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1.
公开(公告)号:US20210087176A1
公开(公告)日:2021-03-25
申请号:US17105870
申请日:2020-11-27
发明人: Travis Remarchuk , Anantha Sudhakar
IPC分类号: C07D403/12
摘要: The present disclosure relates to crystalline polymorph and amorphous forms of 2-methyl-2-(3-methyl-4-(4-(methylamino)-5-(trifluoromethyl)pyrimidin-2-ylamino)-1H-pyrazol-1-yl)propanenitrile or solvates, tautomers, and pharmaceutically acceptable salts or cocrystals thereof, and processes for their preparation.
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2.
公开(公告)号:US10370361B2
公开(公告)日:2019-08-06
申请号:US16197037
申请日:2018-11-20
发明人: Travis Remarchuk , Anantha Sudhakar
IPC分类号: C07D403/12 , A61P25/28 , A61K9/20
摘要: The present disclosure relates to crystalline polymorph and amorphous forms of 2-methyl-2-(3-methyl-4-(4-(methylamino)-5-(trifluoromethyl)pyrimidin-2-ylamino)-1H-pyrazol-1-yl)propanenitrile or solvates, tautomers, and pharmaceutically acceptable salts or cocrystals thereof, and processes for their preparation.
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公开(公告)号:US20220411433A1
公开(公告)日:2022-12-29
申请号:US17531039
申请日:2021-11-19
发明人: Robert A. Craig, II , Javier de Vicente Fidalgo , Anthony A. Estrada , Jianwen A. Feng , Brian M. Fox , Christopher R.H. Hale , Katrina W. Lexa , Maksim Osipov , Travis Remarchuk , Zachary K. Sweeney
IPC分类号: C07D491/048 , C07C235/22 , C07D207/27 , C07D233/36 , C07D233/42 , C07D233/61 , C07D233/64 , C07D249/04 , C07D249/08 , C07D257/04 , C07D261/04 , C07D261/08 , C07D263/32 , C07D263/38 , C07D263/56 , C07D271/06 , C07D271/10 , C07D291/04 , C07D401/12 , C07D403/04 , C07D403/12 , C07D413/04 , C07D413/06 , C07D413/12 , C07D417/04 , C07D471/04 , C07D487/04
摘要: The present disclosure relates generally to eukaryotic initiation factor 2B modulators, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers or prodrug thereof, and methods of making and using thereof.
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公开(公告)号:US11236100B2
公开(公告)日:2022-02-01
申请号:US16637718
申请日:2018-08-08
发明人: Robert A. Craig, II , Javier de Vicente Fidalgo , Anthony A. Estrada , Jianwen A. Feng , Brian M. Fox , Christopher R. H. Hale , Katrina W. Lexa , Maksim Osipov , Travis Remarchuk , Zachary K. Sweeney
IPC分类号: C07D491/048 , C07C235/22 , C07C233/05 , C07C217/52 , C07C211/38 , C07D207/27 , C07D233/36 , C07D233/42 , C07D233/61 , C07D233/64 , C07D249/04 , C07D249/08 , C07D257/04 , C07D261/04 , C07D261/08 , C07D263/32 , C07D263/38 , C07D263/56 , C07D271/06 , C07D271/10 , C07D291/04 , C07D401/12 , C07D403/04 , C07D403/12 , C07D413/04 , C07D413/06 , C07D413/12 , C07D417/04 , C07D471/04 , C07D487/04
摘要: The present disclosure relates generally to eukaryotic initiation factor 2B modulators, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers or prodrug thereof, and methods of making and using thereof.
