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    Passively addressable fluid valves having S-shaped blocking films
    1.
    发明授权
    Passively addressable fluid valves having S-shaped blocking films 失效
    具有S形阻挡膜的被动寻址流体阀

    公开(公告)号：US5897097A

    公开(公告)日：1999-04-27

    申请号：US711299

    申请日：1996-09-06

    申请人： David K. Biegelsen ,  Patrick C. P. Cheung ,  Andrew A. Berlin ,  Warren B. Jackson ,  Lars-Erik Swartz ,  Raj B. Apte ,  Richard H. Bruce

    发明人： David K. Biegelsen ,  Patrick C. P. Cheung ,  Andrew A. Berlin ,  Warren B. Jackson ,  Lars-Erik Swartz ,  Raj B. Apte ,  Richard H. Bruce

    IPC分类号： B65H5/22 ,  B65H29/24 ,  F15C5/00 ,  F16K31/02

    CPC分类号： F15C5/00 ,  Y10S251/901 ,  Y10T137/87249

    摘要： A bistable valve useful for paper handling applications is disclosed. The valve can be batch fabricated in two dimensional valve arrays, with each valve in the array being controlled by passive matrix addressing. Typically, each valve includes a valve housing having an aperture plate defining an aperture therethrough, and an opposing plate positioned in spaced apart relationship to the aperture plate. A flexible film or strip is attached at its first end to the aperture plate and at its second end to the opposing plate. Valve action is provided by use of at least two switching electrodes for moving the flexible film between an aperture blocking position and an aperture open position, with at least one of the switching electrodes positioned adjacent to the aperture plate and at least one of the switching electrodes positioned adjacent to the opposing plate. To reduce unswitched movement when the switching electrode bias is reduced or not present, at least two electrostatic or mechanical catches are used.

    摘要翻译： 公开了一种用于纸张处理应用的双稳态阀。 阀门可以批量制造在二维阀门阵列中，阵列中的每个阀门都被无源矩阵寻址控制。 通常，每个阀包括具有限定穿过其中的孔的孔板的阀壳体和与孔板间隔开的关系。 柔性膜或带在其第一端附接到孔板并且在其第二端附接到相对的板。 通过使用至少两个开关电极来提供阀动作，所述至少两个开关电极用于在孔闭阻位置和孔打开位置之间移动柔性膜，其中至少一个开关电极位于孔板附近，并且至少一个开关电极 定位在相对的板附近。 为了在开关电极偏压减小或不存在时减少非开关动作，使用至少两个静电或机械捕捉。

    Method of detecting the concentration of an analyte
    3.
    发明授权
    Method of detecting the concentration of an analyte 有权
    检测分析物浓度的方法

    公开(公告)号：US07961326B2

    公开(公告)日：2011-06-14

    申请号：US12195997

    申请日：2008-08-21

    申请人： Joerg Martini ,  Richard H. Bruce ,  Francisco E. Torres ,  Peter Kiesel ,  Michael I. Recht ,  Jeffrey N. Roe

    发明人： Joerg Martini ,  Richard H. Bruce ,  Francisco E. Torres ,  Peter Kiesel ,  Michael I. Recht ,  Jeffrey N. Roe

    IPC分类号： A61B5/00 ,  G01J3/46

    CPC分类号： A61B5/1459 ,  A61B5/0031 ,  A61B5/14532 ,  G01N21/33 ,  G01N21/359

    摘要： A system and method is provided for detecting concentration of an analyte in a fluid. The method comprises detecting an optical property of a first region of two or more regions in a system, the first region located in a container having a reservoir for one or more modifiers of one or more optical properties of the first region. The movement of the one or more modifiers is responsive to changes in concentration of the analyte. A next step detects an optical property of a second region of the two or more regions in the system, the second region located in a container having a reservoir for one or more modifiers of one or more optical properties of the second region. The movement of the one or more modifiers is responsive to changes in concentration of a compound, where the compound is something other than the analyte. The detected optical property of the first region and the detected optical property of the second region are used in embodiments to separate the effect of the analyte on the detected optical property of the first region from the effect of the compound, where the compound is an interfering compound.

    摘要翻译： 提供了用于检测流体中分析物的浓度的系统和方法。 该方法包括检测系统中两个或更多个区域的第一区域的光学性质，位于容器中的第一区域具有用于一个或多个第一区域的一个或多个光学特性的改性剂的储存器。 一种或多种改性剂的运动响应于分析物浓度的变化。 下一步骤检测系统中两个或更多个区域的第二区域的光学性质，位于容器中的第二区域具有用于一个或多个第二区域的一个或多个光学特性的改性剂的储存器。 一种或多种改性剂的运动响应化合物浓度的变化，其中化合物是除分析物以外的物质。 检测到的第一区域的光学特性和第二区域的检测光学特性用于实施例中以将分析物对第一区域的检测光学性质的影响与化合物的影响分开，其中化合物是干扰 复合。

    Method for a nanocalorimeter for detecting chemical reactions
    5.
    发明授权
    Method for a nanocalorimeter for detecting chemical reactions 失效
    用于检测化学反应的纳米光度计的方法

