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40 条记录 (耗时 0.044 秒)

    Method of identifying inhibitors of Lck
    6.
    发明授权
    Method of identifying inhibitors of Lck 有权
    鉴定Lck抑制剂的方法

    公开(公告)号：US07400979B2

    公开(公告)日：2008-07-15

    申请号：US10212346

    申请日：2002-08-05

    申请人： David W. Borhani ,  David Calderwood ,  Richard W. Dixon ,  Gavin C. Hirst ,  Peter Hrnciar ,  Andreas Loew ,  Adelaine Leung ,  Kurt Ritter

    发明人： David W. Borhani ,  David Calderwood ,  Richard W. Dixon ,  Gavin C. Hirst ,  Peter Hrnciar ,  Andreas Loew ,  Adelaine Leung ,  Kurt Ritter

    IPC分类号： G06F17/11 ,  G06F17/50 ,  G06F19/00

    CPC分类号： C12N9/1205 ,  C07K2299/00

    摘要： The present invention relates to polypeptides which comprise the ligand binding domain of Lck, crystalline forms of these polypeptides, and the use of these crystalline forms to determine the three dimensional structure of the catalytic domain of Lck. The invention also relates to the use of the three dimensional structure of the Lck catalytic domain both alone, or in complex with inhibitors, in methods of designing and/or identifying potential inhibitors of Lck activity, for example, compounds which inhibit the binding of a native substrate to the Lck catalytic domain. The invention also relates to the use of the three dimensional structure of the Lck catalytic domain both alone, or in complex with inhibitors, in methods of designing and/or identifying potential selective inhibitors of Lck activity, for example, compounds which inhibit the binding of a native substrate to the Lck catalytic domain selectively.

    摘要翻译： 本发明涉及包含Lck的配体结合结构域，这些多肽的结晶形式的多肽，以及这些结晶形式用于确定Lck催化结构域的三维结构的多肽。 本发明还涉及在设计和/或鉴定Lck活性的潜在抑制剂的方法中单独或与抑制剂复合的Lck催化结构域的三维结构的用途，例如抑制结合的化合物 天然底物到Lck催化结构域。 本发明还涉及在设计和/或鉴定Lck活性的潜在选择性抑制剂的方法中单独或与抑制剂复合的Lck催化结构域的三维结构的用途，例如抑制Lck活性结合的化合物 选择性地对Lck催化结构域的天然底物。

    Seat bottom extension mechanism for passenger seats
    7.
    发明授权
    Seat bottom extension mechanism for passenger seats 失效
    座椅底座延伸机构

    公开(公告)号：US5560681A

    公开(公告)日：1996-10-01

    申请号：US407621

    申请日：1995-03-21

    申请人： Richard W. Dixon ,  Tommy G. Plant ,  Ralph J. Nolan, Jr.

    发明人： Richard W. Dixon ,  Tommy G. Plant ,  Ralph J. Nolan, Jr.

    IPC分类号： A47C1/023 ,  A47C7/50 ,  B60N2/90 ,  A47C3/025

    CPC分类号： B60N2/4495 ,  B64D11/06 ,  B64D11/0643

    摘要： A seat having a seat frame mounting a seat bottom, a seat back extending upwardly from the back of the seat bottom and a leg rest extending downwardly in an area forward of a front side of the seat bottom. The seat includes the combination of a seat bottom extension for increasing or decreasing the length of the seat bottom between the seat back and the leg rest to fit the distance between the buttocks and the back of the knees of the occupant. The seat bottom extension has a seat bottom extension assembly on which the leg rest is mounted for movement therewith and an adjustment assembly for adjustably mounting the seat bottom extension assembly to the front side of the seat bottom. The seat bottom extension is mounted for incremental movement between a first position wherein the seat bottom extension is retracted to a position adjacent the front side of the seat bottom and a second position wherein the seat bottom extension is extended to a position spaced apart from the front side of the seat bottom to thereby increase the length of the seat bottom between the seat back and the leg rest to fit the distance between the buttocks and the back of the knees of the occupant.

    摘要翻译： 具有安装座椅底部的座椅框架的座椅，从座椅底部的后部向上延伸的座椅靠背和在座椅底部的前侧的前方的区域中向下延伸的腿托。 座椅包括座椅底部延伸部的组合，用于增加或减少座椅靠背和腿部座椅之间的座椅底部的长度，以适应臀部和乘员膝盖后部之间的距离。 座椅底部延伸部具有座椅底部延伸组件，腿部支架安装在该座椅底部延伸组件上以与其一起运动，以及用于将座椅底部延伸组件可调节地安装到座椅底部的前侧的调节组件。 座椅底部延伸部被安装用于在座椅底部延伸部缩回到邻近座椅底部前侧的位置的第一位置和第二位置之间进行增量运动，其中座椅底部延伸部延伸到与前部隔开的位置 从而增加座椅靠背和腿部支架之间的座椅底部的长度，以适应臀部和乘员膝盖后部之间的距离。

