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公开(公告)号:US09278940B2
公开(公告)日:2016-03-08
申请号:US14729959
申请日:2015-06-03
申请人: David John Fairfax , Bryan Cordell Duffy , Gregory Scott Martin , John Frederick Quinn , Shuang Liu , Gregory Steven Wagner , Peter Ronald Young
发明人: David John Fairfax , Bryan Cordell Duffy , Gregory Scott Martin , John Frederick Quinn , Shuang Liu , Gregory Steven Wagner , Peter Ronald Young
IPC分类号: A61K31/517 , C07D239/91 , C07D265/32 , A61K45/06 , C07D401/04 , A61K31/5377 , C07D401/14
CPC分类号: C07D239/91 , A61K31/517 , A61K31/5377 , A61K45/06 , C07D265/32 , C07D401/04 , C07D401/14 , Y02A50/467 , A61K2300/00
摘要: The present disclosure relates to compounds, which are useful for inhibition of BET protein function by binding to bromodomains, and their use in therapy.
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公开(公告)号:US20140142102A1
公开(公告)日:2014-05-22
申请号:US14085545
申请日:2013-11-20
申请人: David John Fairfax , Bryan Cordell Duffy , Gregory Scott Martin , John Frederick Quinn , Shuang Liu , Gregory Steven Wagner , Peter Ronald Young
发明人: David John Fairfax , Bryan Cordell Duffy , Gregory Scott Martin , John Frederick Quinn , Shuang Liu , Gregory Steven Wagner , Peter Ronald Young
IPC分类号: C07D265/32 , C07D401/04 , A61K31/5377 , A61K45/06 , C07D239/91 , A61K31/517
CPC分类号: C07D239/91 , A61K31/517 , A61K31/5377 , A61K45/06 , C07D265/32 , C07D401/04 , C07D401/14 , Y02A50/467 , A61K2300/00
摘要: The present disclosure relates to compounds, which are useful for inhibition of BET protein function by binding to bromodomains, and their use in therapy.
摘要翻译: 本公开涉及通过结合溴结构域来抑制BET蛋白质功能的化合物及其在治疗中的用途。
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公开(公告)号:US20140140956A1
公开(公告)日:2014-05-22
申请号:US14085544
申请日:2013-11-20
申请人: David John Fairfax , Gregory Scott Martin , John Frederick Quinn , Bryan Cordell Duffy , Gregory Steven Wagner , Peter Ronald Young
发明人: David John Fairfax , Gregory Scott Martin , John Frederick Quinn , Bryan Cordell Duffy , Gregory Steven Wagner , Peter Ronald Young
IPC分类号: C07D239/91 , A61K31/5377 , A61K31/517 , C07D401/14 , C07D401/04 , C07D409/12 , A61K45/06 , C07D401/12 , A61K31/4725
CPC分类号: C07D239/91 , A61K31/4725 , A61K31/517 , A61K45/06 , C07D401/04 , C07D401/12 , C07D401/14 , C07D409/04 , C07D409/12 , Y02A50/467 , A61K2300/00
摘要: The present disclosure relates to compounds, which are useful for inhibition of BET protein function by binding to bromodomains, and their use in therapy.
摘要翻译: 本公开涉及通过结合溴结构域可用于抑制BET蛋白功能的化合物及其在治疗中的用途。
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公开(公告)号:US09073878B2
公开(公告)日:2015-07-07
申请号:US14085545
申请日:2013-11-20
申请人: David John Fairfax , Bryan Cordell Duffy , Gregory Scott Martin , John Frederick Quinn , Shuang Liu , Gregory Steven Wagner , Peter Ronald Young
发明人: David John Fairfax , Bryan Cordell Duffy , Gregory Scott Martin , John Frederick Quinn , Shuang Liu , Gregory Steven Wagner , Peter Ronald Young
IPC分类号: C07D239/91 , C07D265/32 , A61K45/06 , C07D401/04 , C07D401/14 , A61K31/517
CPC分类号: C07D239/91 , A61K31/517 , A61K31/5377 , A61K45/06 , C07D265/32 , C07D401/04 , C07D401/14 , Y02A50/467 , A61K2300/00
摘要: The present disclosure relates to compounds, which are useful for inhibition of BET protein function by binding to bromodomains, and their use in therapy.
