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公开(公告)号:US06552203B2
公开(公告)日:2003-04-22
申请号:US09973991
申请日:2001-10-11
申请人: Deborah E. Bertenshaw , Daniel Getman , Robert M. Heintz , John J. Talley , Kathryn L. Reed , Robert Alan Chrusciel , Michael Clare
发明人: Deborah E. Bertenshaw , Daniel Getman , Robert M. Heintz , John J. Talley , Kathryn L. Reed , Robert Alan Chrusciel , Michael Clare
IPC分类号: C07D49500
CPC分类号: C07D333/48 , C07D231/12 , C07D233/56 , C07D249/08 , C07D279/12 , C07D335/02 , C07D409/12
摘要: The present invention relates to cyclic sulfone moiety-containing hydroxyethylamine protease inhibitor compounds and pharmaceutical or method of use therefor, particularly as an inhibitor of HIV protease.
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公开(公告)号:US06265583B1
公开(公告)日:2001-07-24
申请号:US09177100
申请日:1998-10-22
申请人: Deborah E. Bertenshaw , Daniel Getman , Robert M. Heintz , John J. Talley , Kathryn L. Reed , Robert Alan Chrusciel , Michael Clare
发明人: Deborah E. Bertenshaw , Daniel Getman , Robert M. Heintz , John J. Talley , Kathryn L. Reed , Robert Alan Chrusciel , Michael Clare
IPC分类号: C07D28506
CPC分类号: C07D333/48 , C07D231/12 , C07D233/56 , C07D249/08 , C07D279/12 , C07D335/02 , C07D409/12
摘要: The present invention relates to cyclic sulfone moiety-containing hydroxyethylamine protease inhibitor compounds and pharmaceutical or method of use therefor, particularly as an inhibitor of HIV protease.
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公开(公告)号:US5849784A
公开(公告)日:1998-12-15
申请号:US556883
申请日:1995-11-02
申请人: Deborah E. Bertenshaw , Daniel Getman , Robert M. Heintz , John J. Talley , Kathryn L. Reed , Robert Alan Chrusciel , Michael Clare
发明人: Deborah E. Bertenshaw , Daniel Getman , Robert M. Heintz , John J. Talley , Kathryn L. Reed , Robert Alan Chrusciel , Michael Clare
IPC分类号: A61K31/38 , A61K31/381 , A61K31/382 , A61K31/415 , A61K31/425 , A61K31/4433 , A61K31/445 , A61K31/54 , A61P31/12 , A61P43/00 , C07D279/12 , C07D283/00 , C07D333/48 , C07D335/02 , C07D409/12 , C07D417/12 , C07D521/00
CPC分类号: C07D333/48 , C07D231/12 , C07D233/56 , C07D249/08 , C07D279/12 , C07D335/02 , C07D409/12
摘要: The present invention relates to cyclic sulfone moiety-containing hydroxyethylamine protease inhibitor compounds and pharmaceutical or method of use therefor, particularly as an inhibitor of HIV protease.
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公开(公告)号:US06875790B2
公开(公告)日:2005-04-05
申请号:US10369197
申请日:2003-02-20
申请人: Deborah E. Bertenshaw , Daniel Getman , Robert M. Heintz , John J. Talley , Kathryn L. Reed , Robert Alan Chrusciel , Michael Clare
发明人: Deborah E. Bertenshaw , Daniel Getman , Robert M. Heintz , John J. Talley , Kathryn L. Reed , Robert Alan Chrusciel , Michael Clare
IPC分类号: A61K31/38 , A61K31/381 , A61K31/382 , A61K31/415 , A61K31/425 , A61K31/4433 , A61K31/445 , A61K31/54 , A61P31/12 , A61P43/00 , C07D279/12 , C07D283/00 , C07D333/48 , C07D335/02 , C07D409/12 , C07D417/12 , C07D521/00 , A61K31/335 , C07D215/16 , C07D337/00
CPC分类号: C07D333/48 , C07D231/12 , C07D233/56 , C07D249/08 , C07D279/12 , C07D335/02 , C07D409/12
摘要: The present invention relates to cyclic sulfone moiety-containing hydroxyethylamine protease inhibitor compounds and pharmaceutical or method of use therefor, particularly as an inhibitor of HIV protease.
摘要翻译: 本发明涉及含环状砜部分的羟乙基胺蛋白酶抑制剂化合物及其用途的药物或方法,特别是作为HIV蛋白酶的抑制剂。
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公开(公告)号:US06329524B1
公开(公告)日:2001-12-11
申请号:US09870748
申请日:2001-06-01
申请人: Deborah E. Bertenshaw , Daniel Getman , Robert M. Heintz , John J. Talley , Kathryn L. Reed , Robert Alan Chrusciel , Michael Clare
发明人: Deborah E. Bertenshaw , Daniel Getman , Robert M. Heintz , John J. Talley , Kathryn L. Reed , Robert Alan Chrusciel , Michael Clare
IPC分类号: C07D21706
CPC分类号: C07D333/48 , C07D231/12 , C07D233/56 , C07D249/08 , C07D279/12 , C07D335/02 , C07D409/12
摘要: The present invention relates to cyclic sulfone moiety-containing hydroxyethylamine protease inhibitor compounds and pharmaceutical or method of use therefor, particularly as an inhibitor of HIV protease.
