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公开(公告)号:US06979693B2
公开(公告)日:2005-12-27
申请号:US10066040
申请日:2002-02-01
申请人: David Michael Goldstein , Sharada Shenvi Labadie , David Mark Rotstein , Eric Brian Sjogren , Francisco Xavier Talamas
发明人: David Michael Goldstein , Sharada Shenvi Labadie , David Mark Rotstein , Eric Brian Sjogren , Francisco Xavier Talamas
IPC分类号: B01L3/00 , C07D231/38 , C07D401/10 , C07D401/12 , C07D403/12 , G01N21/01 , G01N21/27 , G01N33/49 , G01N33/543 , G01N33/558 , A61K31/415 , A61K31/4155 , C07D401/06
CPC分类号: C07D231/38 , C07D401/10 , C07D401/12 , C07D403/12 , G01N21/01 , G01N21/27 , G01N33/4905 , G01N33/54366 , G01N33/558
摘要: The present invention relates to certain pyrazole derivatives of Formula (I): that are p-38 MAP kinase inhibitors, pharmaceutical compositions containing them, methods for their use, and methods for preparing these compounds.
摘要翻译: 本发明涉及某些式(I)的吡唑衍生物:其为p-38MAP激酶抑制剂,含有它们的药物组合物,其使用方法和制备这些化合物的方法。
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公开(公告)号:US06444696B1
公开(公告)日:2002-09-03
申请号:US09909966
申请日:2001-07-19
申请人: David Michael Goldstein , Sharada Shenvi Labadie , David Mark Rotstein , Eric Brian Sjogren , Francisco Xavier Talamas
发明人: David Michael Goldstein , Sharada Shenvi Labadie , David Mark Rotstein , Eric Brian Sjogren , Francisco Xavier Talamas
IPC分类号: A61K314155
CPC分类号: C07D231/38 , C07D401/10 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/06
摘要: The present invention relates to certain pyrazole derivatives of Formula (I): that are p-38 MAP kinase inhibitors, pharmaceutical compositions containing them, methods for their use, and methods for preparing these compounds.
摘要翻译: 本发明涉及某些式(I)的吡唑衍生物:其为p-38MAP激酶抑制剂,含有它们的药物组合物,其使用方法和制备这些化合物的方法。
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公开(公告)号:US06376527B1
公开(公告)日:2002-04-23
申请号:US09305737
申请日:1999-05-05
申请人: David Michael Goldstein , Sharada Shenvi Labadie , David Mark Rotstein , Eric Brian Sjogren , Francisco Xavier Talamas
发明人: David Michael Goldstein , Sharada Shenvi Labadie , David Mark Rotstein , Eric Brian Sjogren , Francisco Xavier Talamas
IPC分类号: A61K31415
CPC分类号: C07D231/38 , C07D401/10 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/06
摘要: The present invention relates to certain pyrazole derivatives of Formula (I): that are p-38 MAP kinase inhibitors, pharmaceutical compositions containing them, methods for their use, and methods for preparing these compounds.
摘要翻译: 本发明涉及某些式(I)的吡唑衍生物:其为p-38MAP激酶抑制剂,含有它们的药物组合物,其使用方法和制备这些化合物的方法。
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公开(公告)号:US06316466B1
公开(公告)日:2001-11-13
申请号:US09401141
申请日:1999-09-22
申请人: David Michael Goldstein , Sharada Shenvi Labadie , David Mark Rotstein , Eric Brian Sjogren , Francisco Xavier Talamas
发明人: David Michael Goldstein , Sharada Shenvi Labadie , David Mark Rotstein , Eric Brian Sjogren , Francisco Xavier Talamas
IPC分类号: A61K314155
CPC分类号: C07D231/38 , C07D401/10 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/06
摘要: The present invention relates to certain pyrazole derivatives of Formula (I): that are p-38 MAP kinase inhibitors, pharmaceutical compositions containing them, methods for their use, and methods for preparing these compounds.
