公开(公告)号：US20050240725A1

公开(公告)日：2005-10-27

申请号：US10831936

申请日：2004-04-26

申请人： David Robinson ,  Brian Wong ,  Spencer Shepler ,  Richard McDougall

发明人： David Robinson ,  Brian Wong ,  Spencer Shepler ,  Richard McDougall

IPC分类号： G06F3/06 ,  G06F12/00

CPC分类号： G06F3/0643 ,  G06F3/0613 ,  G06F3/0632 ,  G06F3/0689 ,  G06F11/1076

摘要： A file is striped across multiple filers, file servers or other devices, to create a sparsely striped multi-component file. Each filer stores one sparse component. In particular, each component physically stores only those stripes allocated to that component. The other stripes are represented as holes. Thus, instead of contiguously packing each component's stripes at the block level, each component is a file having the same logical structure. A component of a sparsely striped multi-component file can be easily converted to a mirror by filling in its holes. Similarly, a mirror can be easily converted to one component of a sparsely striped multi-component file by removing or ignoring it unallocated stripes. In either case, the layout or logical of the component does not need to be reconfigured.

摘要翻译： 文件跨多个文件管理器，文件服务器或其他设备进行条带化，以创建一个稀疏条纹的多组件文件。 每个文件管理器存储一个稀疏组件。 特别地，每个组件仅物理地存储分配给该组件的那些条带。 其他条纹表示为孔。 因此，代替在块级别连续地打包每个组件的条带，每个组件是具有相同逻辑结构的文件。 稀疏条纹的多组分文件的一个组件可以通过填充其孔洞轻松地转换成镜像。 类似地，通过删除或忽略它未分配的条纹，可以容易地将镜像转换为稀疏条纹的多组分文件的一个组件。 在这两种情况下，组件的布局或逻辑不需要重新配置。

公开(公告)号：US20050240632A1

公开(公告)日：2005-10-27

申请号：US10831096

申请日：2004-04-23

申请人： Brian Wong ,  David Robinson ,  Richard McDougall ,  Spencer Shepler

发明人： Brian Wong ,  David Robinson ,  Richard McDougall ,  Spencer Shepler

IPC分类号： G06F11/14 ,  G06F17/30 ,  G06F12/00

CPC分类号： G06F17/30088

摘要： A system and method for facilitating a consistent point-in-time copy (PITC). A data provider offers access to data by one or more clients. A client issues a PITC request for a set of data to the data provider, or the provider initiates its own request. The data provider instructs one or more clients, particularly clients accessing the set of data, to flush any pending updates involving the files. The clients acknowledge the flush request, flush their data, and notify the data provider when their flushes are complete. Post-consistency updates are deferred (e.g., using a write-aside buffer). If a client fails to acknowledge the flush request or notify of flush completion, the data provider may abort the PITC or continue because the data may not be consistent or consistency may not be assured. If not aborted, the PITC may be marked to indicate that it is incomplete.

摘要翻译： 用于促进一致的时间点复制（PITC）的系统和方法。 数据提供者提供一个或多个客户端对数据的访问。 客户端向数据提供者发出一组数据的PITC请求，或者提供者发起自己的请求。 数据提供者指示一个或多个客户端，特别是访问该组数据的客户端，以刷新涉及文件的任何未决更新。 客户端确认刷新请求，刷新其数据，并在其刷新完成时通知数据提供者。 后期一致性更新被推迟（例如，使用写入缓冲区）。 如果客户端无法确认刷新请求或通知刷新完成，则数据提供者可能会中止PITC或继续，因为数据可能不一致或一致性可能无法保证。 如果没有中止，PITC可能被标记为表示它是不完整的。

公开(公告)号：US20080010515A1

公开(公告)日：2008-01-10

申请号：US11434344

申请日：2006-05-15

申请人： David Robinson ,  Brian Wong ,  Spencer Shepler ,  Richard McDougall

发明人： David Robinson ,  Brian Wong ,  Spencer Shepler ,  Richard McDougall

IPC分类号： G06F11/00

CPC分类号： G06F11/2082

摘要： A method for dirty region logging of a file that includes receiving a request to open the file, determining each of a plurality of component files associated with the file, opening each of the plurality of component files, writing to a region of the at least one of the plurality component files, and updating a dirty region log (DRL) associated with the one of the plurality of component files to reflect the write to the region.