摘要翻译: 本发明涉及含环状砜部分的羟乙基胺蛋白酶抑制剂化合物及其用途的药物或方法,特别是作为HIV蛋白酶的抑制剂。
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公开(公告)号:US5514801A
公开(公告)日:1996-05-07
申请号:US998187
申请日:1992-12-29
IPC分类号: A61K31/38 , A61K31/381 , A61K31/382 , A61K31/415 , A61K31/425 , A61K31/4433 , A61K31/445 , A61K31/54 , A61P31/12 , A61P43/00 , C07D279/12 , C07D283/00 , C07D333/48 , C07D335/02 , C07D409/12 , C07D417/12 , C07D521/00 , C07D217/22 , C07D217/14
CPC分类号: C07D333/48 , C07D231/12 , C07D233/56 , C07D249/08 , C07D279/12 , C07D335/02 , C07D409/12
摘要: The present invention relates to cyclic sulfone moiety-containing hydroxyethylamine protease inhibitor compounds and pharmaceutical or method of use therefor, particularly as an inhibitor of HIV protease.
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公开(公告)号:US07112683B2
公开(公告)日:2006-09-26
申请号:US10932331
申请日:2004-09-02
申请人: Deborah E. Bertenshaw , Daniel P. Getman , Robert M. Heintz , John J. Talley , Kathryn L. Reed , Robert A. Chrusciel , Michael Clare
发明人: Deborah E. Bertenshaw , Daniel P. Getman , Robert M. Heintz , John J. Talley , Kathryn L. Reed , Robert A. Chrusciel , Michael Clare
IPC分类号: C07D221/18 , C07D221/22
CPC分类号: C07D333/48 , C07D231/12 , C07D233/56 , C07D249/08 , C07D279/12 , C07D335/02 , C07D409/12
摘要: The present invention relates to cyclic sulfone moiety-containing hydroxyethylamine protease inhibitor compounds and pharmaceutical or method of use therefor, particularly as an inhibitor of HIV protease.
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公开(公告)号:US06180646B2
公开(公告)日:2001-01-30
申请号:US09140922
申请日:1998-08-26
申请人: John J. Talley , Daniel P. Getman , Gary A. DeCrescenzo , Kathryn L. Reed , Ko-Chung Lin , John Nicholas Freskos , Michael Clare , Donald Joseph Rogier, Jr. , Robert M. Heintz , Michael L. Vazquez , Richard A. Mueller
发明人: John J. Talley , Daniel P. Getman , Gary A. DeCrescenzo , Kathryn L. Reed , Ko-Chung Lin , John Nicholas Freskos , Michael Clare , Donald Joseph Rogier, Jr. , Robert M. Heintz , Michael L. Vazquez , Richard A. Mueller
IPC分类号: C07C3147
CPC分类号: C07D401/12 , C07D207/16 , C07D211/60 , C07D217/26
摘要: N-heterocyclic moiety containing hydroxyethylamine compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease.
摘要翻译: 含有羟基胺化合物的N-杂环部分作为逆转录病毒蛋白酶抑制剂是有效的,特别是作为HIV蛋白酶抑制剂。
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公开(公告)号:US5948790A
公开(公告)日:1999-09-07
申请号:US835528
申请日:1997-04-08
申请人: John J. Talley , Daniel P. Getman , Gary A. DeCrescenzo , Kathryn L. Reed , Ko-Chung Lin , John Nicholas Freskos , Michael Clare , Donald Joseph Rogier, Jr. , Robert M. Heintz , Michael L. Vazquez , Richard A. Mueller
发明人: John J. Talley , Daniel P. Getman , Gary A. DeCrescenzo , Kathryn L. Reed , Ko-Chung Lin , John Nicholas Freskos , Michael Clare , Donald Joseph Rogier, Jr. , Robert M. Heintz , Michael L. Vazquez , Richard A. Mueller
IPC分类号: A61K31/40 , A61K31/4427 , A61K31/445 , A61K31/4468 , A61K31/47 , A61K31/472 , A61K38/55 , A61P31/12 , C07D207/16 , C07D211/60 , C07D217/26 , C07D241/04 , C07D401/12 , C07K5/06 , C07K14/81
CPC分类号: C07D401/12 , C07D207/16 , C07D211/60 , C07D217/26
摘要: N-heterocyclic moiety containing hydroxyethylamine compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease.
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公开(公告)号:US06762187B2
公开(公告)日:2004-07-13
申请号:US10245710
申请日:2002-09-18
申请人: John J. Talley , Daniel P. Getman , Gary A. DeCrescenzo , Kathryn L. Reed , Ko-Chung Lin , John Nicholas Freskos , Michael Clare , Donald Joseph Rogier, Jr. , Robert M. Heintz , Michael L. Vazquez , Richard A. Mueller
发明人: John J. Talley , Daniel P. Getman , Gary A. DeCrescenzo , Kathryn L. Reed , Ko-Chung Lin , John Nicholas Freskos , Michael Clare , Donald Joseph Rogier, Jr. , Robert M. Heintz , Michael L. Vazquez , Richard A. Mueller
IPC分类号: A61K314965
CPC分类号: C07D401/12 , C07D207/16 , C07D211/60 , C07D217/26
摘要: N-heterocyclic moiety containing hydroxyethylamine compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease.
摘要翻译: 含有羟基胺化合物的N-杂环部分作为逆转录病毒蛋白酶抑制剂是有效的,特别是作为HIV蛋白酶抑制剂。
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