公开(公告)号：US20060024273A1

公开(公告)日：2006-02-02

申请号：US11153458

申请日：2005-06-16

申请人： Daniel Henderson ,  De Yu

发明人： Daniel Henderson ,  De Yu

IPC分类号： A61K48/00 ,  C12N15/861

CPC分类号： C12N15/86 ,  A61K35/761 ,  A61K38/193 ,  A61K38/45 ,  A61K48/0058 ,  C12N2710/10332 ,  C12N2710/10343 ,  C12N2830/00 ,  C12N2830/002 ,  C12N2830/008 ,  C12N2830/85 ,  A61K2300/00

摘要： The invention provides adenoviral vectors (preferably replication competent) comprising both an E3 sequence and at least one adenoviral gene under transcriptional control of a target cell-specific transcriptional response element. These vectors display significantly improved cytotoxicity, which is especially useful in the cancer context, in which selective destruction of target cells is desirable. The invention further provides host cells comprising the vectors. The invention further provides methods of using the adenoviral vectors.

公开(公告)号：US20060188479A1

公开(公告)日：2006-08-24

申请号：US11206135

申请日：2005-08-18

申请人： De Yu ,  Daniel Henderson

发明人： De Yu ,  Daniel Henderson

IPC分类号： C12N15/861 ,  A61K48/00

CPC分类号： A61K48/0058 ,  A61K35/13 ,  C12N15/86 ,  C12N2710/10343 ,  C12N2710/10345 ,  C12N2830/002 ,  C12N2830/007 ,  C12N2830/008

摘要： The present invention provides adenoviral vectors comprising cell status-specific transcriptional regulatory elements which confer cell status-specific transcriptional regulation on an adenoviral gene. A “cell status” is generally a reversible physiological and/or environmental state. The invention further provides compositions and host cells comprising the vectors, as well as methods of using the vectors.

公开(公告)号：US20050169890A1

公开(公告)日：2005-08-04

申请号：US10938227

申请日：2004-09-09

申请人： De Yu ,  Daniel Henderson

发明人： De Yu ,  Daniel Henderson

IPC分类号： C12N15/09 ,  A61K35/76 ,  A61K48/00 ,  A61P35/00 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N7/02 ,  C12N15/86 ,  C12N15/861 ,  C12Q1/68 ,  C12N7/00

CPC分类号： A61K48/0058 ,  A61K35/13 ,  C12N15/86 ,  C12N2710/10343 ,  C12N2710/10345 ,  C12N2830/002 ,  C12N2830/007 ,  C12N2830/008

摘要： The present invention provides adenoviral vectors comprising cell status-specific transcriptional regulatory elements which confer cell status-specific transcriptional regulation on an adenoviral gene. A “cell status” is generally a reversible physiological and/or environmental state. The invention further provides compositions and host cells comprising the vectors, as well as methods of using the vectors.

公开(公告)号：US20080076173A1

公开(公告)日：2008-03-27

申请号：US11977655

申请日：2007-10-24

申请人： De Yu ,  Daniel Henderson

发明人： De Yu ,  Daniel Henderson

IPC分类号： C12N15/00

CPC分类号： A61K48/0058 ,  A61K35/13 ,  C12N15/86 ,  C12N2710/10343 ,  C12N2710/10345 ,  C12N2830/002 ,  C12N2830/007 ,  C12N2830/008

摘要： The present invention provides adenoviral vectors comprising cell status-specific transcriptional regulatory elements which confer cell status-specific transcriptional regulation on an adenoviral gene. A “cell status” is generally a reversible physiological and/or environmental state. The invention further provides compositions and host cells comprising the vectors, as well as methods of using the vectors.

摘要翻译： 本发明提供了包含赋予腺病毒基因的细胞状态特异性转录调节的细胞状态特异性转录调节元件的腺病毒载体。 “细胞状态”通常是可逆的生理和/或环境状态。 本发明还提供了包含载体的组合物和宿主细胞，以及使用载体的方法。

公开(公告)号：US20070293205A1

公开(公告)日：2007-12-20

申请号：US11134669

申请日：2005-05-19

申请人： Daniel Henderson

发明人： Daniel Henderson

IPC分类号： H04M3/42

CPC分类号： H04M1/576 ,  H04M1/578 ,  H04M3/42068

摘要： A method is shown in which a wireless picture phone receives updated contact data from a computer utilizing a wireless connection.

摘要翻译： 示出了一种方法，其中无线画面电话利用无线连接从计算机接收更新的联系人数据。

公开(公告)号：US20060029582A1

公开(公告)日：2006-02-09

申请号：US11166234

申请日：2005-06-27

申请人： De-Chao Yu ,  Yu Chen ,  Daniel Henderson

发明人： De-Chao Yu ,  Yu Chen ,  Daniel Henderson

IPC分类号： A61K48/00 ,  A61K38/21 ,  A61K31/7072 ,  A61K31/704

CPC分类号： A61K31/7048 ,  A61K35/761 ,  A61K38/09 ,  A61K38/212 ,  A61K48/0058 ,  A61K48/0083 ,  C12N15/86 ,  C12N2710/10345 ,  C12N2830/00 ,  C12N2830/008 ,  C12N2830/85 ,  C12N2840/20 ,  C12N2840/203 ,  A61K2300/00

摘要： The invention provides methods of treating neoplasia using combinations of target cell-specific replication competent adenoviral vectors and chemotherapy, radiation therapy or combinations thereof. The adenoviral vectors are target cell-specific for the particular type of neoplasia for which treatment is necessary and the combination with the chemotherapy and/or radiation leads to synergistic treatment over existing adenoviral therapy or traditional chemotherapy and radiation therapy.