    公开(公告)号：US07727768B2

    公开(公告)日：2010-06-01

    申请号：US11149632

    申请日：2005-06-10

    申请人： Alan G. Bell ,  Richard H. Bruce ,  Scott A. Elrod ,  Eric Peeters ,  Francisco E. Torres

    发明人： Alan G. Bell ,  Richard H. Bruce ,  Scott A. Elrod ,  Eric Peeters ,  Francisco E. Torres

    IPC分类号： G01N33/00

    CPC分类号： B82Y15/00 ,  G01N25/4846 ,  G01N25/4866 ,  Y10S977/957 ,  Y10T436/25 ,  Y10T436/25625 ,  Y10T436/2575

    摘要： A method for detecting chemical reactions uses a nanocalorimeter having a substrate including thermal isolation capability residing on the substrate, thermal equilibration regions residing within the thermal isolation capability, and thermal measurement capability residing within each of the thermal equilibration regions. The thermal measurement device is connected to detection electronics. The method includes depositing drops of potentially reactive chemical solutions within the thermal equilibration region. These potentially reactive solution drops are merged through the use of drop merging electrodes residing within the thermal isolation region. The thermal change occurring within the merged solution drops is then measured with the detection electronics.

    摘要翻译： 用于检测化学反应的方法使用具有包含驻留在基底上的热隔离能力的基底，驻留在热隔离能力内的热平衡区域和驻留在每个热平衡区域内的热测量能力的纳米光度计。 热测量设备连接到检测电子设备。 该方法包括在热平衡区域内沉积潜在的反应性化学溶液的液滴。 这些潜在的反应性溶液滴通过使用位于热隔离区域内的滴合并电极而合并。 然后用检测电子元件测量在合并溶液中发生的热变化。

    Screening for ligand binding at specific target sites
    6.
    发明授权
    Screening for ligand binding at specific target sites 有权
    筛选特定靶位点上的配体结合

    公开(公告)号：US07419835B2

    公开(公告)日：2008-09-02

    申请号：US10719457

    申请日：2003-11-21

    申请人： Francisco E. Torres ,  Richard H. Bruce ,  Rodney Turner

    发明人： Francisco E. Torres ,  Richard H. Bruce ,  Rodney Turner

    IPC分类号： G01K17/20 ,  G01N35/00 ,  G01N25/20

    CPC分类号： G01N25/4846 ,  B01J2219/00599 ,  B01J2219/00702 ,  C40B50/08 ,  Y10T436/11 ,  Y10T436/25 ,  Y10T436/25125 ,  Y10T436/2575

    摘要： A method for screening of compounds for binding differentiation at various drug target binding sites is used with a device measuring the enthalpy of reaction for the binding. The method includes merging test ligand with target compound and merging test ligand with target compound in the presence of at least one blocking agent. A first heat of reaction is detected for the merged test ligand and target compound solution and a second heat of reaction is detected for the merged test ligand and target compound solution in the presence of a blocking agent. The two heats of reaction are compared to determine whether a reaction has occurred.

    摘要翻译： 使用用于筛选用于结合各种药物靶标结合位点的分化的化合物的方法，其中测量用于结合的反应焓的装置。 该方法包括在至少一种封闭剂的存在下将试验配体与目标化合物合并，并将试验配体与目标化合物合并。 检测合并的试验配体和目标化合物溶液的第一反应热，并在封闭剂存在下检测合并的试验配体和目标化合物溶液的第二反应热。 比较两个反应热，以确定是否发生反应。

    Time-multiplexed scanning light source for multi-probe, multi-laser fluorescence detection systems
    7.
    发明授权
    Time-multiplexed scanning light source for multi-probe, multi-laser fluorescence detection systems 有权
    多探头多激光荧光检测系统的多路复用扫描光源

    公开(公告)号：US07286224B2

    公开(公告)日：2007-10-23

    申请号：US11018759

    申请日：2004-12-21

    申请人： Douglas N. Curry ,  Richard H. Bruce

    发明人： Douglas N. Curry ,  Richard H. Bruce

    IPC分类号： G01N21/64 ,  G01N21/25 ,  G01J3/24 ,  A61B5/00 ,  G01N21/76

    CPC分类号： G01N21/6456 ,  G01N15/1468 ,  G01N2201/1085

    摘要： An apparatus images a surface. An imager stage linearly translates the surface in a first direction. A light path has a first end defining an input aperture perpendicular to the first direction and parallel to the surface, and a second end defining an output aperture. A plurality of radiation beams linearly scan and interact in time-multiplexed alternating turns with the surface below the input aperture to produce a time-multiplexed light signal that is collected by the input aperture and transmitted by the light path to the output aperture. A photodetector arrangement detects the light signal at the output aperture. A processor processes the detected time-multiplexed light.

