-
公开(公告)号:US08809353B2
公开(公告)日:2014-08-19
申请号:US12050289
申请日:2008-03-18
申请人: Dean Wilson , Lev T. D. Fanning , Paul Krenitsky , Andreas Termin , Pramod Joshi , Urvi Sheth
发明人: Dean Wilson , Lev T. D. Fanning , Paul Krenitsky , Andreas Termin , Pramod Joshi , Urvi Sheth
IPC分类号: A61K31/517 , C07D239/72
CPC分类号: C07D403/04
摘要: The present invention relates to compounds useful as inhibitors of voltage-gated sodium channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
摘要翻译: 本发明涉及可用作电压门控钠通道抑制剂的化合物。 本发明还提供包含本发明化合物的药学上可接受的组合物和使用该组合物治疗各种疾病的方法。
-
公开(公告)号:US08158637B2
公开(公告)日:2012-04-17
申请号:US11598576
申请日:2006-11-13
申请人: Dean Wilson , Lev T. D. Fanning , Paul Krenitsky , Andreas Termin , Pramod Joshi , Urvi Sheth
发明人: Dean Wilson , Lev T. D. Fanning , Paul Krenitsky , Andreas Termin , Pramod Joshi , Urvi Sheth
IPC分类号: A01N43/54 , A61K31/517 , C07D239/72
CPC分类号: C07D403/04
摘要: The present invention relates to compounds useful as inhibitors of voltage-gated sodium channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
摘要翻译: 本发明涉及可用作电压门控钠通道抑制剂的化合物。 本发明还提供包含本发明化合物的药学上可接受的组合物和使用该组合物治疗各种疾病的方法。
-
公开(公告)号:US07880008B2
公开(公告)日:2011-02-01
申请号:US11441487
申请日:2006-05-26
申请人: Dean Wilson , Andreas Termin , Lev T. D. Fanning , Paul Krenitsky , Pramod Joshi
发明人: Dean Wilson , Andreas Termin , Lev T. D. Fanning , Paul Krenitsky , Pramod Joshi
IPC分类号: A61K31/496 , A61K31/454 , C07D417/04 , C07D417/14 , A61P25/00
CPC分类号: C07D277/38 , C07D285/08 , C07D417/04
摘要: The present invention relates to compounds useful as inhibitors of ion channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
摘要翻译: 本发明涉及可用作离子通道抑制剂的化合物。 本发明还提供包含本发明化合物的药学上可接受的组合物和使用该组合物治疗各种疾病的方法。
-
公开(公告)号:US08883781B2
公开(公告)日:2014-11-11
申请号:US11811909
申请日:2007-06-12
申请人: Lev T. D. Fanning , Pramod Joshi , Paul Krenitsky , Andreas Termin , Dean Wilson , Yulian Zhang
发明人: Lev T. D. Fanning , Pramod Joshi , Paul Krenitsky , Andreas Termin , Dean Wilson , Yulian Zhang
IPC分类号: C07D495/04 , C07D495/14 , C07D333/20
CPC分类号: C07D495/14 , C07D333/20 , C07D495/04
摘要: The present invention relates to compounds of formula IA-i useful as inhibitors of ion channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
摘要翻译: 本发明涉及可用作离子通道抑制剂的式IA-i化合物。 本发明还提供包含本发明化合物的药学上可接受的组合物和使用该组合物治疗各种疾病的方法。
-
公开(公告)号:US08329702B2
公开(公告)日:2012-12-11
申请号:US12941435
申请日:2010-11-08
申请人: Dean Wilson , Andreas Termin , Lev T. D. Fanning , Paul Krenitsky , Pramod Joshi
发明人: Dean Wilson , Andreas Termin , Lev T. D. Fanning , Paul Krenitsky , Pramod Joshi
IPC分类号: A61K31/497 , A61K31/445 , C07D417/00
CPC分类号: C07D277/38 , C07D285/08 , C07D417/04
摘要: The present invention relates to compounds useful as inhibitors of ion channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
摘要翻译: 本发明涉及可用作离子通道抑制剂的化合物。 本发明还提供包含本发明化合物的药学上可接受的组合物和使用该组合物治疗各种疾病的方法。
-
公开(公告)号:US20110059984A1
公开(公告)日:2011-03-10
申请号:US12941435
申请日:2010-11-08
申请人: Dean Wilson , Andreas Termin , Lev T. D. Fanning , Paul Krenitsky , Pramod Joshi
发明人: Dean Wilson , Andreas Termin , Lev T. D. Fanning , Paul Krenitsky , Pramod Joshi
IPC分类号: A61K31/496 , A61K31/454 , A61P29/00 , A61P25/06 , A61P25/08 , A61P25/28 , A61P25/22 , A61P25/24 , A61P25/00 , A61P1/00
CPC分类号: C07D277/38 , C07D285/08 , C07D417/04
摘要: The present invention relates to compounds useful as inhibitors of ion channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
摘要翻译: 本发明涉及可用作离子通道抑制剂的化合物。 本发明还提供包含本发明化合物的药学上可接受的组合物和使用该组合物治疗各种疾病的方法。
-
公开(公告)号:US07705002B2
公开(公告)日:2010-04-27
申请号:US11434920
申请日:2006-05-15
