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公开(公告)号：US5468606A
公开(公告)日：1995-11-21
申请号：US923304
申请日：1992-07-31
IPC分类号： G01N21/21 , G01N21/45 , G01N21/47 , G01N21/77 , G01N33/543 , G01N33/551 , G01N33/552 , G01N33/545
CPC分类号： B82Y30/00 , B82Y15/00 , G01N21/211 , G01N21/4738 , G01N21/77 , G01N33/54366 , G01N33/54373 , G01N33/551 , G01N33/552 , G01N21/45 , Y10S435/808 , Y10S436/805
摘要： Device for detecting the presence or amount of an analyte of interest, having a substrate possessing an optically active surface which exhibits a first color in response to light impinging thereon, and exhibits a second color comprising a combination of wavelengths of light different from the first color or comprising an intensity of at least one wavelength of light different from the first color, in response to the light when the analyte is present on the surface in any amount selected from 0.1 nM, 0.1 ng/ml, 50 fg, and 2.times.10.sup.3 organisms comprising the analyte.
摘要翻译： 用于检测感兴趣的分析物的存在或量的装置，具有具有光学活性表面的基底，所述基底表现出响应于其上的光的第一颜色，并且显示第二颜色，其包括与第一颜色不同的光的波长的组合 或者当所述分析物以选自0.1nM，0.1ng / ml，50fg和2x103生物体的任何量存在于所述表面上时，响应于所述光而包含至少一种不同于所述第一颜色的波长的光的强度，所述生物体包含 分析物。
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公开(公告)号：US5955377A
公开(公告)日：1999-09-21
申请号：US403565
申请日：1995-04-17
申请人： Diana M. Maul , Gregory R. Bogart
发明人： Diana M. Maul , Gregory R. Bogart
IPC分类号： G01N33/543 , G01N33/547
CPC分类号： G01N33/543 , G01N33/547 , G01N2333/135 , G01N2333/162 , G01N2333/22 , G01N2333/295 , G01N2333/315 , Y10S435/808 , Y10S435/81 , Y10S436/805
摘要： Method for detecting an analyte of interest, comprising the steps of providing a detection device comprising a light reflective or transmissive substrate supporting one or more layers comprising an adhering attachment layer to which is affixed a receptive material which specifically interacts with the analyte of interest; reacting the device with a sample potentially comprising the analyte under conditions in which the analyte binds to the receptive material; and reacting bound analyte with a reagent which creates a mass change on the surface of the device.
摘要翻译： 用于检测感兴趣分析物的方法，包括以下步骤：提供检测装置，所述检测装置包括支撑一层或多层的光反射或透射基底，所述层包含粘附的附着层，所述粘附附着层与感兴趣的物质特异性相互作用的受体材料固定在其上; 在所述分析物与所述受体材料结合的条件下使所述装置与潜在地包含所述分析物的样品反应; 并使结合的分析物与在装置的表面上产生质量变化的试剂反应。
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公开(公告)号：US5869272A
公开(公告)日：1999-02-09
申请号：US455652
申请日：1995-05-31
IPC分类号： G01N21/21 , G01N21/77 , G01N33/543 , G01N33/551 , G01N33/552 , G01N33/569
CPC分类号： G01N21/78 , G01N21/21 , G01N21/211 , G01N21/6428 , G01N21/77 , G01N33/54366 , G01N33/54373 , G01N33/54386 , G01N33/551 , G01N33/552 , G01N33/56927 , B82Y30/00 , B82Y35/00 , G01N2021/7779 , Y10S435/808 , Y10S435/81 , Y10S436/804 , Y10S436/805 , Y10S436/811 , Y10T436/25 , Y10T436/25375
摘要： Method for the determination of chlamydial or gram negative bacterial antigen comprising contacting a sample potentially containing extracted antigen with an optically active surface comprising an attachment layer, and a layer of non-specific protein.
