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公开(公告)号:US08609696B2
公开(公告)日:2013-12-17
申请号:US13139363
申请日:2009-12-14
申请人: Derek Cogan , Neil Moss , Christopher Ronald Sarko , Samantha Jayne Bamford , Pui Leng Loke , Heather Tye , Mark Whittaker
发明人: Derek Cogan , Neil Moss , Christopher Ronald Sarko , Samantha Jayne Bamford , Pui Leng Loke , Heather Tye , Mark Whittaker
IPC分类号: A61K31/445 , C07D401/04
CPC分类号: C07D401/04 , C07D401/06 , C07D401/14 , C07D403/04 , C07D403/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04
摘要: Disclosed are Serotonin 5-HT2B receptor inhibitors of the formula I. Also disclosed are methods of making and methods of using these compounds.
摘要翻译: 公开了式I的5-羟色胺5-HT 2B受体抑制剂。还公开了制备方法和使用这些化合物的方法。
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公开(公告)号:US20110269742A1
公开(公告)日:2011-11-03
申请号:US13139363
申请日:2009-12-14
申请人: Derek Cogan , Neil Moss , Christopher Ronald Sarko , Samantha Jayne Bamford , Pui Leng Loke , Spencer Charles R. Napier , Heather Tye , Mark Whittaker
发明人: Derek Cogan , Neil Moss , Christopher Ronald Sarko , Samantha Jayne Bamford , Pui Leng Loke , Spencer Charles R. Napier , Heather Tye , Mark Whittaker
IPC分类号: A61K31/454 , C07D401/14 , C07D403/04 , A61K31/4545 , A61K31/506 , A61K31/4439 , A61K31/4178 , A61P9/00 , A61P9/12 , A61P25/06 , A61P15/10 , A61P29/00 , A61P1/00 , A61P25/24 , A61P25/22 , A61P25/28 , A61P25/16 , A61P11/06 , A61P11/00 , A61P13/08 , A61P25/00 , C07D401/04
CPC分类号: C07D401/04 , C07D401/06 , C07D401/14 , C07D403/04 , C07D403/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04
摘要: Disclosed are Serotonin 5-HT2B receptor inhibitors of the formula I. Also disclosed are methods of making and methods of using these compounds.
摘要翻译: 公开了式I的5-羟色胺5-HT 2B受体抑制剂。还公开了制备方法和使用这些化合物的方法。
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公开(公告)号:US09174980B2
公开(公告)日:2015-11-03
申请号:US13752640
申请日:2013-01-29
申请人: Alessandra Bartolozzi , Zhidong Chen , Jonathon Alan Dines , Ho Yin Lo , Pui Leng Loke , Alan Olague , Doris Riether , Heather Tye , Lifen Wu , Renee M. Zindell
发明人: Alessandra Bartolozzi , Zhidong Chen , Jonathon Alan Dines , Ho Yin Lo , Pui Leng Loke , Alan Olague , Doris Riether , Heather Tye , Lifen Wu , Renee M. Zindell
IPC分类号: C07D403/10 , A61K31/404 , C07D471/04 , C07D409/14 , C07D413/14 , C07D403/14 , C07D417/14 , C07D413/10 , C07D417/10 , C07D405/14 , C07D401/14 , C07D401/12
CPC分类号: C07D471/04 , A61K31/404 , C07D401/12 , C07D401/14 , C07D403/10 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/10 , C07D413/14 , C07D417/10 , C07D417/14
摘要: The present invention relates to compound of formula (I): or pharmaceutically acceptable salts thereof, wherein R1-R7, A and HET are as defined herein. The invention also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.
摘要翻译: 本发明涉及式(I)化合物或其药学上可接受的盐,其中R 1 -R 7,A和HET如本文所定义。 本发明还涉及包含这些化合物的药物组合物,使用这些化合物治疗各种疾病和病症的方法,制备这些化合物的方法和可用于这些方法的中间体。
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公开(公告)号:US08658661B2
公开(公告)日:2014-02-25
申请号:US13208582
申请日:2011-08-12
申请人: Alessandra Bartolozzi , Todd Bosanac , Zhidong Chen , Stephane De Lombaert , John D. Huber , Ho Yin Lo , Pui Leng Loke , Weimin Liu , Tina Marie Morwick , Alan Olague , Doris Riether , Heather Tye , Lifen Wu , Renee M. Zindell
发明人: Alessandra Bartolozzi , Todd Bosanac , Zhidong Chen , Stephane De Lombaert , John D. Huber , Ho Yin Lo , Pui Leng Loke , Weimin Liu , Tina Marie Morwick , Alan Olague , Doris Riether , Heather Tye , Lifen Wu , Renee M. Zindell
IPC分类号: A01N43/54 , A61K31/505
CPC分类号: C07D413/14 , C07D413/10 , C07D417/14 , C07D471/04 , C07D498/04
摘要: The present invention relates to compound of formula (I): or pharmaceutically acceptable salts thereof, wherein R1-R5 are as defined herein. The invention also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.