摘要翻译： 本发明提供使用靶细胞特异性复制感受态腺病毒载体和化疗，放射疗法或其组合的组合来治疗瘤形成的方法。 腺病毒载体是需要治疗的特定类型的瘤形成的靶细胞特异性，并且与化疗和/或辐射的组合导致对现有腺病毒疗法或传统化学疗法和放射治疗的协同治疗。

公开(公告)号：US20050036951A1

公开(公告)日：2005-02-17

申请号：US10754485

申请日：2004-01-09

申请人： Daniel Henderson

发明人： Daniel Henderson

IPC分类号： A61K20060101 ,  A61K9/00 ,  A61K9/14 ,  A61K31/7088 ,  A61K38/16 ,  A61K38/20 ,  A61K38/21 ,  A61K39/00 ,  A61K47/42 ,  A61K47/48 ,  A61K48/00 ,  A61L9/04 ,  A61P11/00

CPC分类号： A61K9/0073 ,  A61K38/2013 ,  A61K47/6813 ,  A61K47/6849

摘要： The present invention discloses compositions and methods for treating lung diseases. In preferred embodiments the methods involve administering to the subject via a pulmonary, oropharyngeal, or nasopharyngeal route a compound or composition that contains a therapeutic agent and a targeting element directed to a ligand. The ligand is preferably an epitope on pIgR receptor.

摘要翻译： 本发明公开了治疗肺部疾病的组合物和方法。 在优选的实施方案中，所述方法包括通过肺，口咽或鼻咽途径向受试者施用含有治疗剂和靶向配体的靶向元件的化合物或组合物。 配体优选是pIgR受体上的表位。

公开(公告)号：US20070275708A1

公开(公告)日：2007-11-29

申请号：US10692179

申请日：2003-10-23

申请人： Daniel Henderson

发明人： Daniel Henderson

IPC分类号： H04M3/42

CPC分类号： H04M1/576 ,  H04M1/2745

摘要： A message originator sends a picture or video message to a message center along with caller identifying information. The message is stored in a memory and transmitted to a wireless picture phone, PDA or portable computing device, or stored at the message center in a memory or hard disk drive for later retrieval by a message recipient. The picture or video message may be encoded, encrypted or compressed prior to receipt by the wireless device.

摘要翻译： 消息发起者将消息中心的图片或视频消息与呼叫者识别信息一起发送。 该消息存储在存储器中并被发送到无线图片电话，PDA或便携式计算设备，或者存储在消息中心的存储器或硬盘驱动器中，以供稍后由消息接收者检索。 图像或视频消息可以在无线设备接收之前被编码，加密或压缩。

公开(公告)号：US20180242782A1

公开(公告)日：2018-08-30

申请号：US15442751

申请日：2017-02-27

申请人： Daniel Henderson ,  Timothy J. Henderson ,  Eric Daniels ,  Gwendolyn L. Daniels

发明人： Daniel Henderson ,  Timothy J. Henderson ,  Eric Daniels ,  Gwendolyn L. Daniels

IPC分类号： A47J37/04 ,  A47J36/02

CPC分类号： A47J37/049 ,  A47J36/02 ,  A47J37/067 ,  A47J37/0694

摘要： The problem of evenly cooking a food item so that all sides cook and brown evenly is solved by the use of a roasting platform that raises above rendered substances that can cause a steam and wetness to the surface of a food item. The roasting platform can be foldable or compressed, so that it takes up minimal storage space and can be deployed for use. Drain holes allow rendered substances to be more quickly separated from the surface of a food item. The same drain holes can be used as visual indicators when deploying the roasting platform to show when he folds of a roasting platform are sufficiently separated for maximum usable area and support for a weight placed thereon.

公开(公告)号：US20070293204A1

公开(公告)日：2007-12-20

申请号：US10728440

申请日：2003-12-05

申请人： Daniel Henderson

发明人： Daniel Henderson

IPC分类号： H04M3/42

CPC分类号： H04M1/576 ,  H04M1/2745

摘要： In a wireless picturephone system and device, a method is shown for alerting a message recipient of a picture or video message transmitted from a message center. The alert in one embodiment includes a stored sound or textual data such as a name or other useful information associated with data that identifies the message originator.

摘要翻译： 在无线电话电话系统和设备中，示出了用于警告从消息中心发送的图片或视频消息的消息接收者的方法。 一个实施例中的警报包括存储的声音或文本数据，例如与识别消息始发者的数据相关联的名称或其他有用信息。