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公开(公告)号：US08852630B2
公开(公告)日：2014-10-07
申请号：US13173480
申请日：2011-06-30
申请人： David Spiegel , Ryan Murelli , Andrew Zhang
发明人： David Spiegel , Ryan Murelli , Andrew Zhang
IPC分类号： A61K9/127
CPC分类号： C07K16/44 , A61K9/0019 , A61K31/4192 , A61K45/06 , A61K47/48023 , A61K47/48092 , A61K47/481 , A61K47/4833 , A61K47/48653 , A61K47/48723 , A61K47/54 , A61K47/549 , A61K47/55 , A61K47/646 , A61K47/68 , A61K47/6803 , A61K47/6869 , A61K47/6873 , A61K47/6891 , C07D249/04 , C07K16/3069 , C07K2317/31
摘要： The present invention relates to chimeric chemical compounds which are used to recruit antibodies to cancer cells, in particular, prostate cancer cells or metastasized prostate cancer cells. The compounds according to the present invention comprise an antibody binding terminus (ABT) moiety covalently bonded to a cell binding terminus (CBT) through a linker and optionally, a connector molecule.
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2.发明申请CHIMERIC SMALL MOLECULES FOR THE RECRUITMENT OF ANTIBODIES TO CANCER CELLS 有权用于诱导癌细胞的抗体的CHIMERIC小分子公开(公告)号：US20120034295A1
公开(公告)日：2012-02-09
申请号：US13173480
申请日：2011-06-30
申请人： David Spiegel , Ryan Murelli , Andrew Zhang
发明人： David Spiegel , Ryan Murelli , Andrew Zhang
IPC分类号： A61K9/127
CPC分类号： C07K16/44 , A61K9/0019 , A61K31/4192 , A61K45/06 , A61K47/48023 , A61K47/48092 , A61K47/481 , A61K47/4833 , A61K47/48653 , A61K47/48723 , A61K47/54 , A61K47/549 , A61K47/55 , A61K47/646 , A61K47/68 , A61K47/6803 , A61K47/6869 , A61K47/6873 , A61K47/6891 , C07D249/04 , C07K16/3069 , C07K2317/31
摘要： The present invention relates to chimeric chemical compounds which are used to recruit antibodies to cancer cells, in particular, prostate cancer cells or metastasized prostate cancer cells. The compounds according to the present invention comprise an antibody binding terminus (ABT) moiety covalently bonded to a cell binding terminus (CBT) through a linker and optionally, a connector molecule.
摘要翻译： 本发明涉及用于向癌细胞，特别是前列腺癌细胞或转移前列腺癌细胞募集抗体的嵌合化合物。 根据本发明的化合物包含通过接头和任选的连接体分子共价键合到细胞结合末端（CBT）的抗体结合末端（ABT）部分。
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3.发明授权公开(公告)号：US08859509B2
公开(公告)日：2014-10-14
申请号：US12991926
申请日：2009-05-13
申请人： David Spiegel , Ryan Murelli , Andrew Zhang
发明人： David Spiegel , Ryan Murelli , Andrew Zhang
IPC分类号： A61K31/702 , A61K31/675 , A61K31/66 , A61K31/4192 , A61K31/195 , C07H99/00 , A61K47/48 , C07K16/44 , A61K39/00
CPC分类号： C07K16/44 , A61K47/54 , A61K47/549 , A61K47/55 , A61K47/555 , A61K47/646 , A61K2039/505
摘要： The present invention relates to chimeric chemical compounds which are used to recruit antibodies to cancer cells, in particular, prostate cancer cells or metastasized prostate cancer cells. The compounds according to the present invention comprise an antibody binding terminus (ABT) moiety covalently bonded to a cell binding terminus (CBT) through a linker and optionally, a connector molecule.
摘要翻译： 本发明涉及用于向癌细胞，特别是前列腺癌细胞或转移前列腺癌细胞募集抗体的嵌合化合物。 根据本发明的化合物包含通过接头和任选的连接体分子共价键合到细胞结合末端（CBT）的抗体结合末端（ABT）部分。
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4.发明申请CHIMERIC SMALL MOLECULES FOR THE RECRUITMENT OF ANTIBODIES TO CANCER CELLS 有权用于诱导癌细胞的抗体的CHIMERIC小分子公开(公告)号：US20110201563A1
公开(公告)日：2011-08-18
申请号：US12991926
申请日：2009-05-13
申请人： David Spiegel , Ryan Murelli , Andrew Zhang
发明人： David Spiegel , Ryan Murelli , Andrew Zhang
IPC分类号： A61K31/702 , A61K31/675 , A61K31/66 , A61K31/4192 , A61K31/195 , C07H99/00 , C07F9/28 , C07D249/04 , C07C321/00 , C07D403/14 , A61P35/02 , A61P35/00
CPC分类号： C07K16/44 , A61K47/54 , A61K47/549 , A61K47/55 , A61K47/555 , A61K47/646 , A61K2039/505
摘要： The present invention relates to chimeric chemical compounds which are used to recruit antibodies to cancer cells, in particular, prostate cancer cells or metastasized prostate cancer cells. The compounds according to the present invention comprise an antibody binding terminus (ABT) moiety covalently bonded to a cell binding terminus (CBT) through a linker and optionally, a connector molecule.
摘要翻译： 本发明涉及用于向癌细胞，特别是前列腺癌细胞或转移前列腺癌细胞募集抗体的嵌合化合物。 根据本发明的化合物包含通过接头和任选的连接体分子共价键合到细胞结合末端（CBT）的抗体结合末端（ABT）部分。
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