    Method for bundling newspapers
    8.
    发明授权
    Method for bundling newspapers 失效
    捆绑报纸的方法

    公开(公告)号：US5272966A

    公开(公告)日：1993-12-28

    申请号：US53158

    申请日：1993-04-27

    申请人： Richard W. Dixon

    发明人： Richard W. Dixon

    IPC分类号： B65B27/08 ,  B65B13/02

    CPC分类号： B65B27/083

    摘要： A device for bundling newspapers and the like comprises a pair of upright walls each having an upwardly open substantially V-shaped notch formed by elements of the walls that converge downwardly and that define an interior angle of about 90.degree., the notches being in parallel alignment. In a preferred embodiment, the walls are longitudinal side walls of a box having upright end walls and having sloping top walls extending between corresponding notch-defining elements of the side walls. Newspapers are stacked on one of the top walls, with an edge thereof engaging the other top wall, and with portions extending beyond the side walls. Cords are tied around those portions to bundle the newspapers. The end walls have openings forming hand holds by which the box is lifted and which provide access to the interior of the box. The box has a shelf therein and contains a supply of cord, a cord cutter being provided along an edge of one opening. A strap may be placed over the stack centrally and is detachably engaged with portions of the top walls.

    摘要翻译： 用于捆扎报纸等的装置包括一对直立壁，每个竖立壁具有向上敞开的基本上为V形的凹口，该凹口由壁的元件向下收敛并限定约90度的内角，该凹口处于平行对准 。 在优选实施例中，壁是具有直立端壁并具有在侧壁的相应凹口限定元件之间延伸的倾斜顶壁的盒的纵向侧壁。 报纸层叠在一个顶壁上，其边缘与另一个顶壁接合，并且部分延伸超出侧壁。 电线捆绑在这些部分捆绑报纸。 端壁具有形成手柄的开口，通过该开口，盒被提起并且提供进入箱体内部的通路。 盒子里面有一个搁板，它包含一根电源线，沿着一个开口的边缘设置一个电线切割器。 带子可以在中心堆放在堆叠上方并且可拆卸地与顶壁的部分接合。

    IL-12/p40 binding proteins
    9.
    发明授权
    IL-12/p40 binding proteins 失效
    IL-12 / p40结合蛋白

    公开(公告)号：US08629257B2

    公开(公告)日：2014-01-14

    申请号：US12763048

    申请日：2010-04-19

    申请人： Susan E. Lacy ,  Emma Fung ,  Jonathan P. Belk ,  Richard W. Dixon ,  Michael Roguska ,  Paul R. Hinton ,  Shankar Kumar

    发明人： Susan E. Lacy ,  Emma Fung ,  Jonathan P. Belk ,  Richard W. Dixon ,  Michael Roguska ,  Paul R. Hinton ,  Shankar Kumar

    IPC分类号： C07H21/04

    CPC分类号： C07K16/244 ,  A61K39/3955 ,  A61K45/06 ,  C07K2317/24 ,  C07K2317/567 ,  C07K2317/76 ,  C07K2317/92 ,  G01N33/6869

    摘要： The present invention encompasses IL-12p40 binding proteins, particularly antibodies that bind human interleukin-12 (hIL-12) and/or human IL-23 (hIL-23). Specifically, the invention relates to antibodies that are chimeric, CDR grafted and humanized antibodies. Preferred antibodies have high affinity for hIL-12 and/or hIL-23 and neutralize h IL-12 and/or hIL-23 activity in vitro and in vivo. An antibody of the invention can be a full-length antibody or an antigen-binding portion thereof. Method of making and method of using the antibodies of the invention are also provided. The antibodies, or antibody portions, of the invention are useful for detecting hIL-12 and/or hIL-23 and for inhibiting hIL-12 and/or hIL-23 activity, e.g., in a human subject suffering from a disorder in which hIL-12 and/or hIL-23 activity is detrimental.

    摘要翻译： 本发明包括IL-12p40结合蛋白，特别是结合人白细胞介素-12（hIL-12）和/或人IL-23（hIL-23）的抗体。 具体地，本发明涉及作为嵌合，CDR移植和人源化抗体的抗体。 优选的抗体对hIL-12和/或hIL-23具有高亲和力，并在体外和体内中和h IL-12和/或hIL-23活性。 本发明的抗体可以是全长抗体或其抗原结合部分。 还提供了制备方法和使用本发明抗体的方法。 本发明的抗体或抗体部分可用于检测hIL-12和/或hIL-23和用于抑制hIL-12和/或hIL-23活性，例如在患有hIL -12和/或hIL-23活性是有害的。