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公开(公告)号:US20090258888A1
公开(公告)日:2009-10-15
申请号:US11918016
申请日:2006-04-07
申请人: Dhanapalan Nagarathnam , Yuanwei Chen , Wenlang Fu , Donald Bierer , Ming Wang , Michael Brands , Yamin Wang , Brian R. Bear , Aaron Schmitt , Eric Mull , David Miller , Jin Zhao
发明人: Dhanapalan Nagarathnam , Yuanwei Chen , Wenlang Fu , Donald Bierer , Ming Wang , Michael Brands , Yamin Wang , Brian R. Bear , Aaron Schmitt , Eric Mull , David Miller , Jin Zhao
IPC分类号: A61K31/506 , C07D239/46 , A61P35/00
CPC分类号: C07D401/12
摘要: This invention relates to novel compounds and processes for their preparation, methods of treating diseases, particularly cancer, comprising administering said compounds, and methods of making pharmaceutical compositions for the treatment or prevention of disorders, particularly cancer.
摘要翻译: 本发明涉及新化合物及其制备方法,治疗疾病,特别是癌症的方法,包括给药所述化合物,以及制备用于治疗或预防病症,特别是癌症的药物组合物的方法。
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公开(公告)号:US20090286785A1
公开(公告)日:2009-11-19
申请号:US11887976
申请日:2006-04-07
申请人: Dhanapalan Nagarathnam , Yuanwei Chen , Wenlang Fu , Donald Bierer , Ming Wang , Michael Brands , Yamin Wang , Brian R. Bear
发明人: Dhanapalan Nagarathnam , Yuanwei Chen , Wenlang Fu , Donald Bierer , Ming Wang , Michael Brands , Yamin Wang , Brian R. Bear
IPC分类号: A61K31/5377 , C07D413/14 , A61P35/00 , C07D401/14 , A61K31/506
CPC分类号: C07D401/12 , C07D401/14 , C07D405/14
摘要: This invention relates to novel compounds (I) and processes for their preparation, methods of treating diseases, particularly cancer, comprising administering said compounds, and methods of making pharmaceutical compositions for the treatment or prevention of disorders, particularly cancer.
摘要翻译: 本发明涉及新化合物(I)及其制备方法,治疗疾病,特别是癌症的方法,包括给药所述化合物,以及制备用于治疗或预防病症,特别是癌症的药物组合物的方法。
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公开(公告)号:US20110195110A1
公开(公告)日:2011-08-11
申请号:US12095611
申请日:2006-12-01
申请人: Roger Smith , Holia N. Hatoum-Mokdad , Louis David Cantin , Donald E. Bierer , Wenlang Fu , Dhanapalan Nagarathnam , Gaetan Ladouceur , Yamin Wang , Herbert Ogutu , Scot Wilhelm , Ian Taylor , Sanjeeva Reddy , Richard Gedrich , Christopher Carter , Aaron Schmitt , Xiaomei Zhang
发明人: Roger Smith , Holia N. Hatoum-Mokdad , Louis David Cantin , Donald E. Bierer , Wenlang Fu , Dhanapalan Nagarathnam , Gaetan Ladouceur , Yamin Wang , Herbert Ogutu , Scot Wilhelm , Ian Taylor , Sanjeeva Reddy , Richard Gedrich , Christopher Carter , Aaron Schmitt , Xiaomei Zhang
IPC分类号: A61K9/127 , C07D401/12 , C07D401/14 , A61K31/4439 , A61K31/506 , A61K31/444 , A61K31/4375 , A61K31/4535 , A61K38/20 , A61K33/24 , A61K38/21 , A61K33/36 , A61K39/395 , A61P35/00 , A61P35/02 , A61P35/04
CPC分类号: C07D401/12 , C07D401/14
摘要: Pyrazole urea compounds, pharmaceutical compositions which contain them and methods for treating cancer using them.
