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公开(公告)号：US5968034A
公开(公告)日：1999-10-19
申请号：US103756
申请日：1998-06-24
CPC分类号： A61B18/203 , A61B2017/00057 , A61B2018/00005 , A61B2018/00452 , A61B2018/0047 , A61B2018/00476 , A61B2018/1807 , A61N5/0617
摘要： A high energy filament lamp light source, such as a quartz tungsten halogen lamp, operated in a pulsed mode with a high voltage input, creates a particular energy output. Applications of such apparatus and methods include treatment of the dermis and/or sub-epidermal tissues for the purpose of skin recontouring, thermal destruction of hair follicles for the purpose of hair removal, and others, and a method which selectively preheats a subsurface region in targeted tissue to sub-thermal modification threshold values without significant heat damage to surrounding layers prior to further treatment.
摘要翻译： 在具有高电压输入的脉冲模式下操作的高能量白炽灯光源（例如石英卤钨灯）产生特定的能量输出。 这样的装置和方法的应用包括为了皮肤再造，毛发去除毛囊的热破坏等目的对真皮和/或亚表皮组织进行处理，以及选择性地预热毛发去除的地下区域的方法 目标组织到亚热修饰阈值，在进一步治疗之前没有对周围层的显着的热损伤。
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公开(公告)号：US5885274A
公开(公告)日：1999-03-23
申请号：US881539
申请日：1997-06-24
CPC分类号： A61B18/203 , A61B2017/00057 , A61B2018/00005 , A61B2018/00452 , A61B2018/0047 , A61B2018/00476 , A61B2018/1807 , A61N5/0617
摘要： Thermal modification of dermatological tissue using non-laser infrared light energy. A high energy incandescent-type lamp, such as a quartz tungsten halogen lamp, operated in a pulsed mode with a high voltage input, creates a particular energy output. Applications of such apparatus and methods include treatment of the dermis and/or sub-epidermal tissues for the purpose of skin recontouring, thermal destruction of hair follicles for the purpose of hair removal, and others.
摘要翻译： 使用非激光红外光能对皮肤病组织进行热修饰。 以高电压输入的脉冲模式操作的高能量白炽灯（例如石英卤钨灯）产生特定的能量输出。 这样的设备和方法的应用包括为了皮肤重塑，毛发去除毛囊的热破坏等目的，治疗真皮和/或亚表皮组织等。
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公开(公告)号：US5591157A
公开(公告)日：1997-01-07
申请号：US301911
申请日：1994-09-07
CPC分类号： A61B18/20 , A61B18/22 , A61B34/72 , A61B2017/00787 , A61B2018/00636 , A61B2018/2025 , A61B2034/742
摘要： The tympanic membrane can be tightened by directing energy on spots of the tympanic membrane so as to heat up the collagen matrix layer and cause it to shrink. Energy in the frequency range of 1.4 to 2.6 microns, which roughly corresponds to a collagen absorption range of from 10 to 150 cm.sup.-1, is used.
摘要翻译： 可以通过将能量引导到鼓膜的斑点上来加强鼓膜，以加热胶原基质层并使其收缩。 在1.4至2.6微米的频率范围内的能量大致对应于10至150cm -1的胶原吸收范围。
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公开(公告)号：US5976123A
公开(公告)日：1999-11-02
申请号：US938923
申请日：1997-09-26
IPC分类号： A61B1/12 , A61B17/00 , A61B17/32 , A61B18/00 , A61B18/02 , A61B18/14 , A61B18/20 , A61B18/22 , A61N1/40 , A61N5/06 , A61B17/38
CPC分类号： A61B18/0218 , A61B18/00 , A61B18/203 , A61N1/40 , A61B1/12 , A61B17/320068 , A61B18/14 , A61B18/20 , A61B18/22 , A61B2017/00057 , A61B2017/00084 , A61B2017/00747 , A61B2017/00756 , A61B2018/00005 , A61B2018/00023 , A61B2018/00029 , A61B2018/00041 , A61B2018/00452 , A61B2018/00476 , A61B2018/00916 , A61B2018/0231 , A61B2218/005 , A61N5/0616
摘要： A cooling handpiece and method for use in therapeutic, cosmetic or aesthetic, diagnostic, exploratory, interventional or other medical procedures, the handpiece for use in conjunction with a controllable energy source such as coherent light, non-coherent light or laser light, ultrasound energy, radio frequency energy and other types of electromagnetic and mechanical energy, the handpiece comprising a main body portion adapted for directing the energy to target tissue, the main body portion further adapted for receiving a removable reservoir containing coolant fluid, the reservoir having an attachment means for releasable attachment of the reservoir to the handpiece, and the handpiece having a controllable valve for delivery of a portion of the coolant fluid to the target tissue.