摘要翻译： 用于测定衣原体或革兰氏阴性细菌抗原的方法，包括使潜在含有提取的抗原的样品与包含附着层的光学活性表面和非特异性蛋白质层接触。
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公开(公告)号：US5541057A
公开(公告)日：1996-07-30
申请号：US075952
申请日：1993-06-10
IPC分类号： G01N21/21 , G01N21/77 , G01N33/543 , G01N33/551 , G01N33/552 , G01N33/569 , C12Q1/70 , G01N21/00 , G01N33/53
CPC分类号： G01N21/78 , G01N21/21 , G01N21/211 , G01N21/6428 , G01N21/77 , G01N33/54366 , G01N33/54373 , G01N33/54386 , G01N33/551 , G01N33/552 , G01N33/56927 , B82Y30/00 , B82Y35/00 , G01N2021/7779 , Y10S435/808 , Y10S435/81 , Y10S436/804 , Y10S436/805 , Y10S436/811 , Y10T436/25 , Y10T436/25375
摘要： Method for detecting the presence or amount of an analyte of interest in a sample by providing a substrate having an optically active surface exhibiting a first color in response to light impinging thereon, and exhibiting a second color comprising a combination of wavelengths of light different from the first color or comprising an intensity of at least one wavelength of light different from the first color, in response to the light when the analyte is present on the surface in an amount selected from any one of 0.1 nM, 0.1 ng/ml, 50 fg, 2.times.10.sup.3 organisms comprising the analyte; and contacting the optically active surface with a sample potentially comprising the analyte of interest under conditions in which the analyte can interact with the optically active surface to cause the optically active surface to exhibit the second color when the analyte is present.
摘要翻译： 用于通过提供具有响应于照射在其上的光呈现出第一颜色的光学活性表面的基底来检测样品中感兴趣分析物的存在或量的方法，以及显示第二种颜色，其包括与 响应于当分析物以0.1nM，0.1ng / ml，50fg中的任一种的形式存在于表面上时的光，第一颜色或包含与第一颜色不同的至少一种波长的光强度 ，包含分析物的2×103个生物体; 并且在分析物可与光学活性表面相互作用的条件下使光学活性表面与潜在地包含感兴趣的分析物的样品接触，以使得当分析物存在时使光学活性表面显示第二种颜色。
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5.发明授权
公开(公告)号：US5482830A
公开(公告)日：1996-01-09
申请号：US76320
申请日：1993-06-10
IPC分类号： G01N21/21 , G01N21/45 , G01N21/47 , G01N21/77 , G01N33/52 , G01N33/543 , G01N33/551 , G01N33/552 , G01N33/544 , C12Q1/00
CPC分类号： B82Y30/00 , B82Y15/00 , G01N21/211 , G01N21/4738 , G01N21/77 , G01N33/526 , G01N33/54366 , G01N33/54373 , G01N33/54386 , G01N33/551 , G01N33/552 , G01N21/45 , Y10S435/808 , Y10S436/805
摘要： Device for detecting the presence or amount of an analyte of interest, having a substrate possessing an optically active surface which exhibits a first color in response to light impinging thereon, and exhibits a second color comprising a combination of wavelengths of light different from the first color or comprising an intensity of at least one wavelength of light different from the first color, in response to the light when the analyte is present on the surface of any amount selected from 0.1 nM, 0.1 ng/ml, 50 fg, and 2.times.10.sup.3 organisms comprising the analyte.
摘要翻译： 用于检测感兴趣的分析物的存在或量的装置，具有具有光学活性表面的基底，所述基底表现出响应于其上的光的第一颜色，并且显示第二颜色，其包括与第一颜色不同的光的波长的组合 或者当分析物存在于选自0.1nM，0.1ng / ml，50fg和2x103生物体的任何量的表面上时响应于光的光包含至少一种不同于第一颜色的波长的强度的强度，包括 分析物。
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6.发明授权Method and instrument for detection of change of thickness or refractive index for a thin film substrate 失效用于检测薄膜基底的厚度或折射率变化的方法和仪器
公开(公告)号：US5631171A
公开(公告)日：1997-05-20
申请号：US455493
申请日：1995-05-31
申请人： Torbjorn Sandstrom , Lars Stiblert , Diana M. Maul
发明人： Torbjorn Sandstrom , Lars Stiblert , Diana M. Maul
IPC分类号： G01N21/41 , G01N21/77 , G01N33/543 , G01N33/569 , G01N33/552
CPC分类号： G01N21/21 , G01N21/4133 , G01N21/77 , G01N33/54366 , G01N33/54386 , G01N33/56911 , G01N33/56927 , G01N33/56944 , G01N33/56983 , G01N33/56988 , Y10S435/808 , Y10S436/805
摘要： An instrument configured and arranged to detect a change in thickness or refractive index of a thin film substrate. A method for optimizing the instrument and a method for detecting a change in thickness or refractive index of a thin film substrate.