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公开(公告)号:US20210147435A1
公开(公告)日:2021-05-20
申请号:US16637718
申请日:2018-08-08
发明人: Robert A. Craig, II , Javier de Vicente Fidalgo , Anthony A. Estrada , Jianwen A. Feng , Brian M. Fox , Christopher R.H. Hale , Katrina W. Lexa , Maksim Osipov , Travis Remarchuk , Zachary K. Sweeney
IPC分类号: C07D491/048 , C07D413/04 , C07D271/10 , C07D249/04 , C07D261/04 , C07D261/08 , C07D263/32 , C07C235/22 , C07D249/08 , C07D233/61 , C07D413/12 , C07D487/04 , C07D471/04 , C07D413/06 , C07D403/12 , C07D401/12 , C07D271/06 , C07D263/38 , C07D207/27 , C07D233/42 , C07D233/36 , C07D403/04 , C07D263/56 , C07D233/64 , C07D257/04 , C07D417/04 , C07D291/04
摘要: The present disclosure relates generally to eukaryotic initiation factor 2B modulators, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers or prodrug thereof, and methods of making and using thereof.
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6.
公开(公告)号:US10851088B2
公开(公告)日:2020-12-01
申请号:US16447713
申请日:2019-06-20
发明人: Travis Remarchuk , Anantha Sudhakar
IPC分类号: C07D403/12 , A61P25/28 , A61K9/20
摘要: The present disclosure relates to crystalline polymorph and amorphous forms of 2-methyl-2-(3-methyl-4-(4-(methylamino)-5-(trifluoromethyl)pyrimidin-2-ylamino)-1H-pyrazol-1-yl)propanenitrile or solvates, tautomers, and pharmaceutically acceptable salts or cocrystals thereof, and processes for their preparation.
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7.
公开(公告)号:US11427571B2
公开(公告)日:2022-08-30
申请号:US17105870
申请日:2020-11-27
发明人: Travis Remarchuk , Anantha Sudhakar
IPC分类号: C07D403/12 , A61P25/28 , A61K9/20
摘要: The present disclosure relates to crystalline polymorph and amorphous forms of 2-methyl-2-(3-methyl-4-(4-(methylamino)-5-(trifluoromethyl)pyrimidin-2-ylamino)-1H-pyrazol-1-yl)propanenitrile or solvates, tautomers, and pharmaceutically acceptable salts or cocrystals thereof, and processes for their preparation.
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公开(公告)号:US20210009566A1
公开(公告)日:2021-01-14
申请号:US16955717
申请日:2018-12-19
发明人: Travis Remarchuk , Anantha Sudhakar
IPC分类号: C07D403/12
摘要: The present disclosure relates to methods of making LRRK2-inhibiting, pyrimidinyl-4-aminopyrazole compounds and intermediates of formulae I and IV: The compounds are useful as LRRK2 inhibitors in the treatment of LRRK2 mediated diseases, and as intermediates for their manufacture.
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9.
公开(公告)号:US20190315723A1
公开(公告)日:2019-10-17
申请号:US16447713
申请日:2019-06-20
发明人: Travis Remarchuk , Anantha Sudhakar
IPC分类号: C07D403/12
摘要: The present disclosure relates to crystalline polymorph and amorphous forms of 2-methyl-2-(3-methyl-4-(4-(methylamino)-5-(trifluoromethyl)pyrimidin-2-ylamino)-1H-pyrazol-1-yl)propanenitrile or solvates, tautomers, and pharmaceutically acceptable salts or cocrystals thereof, and processes for their preparation.
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10.
公开(公告)号:US20190194170A1
公开(公告)日:2019-06-27
申请号:US16197037
申请日:2018-11-20
发明人: Travis Remarchuk , Anantha Sudhakar
IPC分类号: C07D403/12
CPC分类号: C07D403/12 , A61K9/20 , A61P25/28 , C07B2200/13
摘要: The present disclosure relates to crystalline polymorph and amorphous forms of 2-methyl-2-(3-methyl-4-(4-(methylamino)-5-(trifluoromethyl)pyrimidin-2-ylamino)-1H-pyrazol-1-yl)propanenitrile or solvates, tautomers, and pharmaceutically acceptable salts or cocrystals thereof, and processes for their preparation.
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