摘要翻译: 本公开涉及通过结合溴结构域可用于抑制BET蛋白功能的化合物及其在治疗中的用途。
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公开(公告)号:US20150344442A1
公开(公告)日:2015-12-03
申请号:US14729959
申请日:2015-06-03
申请人: David John Fairfax , Bryan Cordell Duffy , Gregory Scott Martin , John Frederick Quinn , Shuang Liu , Gregory Steven Wagner , Peter Ronald Young
发明人: David John Fairfax , Bryan Cordell Duffy , Gregory Scott Martin , John Frederick Quinn , Shuang Liu , Gregory Steven Wagner , Peter Ronald Young
IPC分类号: C07D239/91 , C07D401/14 , A61K31/5377 , A61K45/06 , A61K31/517 , C07D401/04
CPC分类号: C07D239/91 , A61K31/517 , A61K31/5377 , A61K45/06 , C07D265/32 , C07D401/04 , C07D401/14 , Y02A50/467 , A61K2300/00
摘要: The present disclosure relates to compounds, which are useful for inhibition of BET protein function by binding to bromodomains, and their use in therapy.
摘要翻译: 本公开涉及通过结合溴结构域可用于抑制BET蛋白功能的化合物及其在治疗中的用途。
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公开(公告)号:US09271978B2
公开(公告)日:2016-03-01
申请号:US14134793
申请日:2013-12-19
申请人: Shuang Liu , Bryan Cordell Duffy , John Frederick Quinn , May Xiaowu Jiang , Ruifang Wang , Gregory Scott Martin , He Zhao , Bruce Francis Molino , Peter Ronald Young
发明人: Shuang Liu , Bryan Cordell Duffy , John Frederick Quinn , May Xiaowu Jiang , Ruifang Wang , Gregory Scott Martin , He Zhao , Bruce Francis Molino , Peter Ronald Young
IPC分类号: A61K31/501 , C07D413/04 , C07D401/12 , A61K31/4439 , C07D417/04 , C07D413/14 , A61K31/496 , C07D237/04 , A61K31/50 , A61K45/06
CPC分类号: A61K31/5377 , A61K31/4375 , A61K31/4412 , A61K31/4439 , A61K31/444 , A61K31/4545 , A61K31/4709 , A61K31/472 , A61K31/4725 , A61K31/496 , A61K31/497 , A61K31/498 , A61K31/50 , A61K31/501 , A61K31/502 , A61K31/506 , A61K31/513 , A61K45/06 , C07D213/64 , C07D213/74 , C07D237/04 , C07D237/14 , C07D237/22 , C07D237/32 , C07D401/12 , C07D413/04 , C07D413/14 , C07D417/04 , Y02A50/467
摘要: The present disclosure relates to compounds, which are useful for inhibition of BET protein function by binding to bromodomains, and their use in therapy.
摘要翻译: 本公开涉及通过结合溴结构域可用于抑制BET蛋白功能的化合物及其在治疗中的用途。
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公开(公告)号:US20140179648A1
公开(公告)日:2014-06-26
申请号:US14134793
申请日:2013-12-19
申请人: Shuang Liu , Bryan Cordell Duffy , John Frederick Quinn , May Xiaowu Jiang , Ruifang Wang , Gregory Scott Martin , He Zhao , Bruce Francis Molino , Peter Ronald Young
发明人: Shuang Liu , Bryan Cordell Duffy , John Frederick Quinn , May Xiaowu Jiang , Ruifang Wang , Gregory Scott Martin , He Zhao , Bruce Francis Molino , Peter Ronald Young
IPC分类号: A61K31/501 , C07D401/12 , A61K31/4439 , A61K45/06 , C07D413/14 , A61K31/496 , C07D237/04 , A61K31/50 , C07D413/04 , C07D417/04
CPC分类号: A61K31/5377 , A61K31/4375 , A61K31/4412 , A61K31/4439 , A61K31/444 , A61K31/4545 , A61K31/4709 , A61K31/472 , A61K31/4725 , A61K31/496 , A61K31/497 , A61K31/498 , A61K31/50 , A61K31/501 , A61K31/502 , A61K31/506 , A61K31/513 , A61K45/06 , C07D213/64 , C07D213/74 , C07D237/04 , C07D237/14 , C07D237/22 , C07D237/32 , C07D401/12 , C07D413/04 , C07D413/14 , C07D417/04 , Y02A50/467
摘要: The present disclosure relates to compounds, which are useful for inhibition of BET protein function by binding to bromodomains, and their use in therapy.
摘要翻译: 本公开涉及通过结合溴结构域可用于抑制BET蛋白功能的化合物及其在治疗中的用途。
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