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公开(公告)号:US20050192304A1
公开(公告)日:2005-09-01
申请号:US11107793
申请日:2005-04-18
申请人: Dhanapalan Nagarathnam , Jacques Dumas , Holia Hatoum-Mokdad , Stephen Boyer , Chunguang Wang , Hans Pluempe , Achim Feurer , Samir Bennabi
发明人: Dhanapalan Nagarathnam , Jacques Dumas , Holia Hatoum-Mokdad , Stephen Boyer , Chunguang Wang , Hans Pluempe , Achim Feurer , Samir Bennabi
IPC分类号: A61K31/505 , A61K31/506 , A61K31/517 , A61K31/519 , A61P7/02 , A61P9/10 , A61P9/12 , A61P9/14 , A61P11/06 , A61P15/10 , A61P19/10 , A61P25/00 , A61P25/28 , A61P27/06 , A61P35/00 , A61P43/00 , C07B57/00 , C07D239/48 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/14 , C07D409/14 , C07D413/12 , C07D413/14 , C07D471/04 , C07D43/02
CPC分类号: C07D239/48 , A61K31/506 , C07D401/12 , C07D403/12 , C07D409/14 , C07D413/12 , C07D413/14 , C07D471/04
摘要: Disclosed are compounds and derivatives thereof, their synthesis, and their use as Rho-kinase inhibitors. These compounds are useful for inhibiting tumor growth, treating erectile dysfunction, and treating other indications mediated by Rho-kinase, e.g., coronary heart disease.
摘要翻译: 公开了其化合物及其衍生物,其合成及其作为Rho-激酶抑制剂的用途。 这些化合物可用于抑制肿瘤生长,治疗勃起功能障碍和治疗由Rho-激酶介导的其它适应症,例如冠心病。
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公开(公告)号:US06924290B2
公开(公告)日:2005-08-02
申请号:US10349177
申请日:2003-01-23
申请人: Dhanapalan Nagarathnam , Jacques Dumas , Holia Hatoum-Mokdad , Stephen Boyer , Chunguang Wang , Hans Pluempe , Achim Feurer , Samir Bennabi
发明人: Dhanapalan Nagarathnam , Jacques Dumas , Holia Hatoum-Mokdad , Stephen Boyer , Chunguang Wang , Hans Pluempe , Achim Feurer , Samir Bennabi
IPC分类号: A61K31/505 , A61K31/506 , A61K31/517 , A61K31/519 , A61P7/02 , A61P9/10 , A61P9/12 , A61P9/14 , A61P11/06 , A61P15/10 , A61P19/10 , A61P25/00 , A61P25/28 , A61P27/06 , A61P35/00 , A61P43/00 , C07B57/00 , C07D239/48 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/14 , C07D409/14 , C07D413/12 , C07D413/14 , C07D471/04
CPC分类号: C07D239/48 , A61K31/506 , C07D401/12 , C07D403/12 , C07D409/14 , C07D413/12 , C07D413/14 , C07D471/04
摘要: Disclosed are compounds and derivatives thereof, their synthesis, and their use as Rho-kinase inhibitors. These compounds are useful for inhibiting tumor growth, treating erectile dysfunction, and treating other indications mediated by Rho-kinase, e.g., coronary heart disease.