摘要翻译: 吡唑脲化合物,含有它们的药物组合物和使用它们治疗癌症的方法。
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4.Substituted indoles, pharmaceutical compounds containing such indoles and their use as PPAR-&ggr; binding agents 失效
标题翻译: 取代的吲哚,含有这种吲哚的药物化合物及其作为PPAR-γ结合剂的用途公开(公告)号:US06787651B2
公开(公告)日:2004-09-07
申请号:US09974319
申请日:2001-10-09
申请人: Andreas Stolle , Jacques P. Dumas , William Carley , Philip D. G. Coish , Steven R. Magnuson , Yamin Wang , Dhanapalan Nagarathnam , Derek B. Lowe , Ning Su , William H. Bullock , Ann-Marie Campbell , Ning Qi , Jeremy L. Baryza , James H. Cook
发明人: Andreas Stolle , Jacques P. Dumas , William Carley , Philip D. G. Coish , Steven R. Magnuson , Yamin Wang , Dhanapalan Nagarathnam , Derek B. Lowe , Ning Su , William H. Bullock , Ann-Marie Campbell , Ning Qi , Jeremy L. Baryza , James H. Cook
IPC分类号: C07D20934
CPC分类号: C07D401/12 , A61K31/404 , A61K31/407 , A61K31/423 , A61K31/427 , A61K31/4709 , A61K31/496 , A61K31/5377 , C07D209/12 , C07D209/42 , C07D209/48 , C07D403/12 , C07D405/04 , C07D405/10 , C07D405/12 , C07D409/04 , C07D413/04 , C07D413/12 , C07D417/04 , C07D417/12 , C07D417/14 , C07D491/04
摘要: Disclosed are substituted indoles, pharmaceutical compositions containing such indoles, and their use in treating or preventing PPAR-&ggr; mediated diseases or conditions, such as osteopenia, osteoporosis, cancer, diabetes and atherosclerosis.
摘要翻译: 公开了取代的吲哚,含有这种吲哚的药物组合物,以及它们在治疗或预防PPAR-γ介导的疾病或病症如骨质减少,骨质疏松症,癌症,糖尿病和动脉粥样硬化中的用途。
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5.Hydroxamic acids useful in the treatment of hyper-proliferative disorders 审中-公开
标题翻译: 羟肟酸可用于治疗高增殖性疾病公开(公告)号:US20060063760A1
公开(公告)日:2006-03-23
申请号:US10554390
申请日:2004-04-16
申请人: Yamin Wang , Maio Dai , Holia Hatoum-Mokdad , Zhengqiu Hong , Harold Kluender , Gaetan Ladouceur , Tindy Li , Derek Lowe , Eric Mull , Tatiana Shelekhin , Roger Smith , Wai Wong
发明人: Yamin Wang , Maio Dai , Holia Hatoum-Mokdad , Zhengqiu Hong , Harold Kluender , Gaetan Ladouceur , Tindy Li , Derek Lowe , Eric Mull , Tatiana Shelekhin , Roger Smith , Wai Wong
IPC分类号: A61K31/54 , A61K31/537 , A61K31/445 , A61K31/495 , A61K31/4172
CPC分类号: C07C259/06 , C07C311/08 , C07C311/29 , C07C317/32 , C07C2602/08 , C07D209/14 , C07D209/16 , C07D209/26 , C07D213/38 , C07D213/53 , C07D215/12 , C07D265/30 , C07D307/52 , C07D307/81 , C07D333/58 , C07D403/12 , C07D413/12
摘要: This invention relates to a compound of Formula (I) and its use in treating hyper-proliferative disorders.
摘要翻译: 本发明涉及式(I)化合物及其在治疗高增殖性疾病中的用途。
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6.1, 8-Naphthyridine derivatives and their use to treat diabetes and related disorders 审中-公开
标题翻译: 1,8-萘啶衍生物及其用于治疗糖尿病和相关疾病的用途公开(公告)号:US20060189609A1
公开(公告)日:2006-08-24
申请号:US11409536
申请日:2006-04-21
申请人: Yamin Wang , William Bullock , David Gunn , Qingjie Liu , Sidney Liang , Donglei Liu , Steven Magnuson , Tindy Li , Eric Mull , Jill Wood , Ning Qi
发明人: Yamin Wang , William Bullock , David Gunn , Qingjie Liu , Sidney Liang , Donglei Liu , Steven Magnuson , Tindy Li , Eric Mull , Jill Wood , Ning Qi
IPC分类号: A61K31/5377 , A61K31/496 , A61K31/4745 , C07D471/02
CPC分类号: A61K45/06 , A61K31/44 , A61K31/496 , A61K31/5377 , A61K31/541 , C07D471/04 , A61K2300/00
摘要: The invention relates generally to naphthyridine derivatives of the formula wherein one of U, X, Y and Z is nitrogen and the others are C—R, where R is hydrogen or a substituent. More specifically, the invention relates to 1,8-naphthyridine derivatives and pharmaceutical compositions containing such derivatives. Methods of the invention comprise administration of a naphthyridine derivative of the invention for the treatment of diabetes and related disorders.
摘要翻译: 本发明一般涉及下式的萘啶衍生物,其中U,X,Y和Z中的一个为氮,其余为C-R,其中R为氢或取代基。 更具体地,本发明涉及1,8-萘啶衍生物和含有这些衍生物的药物组合物。 本发明的方法包括施用本发明的萘啶衍生物用于治疗糖尿病和相关疾病。
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公开(公告)号:US20090247590A1
公开(公告)日:2009-10-01
申请号:US11665407
申请日:2005-10-14
申请人: Yamin Wang , Tindy Li , Eric Mull
发明人: Yamin Wang , Tindy Li , Eric Mull
IPC分类号: A61K31/404 , C07D209/14 , C07D213/36 , A61K31/4406 , A61P35/00
CPC分类号: C07D213/30 , C07C237/48 , C07C271/56 , C07C275/26 , C07C275/28 , C07C275/30 , C07C275/34 , C07D209/16 , C07D213/40 , C07D213/56 , C07D213/65 , C07D277/82
摘要: The invention relates to novel compounds and processes for their preparation and their use for preparing medicaments for the treatment of disorders, especially hyper-proliferative disorders.