摘要翻译： 用于治疗，化妆品或美学，诊断，探索，介入或其他医学过程的冷却手持件和方法，与可控能源结合使用的手持件，例如相干光，非相干光或激光，超声能量 射频能量和其它类型的电磁和机械能，所述手持件包括适于将能量引导到目标组织的主体部分，所述主体部分还适于接收容纳冷却剂流体的可移除储存器，所述储存器具有附接装置 用于将储存器可释放地附接到手持件，以及具有用于将一部分冷却剂流体输送到目标组织的可控阀的手持件。
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公开(公告)号：US5304169A
公开(公告)日：1994-04-19
申请号：US930973
申请日：1992-08-17
申请人： Bruce J. Sand
发明人： Bruce J. Sand
CPC分类号： A61F9/008 , A61F2009/00853 , A61F2009/00872
摘要： A method for shrinkage of collagen tissue by application of coherent infrared energy, in which the threshold shrinkage temperature is substantially reduced by application of a reagent such as lysozyme to the tissue prior to heating. The method is especially useful in ophthalmology for shape modification of a cornea, and is enhanced by using a corneal collagen shield as a carrier and delivery agent for the reagent and an admixed anaesthetic.
摘要翻译： 通过施加相干红外能量来收缩胶原组织的方法，其中通过在加热之前向组织施加诸如溶菌酶的试剂，阈值收缩温度显着降低。 该方法在用于角膜形状修饰的眼科中特别有用，并且通过使用角膜胶原屏蔽作为载体和用于试剂的输送剂和混合麻醉剂来增强。
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公开(公告)号：US4976709A
公开(公告)日：1990-12-11
申请号：US374958
申请日：1989-06-30
申请人： Bruce J. Sand
发明人： Bruce J. Sand
CPC分类号： A61F9/008 , A61F2009/00853 , A61F2009/00872
摘要： A method for controlled thermal shrinkage of collagen tissue by irradiation with coherent energy in the wavelength band of 1.80 to 2.55 microns as generated by a laser. A specific application to ophthalmological corneal reshaping is described.
摘要翻译： 在激光产生的波长范围为1.80-2.55微米的相干能量照射下，可以控制胶原组织热收缩的方法。 描述了对眼科角膜重塑的具体应用。
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7.发明申请TRANSDERMAL DRUG DELIVERY COMPOSITIONS AND TOPICAL COMPOSITIONS FOR APPLICATION ON THE SKIN 审中-公开透皮药物输送组合物和适用于皮肤的局部组合物公开(公告)号：US20090053290A1
公开(公告)日：2009-02-26
申请号：US12281768
申请日：2007-03-08
IPC分类号： A61K9/70 , A61K47/42 , A61K47/10 , A61K47/02 , A61K31/4172 , A61K31/351 , A61K39/08 , A61K9/10 , A61K31/496 , A61K31/164 , A61K31/4545 , A61K31/7042 , A61K31/60
摘要： Transdermal delivery compositions and topical compositions for application to the skin are provided. The transdermal delivery composition includes at least two penetrants working synergistically but by disparate biochemical pathways. In one embodiment, the transdermal delivery system includes benzyl alcohol and lecithin organogel. The transdermal delivery compositions are used in a variety of topical compositions as a means of transdermally delivering and topically administering different drugs and agents, including compositions promoting collagen biosynthesis, retinoids and skin lighteners, chemical denervation agents such as BOTOX®, anti-fungal agents, anesthetics and non-steroidal anti-inflammatory drugs (NSAIDs). In addition, these topical compositions may be used in combination with non-ablative treatment modalities, such as microdermabrasion, laser-based skin remodeling and radio-frequency-based skin remodeling.
