joel D. Phillips ,  Mark R. Christianson ,  Dennis W. Wahr

IPC分类号： A61B17/03

CPC分类号： A61B17/0469 ,  A61B17/00491 ,  A61B17/0057 ,  A61B17/0401 ,  A61B2017/00575 ,  A61B2017/00592 ,  A61B2017/00615 ,  A61B2017/0409 ,  A61B2017/0458 ,  A61B2017/0464 ,  A61B2017/0474 ,  A61B2017/0496 ,  A61B2017/22051

摘要： Devices and methods for sealing a passageway formed by a patent foramen ovale (PFO track) in the heart are provided. One method includes providing an abrading device to the PFO track and abrading the tissue within the PFO track. The abraded tissue forming the PFO track is then held together under pressure, either via lowering right atrial pressure or via applying suction to the septum primum to pull it into apposition against the septum secundum. After a sufficient period of time, the pressure is released and the abraded tissue heals to form a robust seal over the PFO track. Additionally, several devices are provided which can be placed into the PFO track to apply adhesive to the walls of the PFO track. The devices may or may not be left within the PFO track. If the devices are not left within the PFO track, the walls of the PFO track, covered with adhesive, are brought into apposition with one another and adhered together. If the device is left within the PFO track, the device is flattened from an expanded configuration to a flattened configuration, and the walls of the PFO track, adhering to the outer surface of the device, are pulled toward each other as the device flattens. The device may also include interior structure to hold the device in a flattened configuration.

摘要翻译： 提供用于密封由心脏中的卵圆孔卵孔（PFO轨迹）形成的通道的装置和方法。 一种方法包括向PFO轨道提供研磨装置并研磨PFO轨道内的组织。 形成PFO轨道的磨损组织然后在压力下保持在一起，或者通过降低右心房压力或通过向隔膜施加抽吸使其与隔膜隔层相对。 经过足够的时间后，释放压力，磨损的组织愈合，在PFO轨迹上形成牢固的密封。 另外，提供了可以放置到PFO轨道中以将粘合剂施加到PFO轨道的壁上的几个装置。 设备可能会留在PFO轨道中，也可能不会留在PFO轨道中。 如果设备不在PFO轨道内，PFO轨道的墙壁被粘合剂覆盖，彼此并置并粘合在一起。 如果设备留在PFO轨道内，则设备将从扩展配置平坦化到平坦的配置，并且随着设备平坦化，PFO轨道的粘附在设备外表面上的墙壁会相互拉紧。 该装置还可以包括用于将装置保持在扁平结构中的内部结构。

公开(公告)号：US08372112B2

公开(公告)日：2013-02-12

申请号：US10934735

申请日：2004-09-07

申请人： Mark R. Christianson ,  Scott A. Olson ,  Edward J. Anderson ,  Philip J. Haarstad ,  Douglas J. Krone ,  Dennis W. Wahr ,  David J. Blaeser

发明人： Mark R. Christianson ,  Scott A. Olson ,  Edward J. Anderson ,  Philip J. Haarstad ,  Douglas J. Krone ,  Dennis W. Wahr ,  David J. Blaeser

IPC分类号： A61B17/08

CPC分类号： A61B17/0057 ,  A61B17/22032 ,  A61B17/221 ,  A61B90/39 ,  A61B2017/00243 ,  A61B2017/00575 ,  A61B2017/00592 ,  A61B2017/00597 ,  A61B2017/00606 ,  A61B2017/00619 ,  A61B2017/00623 ,  A61B2017/2215 ,  A61F2002/011

摘要： A closure device for sealing a patent foramen ovale (PFO) in the heart includes a left atrial anchor adapted to be placed in a left atrium of the heart, a right atrial anchor adapted to be placed in a right atrium of the heart, and a flexible elongate member adapted to extend through the passageway and connect the left and right atrial anchors. A delivery system for delivering the closure device includes a lock push tube for moving a lock along the elongate member and a wire release tube surrounding a wire for controlling movement of the right atrial anchor along the elongate member. The lock push tube and the wire release tube extend in a side-by-side relationship. A handle includes knobs for controlling the lock push tube and the wire. A device for retrieving a mis-deployed closure device includes a shaft portion and an expandable retrieval portion.

摘要翻译： 用于密封心脏中卵圆孔（PFO）的闭合装置包括适于放置在心脏左心房的左心房锚，适于置于心脏右心房的右心房锚， 柔性细长构件适于延伸穿过通道并连接左心房和右心房。 用于输送闭合装置的输送系统包括用于沿着细长构件移动锁的锁定推动管和围绕线的线释放管，用于控制沿着细长构件的右心房锚的运动。 锁定推动管和导线释放管以并排的关系延伸。 手柄包括用于控制锁定推动管和线的旋钮。 用于检索错误展开的闭合装置的装置包括轴部分和可扩张的回缩部分。

公开(公告)号：US20120253382A1

公开(公告)日：2012-10-04

申请号：US13525047

申请日：2012-06-15

申请人： Dennis W. Wahr ,  Thomas V. Ressemann ,  Peter T. Keith ,  David J. Blaeser ,  Michael Berman

发明人： Dennis W. Wahr ,  Thomas V. Ressemann ,  Peter T. Keith ,  David J. Blaeser ,  Michael Berman