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公开(公告)号:US20120053179A1
公开(公告)日:2012-03-01
申请号:US13289782
申请日:2011-11-04
申请人: Dhanapalan Nagarathnam , Jacques Dumas , Holia Hatoum-Mokdad , Stephen Boyer , Chunguang Wang , Hans Pluempe , Achim Feurer , Samir Bennabi
发明人: Dhanapalan Nagarathnam , Jacques Dumas , Holia Hatoum-Mokdad , Stephen Boyer , Chunguang Wang , Hans Pluempe , Achim Feurer , Samir Bennabi
IPC分类号: A61K31/5377 , C07D401/14 , C07D471/04 , C07D401/12 , C07D405/14 , C07D409/14 , C07D413/14 , A61K31/505 , A61K31/506 , A61K31/517 , A61K31/519 , A61P9/12 , A61P9/10 , A61P25/00 , A61P25/28 , A61P35/00 , A61P7/02 , A61P11/06 , A61P27/06 , A61P19/10 , A61P15/00 , C07D239/48
CPC分类号: C07D239/48 , A61K31/506 , C07D401/12 , C07D403/12 , C07D409/14 , C07D413/12 , C07D413/14 , C07D471/04
摘要: Disclosed are compounds and derivatives thereof, their synthesis, and their use as Rho-kinase inhibitors. These compounds are useful for inhibiting tumor growth, treating erectile dysfunction, and treating other indications mediated by Rho-kinase, e.g., coronary heart disease.
摘要翻译: 公开了其化合物及其衍生物,其合成及其作为Rho-激酶抑制剂的用途。 这些化合物可用于抑制肿瘤生长,治疗勃起功能障碍和治疗由Rho-激酶介导的其它适应症,例如冠心病。
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公开(公告)号:US06943172B2
公开(公告)日:2005-09-13
申请号:US10349176
申请日:2003-01-23
IPC分类号: C07D239/48 , A61K31/505 , A61K31/506 , A61K31/517 , A61P7/02 , A61P9/00 , A61P9/10 , A61P9/12 , A61P11/06 , A61P15/10 , A61P19/10 , A61P25/00 , A61P25/06 , A61P25/28 , A61P27/06 , A61P35/00 , A61P43/00 , C07D401/12 , C07D401/14
CPC分类号: C07D401/12 , C07D401/14
摘要: Disclosed are compounds and derivatives thereof, their synthesis, and their use as Rho-kinase inhibitors. These compounds are useful for inhibiting tumor growth, treating erectile dysfunction, and treating other indications mediated by Rho-kinase, e.g., coronary heart disease.
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公开(公告)号:US20050209261A1
公开(公告)日:2005-09-22
申请号:US11111704
申请日:2005-04-22
IPC分类号: C07D239/48 , A61K31/505 , A61K31/506 , A61K31/517 , A61P7/02 , A61P9/00 , A61P9/10 , A61P9/12 , A61P11/06 , A61P15/10 , A61P19/10 , A61P25/00 , A61P25/06 , A61P25/28 , A61P27/06 , A61P35/00 , A61P43/00 , C07D401/12 , C07D401/14 , C07D43/14
CPC分类号: C07D401/12 , C07D401/14
摘要: Disclosed are compounds and derivatives thereof, their synthesis, and their use as Rho-kinase inhibitors. These compounds are useful for inhibiting tumor growth, treating erectile dysfunction, and treating other indications mediated by Rho-kinase, e.g., coronary heart disease.
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公开(公告)号:US20120302587A1
公开(公告)日:2012-11-29
申请号:US13567863
申请日:2012-08-06
IPC分类号: A61K31/506 , C07D401/12 , A61K31/517 , A61P9/12 , A61P9/10 , A61P9/00 , A61P25/00 , A61P25/28 , A61P35/00 , A61P7/02 , A61P11/06 , A61P27/06 , A61P19/08 , A61P15/00 , C07D401/14
CPC分类号: C07D401/12 , C07D401/14
摘要: Disclosed are compounds and derivatives thereof, their synthesis, and their use as Rho-kinase inhibitors. These compounds are useful for inhibiting tumor growth, treating erectile dysfunction, and treating other indications mediated by Rho-kinase, e.g., coronary heart disease.
摘要翻译: 公开了其化合物及其衍生物,其合成及其作为Rho-激酶抑制剂的用途。 这些化合物可用于抑制肿瘤生长,治疗勃起功能障碍和治疗由Rho-激酶介导的其它适应症,例如冠心病。
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