摘要翻译: 本发明涉及式(I)化合物或其药学上可接受的盐,其中R 1 -R 5如本文所定义。 本发明还涉及包含这些化合物的药物组合物,使用这些化合物治疗各种疾病和病症的方法,制备这些化合物的方法和可用于这些方法的中间体。
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公开(公告)号:US08575201B2
公开(公告)日:2013-11-05
申请号:US13237112
申请日:2011-09-20
申请人: Alessandra Bartolozzi , Todd Bosanac , Zhidong Chen , Stephane De Lombaert , Jonathon Alan Dines , John D. Huber , Weimin W. Liu , Pui Leng Loke , Tina Marie Morwick , Alan Olague , Doris Riether , Heather Tye , Lifen Wu , Renee M. Zindell
发明人: Alessandra Bartolozzi , Todd Bosanac , Zhidong Chen , Stephane De Lombaert , Jonathon Alan Dines , John D. Huber , Weimin W. Liu , Pui Leng Loke , Tina Marie Morwick , Alan Olague , Doris Riether , Heather Tye , Lifen Wu , Renee M. Zindell
CPC分类号: C07D413/14
摘要: The present invention relates to compounds of formula (I) and (IA): and pharmaceutically acceptable salts thereof, wherein R1-R5 are as defined herein. The invention also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.
摘要翻译: 本发明涉及式(I)和(IA)化合物及其药学上可接受的盐,其中R 1 -R 5如本文所定义。 本发明还涉及包含这些化合物的药物组合物,使用这些化合物治疗各种疾病和病症的方法,制备这些化合物的方法和可用于这些方法的中间体。
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公开(公告)号:US08420655B2
公开(公告)日:2013-04-16
申请号:US12957766
申请日:2010-12-01
申请人: Zhidong Chen , Ming-Hong Hao , Weimin Liu , Ho-Yin Lo , Pui Leng Loke , Chuk Chui Man , Tina Marie Morwick , Peter Allen Nemoto , Hidenori Takahashi , Heather Tye , Lifen Wu
发明人: Zhidong Chen , Ming-Hong Hao , Weimin Liu , Ho-Yin Lo , Pui Leng Loke , Chuk Chui Man , Tina Marie Morwick , Peter Allen Nemoto , Hidenori Takahashi , Heather Tye , Lifen Wu
IPC分类号: A61K31/506 , C07D403/14
CPC分类号: C07D471/04 , C07D401/12 , C07D403/12 , C07D409/12 , C07D413/12 , C07D417/12
摘要: The present invention relates to compounds of formula (I): and pharmaceutically acceptable salt thereof, wherein R1-R7 are as defined herein. The invention also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.
摘要翻译: 本发明涉及式(I)化合物及其药学上可接受的盐,其中R 1 -R 7如本文所定义。 本发明还涉及包含这些化合物的药物组合物,使用这些化合物治疗各种疾病和病症的方法,制备这些化合物的方法和可用于这些方法的中间体。
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公开(公告)号:US08580829B2
公开(公告)日:2013-11-12
申请号:US13215654
申请日:2011-08-23
申请人: Alessandra Bartolozzi , Todd Bosanac , Zhidong Chen , Stephane De Lombaert , Jonathon Alan Dines , John D. Huber , Weimin Liu , Ho Yin Lo , Pui Leng Loke , Tina Marie Morwick , Peter Allen Nemoto , Alan Olague , Doris Riether , Heather Tye , Lifen Wu , Renee M. Zindell
发明人: Alessandra Bartolozzi , Todd Bosanac , Zhidong Chen , Stephane De Lombaert , Jonathon Alan Dines , John D. Huber , Weimin Liu , Ho Yin Lo , Pui Leng Loke , Tina Marie Morwick , Peter Allen Nemoto , Alan Olague , Doris Riether , Heather Tye , Lifen Wu , Renee M. Zindell
CPC分类号: C07D413/14 , A61K31/4245 , C07D413/10 , C07D417/14
摘要: The present invention relates to compounds of formula (I): and pharmaceutically acceptable salts thereof, wherein R1-R5 are as defined herein. The invention also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.
