公开(公告)号：US20110301700A1

公开(公告)日：2011-12-08

申请号：US13038361

申请日：2011-03-01

申请人： R. David FISH ,  David PANIAGUA

发明人： R. David FISH ,  David PANIAGUA

IPC分类号： A61F2/24 ,  B32B38/16 ,  B23P11/00

CPC分类号： A61F2/2427 ,  A61F2/0095 ,  A61F2/2412 ,  A61F2/2415 ,  A61F2/2418 ,  A61F2/2433 ,  A61F2220/0075 ,  Y10T29/49908 ,  Y10T156/10

摘要： A prosthetic heart valve implantable by catheter without surgery includes a substantially “dry” membrane or tissue material. In at least one embodiment, the tissue is folded in a dry state to form a tissue leaflet assembly that is then attached to a frame to form an implantable prosthetic heart valve. Alternatively, one or more tissue leaflets are operatively associated with a frame to form an implantable prosthetic heart valve. The implantable prosthetic heart valve is subsequently pre-mounted on an integrated catheter delivery system. The catheter delivery system that includes the implantable prosthetic heart valve is then packaged and transported while the tissue remains dry. The implantable prosthetic heart valve, while remaining substantially dry, can then be implanted into the receiving patient.

摘要翻译： 通过没有手术的导管植入的假体心脏瓣膜包括基本上“干”的膜或组织材料。 在至少一个实施例中，组织以干燥状态折叠以形成组织小叶组件，然后将组织小叶组件附接到框架以形成可植入的假体心脏瓣膜。 或者，一个或多个组织小叶与框架可操作地相关联以形成可植入假体心脏瓣膜。 随后将可植入式假体心脏瓣膜预先安装在集成的导管递送系统上。 包括可植入假体心脏瓣膜的导管递送系统然后在组织保持干燥时被包装和运输。 可植入假体心脏瓣膜虽然保持基本上干燥，然后可以植入接受患者。

公开(公告)号：US20120078356A1

公开(公告)日：2012-03-29

申请号：US13243980

申请日：2011-09-23

申请人： R. David FISH ,  David PANIAGUA ,  Eduardo INDUNI

发明人： R. David FISH ,  David PANIAGUA ,  Eduardo INDUNI

IPC分类号： A61F2/24 ,  B21D51/16

CPC分类号： A61F2/2418 ,  A61F2/2415 ,  A61F2/2433 ,  A61F2/2475 ,  A61F2220/005 ,  A61F2220/0066 ,  A61F2220/0075 ,  A61F2230/0054 ,  Y10T29/49405

摘要： A prosthetic valve implantable by catheter without surgery includes a frame with an abluminal surface extending between a proximal end of the frame and a distal end of the frame, and a single layer of a biocompatible membrane material mounted to the abluminal surface of the frame. The single layer of biocompatible membrane is located such that an interior surface of the membrane sheet extends between the proximal end of the frame and the distal end of the frame, and resides radially exterior the abluminal surface of the frame. In at least one embodiment, the disposition of membrane sheet at all points of attachment is entirely exterior/abluminal to the frame, such that no part of the abluminal surface of the membrane sheet contacts the frame.

摘要翻译： 可以通过没有手术的导管植入的假体瓣膜包括具有在框架的近端和框架的远端之间延伸的腹腔表面的框架，以及安装到框架的外侧表面的单层生物相容性膜材料。 单层生物相容性膜被定位成使得膜片的内表面在框架的近端和框架的远端之间延伸，并且位于框架的外侧表面的径向外侧。 在至少一个实施方案中，膜片在所有连接点处的布置完全是外框/外框，使得膜片的外表面的一部分不接触框架。

公开(公告)号：US20120310041A1

公开(公告)日：2012-12-06

申请号：US13367252

申请日：2012-02-06

申请人： David PANIAGUA ,  Eduardo INDUNI ,  R. David FISH

发明人： David PANIAGUA ,  Eduardo INDUNI ,  R. David FISH

IPC分类号： A61F2/24

CPC分类号： A61F2/2412 ,  A61B8/12 ,  A61F2/24 ,  A61F2/2415 ,  A61F2/2418 ,  A61F2/2427 ,  A61F2/2433 ,  A61F2/2436 ,  A61F2/2439 ,  A61F2/2475 ,  A61F2002/9534 ,  A61F2210/0014 ,  A61F2210/0076 ,  A61F2220/0008 ,  A61F2220/0016 ,  A61F2220/0025 ,  A61F2220/0075 ,  A61F2230/001 ,  A61F2230/0013 ,  A61F2230/0067 ,  A61F2230/0078 ,  A61F2230/0095 ,  A61F2240/001 ,  A61F2250/0039 ,  A61F2310/00371 ,  A61L27/3604 ,  A61L27/3683 ,  A61L27/3687 ,  A61L27/3691 ,  Y10S623/917 ,  Y10S623/918 ,  Y10T29/49412

摘要： A method of making a replacement heart valve device whereby a fragment of biocompatible tissue material is treated and soaked in one or more alcohol solutions and a solution of glutaraldehyde. The dried biocompatible tissue material is folded and rehydrated in such a way that forms a two- or three-leaflet/cusp valve without affixing of separate cusps or leaflets or cutting slits into the biocompatible tissue material to form the cusps or leaflets. After the biocompatible tissue material is folded, it is affixed at one or more points on the outer surface to the inner cavity or a stent.