IPC分类号： A61M29/00

CPC分类号： A61B17/12136 ,  A61B17/12045 ,  A61B17/12109 ,  A61B90/39 ,  A61B2017/12127 ,  A61B2017/22067 ,  A61F2/95

摘要： An embolic protection system and method of treating occluded vessels which reduces the risk of distal embolization during vascular interventions is provided. The embolic protection system includes a guide catheter, a multi-lumen tube having a sealing surface on the distal end and an interventional device. A method of treating a blood vessel includes providing a guide catheter and a multi-lumen elongate member having proximal and distal ends, evacuation and inflation lumens extending therebetween and a sealing surface on the distal end. The elongate member is advanced through the guide catheter into a blood vessel that supplies blood to the heart proximal a lesion. The sealing surface is expanded to engage the endoluminal surface of the blood vessel and stop antegrade flow. An interventional device is advanced through the evacuation lumen to treat the lesion.

摘要翻译： 提供了栓塞保护系统和治疗闭塞血管的方法，其减少血管干预期间远端栓塞的风险。 栓塞保护系统包括引导导管，具有远端密封表面的多腔管和介入装置。 治疗血管的方法包括提供导向导管和具有近端和远端的多腔细长构件，在其间延伸的抽空和充气腔以及远端上的密封表面。 细长构件通过引导导管前进到血管，该血管将血液提供给病灶附近的心脏。 密封表面被膨胀以与血管的内腔表面接合并停止顺行流动。 介入装置通过疏散腔前进以治疗病变。

公开(公告)号：US07654978B2

公开(公告)日：2010-02-02

申请号：US11034824

申请日：2005-01-14

申请人： Dennis W. Wahr ,  Thomas V. Ressemann ,  Peter T. Keith ,  David J. Blaeser ,  Michael Berman

发明人： Dennis W. Wahr ,  Thomas V. Ressemann ,  Peter T. Keith ,  David J. Blaeser ,  Michael Berman

IPC分类号： A61M29/00

CPC分类号： A61B17/12136 ,  A61B17/12045 ,  A61B17/12109 ,  A61B90/39 ,  A61B2017/12127 ,  A61B2017/22067 ,  A61F2/95

摘要： An evacuation sheath assembly and method of treating occluded vessels which reduces the risk of distal embolization during vascular interventions is provided. The evacuation sheath assembly includes an elongated tube defining an evacuation lumen having proximal and distal ends. A proximal sealing surface is provided on a proximal portion of the tube and is configured to form a seal with a lumen of a guided catheter. A distal sealing surface is provided on a distal portion of the tube and is configured to form a seal with a blood vessel. A method of treatment of a blood vessel using the evacuation sheath assembly includes advancing the evacuation sheath assembly into the blood vessel through a guide catheter. Prior to advancing a device across a stenosis to be treated, normal antegrade blood flow in the blood vessel proximate to the stenosis is stopped. While blood flow is stopped, the stenosis is treated. Retrograde blood flow is induced within the blood vessel to carry embolic material dislodged during treating into the evacuation sheath assembly.

摘要翻译： 提供疏散鞘组件和治疗闭塞血管的方法，其减少血管干预期间远端栓塞的风险。 抽真空组件包括限定具有近端和远端的抽空腔的细长管。 近侧密封表面设置在管的近端部分上，并被构造成与引导导管的内腔形成密封。 远端密封表面设置在管的远端部分上并构造成与血管形成密封。 使用排气鞘组件治疗血管的方法包括通过引导导管将排空鞘组件推进到血管中。 在将装置推进通过待治疗的狭窄之前，停止在狭窄附近的血管中的正常顺行血流。 当血流停止时，狭窄处理。 在血管内引起逆行血流，以便在处理进入抽真空鞘组件期间将栓塞物移走。

公开(公告)号：US07959603B2

公开(公告)日：2011-06-14

申请号：US11824451

申请日：2007-06-29

申请人： Dennis W. Wahr ,  Thomas V. Ressemann ,  Peter T. Keith ,  David J. Blaeser ,  Michael Berman

发明人： Dennis W. Wahr ,  Thomas V. Ressemann ,  Peter T. Keith ,  David J. Blaeser ,  Michael Berman

IPC分类号： A61M29/00

CPC分类号： A61B17/12136 ,  A61B17/12045 ,  A61B17/12109 ,  A61B90/39 ,  A61B2017/12127 ,  A61B2017/22067 ,  A61F2/95

摘要： An evacuation sheath assembly and method of treating occluded vessels which reduces the risk of distal embolization during vascular interventions is provided. A method of treating a blood vessel, includes providing an elongate member having proximal and distal ends, a lumen therebetween, the distal end having a braided sheath expandable between a reduced and expanded diameter, and a fluid-tight covering. The elongate member is advanced into a blood vessel that supplies blood to the heart. The braided sheath is expanded to engage the endoluminal surface of the blood vessel and stop antegrade flow.

摘要翻译： 提供疏散鞘组件和治疗闭塞血管的方法，其减少血管干预期间远端栓塞的风险。 一种治疗血管的方法，包括提供具有近端和远端的细长构件，其间的腔，所述远端具有可在缩径和扩张直径之间扩张的编织护套和流体密封的覆盖物。 细长构件前进到向心脏供应血液的血管。 编织的鞘被扩张以接合血管的内腔表面并停止顺行的流动。