摘要翻译: 本发明涉及某些式(I)的吡唑衍生物:其为p-38MAP激酶抑制剂,含有它们的药物组合物,其使用方法和制备这些化合物的方法。
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公开(公告)号:US6150397A
公开(公告)日:2000-11-21
申请号:US337695
申请日:1999-06-21
IPC分类号: C07D295/12 , A61K31/10 , A61K31/12 , A61K31/18 , A61K31/195 , A61K31/27 , A61K31/275 , A61K31/341 , A61K31/40 , A61K31/4015 , A61K31/4402 , A61K31/4409 , A61K31/445 , A61K31/453 , A61K31/5375 , A61P29/00 , A61P37/06 , A61P43/00 , C07C311/15 , C07C311/16 , C07C311/29 , C07C311/37 , C07C311/51 , C07C317/22 , C07C317/24 , C07C317/44 , C07C323/22 , C07C323/67 , C07D207/26 , C07D207/27 , C07D207/48 , C07D211/54 , C07D211/58 , C07D213/42 , C07D295/13 , C07D295/26 , C07D307/38 , C07D307/46 , C07D307/52 , C07D307/56 , C07D333/06 , C07D333/22 , C07D405/06 , A61K31/381
CPC分类号: C07D207/26 , C07C311/16 , C07C311/29 , C07C311/51 , C07C317/22 , C07C317/24 , C07C317/44 , C07C323/22 , C07C323/67 , C07D211/58 , C07D213/42 , C07D295/13 , C07D295/26 , C07D307/46 , C07D307/52 , C07D333/22 , C07D405/06 , C07C2101/04 , C07C2101/14
摘要: The present invention relates to certain 5-aroylnaphthalene derivatives of formula (I): ##STR1## that are inhibitors of prostaglandin G/H synthase, pharmaceutical compositions containing them, methods for their use, and methods for preparing these compounds.
摘要翻译: 本发明涉及某些式(I)的5-芳酰基萘衍生物:其为前列腺素G / H合成酶的抑制剂,含有它们的药物组合物,其用途及其制备方法。
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公开(公告)号:US06777418B2
公开(公告)日:2004-08-17
申请号:US09968425
申请日:2001-10-01
IPC分类号: A01N4354
CPC分类号: C07D207/27 , C07C65/19 , C07C65/28 , C07C229/38 , C07C233/83 , C07C311/13 , C07C317/44 , C07C323/56 , C07C2602/10 , C07D207/327 , C07D211/76 , C07D231/12 , C07D231/14 , C07D233/56 , C07D233/84 , C07D239/26 , C07D239/38 , C07D249/08 , C07D249/12 , C07D257/04 , C07D277/16 , C07D277/30 , C07D277/74 , C07D285/125 , C07D295/155 , C07D307/38 , C07D333/22 , C07D333/24 , C07D333/60
摘要: The current invention provide novel retinoid compounds and methods for their synthesis, methods of treating or preventing emphysema, cancer and dermatological disorders and pharmaceutical compositions suitable for the treatment or prevention of emphysema, cancer and dermatological disorders.
摘要翻译: 本发明提供了新颖的类视色素化合物及其合成方法,治疗或预防肺气肿,癌症和皮肤病学障碍的方法以及适用于治疗或预防肺气肿,癌症和皮肤疾病的药物组合物。
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公开(公告)号:US5962531A
公开(公告)日:1999-10-05
申请号:US13328
申请日:1998-01-26
IPC分类号: C07D295/12 , A61K31/10 , A61K31/12 , A61K31/18 , A61K31/195 , A61K31/27 , A61K31/275 , A61K31/341 , A61K31/40 , A61K31/4015 , A61K31/4402 , A61K31/4409 , A61K31/445 , A61K31/453 , A61K31/5375 , A61P29/00 , A61P37/06 , A61P43/00 , C07C311/15 , C07C311/16 , C07C311/29 , C07C311/37 , C07C311/51 , C07C317/22 , C07C317/24 , C07C317/44 , C07C323/22 , C07C323/67 , C07D207/26 , C07D207/27 , C07D207/48 , C07D211/54 , C07D211/58 , C07D213/42 , C07D295/13 , C07D295/26 , C07D307/38 , C07D307/46 , C07D307/52 , C07D307/56 , C07D333/06 , C07D333/22 , C07D405/06 , C07C311/14
CPC分类号: C07D207/26 , C07C311/16 , C07C311/29 , C07C311/51 , C07C317/22 , C07C317/24 , C07C317/44 , C07C323/22 , C07C323/67 , C07D211/58 , C07D213/42 , C07D295/13 , C07D295/26 , C07D307/46 , C07D307/52 , C07D333/22 , C07D405/06 , C07C2101/04 , C07C2101/14
摘要: The present invention relates to certain 5-aroylnaphthalene derivatives of formula (I): ##STR1## that are inhibitors of prostaglandin G/H synthase, pharmaceutical compositions containing them, methods for their use, and methods for preparing these compounds.