    摘要翻译： 装置对表面进行成像。 成像器台沿第一方向线性平移表面。 光路具有限定垂直于第一方向并平行于表面的输入孔的第一端，以及限定输出孔的第二端。 多个辐射束在时间多路复用的交替匝中线性扫描并与输入孔下方的表面相互作用，以产生由输入孔收集并由光路传输到输出孔的时间复用光信号。 光电检测器装置检测输出孔处的光信号。 处理器处理检测到的时间复用光。

    Method of scanning and light collection for a rare cell detector
    9.
    发明授权
    Method of scanning and light collection for a rare cell detector 有权
    稀有细胞检测器的扫描和光采集方法

    公开(公告)号：US07280261B2

    公开(公告)日：2007-10-09

    申请号：US11017440

    申请日：2004-12-20

    申请人： Douglas N. Curry ,  Richard H. Bruce ,  Robert T. Krivacic

    发明人： Douglas N. Curry ,  Richard H. Bruce ,  Robert T. Krivacic

    IPC分类号： G02B26/08

    CPC分类号： G01N21/6456 ,  G01N21/6428 ,  G01N2021/6484 ,  G01N2201/1085

    摘要： An apparatus images a surface. An imager stage has a planar surface for supporting a sample. A fiber optic bundle has a first end of parallel first fiber ends that are arranged to define an input aperture for viewing the sample on the imager stage. A distal bundle end is arranged to define an output aperture disposed away from the imager stage. A scanning radiation source scans a radiation beam along a path that is perpendicular to the sample on the imager stage. The input aperture of the fiber optic bundle receives a light signal that is produced by the radiation source scan of the imager stage sample. The light signal is transmitted to the bundle output aperture. A photodetector detects the light signal at the distal bundle end, and a processor processes the detected light.

    摘要翻译： 装置对表面进行成像。 成像器台具有用于支撑样品的平坦表面。 光纤束具有平行的第一光纤端的第一端，其布置成限定用于观察成像器台上的样品的输入孔。 远侧束端布置成限定远离成像器台布置的输出孔。 扫描辐射源沿着与成像器台上的样品垂直的路径扫描辐射束。 光纤束的输入孔径接收由成像器台样品的辐射源扫描产生的光信号。 光信号被传输到束输出孔径。 光电检测器检测远侧束端处的光信号，并且处理器处理检测到的光。

    Testing method and configurations for multi-ejector system
    10.
    发明授权
    Testing method and configurations for multi-ejector system 失效
    多喷射器系统的测试方法和配置

    公开(公告)号：US06740530B1

    公开(公告)日：2004-05-25

    申请号：US09718733

    申请日：2000-11-22

    申请人： Richard H. Bruce ,  Scott A. Elrod ,  Jaan Noolandi ,  David A. Horine ,  Babur B. Hadimioglu

    发明人： Richard H. Bruce ,  Scott A. Elrod ,  Jaan Noolandi ,  David A. Horine ,  Babur B. Hadimioglu

    IPC分类号： G01N110

    CPC分类号： B01L3/0268 ,  B01J19/0046 ,  B01J2219/00378 ,  B01J2219/00585 ,  B01J2219/00596 ,  B01J2219/00603 ,  B01J2219/00659 ,  B01J2219/00693 ,  B41J2/14008 ,  B41J2002/14322 ,  C40B60/14 ,  Y10T436/25 ,  Y10T436/2575

    摘要： Methods for testing proper operation of drop ejection units in a multi-ejector system are provided to determine whether the drop ejectors have been properly filled and/or the ejectors are emitting fully formed droplets. The methods include testing the ejectors prior to drop ejection. In this method, a priming system is used wherein fluid received by the priming system is ejected onto a test substrate to allow a scanner to determine the existence of the fluids at selected locations. The selected locations are correlated to the drop ejection units to determine which ejection units do not have biofluid or sufficient biofluid. A further method allows for ejection prior to printing, on a test substrate wherein testing for both the fullness of the ejector units as well as proper emission of the ejectors of droplets may be tested. The ejectors after being primed, eject the biofluids which are then scanned and correlated to each individual ejector. A further method provided is a laser scattering method wherein a laser beam is interposed between the drop emission path of the ejectors. Laser detection then determines whether a correlated drop ejector is properly emitting droplets.

    摘要翻译： 提供了用于测试多喷射器系统中液滴喷射单元的正确操作的方法，以确定液滴喷射器是否已经被适当地填充和/或喷射器正在发射完全形成的液滴。 这些方法包括在喷射之前测试喷射器。 在该方法中，使用起动系统，其中由起动系统接收的流体被喷射到测试基板上，以允许扫描仪确定在选定位置处的流体的存在。 所选择的位置与液滴喷射单元相关，以确定哪些喷射单元不具有生物流体或足够的生物流体。 另外的方法允许在打印之前在测试基板上进行喷射，其中可以测试喷射器单元的充满度以及液滴喷射器的适当发射。 喷射器被喷涂后，喷射生物流体，然后将其扫描并与每个喷射器相关联。 提供的另一种方法是激光散射方法，其中激光束插入在喷射器的液滴发射路径之间。 然后，激光检测确定相关的液滴喷射器是否正确地发射液滴。