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公开(公告)号:US06136844A
公开(公告)日:2000-10-24
申请号:US275542
申请日:1999-03-24
IPC分类号: C07D207/32 , A61K31/00 , A61K31/40 , A61K31/4025 , A61K31/44 , A61K31/4427 , A61K31/443 , A61K31/4433 , A61K31/4439 , A61K31/445 , A61K31/4465 , A61K31/4523 , A61K31/454 , A61K31/495 , A61K31/496 , A61K31/535 , A61K31/5375 , A61K31/5377 , A61P29/00 , A61P37/00 , A61P37/06 , A61P37/08 , A61P43/00 , C07D207/333 , C07D207/34 , C07D401/06 , C07D401/12 , C07D405/12 , C07D405/14 , C07D409/06 , C07D409/12 , C07D409/14
CPC分类号: C07D207/333 , C07D401/06 , C07D405/14 , C07D409/06 , C07D409/14
摘要: Compounds selected from the group of compounds represented by formula I: ##STR1## where: R.sub.10 is represented by the formula (A), (B), or (C): ##STR2## R.sub.20 is represented by the formula (U), (V), or (W): ##STR3## and the other substituents are as defined in the specification; and their pharmaceutically acceptable salts;are inhibitors of prostaglandin G/H synthase and are anti-inflammatory and analgesic agents.
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公开(公告)号:US06127402A
公开(公告)日:2000-10-03
申请号:US275540
申请日:1999-03-24
IPC分类号: C07D207/32 , A61K31/00 , A61K31/40 , A61K31/4025 , A61K31/44 , A61K31/4427 , A61K31/443 , A61K31/4433 , A61K31/4439 , A61K31/445 , A61K31/4465 , A61K31/4523 , A61K31/454 , A61K31/495 , A61K31/496 , A61K31/535 , A61K31/5375 , A61K31/5377 , A61P29/00 , A61P37/00 , A61P37/06 , A61P37/08 , A61P43/00 , C07D207/333 , C07D207/34 , C07D401/06 , C07D401/12 , C07D405/12 , C07D405/14 , C07D409/06 , C07D409/12 , C07D409/14 , C07D209/52 , A61K31/403
CPC分类号: C07D207/333 , C07D401/06 , C07D405/14 , C07D409/06 , C07D409/14
摘要: Compounds selected from the group of compounds represented by formula I: where:R.sub.10 is represented by the formula (A), (B), or (C): ##STR1## R.sub.20 is represented by the formula (U), (V), or (W): ##STR2## and the other substituents are as defined in the specification; and their pharmaceutically acceptable salts;are inhibitors of prostaglandin G/H synthase and are anti-inflammatory and analgesic agents.
摘要翻译: 选自由式I表示的化合物的化合物:其中:R 10由式(A),(B)或(C)表示:R 20由式(U),(V)或(W ):其它取代基如说明书中所定义; 及其药学上可接受的盐; 是前列腺素G / H合酶的抑制剂,是抗炎和止痛剂。
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公开(公告)号:US5952368A
公开(公告)日:1999-09-14
申请号:US864703
申请日:1997-05-28
IPC分类号: C07D207/32 , A61K31/00 , A61K31/40 , A61K31/4025 , A61K31/44 , A61K31/4427 , A61K31/443 , A61K31/4433 , A61K31/4439 , A61K31/445 , A61K31/4465 , A61K31/4523 , A61K31/454 , A61K31/495 , A61K31/496 , A61K31/535 , A61K31/5375 , A61K31/5377 , A61P29/00 , A61P37/00 , A61P37/06 , A61P37/08 , A61P43/00 , C07D207/333 , C07D207/34 , C07D401/06 , C07D401/12 , C07D405/12 , C07D405/14 , C07D409/06 , C07D409/12 , C07D409/14
CPC分类号: C07D207/333 , C07D401/06 , C07D405/14 , C07D409/06 , C07D409/14
摘要: Compounds selected from the group of compounds represented by formula I: ##STR1## where: R.sub.10 is represented by the formula (A), (B), or (C): ##STR2## R.sub.20 is represented by the formula (U), (V), or (W): ##STR3## and the other substituents are as defined in the specification; and their pharmaceutically acceptable salts; are inhibitors of prostaglandin G/H synthase and are anti-inflammatory and analgesic agents.
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