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18 条记录 (耗时 0.026 秒)

    Active-substance preparation for oral administration, especially to ruminants
    1.
    发明授权
    Active-substance preparation for oral administration, especially to ruminants 失效
    用于口服给药的活性物质制剂，特别是反刍动物

    公开(公告)号：US5279832A

    公开(公告)日：1994-01-18

    申请号：US820777

    申请日：1992-01-15

    申请人： Dieter Greissinger ,  Heidermarie Kniesel ,  Winfried Heimbeck ,  Herbert Tanner

    发明人： Dieter Greissinger ,  Heidermarie Kniesel ,  Winfried Heimbeck ,  Herbert Tanner

    IPC分类号： A23K40/35 ,  A61K9/22 ,  A61K9/36 ,  A61K9/50 ,  A61K9/52 ,  A61K45/08 ,  A61P3/00 ,  A61K9/44

    CPC分类号： A61K9/5073 ,  A23K40/35

    摘要： A dosage form for administering physiologically active substances to animals, especially ruminant animals. The dosage unit includes a core which contains the active substance and a coating. The coating has selected areas which are thinner than the average thickness of the coating and/or areas which are predetermined rupture sites. These thin areas or predetermined rupture sites are constructed and arranged so as to detach and/or rupture under the conditions which are present after oral administration of the dosage form. As a result, the delayed release of the physiologically-active substance is accelerated. For example, the coating may be formulated to not be affected in the first stomach of a ruminant but to rapidly disintegrate in the animal's second stomach.

    摘要翻译： 2.1饲料添加剂和药物等活性成分通常以延迟方式释放，或者经口给药缓慢释放。 特别是在反刍动物的情况下，在瘤胃中应该释放很少或没有。 适当的封装是昂贵的，并且特别是对于相对大量的产品的管理而言是不合适的并且太昂贵。 这种类型的已知包封也具有可疑的生理可接受性和/或不允许的缺点。 2.2新型封装包含相对薄的区域和/或预定的断裂点，与基本上均匀的涂层相比，其加速了释放。 诸如颗粒的角度细节优选地被包封，所述包封以这样的方式形成，使得在口服给药之后胶囊可以在边缘断裂。 封装优选由两层组成，内层含有填料加成膜剂，外层仅含有成膜剂。 2.3包封适用于营养目的的活性剂的保护管理，例如甲硫氨酸，或用于医疗，特别是兽医，特别是反刍动物的治疗。

    Nucleotide sequences which code for the sahH gene
    8.
    发明授权
    Nucleotide sequences which code for the sahH gene 有权
    编码sahH基因的核苷酸序列

    公开(公告)号：US06759224B2

    公开(公告)日：2004-07-06

    申请号：US09919854

    申请日：2001-08-02

    申请人： Mike Farwick ,  Klaus Huthmacher ,  Jennifer Brehme ,  Walter Pfefferle ,  Michael Binder ,  Dieter Greissinger ,  Georg Thierbach

    发明人： Mike Farwick ,  Klaus Huthmacher ,  Jennifer Brehme ,  Walter Pfefferle ,  Michael Binder ,  Dieter Greissinger ,  Georg Thierbach

    IPC分类号： C12N914

    CPC分类号： C12N9/88 ,  A23K10/12 ,  A23K20/142 ,  A23K40/35 ,  A23K50/10 ,  C12P13/08 ,  C12P13/12

    摘要： An isolated polynucleotide comprising a polynucleotide sequence selected from the group consisting of a) polynucleotide which is at least 70% identical to a polynucleotide that codes for a polypeptide which comprises the amino acid sequence of SEQ ID No. 2, b) polynucleotide which codes for a polypeptide that comprises an amino acid sequence which is at least 70% identical to the amino acid sequence of SEQ ID No. 2, c) polynucleotide which is complementary to the polynucleotides of a) or b), and d) polynucleotide comprising at least 15 successive nucleotides of the polynucleotide sequence of a), b) or c), and a process for the fermentative preparation of L-amino acids using coryneform bacteria, in which at least the sahH gene is present in enhanced form, and the use of polynucleotides which contain the sequences according to the invention as hybridization probes.

    摘要翻译： 一种分离的多核苷酸，其包含选自以下的多核苷酸序列：a）与编码包含SEQ ID No.2的氨基酸序列的多肽的多核苷酸至少70％相同的多核苷酸，b）编码 多肽，其包含与SEQ ID No.2的氨基酸序列至少70％相同的氨基酸序列，c）与a）或b）的多核苷酸互补的多核苷酸，和d）包含至少15个连续的多核苷酸的多核苷酸 a），b）或c）的多核苷酸序列的核苷酸，以及使用棒状细菌发酵制备L-氨基酸的方法，其中至少sahH基因以增强形式存在，以及使用多核苷酸 含有根据本发明的序列作为杂交探针。