摘要翻译： 一种用于对文件进行脏区域记录的方法，包括接收打开所述文件的请求，确定与所述文件相关联的多个组件文件中的每一个，打开所述多个组件文件中的每一个，写入所述至少一个 并且更新与所述多个组件文件中的所述一个组件文件相关联的脏区域日志（DRL）以反映对所述区域的写入。

公开(公告)号：US09102963B2

公开(公告)日：2015-08-11

申请号：US14110964

申请日：2012-04-12

申请人： Anupam Gohel ,  Derek Smith ,  Brian Wong ,  Joly Sukumaran ,  Wan Lin Yeo ,  Steven J. Collier ,  Scott Novick

发明人： Anupam Gohel ,  Derek Smith ,  Brian Wong ,  Joly Sukumaran ,  Wan Lin Yeo ,  Steven J. Collier ,  Scott Novick

IPC分类号： C12P17/10 ,  C12N9/02 ,  C07D223/22 ,  C07D223/28 ,  C07D453/02 ,  C12P41/00 ,  C12N9/04

CPC分类号： C12P17/10 ,  C07D223/22 ,  C07D223/28 ,  C07D453/02 ,  C12N9/0006 ,  C12N9/004 ,  C12N11/00 ,  C12P41/002 ,  C12Y101/00 ,  Y02P20/52

摘要： The present disclosure relates to biocatalysts and its uses for the efficient preparation of eslicarbazepine, eslicarbazepine acetate, and analogs thereof.

摘要翻译： 本公开涉及生物催化剂及其用于有效制备西酞西泮，醋酸西拉西平及其类似物的用途。

公开(公告)号：US20110106350A1

公开(公告)日：2011-05-05

申请号：US12609545

申请日：2009-10-30

申请人： Bassam D. Jalbout ,  Brian Wong

发明人： Bassam D. Jalbout ,  Brian Wong

IPC分类号： G06F19/00

CPC分类号： B60W10/08 ,  B60K28/16 ,  B60L11/00 ,  B60L15/08 ,  B60L15/2045 ,  B60L15/2072 ,  B60L2200/26 ,  B60W2520/26 ,  B60W2550/148 ,  Y02T10/645 ,  Y02T10/646 ,  Y02T10/7283

摘要： Fixed frequency, fixed duration pulse streams are used to control power switches for one or more electrical motors of electrically powered vehicles or hybrid vehicles having one or more electric motors. The advantages of a pulse system are increased power efficiency and system simplicity over analog systems. The capability of system calibration with a single pulse allows the system to be used under any conditions, and real time adaptation to changes in conditions. Such system and methods provide much improved acceleration over other electrical systems, by making the best use of the coefficient of starting or static friction. The systems and methods provide a non slip traction control system, and the use of an off state in the pulse stream is superior to the use of braking systems for the same purpose, which waste power and cause mechanical wear. In addition, related computer program products are described.

摘要翻译： 固定频率固定持续时间脉冲流被用于控制具有一个或多个电动机的电动车辆或混合动力车辆的一个或多个电动机的电力开关。 脉冲系统的优点是提高了模拟系统的功率效率和系统简单性。 使用单个脉冲进行系统校准的能力允许系统在任何条件下使用，并实时适应条件变化。 这种系统和方法通过充分利用起动或静摩擦系数提供比其他电气系统更大的改进的加速度。 这些系统和方法提供了非滑动牵引力控制系统，并且在脉冲流中使用关闭状态优于使用相同目的的制动系统，其浪费功率并引起机械磨损。 此外，还描述了相关的计算机程序产品。

公开(公告)号：US20100264314A1

公开(公告)日：2010-10-21

申请号：US12426545

申请日：2009-04-20

申请人： Bassam D. Jalbout ,  Brian Wong

发明人： Bassam D. Jalbout ,  Brian Wong

IPC分类号： G01J5/02 ,  G01J5/00 ,  H05B41/36

CPC分类号： H05B37/0272

摘要： Disclosed are lighting techniques, including systems, apparatus, and methods, that employ optical transmission of two-dimensional control signals to manipulate lighting elements. The lighting apparatus can include a projector with an IR LED array to wirelessly transmit pixel information onto a target space. The pixel information controls lighting elements within the target space. The two-dimensional control signals can includes subareas corresponding to lighting elements in a control array. The lighting elements can be lights of desired wavelengths including infrared and/or visible wavelengths. LEDs can be used as light sources in exemplary embodiments.

