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公开(公告)号:US08283354B2
公开(公告)日:2012-10-09
申请号:US11216376
申请日:2005-08-31
申请人: Dean Wilson , Andreas Termin , Jesus Gonzalez , Lev Fanning , Timothy Neubert , Paul Krenitsky , Pramod Joshi , Dennis Hurley , Urvi Sheth
发明人: Dean Wilson , Andreas Termin , Jesus Gonzalez , Lev Fanning , Timothy Neubert , Paul Krenitsky , Pramod Joshi , Dennis Hurley , Urvi Sheth
IPC分类号: A01N43/54 , A61K31/517 , C07D401/00
CPC分类号: C07D239/94 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/12 , C07D405/14
摘要: The present invention relates to compounds useful as inhibitors of voltage-gated sodium channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
摘要翻译: 本发明涉及可用作电压门控钠通道抑制剂的化合物。 本发明还提供包含本发明化合物的药学上可接受的组合物和使用该组合物治疗各种疾病的方法。
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公开(公告)号:US20060173018A1
公开(公告)日:2006-08-03
申请号:US11216376
申请日:2005-08-31
申请人: Dean Wilson , Andreas Termin , Jesus Gonzalez , Lev Fanning , Timothy Neubert , Paul Krenitsky , Pramod Joshi , Dennis Hurley , Urvi Sheth
发明人: Dean Wilson , Andreas Termin , Jesus Gonzalez , Lev Fanning , Timothy Neubert , Paul Krenitsky , Pramod Joshi , Dennis Hurley , Urvi Sheth
IPC分类号: A61K31/517 , C07D403/04
CPC分类号: C07D239/94 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/12 , C07D405/14
摘要: The present invention relates to compounds useful as inhibitors of voltage-gated sodium channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
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公开(公告)号:US20090312342A1
公开(公告)日:2009-12-17
申请号:US11367954
申请日:2006-03-03
申请人: Dean Wilson , Andreas Termin , Jesus Gonzalez , Lev Fanning , Timothy Neubert , Paul Krenitsky , Pramod Joshi , Dennis Hurley , Urvi Sheth
发明人: Dean Wilson , Andreas Termin , Jesus Gonzalez , Lev Fanning , Timothy Neubert , Paul Krenitsky , Pramod Joshi , Dennis Hurley , Urvi Sheth
IPC分类号: A61K31/496 , C07D403/12 , A61K31/517 , A61P29/00 , A61P19/02 , A61P25/00 , A61P25/06 , A61P25/08 , A61P25/24 , A61P25/28 , A61P25/22
CPC分类号: C07D239/94 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/12 , C07D405/14 , C07D493/04
摘要: The present invention relates to compounds useful as inhibitors of voltage-gated sodium channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
摘要翻译: 本发明涉及可用作电压门控钠通道抑制剂的化合物。 本发明还提供包含本发明化合物的药学上可接受的组合物和使用该组合物治疗各种疾病的方法。
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公开(公告)号:US07928107B2
公开(公告)日:2011-04-19
申请号:US11367954
申请日:2006-03-03
申请人: Dean Wilson , Andreas Termin , Jesus Gonzalez , Lev Fanning , Timothy Neubert , Paul Krenitsky , Pramod Joshi , Dennis Hurley , Urvi Sheth
发明人: Dean Wilson , Andreas Termin , Jesus Gonzalez , Lev Fanning , Timothy Neubert , Paul Krenitsky , Pramod Joshi , Dennis Hurley , Urvi Sheth
IPC分类号: A61K31/496 , A61K31/517 , C07D239/94
CPC分类号: C07D239/94 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/12 , C07D405/14 , C07D493/04
摘要: The present invention relates to compounds useful as inhibitors of voltage-gated sodium channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
摘要翻译: 本发明涉及可用作电压门控钠通道抑制剂的化合物。 本发明还提供包含本发明化合物的药学上可接受的组合物和使用该组合物治疗各种疾病的方法。
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公开(公告)号:US20080027067A1
公开(公告)日:2008-01-31
申请号:US11643622
申请日:2006-12-21
申请人: Esther Martinborough , Lev Fanning , Urvi Sheth , Dean Wilson , Andreas Termin , Timothy Neubert , Nicole Zimmermann , Tara Knoll , Tara Whitney , Arati Kawatkar , Danielle Lehsten , Dean Stamos , Jinglan Zhou , Vijayalaksmi Arumugam , Corey Gutierrez
发明人: Esther Martinborough , Lev Fanning , Urvi Sheth , Dean Wilson , Andreas Termin , Timothy Neubert , Nicole Zimmermann , Tara Knoll , Tara Whitney , Arati Kawatkar , Danielle Lehsten , Dean Stamos , Jinglan Zhou , Vijayalaksmi Arumugam , Corey Gutierrez
IPC分类号: A61K31/495 , A61K31/426 , A61P29/00 , C07D401/00 , C07D403/00 , C07D277/02 , A61K31/445
CPC分类号: C07D417/12 , C07D239/42 , C07D401/12 , C07D405/12 , C07D417/14 , C07D471/10 , C07D491/10
摘要: The present invention relates to heterocyclic derivatives useful as inhibitors of ion channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
摘要翻译: 本发明涉及可用作离子通道抑制剂的杂环衍生物。 本发明还提供包含本发明化合物的药学上可接受的组合物和使用该组合物治疗各种疾病的方法。
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公开(公告)号:US20070287717A1
公开(公告)日:2007-12-13