摘要翻译： 一种配置和布置成检测薄膜基底的厚度或折射率变化的仪器。 一种用于优化仪器的方法和用于检测薄膜衬底的厚度或折射率变化的方法。
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7.发明授权
公开(公告)号：US5494829A
公开(公告)日：1996-02-27
申请号：US75128
申请日：1993-06-10
申请人： Torbjorn Sandstrom , Lars Stiblert , Diana M. Maul
发明人： Torbjorn Sandstrom , Lars Stiblert , Diana M. Maul
IPC分类号： G01N21/41 , G01N21/77 , G01N33/543 , G01N33/569 , G01N33/551
CPC分类号： G01N21/21 , G01N21/4133 , G01N21/77 , G01N33/54366 , G01N33/54386 , G01N33/56911 , G01N33/56927 , G01N33/56944 , G01N33/56983 , G01N33/56988 , Y10S435/808 , Y10S436/805
摘要： Instrument configured and arranged to detect the presence or amount of an analyte of interest on the substrate of an optical device. The instrument has a source of linearly polarized, monochromatic light positioned at an angle other than Brewster's angle relative to the substrate; and an analyzer positioned at the same angle relative to the substrate at a location suitable for detecting reflected polarized light from the substrate; wherein the analyzer is configured and arranged to approximately maximize the change in intensity of the light reflected from the substrate that is transmitted through the analyzer when a change in mass occurs at the substrate relative to an unreacted surface.
摘要翻译： 配置和布置用于检测光学装置的基板上的感兴趣分析物的存在或量的仪器。 该仪器具有线性偏振的单色光源，其相对于衬底以不同于布鲁斯特角度的角度定位; 以及在适于检测来自所述衬底的反射偏振光的位置处相对于所述衬底以相同角度定位的分析器; 其中所述分析器被配置和布置成当在所述衬底相对于未反应的表面发生质量变化时，大致最大化从通过所述分析器的衬底反射的光的强度变化。
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公开(公告)号：US5418136A
公开(公告)日：1995-05-23
申请号：US76719
申请日：1993-06-10
申请人： B. John Miller , Diana M. Maul , James Blessing , Mark Crosby , Howard Kelley
发明人： B. John Miller , Diana M. Maul , James Blessing , Mark Crosby , Howard Kelley
IPC分类号： G01N33/543 , G01N37/00 , G01N33/544 , G01N33/552 , G01N33/569
CPC分类号： G01N33/54373 , Y10S435/808 , Y10S435/974 , Y10S436/805
摘要： Optical assay device having an active receptive surface supported on a pedestal and held within a first container; the first container comprising first absorbent material located at the base of the pedestal, configured and arranged to absorb liquid draining from the surface, and having a second container, hingedly connected to one side of the first container, the second container comprising a second absorbent material, wherein the second container can be closed to the first container by rotation about the hinge, and wherein such closing causes the second absorbent material to contact the surface.
摘要翻译： 光学测定装置，其具有支撑在基座上并保持在第一容器内的主动接收表面; 所述第一容器包括位于所述基座的基部处的第一吸收材料，所述第一容器被构造和布置成吸收从所述表面排出的液体，并且具有铰接地连接到所述第一容器的一侧的第二容器，所述第二容器包括第二吸收材料 ，其中所述第二容器可以通过绕所述铰链旋转而关闭到所述第一容器，并且其中所述关闭导致所述第二吸收材料接触所述表面。
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