摘要翻译： 提供用于皮肤的透皮递送组合物和局部组合物。 透皮递送组合物包括至少两种渗透剂，其协同作用，但通过不同的生化途径。 在一个实施方案中，透皮递送系统包括苄醇和卵磷脂有机凝胶。 透皮递送组合物用于多种局部组合物中，作为经皮递送和局部施用不同药物和试剂的手段，包括促进胶原生物合成的组合物，类视色素和皮肤增亮剂，化学去神经调节剂如BOTOX，抗真菌剂 药物，麻醉剂和非甾体抗炎药（NSAIDs）。 此外，这些局部组合物可以与非消融治疗方式组合使用，例如微磨皮，基于激光的皮肤重塑和基于射频的皮肤重塑。
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公开(公告)号：US07044945B2
公开(公告)日：2006-05-16
申请号：US10400173
申请日：2003-03-26
申请人： Bruce J. Sand
发明人： Bruce J. Sand
IPC分类号： A61B18/04
CPC分类号： A61F9/008 , A61B2018/00005 , A61F9/00781 , A61F2009/00865 , A61F2009/00868 , A61F2009/00872 , A61F2009/00891 , A61F2009/00895
摘要： Methods and apparatus are provided that prevent or inhibit functional regression caused by the stromal remodeling resulting from epithelial or fibroblastic apoptosis or necrosis in patients who will undergo or have undergone a thermal ciliary muscle tendinoplasty or scleral collagen shrinkage procedures. Methods and compositions are provided that prevent apoptosis in epithelial cells by stromal cooling during thermal tendinoplasty procedures; that create or restore stabilizing molecular cross-links between scleral stromal lamellar fibers; and that interrupt at least one step in the stromal remodeling response including inhibition of apoptosis, fibroblastic proliferation and migration, and inhibition of collagenesis.
摘要翻译： 提供了预防或抑制由经历或已进行热睫状肌腱成形术或巩膜胶原收缩程序的患者中上皮细胞或成纤维细胞凋亡或坏死引起的基质重塑引起的功能退化的方法和装置。 提供了方法和组合物，其通过在热成形术程序期间的基质冷却来预防上皮细胞凋亡; 其产生或恢复巩膜基质层状纤维之间稳定的分子交联; 并且中断至少一个阶段的基质重塑反应，包括凋亡抑制，成纤维细胞增殖和迁移，以及胶原蛋白的抑制。
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公开(公告)号：US5374265A
公开(公告)日：1994-12-20
申请号：US926331
申请日：1992-08-06
申请人： Bruce J. Sand
发明人： Bruce J. Sand
CPC分类号： A61F9/008 , A61F2009/00853 , A61F2009/00872
摘要： A method and apparatus for controlled thermal shrinkage of collagen tissue by irradiation with coherent energy in the wavelength band of 1.80 to 2.55 microns as generated by a laser. A specific application to ophthalmological corneal reshaping is described.
摘要翻译： 通过用激光产生的1.80〜2.55微米的波长范围内的相干能量照射，可以控制胶原组织热收缩的方法和装置。 描述了对眼科角膜重塑的具体应用。
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公开(公告)号：US5618284A
公开(公告)日：1997-04-08
申请号：US484669
申请日：1995-06-07
申请人： Bruce J. Sand
发明人： Bruce J. Sand
CPC分类号： A61F9/008 , A61B2017/22082 , A61B2017/22087 , A61F2009/00853 , A61F2009/00872
摘要： A method and apparatus for controlled thermal shrinkage of collagen tissue by irradiation with coherent energy in the wavelength band of 1.80 to 2.55 microns as generated by a laser. A specific application to ophthalmological corneal reshaping is described. A method for shrinkage of collagen tissue by application of coherent infrared energy, in which the threshold shrinkage temperature is substantially reduced by application of a reagent such as lysozyme to the tissue prior to heating. The method is especially useful in ophthalmology for shape modification of a cornea, and is enhanced by using a corneal collagen shield as a carrier and delivery agent for the reagent and an admixed anaesthetic.
摘要翻译： 通过用激光产生的1.80〜2.55微米的波长范围内的相干能量照射，可以控制胶原组织热收缩的方法和装置。 描述了对眼科角膜重塑的具体应用。 通过施加相干红外能量来收缩胶原组织的方法，其中通过在加热之前向组织施加诸如溶菌酶的试剂，阈值收缩温度显着降低。 该方法在用于角膜形状修饰的眼科中特别有用，并且通过使用角膜胶原屏蔽作为载体和用于试剂的输送剂和混合麻醉剂来增强。
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