申请人: Andreas Termin , Dean Wilson , Lev T. D. Fanning , Paul Krenitsky , Pramod Joshi
发明人: Andreas Termin , Dean Wilson , Lev T. D. Fanning , Paul Krenitsky , Pramod Joshi
IPC分类号: A61K31/4965 , C07D295/03
CPC分类号: C07D295/185 , C07D295/15
摘要: The present invention relates to compounds useful as inhibitors of ion channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
摘要翻译: 本发明涉及可用作离子通道抑制剂的化合物。 本发明还提供包含本发明化合物的药学上可接受的组合物和使用该组合物治疗各种疾病的方法。
-
公开(公告)号:US07799822B2
公开(公告)日:2010-09-21
申请号:US11643622
申请日:2006-12-21
申请人: Esther Martinborough , Lev T. D. Fanning , Urvi Sheth , Dean Wilson , Andreas Termin , Timothy Neubert , Nicole Zimmermann , Tara Knoll , Tara Whitney , Aarti Kawatkar , Danielle Lehsten , Dean Stamos , Jinglan Zhou , Vijayalaksmi Arumugam , Corey Gutierrez
发明人: Esther Martinborough , Lev T. D. Fanning , Urvi Sheth , Dean Wilson , Andreas Termin , Timothy Neubert , Nicole Zimmermann , Tara Knoll , Tara Whitney , Aarti Kawatkar , Danielle Lehsten , Dean Stamos , Jinglan Zhou , Vijayalaksmi Arumugam , Corey Gutierrez
IPC分类号: A01N43/36
CPC分类号: C07D417/12 , C07D239/42 , C07D401/12 , C07D405/12 , C07D417/14 , C07D471/10 , C07D491/10
摘要: The present invention relates to phenyl sulfonamides useful as inhibitors of ion channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders, including for example the treatment of pain.
摘要翻译: 本发明涉及可用作离子通道抑制剂的苯基磺酰胺。 本发明还提供包含本发明化合物的药学上可接受的组合物和使用该组合物治疗各种疾病(包括例如治疗疼痛)的方法。
-
9.
公开(公告)号:US08163720B2
公开(公告)日:2012-04-24
申请号:US12844047
申请日:2010-07-27
申请人: Esther Martinborough , Lev T. D. Fanning , Urvi Sheth , Dean Wilson , Andreas P. Termin , Timothy D. Neubert , Nicole Hilgraf , Tara Leanne Hampton , Tara Whitney , Aarti Sameer Kawatkar , Danielle Lehsten , Dean Stamos , Jinglan Zhou , Vijayalaksmi Arumugam , Corey Anderson
发明人: Esther Martinborough , Lev T. D. Fanning , Urvi Sheth , Dean Wilson , Andreas P. Termin , Timothy D. Neubert , Nicole Hilgraf , Tara Leanne Hampton , Tara Whitney , Aarti Sameer Kawatkar , Danielle Lehsten , Dean Stamos , Jinglan Zhou , Vijayalaksmi Arumugam , Corey Anderson
IPC分类号: A01N51/00 , A61N31/655
CPC分类号: C07D417/12 , C07D239/42 , C07D401/12 , C07D405/12 , C07D417/14 , C07D471/10 , C07D491/10
摘要: The present invention relates to phenyl sulfonamides useful as inhibitors of ion channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders, including for example the treatment of pain.
摘要翻译: 本发明涉及可用作离子通道抑制剂的苯基磺酰胺。 本发明还提供包含本发明化合物的药学上可接受的组合物和使用该组合物治疗各种疾病(包括例如治疗疼痛)的方法。
-
公开(公告)号:US08343980B2
公开(公告)日:2013-01-01
申请号:US12688163
申请日:2010-01-15
申请人: Jesus Gonzalez, III , Dean Wilson , Andreas Termin , Peter D. J. Grootenhuis , Yulian Zhang , Benjamin Petzoldt , Lev T. D. Fanning , Timothy Neubert , Roger Tung , Esther Martinborough , Nicole Hilgraf
发明人: Jesus Gonzalez, III , Dean Wilson , Andreas Termin , Peter D. J. Grootenhuis , Yulian Zhang , Benjamin Petzoldt , Lev T. D. Fanning , Timothy Neubert , Roger Tung , Esther Martinborough , Nicole Hilgraf
IPC分类号: A61K31/517 , A61K31/496 , A61K31/4523 , A61P19/02 , A61P25/06 , A61P25/08 , A61P29/02 , A61P35/00 , C07D401/04 , C07D403/04
CPC分类号: C07D239/94 , C07D239/91 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D409/04 , C07D409/12 , C07D413/12 , C07D417/12 , C07D471/04 , C07D487/04
摘要: The present invention relates to compounds useful as inhibitors of voltage-gated sodium channels and calcium channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
摘要翻译: 本发明涉及可用作电压门控钠通道和钙通道抑制剂的化合物。 本发明还提供包含本发明化合物的药学上可接受的组合物和使用该组合物治疗各种疾病的方法。
-
-
-
-
-
-
-
-
-