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43 条记录 (耗时 0.029 秒)

    Substituted heteroaryl amide modulators of glucocorticoid receptor, AP-1, and/or NF-kB activity and use thereof
    3.
    发明申请
    Substituted heteroaryl amide modulators of glucocorticoid receptor, AP-1, and/or NF-kB activity and use thereof 有权
    糖皮质激素受体，AP-1和/或NF-kB活性的取代的杂芳基酰胺调节剂及其用途

    公开(公告)号：US20060154973A1

    公开(公告)日：2006-07-13

    申请号：US11330553

    申请日：2006-01-12

    申请人： James Sheppeck ,  T.G. Dhar ,  Lidia Doweyko ,  John Gilmore ,  David Weinstein ,  Hai-Yun Xiao ,  Bingwei Yang ,  Arthur Doweyko

    发明人： James Sheppeck ,  T.G. Dhar ,  Lidia Doweyko ,  John Gilmore ,  David Weinstein ,  Hai-Yun Xiao ,  Bingwei Yang ,  Arthur Doweyko

    IPC分类号： A61K31/433 ,  A61K31/4245 ,  A61K31/4196

    CPC分类号： C07D233/91 ,  C07D277/46 ,  C07D417/06

    摘要： The present invention relates to new class of non-steroidal compounds which are useful in treating diseases associated with modulation of the glucocorticoid receptor, AP-1, and/or NF-κB activity including obesity, diabetes, inflammatory- and immune-associated diseases, and have the structure including all stereoisomers thereof, tautomers thereof, or a prodrug thereof, or a pharmaceutically acceptable salt thereof, wherein X is selected from N, O, and S; Y is N or CR6; Z is a ring; and where R, Ra, Rb, Rc, Rd, R1, R2, R3, R4, and R5 are as defined herein. Also provided are pharmaceutical compositions and methods of treating obesity, diabetes and inflammatory or immune associated diseases comprising said compounds.

    摘要翻译： 本发明涉及新类型的非甾体化合物，其可用于治疗与糖皮质激素受体，AP-1和/或NF-κB活性调节有关的疾病，包括肥胖症，糖尿病，炎性和免疫相关疾病， 并且具有包括其所有立体异构体，其互变异构体或其前药或其药学上可接受的盐的结构，其中X选自N，O和S; Y是N或CR 6; Z是一个戒指 并且其中R，R a，R b，R b，R c，R d，R 1， R 2，R 3，R 4和R 5如本文所定义。 还提供了治疗肥胖症，糖尿病和包含所述化合物的炎性或免疫相关疾病的药物组合物和方法。

    Heterocyclic modulators of the glucocorticoid receptor, AP-1, and/or NF-kB activity and use thereof
    5.
    发明申请
    Heterocyclic modulators of the glucocorticoid receptor, AP-1, and/or NF-kB activity and use thereof 有权
    糖皮质激素受体，AP-1和/或NF-kB活性的杂环调节剂及其用途

    公开(公告)号：US20050182083A1

    公开(公告)日：2005-08-18

    申请号：US11035290

    申请日：2005-01-13

    申请人： David Weinstein ,  James Sheppeck ,  John Gilmore

    发明人： David Weinstein ,  James Sheppeck ,  John Gilmore

    IPC分类号： A61K31/4745 ,  C07D403/12 ,  C07D471/18 ,  C07D487/04

    CPC分类号： C07D471/18

    摘要： Novel non-steroidal compounds are provided which are useful in treating diseases associated with modulation of the glucocorticoid receptor, AP-1, and/or NF-κB activity including obesity, diabetes, inflammatory and immune diseases, and have the structure of formula (I) or stereoisomers or prodrugs or solvates or pharmaceutically acceptable salts thereof, wherein A, B, J, K, Z, R, Ra, Rb, Rc, and Rd, are defined herein. Also provided are pharmaceutical compositions and methods of treating obesity, diabetes and inflammatory or immune associated diseases comprising said compounds.

    摘要翻译： 提供了新的非甾体化合物，其可用于治疗与糖皮质激素受体，AP-1和/或NF-κB活性的调节相关的疾病，包括肥胖，糖尿病，炎症和免疫疾病，并且具有式（I ）或其立体异构体或前药或溶剂化物或其药学上可接受的盐，其中A，B，J，K，Z，R，R a，R b， C和/或D，在本文中定义。 还提供了治疗肥胖症，糖尿病和包含所述化合物的炎性或免疫相关疾病的药物组合物和方法。

    METHOD FOR ENHANCING EPITHELIAL CELL PROLIFERATION AND USES THEREOF
    7.
    发明申请
    METHOD FOR ENHANCING EPITHELIAL CELL PROLIFERATION AND USES THEREOF 审中-公开
    用于增强上皮细胞增殖的方法及其用途

    公开(公告)号：US20070010546A1

    公开(公告)日：2007-01-11

    申请号：US11425441

    申请日：2006-06-21

    申请人： David Weinstein

    发明人： David Weinstein

    IPC分类号： A61K31/4745

    CPC分类号： A61K38/13

    摘要： The present invention is directed to uses of GM-284 for enhancing epithelial cell proliferation. The present invention is also provides methods for treating a keratinocyte-associated disorder in a subject in need of treatment.

    摘要翻译： 本发明涉及GM-284用于增强上皮细胞增殖的用途。 本发明还提供了在需要治疗的受试者中治疗角质形成细胞相关病症的方法。