公开(公告)号：US20100183620A1

公开(公告)日：2010-07-22

申请号：US12626534

申请日：2009-11-25

申请人： KAUMUDI BHAWE ,  Elizabeth Bosch ,  Kathleen Boyle ,  Arthur Brace ,  Anuk Das ,  Francis Farrell ,  Pitchumani Sivakumar ,  Jeffrey Finer ,  Kristen Pierce ,  Kathleen M. Sullivan ,  Brian Wong

发明人： KAUMUDI BHAWE ,  Elizabeth Bosch ,  Kathleen Boyle ,  Arthur Brace ,  Anuk Das ,  Francis Farrell ,  Pitchumani Sivakumar ,  Jeffrey Finer ,  Kristen Pierce ,  Kathleen M. Sullivan ,  Brian Wong

IPC分类号： A61K39/395 ,  A61K31/7088 ,  A61K38/02 ,  A61K38/16 ,  A61P21/00 ,  C12Q1/68

CPC分类号： C07K14/811 ,  A61K38/57 ,  C07K16/38 ,  C07K2317/76

摘要： The invention encompasses methods and compositions for increasing or decreasing collagen 1A1 expression and/or α-smooth muscle actin expression in lung fibroblasts using SERPINE2 and antagonists of SERPINE2. The invention also encompasses methods and compositions for increasing or decreasing the formation of myofibroblasts. The invention further provides methods and compositions for treatment of lung diseases, such as idiopathic pulmonary fibrosis and chronic obstructive pulmonary disease.

摘要翻译： 本发明包括使用SERPINE2和SERPINE2拮抗剂增加或减少肺成纤维细胞中胶原1A1表达和/或α-平滑肌肌动蛋白表达的方法和组合物。 本发明还包括用于增加或减少肌成纤维细胞形成的方法和组合物。 本发明进一步提供了治疗肺部疾病如特发性肺纤维化和慢性阻塞性肺疾病的方法和组合物。

公开(公告)号：US07736846B2

公开(公告)日：2010-06-15

申请号：US10652961

申请日：2003-08-28

申请人： Esteban Masuda ,  Brian Wong

发明人： Esteban Masuda ,  Brian Wong

IPC分类号： C12Q1/10 ,  G01N33/53

CPC分类号： G01N33/5011 ,  C12Q1/6883 ,  C12Q2600/158 ,  G01N33/5008 ,  G01N33/502 ,  G01N33/5047 ,  G01N33/5091 ,  G01N33/6893 ,  G01N2333/9015 ,  G01N2510/00

摘要： The present invention relates to regulation of inflammation. More particularly, the present invention is directed to nucleic acids encoding components of the ubiquitin ligation pathway, e.g., ubiquitin and ubiquitin-like molecules, E1, E2, and E3 proteins and their substrates, which are involved in modulation of the inflammatory process. The invention further relates to methods for identifying and using agents, including small molecule chemical compositions, antibodies, peptides, cyclic peptides, nucleic acids, RNAi, antisense nucleic acids, and ribozymes, that modulate the inflammatory process via modulation of the ubiquitin ligation pathway; as well as to the use of expression profiles and compositions in diagnosis and therapy related to regulation of inflammation and modulation of cytokine signaling involved in inflammation, e.g., for treatment of infection, autoimmune disease and other diseases related to the inflammatory process.