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公开(公告)号:US08580825B2
公开(公告)日:2013-11-12
申请号:US13237106
申请日:2011-09-20
申请人: Alessandra Bartolozzi , Todd Bosanac , Zhidong Chen , Stephane De Lombaert , John D. Huber , Weimin Liu , Ho Yin Lo , Pui Leng Loke , Doris Riether , Heather Tye , Lifen Wu , Renee M. Zindell
发明人: Alessandra Bartolozzi , Todd Bosanac , Zhidong Chen , Stephane De Lombaert , John D. Huber , Weimin Liu , Ho Yin Lo , Pui Leng Loke , Doris Riether , Heather Tye , Lifen Wu , Renee M. Zindell
CPC分类号: C07D413/14
摘要: The present invention relates to compounds of formula (I): and pharmaceutically acceptable salts thereof, wherein R1-R5 are as defined herein. The invention also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.
摘要翻译: 本发明涉及式(I)化合物及其药学上可接受的盐,其中R 1 -R 5如本文所定义。 本发明还涉及包含这些化合物的药物组合物,使用这些化合物治疗各种疾病和病症的方法,制备这些化合物的方法和可用于这些方法的中间体。
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公开(公告)号:US09073895B2
公开(公告)日:2015-07-07
申请号:US13325564
申请日:2011-12-14
申请人: Angela Berry , Zhidong Chen , Stephane De Lombaert , Michel Jose Emmanuel , Pui Leng Loke , Chuk Chui Man , Tina Marie Morwick , Hidenori Takahashi
发明人: Angela Berry , Zhidong Chen , Stephane De Lombaert , Michel Jose Emmanuel , Pui Leng Loke , Chuk Chui Man , Tina Marie Morwick , Hidenori Takahashi
IPC分类号: C07D213/72 , A61K31/345 , C07D405/10 , C07D239/42 , C07D403/04 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14
CPC分类号: C07D405/10 , C07D239/42 , C07D403/04 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14
摘要: The present invention relates to compounds of formula (I): and pharmaceutically acceptable salts thereof, wherein A, B, C, R1a, R1b, R2, R3, R4a and R4b are as defined herein. The invention also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.
摘要翻译: 本发明涉及式(I)化合物及其药学上可接受的盐,其中A,B,C,R 1a,R 1b,R 2,R 3,R 4a和R 4b如本文所定义。 本发明还涉及包含这些化合物的药物组合物,使用这些化合物治疗各种疾病和病症的方法,制备这些化合物的方法和可用于这些方法的中间体。
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公开(公告)号:US08901313B2
公开(公告)日:2014-12-02
申请号:US13420988
申请日:2012-03-15
IPC分类号: C07D401/14 , C07D403/04 , C07D405/14 , C07D413/14 , C07D417/14 , C07D487/04 , A61K31/506 , A61K31/53 , A61K31/4184 , A61P19/02 , C07D403/14 , C07D491/10
CPC分类号: C07F7/0805 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/14 , C07D413/14 , C07D417/14 , C07D487/04 , C07D491/08 , C07D491/10 , C07D491/107
摘要: The invention relates to novel compounds of Formula I: wherein A, Y, R1, R2 and the subscript b each has the meaning as described herein and compounds of Formula I, and stereoisomers, geometric isomers, tautomers, solvates, metabolites, isotopes, pharmaceutically acceptable salts, or prodrugs thereof. Compounds of Formula I and pharmaceutical compositions thereof are useful in the treatment of disease and disorders in which undesired or over-activation of NF-kB signaling is observed.
摘要翻译: 本发明涉及式I的新化合物:其中A,Y,R 1,R 2和下标b各自具有本文所述的含义,式I化合物和立体异构体,几何异构体,互变异构体,溶剂合物,代谢物,同位素,药学上 其可接受的盐或前药。 式I化合物及其药物组合物可用于治疗观察到NF-kB信号传导的不期望或过度活化的疾病和病症。
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