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公开(公告)号:US20110301171A1
公开(公告)日:2011-12-08
申请号:US13151326
申请日:2011-06-02
申请人: Humberto Bartolome Arzeno , Lubov K. Filonova , David Michael Goldstein , Leyi Gong , Bradley E. Loe , Erin M. O'Brien , Wylie Solang Palmer , David Mark Rotstein , Tania M. Silva , Yun-Chou Tan
发明人: Humberto Bartolome Arzeno , Lubov K. Filonova , David Michael Goldstein , Leyi Gong , Bradley E. Loe , Erin M. O'Brien , Wylie Solang Palmer , David Mark Rotstein , Tania M. Silva , Yun-Chou Tan
IPC分类号: A61K31/506 , C07D409/14 , A61P3/10 , C07D487/08 , A61P29/00 , A61P11/06 , C07D401/14 , C07D403/14
CPC分类号: C07D403/04 , C07D401/04 , C07D401/14 , C07D403/14 , C07D409/14 , C07D487/02
摘要: Compounds of formula I or pharmaceutically acceptable salts thereof, wherein R5 is a group of formula (a) or (b): and wherein m, n, p, q, X, Y, R1, R2, R3, R4, R5, R6, R7, R8 and R9 are as defined herein. The compounds and compositions disclosed herein are useful to modulate the activity of JNK and treat diseases associated with JNK activity.
摘要翻译: 式I化合物或其药学上可接受的盐,其中R 5是式(a)或(b)的基团:其中m,n,p,q,X,Y,R 1,R 2,R 3,R 4,R 5,R 6 ,R7,R8和R9如本文所定义。 本文公开的化合物和组合物可用于调节JNK的活性并治疗与JNK活性相关的疾病。
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公开(公告)号:US06696471B2
公开(公告)日:2004-02-24
申请号:US10231792
申请日:2002-08-29
IPC分类号: A61K3144
CPC分类号: C07D401/04
摘要: The present invention provides an aminopyrrole compound of the formula: a prodrug, individual isomer, a mixture of isomers or a pharmaceutically acceptable salt thereof, where R1, R2, Ar1 and Ar2 are those defined herein. The present invention also provides methods of using and preparing the aminopyrrole compounds of Formula I.
摘要翻译: 本发明提供下式的氨基吡咯化合物:前药,个体异构体,异构体混合物或其药学上可接受的盐,其中R 1,R 2,Ar 1和Ar 2是那些 本文定义。 本发明还提供了使用和制备式I的氨基吡咯化合物的方法。
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公开(公告)号:US08642601B2
公开(公告)日:2014-02-04
申请号:US13151326
申请日:2011-06-02
申请人: Humberto Bartolome Arzeno , Lubov K. Filonova , David Michael Goldstein , Leyi Gong , Bradley E. Loe , Erin M. O'Brien , Wylie Solang Palmer , David Mark Rotstein , Tania M. Silva , Yun-Chou Tan
发明人: Humberto Bartolome Arzeno , Lubov K. Filonova , David Michael Goldstein , Leyi Gong , Bradley E. Loe , Erin M. O'Brien , Wylie Solang Palmer , David Mark Rotstein , Tania M. Silva , Yun-Chou Tan
IPC分类号: A01N43/54 , C07D239/12 , C07D401/04 , C07D471/04 , C07D471/22 , C07D487/04 , A01N43/56 , A61K31/415
CPC分类号: C07D403/04 , C07D401/04 , C07D401/14 , C07D403/14 , C07D409/14 , C07D487/02
摘要: Compounds of formula I or pharmaceutically acceptable salts thereof, wherein R5 is a group of formula (a) or (b): and wherein m, n, p, q, X, Y, R1, R2, R3, R4, R5, R6, R7, R8 and R9 are as defined herein. The compounds and compositions disclosed herein are useful to modulate the activity of JNK and treat diseases associated with JNK activity.
摘要翻译: 式I化合物或其药学上可接受的盐,其中R 5是式(a)或(b)的基团:其中m,n,p,q,X,Y,R 1,R 2,R 3,R 4,R 5,R 6 ,R7,R8和R9如本文所定义。 本文公开的化合物和组合物可用于调节JNK的活性并治疗与JNK活性相关的疾病。
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