摘要翻译： 本发明涉及炎症的调节。 更具体地，本发明涉及编码泛素连接途径的组分的核酸，例如涉及炎症过程调节的泛素和泛素样分子，E1，E2和E3蛋白及其底物。 本发明还涉及用于鉴别和使用通过调节泛素连接途径调节炎症过程的试剂，包括小分子化学组合物，抗体，肽，环肽，核酸，RNAi，反义核酸和核酶的方法; 以及在与炎症调节相关的诊断和治疗相关的诊断和治疗中使用表达谱和组合物，例如用于治疗感染，自身免疫性疾病和与炎症过程相关的其它疾病。

公开(公告)号：US20100072907A1

公开(公告)日：2010-03-25

申请号：US12625118

申请日：2009-11-24

申请人： Bassam Jalbout ,  Brian Wong

发明人： Bassam Jalbout ,  Brian Wong

IPC分类号： H05B41/36 ,  H05B39/04

CPC分类号： H05B33/0815 ,  H05B33/0824

摘要： A switched preconditioner circuit is provided at the power input end of a light source to effectively drop the voltage of the light source to zero volts whenever the light source is required to be in an OFF state thereby eliminating the problem of unwanted current through the light source. The preconditioner circuit may include a terminal connected to a first power potential, a terminal connected to a power node at the power input end of the light source, and an input to receive a preconditioner control signal to place the preconditioner circuit in one of an ON state and an OFF state. The preconditioner circuit supplies the voltage to the power node in its ON state and effectively eliminates the voltage to the power node in its OFF state. The preconditioner circuit also may include a bleed path connected between the power node and a second or ground potential to shunt all power supplied to the power node when the preconditioner circuit input receives a signal to place the preconditioner circuit in the OFF state.

摘要翻译： 在光源的电源输入端设置开关预处理电路，以便在要求光源处于关断状态时有效地将光源的电压降至零伏，从而消除了通过光源的不期望的电流的问题 。 预处理器电路可以包括连接到第一电源电位的端子，连接到光源的电力输入端处的功率节点的端子和用于接收预处理器控制信号的输入端，以将预处理器电路放置在ON 状态和OFF状态。 预处理器电路将电压提供给处于其导通状态的电源节点，并且有效地消除了电源节点处于其关闭状态的电压。 预处理器电路还可以包括连接在功率节点和第二或接地电位之间的放电路径，以在预处理器电路输入接收到将预处理器电路置于OFF状态的信号时分流供应给功率节点的所有功率。

公开(公告)号：US07638950B1

公开(公告)日：2009-12-29

申请号：US11882322

申请日：2007-07-31

申请人： Bassam Jalbout ,  Brian Wong

发明人： Bassam Jalbout ,  Brian Wong

IPC分类号： H05B41/36

CPC分类号： H05B33/0815 ,  H05B33/0824

摘要： A switched preconditioner circuit is provided at the power input end of a light source to effectively drop the voltage of the light source to zero volts whenever the light source is required to be in an OFF state thereby eliminating the problem of unwanted current through the light source. The preconditioner circuit may include a terminal connected to a first power potential, a terminal connected to a power node at the power input end of the light source, and an input to receive a preconditioner control signal to place the preconditioner circuit in one of an ON state and an OFF state. The preconditioner circuit supplies the voltage to the power node in its ON state and effectively eliminates the voltage to the power node in its OFF state. The preconditioner circuit also may include a bleed path connected between the power node and a second or ground potential to shunt all power supplied to the power node when the preconditioner circuit input receives a signal to place the preconditioner circuit in the OFF state.

摘要翻译： 在光源的电源输入端设置开关预处理电路，以便在要求光源处于关断状态时有效地将光源的电压降至零伏，从而消除了通过光源的不期望的电流的问题 。 预处理器电路可以包括连接到第一电源电位的端子，连接到光源的电力输入端处的功率节点的端子和用于接收预处理器控制信号的输入端，以将预处理器电路放置在ON 状态和OFF状态。 预处理器电路将电压提供给处于其导通状态的电源节点，并且有效地消除了电源节点处于其关闭状态的电压。 预处理器电路还可以包括连接在功率节点和第二或接地电位之间的放电路径，以在预处理器电路输入接收到将预处理器电路置于OFF状态的信号时分流供应给功率节点的所有功率。