摘要翻译： 一种制备置换心脏瓣膜装置的方法，其中生物相容性组织材料的片段被处理并浸泡在一种或多种醇溶液和戊二醛溶液中。 干燥的生物相容性组织材料被折叠并再水化，以形成两个或三个小叶/尖瓣瓣膜，而不必将独立的尖头或小叶或切割狭缝固定到生物相容性组织材料中以形成尖头或小叶。 在生物相容的组织材料折叠之后，将其固定在外表面上的一个或多个点到内腔或支架。

公开(公告)号：US20110300625A1

公开(公告)日：2011-12-08

申请号：US13038260

申请日：2011-03-01

申请人： David PANIAGUA ,  R. David Fish

发明人： David PANIAGUA ,  R. David Fish

IPC分类号： C12N5/071

CPC分类号： A01N1/0231 ,  A61L27/3625 ,  A61L27/3687 ,  A61L2430/40

摘要： A prepared tissue for medical use with a patient is provided. Methods for preparing such tissue are also provided. Implantable tissue is provided by harvesting a tissue, such as but not limited to a pericardium tissue, and exposing the tissue to various cleaning, rinsing, treatment, separating, and fixation steps. The tissue of at least one embodiment is cleaned with distilled water, rinsed with isopropyl alcohol, and treated with a glutaraldehyde solution. The prepared tissue may be allowed to dry or partially hydrated prior to packaging and shipment. As such, the tissue can be implanted into the receiving patient in either a dry or wet state. The relatively thin yet strong tissue material is adapted for implanting within or grafting to human tissue. By way of example, the tissue may be used in a shunt, a valve, as graft material, as a patch, as a prosthetic tissue in a tendon and/or ligament, and a tissue product for wound management.

摘要翻译： 提供了一种用于医疗用途的患者组织。 还提供了制备这种组织的方法。 通过收集组织（例如但不限于心包组织）并将组织暴露于各种清洁，漂洗，处理，分离和固定步骤来提供可植入组织。 至少一个实施方案的组织用蒸馏水清洗，用异丙醇漂洗，并用戊二醛溶液处理。 在包装和运输之前，准备好的组织可以被干燥或部分水合。 因此，可以在干燥或潮湿状态下将组织植入接受患者。 相对薄而强的组织材料适于植入人体组织或移植到人体组织中。 作为示例，组织可以用作分流器，瓣膜，移植材料，补片，肌腱和/或韧带中的假体组织，以及用于伤口管理的组织产品。

公开(公告)号：US20120185038A1

公开(公告)日：2012-07-19

申请号：US13326196

申请日：2011-12-14

申请人： R. David FISH ,  Eduaro INDUNI ,  David PANIAGUA

发明人： R. David FISH ,  Eduaro INDUNI ,  David PANIAGUA

IPC分类号： A61F2/24 ,  B31B1/26

CPC分类号： A61F2/2415 ,  A61F2/2418 ,  A61F2220/0075 ,  A61F2230/0054

摘要： A transcatheter, percutaneously implantable, prosthetic heart valve is provided that comprises a lattice frame and two or more integrated cusp and leaflet folded structures attached to the lattice frame. The two or more integrated cusp and leaflet folded structures each comprise a flat sheet of biocompatible membrane that is folded to include a substantially conical shape according to a flat folding pattern. The substantially conical shape is further formed by joining apposing sides of the substantially conical shape along a seam. The two or more integrated cusp and leaflet folded structures are each attached along their respective seams to the lattice frame in a direction substantially parallel to an axis of the lattice frame. Embodiments of valves described herein have application within the entire vascular system.

摘要翻译： 提供经导管，经皮可植入的假体心脏瓣膜，其包括格子框架和附接到格子框架的两个或更多个集成的尖端和小叶折叠结构。 两个或多个集成的尖头和小叶折叠结构各自包括生物相容性膜的平片，其被折叠以包括基于平坦折叠图案的基本上圆锥形的形状。 基本上圆锥形的形状通过沿着接缝连接基本上圆锥形的侧面而进一步形成。 两个或多个集成的尖头和小叶折叠结构各自沿着它们各自的接缝沿基本上平行于格子框架的轴线的方向附接到格子框架。 本文所述的阀的实施例在整个血管系统内具有应用。