摘要翻译: 本发明涉及新化合物及其制备方法及其用于制备用于治疗疾病,特别是高增殖性疾病的药物的用途。
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8.Compounds and compositions for the treatment of diabetes and diabetes-related disorders 审中-公开
标题翻译: 用于治疗糖尿病和糖尿病相关疾病的化合物和组合物公开(公告)号:US20060009483A1
公开(公告)日:2006-01-12
申请号:US10506230
申请日:2003-05-30
申请人: Yamin Wang , Eric Mull
发明人: Yamin Wang , Eric Mull
IPC分类号: A61K31/4745
CPC分类号: C07D471/04
摘要: The present invention relates to novel compounds which are useful in the treatment of diabetes and diabetes-related disorders. The invention also relates to pharmaceutical compositions comprising said compounds, intermediates useful in the preparation of said compounds, and methods of preparation.
摘要翻译: 本发明涉及可用于治疗糖尿病和糖尿病相关疾病的新型化合物。 本发明还涉及包含所述化合物的药物组合物,可用于制备所述化合物的中间体和制备方法。
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公开(公告)号:US20110152331A1
公开(公告)日:2011-06-23
申请号:US13035638
申请日:2011-02-25
申请人: Derek B. Lowe , Philip L. Wickens , Xin Ma , Mingbao Zhang , William H. Bullock , Philip D. G. Coish , Ingo A. Mugge , Andreas Stolle , Ming Wang , Yamin Wang , Chengzhi Zhang , Hai-Jun Zhang , Lei Zhu , Manami Tsutsumi , James N. Livingston
发明人: Derek B. Lowe , Philip L. Wickens , Xin Ma , Mingbao Zhang , William H. Bullock , Philip D. G. Coish , Ingo A. Mugge , Andreas Stolle , Ming Wang , Yamin Wang , Chengzhi Zhang , Hai-Jun Zhang , Lei Zhu , Manami Tsutsumi , James N. Livingston
IPC分类号: A61K31/421 , C07D263/32 , A61P3/04 , A61P3/10 , A61P3/06 , A61P9/12 , A61P9/00 , A61P35/00
CPC分类号: C07D277/32 , C07B2200/07 , C07C51/412 , C07C51/44 , C07C59/72 , C07C69/732 , C07C69/734 , C07C69/738 , C07C2602/08 , C07D263/32 , C07D277/24 , C07D277/40 , C07D413/04 , C07D413/10 , C07D413/12
摘要: This invention relates to novel indane acetic acid derivatives which are useful in the treatment of diseases such as diabetes, obesity, hyperlipidemia, and atherosclerotic diseases. The invention also relates to intermediates useful in preparation of indane acetic derivatives and to methods of preparation.
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公开(公告)号:US07112597B2
公开(公告)日:2006-09-26
申请号:US10949119
申请日:2004-09-22
申请人: Derek B. Lowe , Philip L. Wickens , Xin Ma , Mingbao Zhang , William H. Bullock , Philip D. G. Coish , Ingo Mugge , Andreas Stolle , Ming Wang , Yamin Wang , Chengzhi Zhang , Hai-Jun Zhang , Lei Zhu , Manami Tsutsumi , James N. Livingston
发明人: Derek B. Lowe , Philip L. Wickens , Xin Ma , Mingbao Zhang , William H. Bullock , Philip D. G. Coish , Ingo Mugge , Andreas Stolle , Ming Wang , Yamin Wang , Chengzhi Zhang , Hai-Jun Zhang , Lei Zhu , Manami Tsutsumi , James N. Livingston
IPC分类号: A61K31/425 , C07D277/30
CPC分类号: C07D277/32 , C07B2200/07 , C07C51/412 , C07C51/44 , C07C59/72 , C07C67/303 , C07C69/732 , C07C69/734 , C07C69/738 , C07C2602/08 , C07D263/32 , C07D277/24 , C07D277/40 , C07D413/04 , C07D413/10 , C07D413/12 , Y02P20/582
摘要: This invention relates to novel indane acetic acid derivatives which are useful in the treatment of diseases such as diabetes, obesity, hyperlipidemia, and atherosclerotic diseases. The invention also relates to intermediates useful in preparation of indane acetic derivatives and to methods of preparation.
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