公开(公告)号：US07074921B2

公开(公告)日：2006-07-11

申请号：US10292093

申请日：2002-11-12

申请人： David R. Kronenthal ,  Rao S. Bhandaru ,  Zhongping Shi ,  Boguslaw M. Mudryk

发明人： David R. Kronenthal ,  Rao S. Bhandaru ,  Zhongping Shi ,  Boguslaw M. Mudryk

IPC分类号： C07D243/14 ,  A61K31/55 ,  A61P35/00

CPC分类号： C07D233/64 ,  C07C255/58 ,  C07C255/61 ,  C07D243/14 ,  C07D333/34 ,  C07D403/06 ,  C07D409/12 ,  C07D409/14 ,  C07F7/1804

摘要： Methods for the synthesis of benzodiazepine compounds having farnesyl protein transferase inhibitory activity.

公开(公告)号：US07541362B2

公开(公告)日：2009-06-02

申请号：US11634574

申请日：2006-12-06

申请人： Karnail S. Atwal ,  Wayne Vaccaro ,  John Lloyd ,  Heather Finlay ,  Lin Yan ,  Rao S. Bhandaru

发明人： Karnail S. Atwal ,  Wayne Vaccaro ,  John Lloyd ,  Heather Finlay ,  Lin Yan ,  Rao S. Bhandaru

IPC分类号： C07D401/06 ,  A61K31/4025

CPC分类号： C07D487/04 ,  A61K31/519

摘要： Novel heterocyclic dihydropyrimidine compounds useful as inhibitors of potassium channel function (especially inhibitors of the Kv1 subfamily of voltage gated K+ channels, especially inhibitors Kv1.5 which has been linked to the ultra-rapidly activating delayed rectifier K+ current IKur), methods of using such compounds in the prevention and treatment of arrhythmia and IKur-associated conditions, and pharmaceutical compositions containing such compounds.

摘要翻译： 可用作钾通道功能抑制剂的新型杂环二氢嘧啶化合物（特别是电压门控K +通道的Kv1亚族抑制剂，特别是与超快速激活延迟整流K +电流IKur连接的抑制剂Kv1.5），使用 预防和治疗心律失常和IKur相关病症的化合物，以及含有这些化合物的药物组合物。

公开(公告)号：US07157451B2

公开(公告)日：2007-01-02

申请号：US10660878

申请日：2003-09-12

申请人： Karnail S. Atwal ,  Wayne Vaccaro ,  John Lloyd ,  Heather Finlay ,  Lin Yan ,  Rao S. Bhandaru

发明人： Karnail S. Atwal ,  Wayne Vaccaro ,  John Lloyd ,  Heather Finlay ,  Lin Yan ,  Rao S. Bhandaru

IPC分类号： C07D401/06 ,  A61K31/4025 ,  A61K31/4162 ,  C07D487/04

CPC分类号： C07D487/04 ,  A61K31/519

摘要： Novel heterocyclic dihydropyrimidine compounds useful as inhibitors of potassium channel function (especially inhibitors of the Kv1 subfamily of voltage gated K+ channels, especially inhibitors Kv1.5 which has been linked to the ultra-rapidly activating delayed rectifier K+ current IKur), methods of using such compounds in the prevention and treatment of arrhythmia and IKur-associated conditions, and pharmaceutical compositions containing such compounds.

公开(公告)号：US06706720B2

公开(公告)日：2004-03-16

申请号：US09729731

申请日：2000-12-05

申请人： Karnail S. Atwal ,  Wayne Vaccaro ,  John Lloyd ,  Heather Finlay ,  Lin Yan ,  Rao S. Bhandaru

发明人： Karnail S. Atwal ,  Wayne Vaccaro ,  John Lloyd ,  Heather Finlay ,  Lin Yan ,  Rao S. Bhandaru

IPC分类号： C07D48704

CPC分类号： C07D487/04 ,  A61K31/519

摘要： Novel heterocyclic dihydropyrimidine compounds useful as inhibitors of potassium channel function (especially inhibitors of the Kv1 subfamily of voltage gated K+ channels, especially inhibitors Kv1.5 which has been linked to the ultra-rapidly activating delayed rectifier K+ current IKur), methods of using such compounds in the prevention and treatment of arrhythmia and IKur-associated conditions, and pharmaceutical compositions containing such compounds.

摘要翻译： 可用作钾通道功能抑制剂的新型杂环二氢嘧啶化合物（特别是电压门控K +通道的Kv1亚族抑制剂，特别是与超快速激活延迟整流K +连接的抑制剂Kv1.5当前IKur ），使用这些化合物预防和治疗心律失常和IKur相关病症的方法，以及含有这些化合物的药物组合物。