申请号:US11811909
申请日:2007-06-12
申请人: Lev Fanning , Pramod Joshi , Paul Krenitsky , Andreas Termin , Dean Wilson , Yulian Zhang
发明人: Lev Fanning , Pramod Joshi , Paul Krenitsky , Andreas Termin , Dean Wilson , Yulian Zhang
IPC分类号: A61K31/519 , C07D498/14 , C07D498/02
CPC分类号: C07D495/14 , C07D333/20 , C07D495/04
摘要: The present invention relates to compounds useful as inhibitors of ion channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
摘要翻译: 本发明涉及可用作离子通道抑制剂的化合物。 本发明还提供包含本发明化合物的药学上可接受的组合物和使用该组合物治疗各种疾病的方法。
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公开(公告)号:US20080090837A1
公开(公告)日:2008-04-17
申请号:US11434920
申请日:2006-05-15
申请人: Andreas Termin , Dean Wilson , Lev Fanning , Paul Krenitsky , Pramod Joshi
发明人: Andreas Termin , Dean Wilson , Lev Fanning , Paul Krenitsky , Pramod Joshi
IPC分类号: A61K31/4965 , A61P43/00 , C07D241/04
CPC分类号: C07D295/185 , C07D295/15
摘要: The present invention relates to compounds useful as inhibitors of ion channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
摘要翻译: 本发明涉及可用作离子通道抑制剂的化合物。 本发明还提供包含本发明化合物的药学上可接受的组合物和使用该组合物治疗各种疾病的方法。
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公开(公告)号:US20060217377A1
公开(公告)日:2006-09-28
申请号:US10935008
申请日:2004-09-02
申请人: Jesus Gonzalez , Dean Wilson , Andreas Termin , Peter Grootenhuis , Yulian Zhang , Benjamin Petzoldt , Lev Fanning , Timothy Neubert , Roger Tung , Esther Martinborough , Nicole Zimmerman
发明人: Jesus Gonzalez , Dean Wilson , Andreas Termin , Peter Grootenhuis , Yulian Zhang , Benjamin Petzoldt , Lev Fanning , Timothy Neubert , Roger Tung , Esther Martinborough , Nicole Zimmerman
IPC分类号: A61K31/5377 , A61K31/517 , C07D413/02 , C07D43/02
CPC分类号: C07D239/91 , C07D239/94 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D409/04 , C07D409/12 , C07D413/12 , C07D417/12 , C07D471/04 , C07D487/04
摘要: The present invention relates to compounds useful as inhibitors of voltage-gated sodium channels and calcium channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
摘要翻译: 本发明涉及可用作电压门控钠通道和钙通道抑制剂的化合物。 本发明还提供包含本发明化合物的药学上可接受的组合物和使用该组合物治疗各种疾病的方法。
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公开(公告)号:US08153642B2
公开(公告)日:2012-04-10
申请号:US12714871
申请日:2010-03-01
申请人: Jesus Gonzalez, III , Dean Wilson , Andreas Termin , Peter Grootenhuis , Yulian Zhang , Benjamin Petzoldt , Lev Fanning , Timothy Neubert , Roger Tung , Esther Martinborough , Nicole Hilgraf
发明人: Jesus Gonzalez, III , Dean Wilson , Andreas Termin , Peter Grootenhuis , Yulian Zhang , Benjamin Petzoldt , Lev Fanning , Timothy Neubert , Roger Tung , Esther Martinborough , Nicole Hilgraf
IPC分类号: A61K31/517 , A61P19/02 , A61P25/06 , A61P25/08 , A61P29/02 , A61P35/00 , C07D239/94 , C07D403/12
CPC分类号: C07D239/91 , C07D239/94 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D409/04 , C07D409/12 , C07D413/12 , C07D417/12 , C07D471/04 , C07D487/04
摘要: The present invention relates to compounds useful as inhibitors of voltage-gated sodium channels and calcium channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
摘要翻译: 本发明涉及可用作电压门控钠通道和钙通道抑制剂的化合物。 本发明还提供包含本发明化合物的药学上可接受的组合物和使用该组合物治疗各种疾病的方法。
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公开(公告)号:US20050209282A1
公开(公告)日:2005-09-22
申请号:US10977609
申请日:2004-10-28
申请人: Dean Wilson , Andreas Termin , Jesus Gonzalez , Nicole Zimmermann , Yulian Zhang , Lev Fanning
发明人: Dean Wilson , Andreas Termin , Jesus Gonzalez , Nicole Zimmermann , Yulian Zhang , Lev Fanning
IPC分类号: A61K31/33 , A61K31/415 , A61K31/4184 , A61K31/454 , C07D209/14 , C07D209/42 , C07D235/06 , C07D235/10 , C07D235/14 , C07D235/18 , C07D401/04 , C07D401/12 , C07D403/04 , C07D403/06 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D43/02
CPC分类号: C07D405/12 , C04B35/632 , C07D209/42 , C07D235/14 , C07D235/18 , C07D401/04 , C07D401/12 , C07D403/06 , C07D403/12 , C07D409/12 , C07D413/12
摘要: The present invention relates to compounds of Formula I: or a pharmaceutically acceptable salt thereof, wherein the R1, Z, Y, RA, and W groups of formula I are as defined herein. The invention also provides pharmaceutically acceptable compositions and methods of using the compositions in the treatment of various disorders.
摘要翻译: 本发明涉及式I化合物或其药学上可接受的盐,其中R 1,Z,Y,R A和W分别为 如本文所定义。 本发明还提供药学上可接受的组合物和使用该组合物治疗各种疾病的方法。
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