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1.发明授权Genomic classification of non-small cell lung carcinoma based on patterns of gene copy number alterations 失效基于基因拷贝数变化模式的非小细胞肺癌基因组分类公开(公告)号：US08498820B2
公开(公告)日：2013-07-30
申请号：US12607079
申请日：2009-10-28
申请人： Dimitri Semizarov , Xin Lu , Ke Zhang , Rick R. Lesniewski
发明人： Dimitri Semizarov , Xin Lu , Ke Zhang , Rick R. Lesniewski
CPC分类号： G06F19/34 , C12Q1/6886 , C12Q2600/118 , C12Q2600/156 , G06F19/18 , G06F19/24 , Y02A90/26
摘要： The invention is directed to methods and kits that allow for classification of non-small cell lung carcinoma tumors and cell lines according to genomic profiles, and methods of diagnosing, predicting clinical outcomes, and stratifying patient populations for clinical testing and treatment using the same.
摘要翻译： 本发明涉及允许根据基因组分布对非小细胞肺癌肿瘤和细胞系进行分类的方法和试剂盒，以及诊断，预测临床结果的方法，以及使用其进行临床测试和治疗的患者人群分层。
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2.发明申请公开(公告)号：US20110130295A1
公开(公告)日：2011-06-02
申请号：US12910892
申请日：2010-10-25
申请人： Dimitri Semizarov , Xin Lu , Ke Zhang , Rick R. Lesniewski , John S. Coon
发明人： Dimitri Semizarov , Xin Lu , Ke Zhang , Rick R. Lesniewski , John S. Coon
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/112 , C12Q2600/118 , C12Q2600/156 , C12Q2600/158
摘要： Disclosed are methods for identifying early-stage non-small-cell lung cancer (NSCLC) patients who will have an unfavorable prognosis for the recurrence of lung cancer after surgical resection. The methods are based in part on the discovery that chromosomal copy number gains at Chr19, 34.7 Mb-35.6 Mb can be used for prognostic classification. The methods preferably use fluorescence in situ hybridization with fluorescently labeled nucleic acid probes to hybridize to patient samples to quantify the chromosomal copy number of this genetic locus.
摘要翻译： 公开了鉴定早期非小细胞肺癌（NSCLC）患者手术切除术后肺癌复发预后不良的方法。 这些方法部分基于发现Chr19,34.7Mb-35.6Mb的染色体拷贝数增加可用于预后分类。 所述方法优选使用与荧光标记的核酸探针的荧光原位杂交以与患者样品杂交以定量该遗传基因座的染色体拷贝数。
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3.发明申请公开(公告)号：US20110105341A1
公开(公告)日：2011-05-05
申请号：US12910891
申请日：2010-10-25
申请人： Dimitri Semizarov , Xin Lu , Ke Zhang , Rick R. Lesniewski , John S. Coon
发明人： Dimitri Semizarov , Xin Lu , Ke Zhang , Rick R. Lesniewski , John S. Coon
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/112 , C12Q2600/118 , C12Q2600/156 , C12Q2600/178 , G01N33/57423 , G01N2800/52 , G01N2800/54 , G01N2800/56 , G01N2800/60
摘要： The present disclosure provides methods for identifying early stage non-small-cell lung cancer (NSCLC) patients who will have an unfavorable prognosis for the recurrence of lung cancer after surgical resection. The methods are based in part on the discovery of chromosomal copy number abnormalities that can be used for prognostic classification. The methods preferably use fluorescence in situ hybridization with fluorescently labeled nucleic acid probes to hybridize to patient samples to quantify the chromosomal copy number of these genetic loci.
摘要翻译： 本公开提供了用于鉴定在手术切除后对肺癌复发有不利预后的早期非小细胞肺癌（NSCLC）患者的方法。 这些方法部分基于可用于预后分类的染色体拷贝数异常的发现。 方法优选使用与荧光标记的核酸探针的荧光原位杂交与患者样品杂交以定量这些遗传基因座的染色体拷贝数。
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4.发明申请GENOMIC CLASSIFICATION OF NON-SMALL CELL LUNG CARCINOMA BASED ON PATTERNS OF GENE COPY NUMBER ALTERATIONS 失效基于遗传复制序列变异图案的非小细胞肺癌基因组分类公开(公告)号：US20100145893A1
公开(公告)日：2010-06-10
申请号：US12607079
申请日：2009-10-28
申请人： Dimitri Semizarov , Xin Lu , Ke Zhang , Rick R. Lesniewski
发明人： Dimitri Semizarov , Xin Lu , Ke Zhang , Rick R. Lesniewski
CPC分类号： G06F19/34 , C12Q1/6886 , C12Q2600/118 , C12Q2600/156 , G06F19/18 , G06F19/24 , Y02A90/26
摘要： The invention is directed to methods and kits that allow for classification of non-small cell lung carcinoma tumors and cell lines according to genomic profiles, and methods of diagnosing, predicting clinical outcomes, and stratifying patient populations for clinical testing and treatment using the same.
摘要翻译： 本发明涉及允许根据基因组分布对非小细胞肺癌肿瘤和细胞系进行分类的方法和试剂盒，以及诊断，预测临床结果的方法，以及使用其进行临床测试和治疗的患者人群分层。
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5.发明申请公开(公告)号：US20100145894A1
公开(公告)日：2010-06-10
申请号：US12607082
申请日：2009-10-28
申请人： Dimitri Semizarov , Xin Lu , Ke Zhang , Rick R. Lesniewski
发明人： Dimitri Semizarov , Xin Lu , Ke Zhang , Rick R. Lesniewski
CPC分类号： G06F19/34 , C12Q1/6886 , C12Q2600/106 , C12Q2600/112 , C12Q2600/156 , G06F19/12 , G06F19/18 , G06F19/24 , G06F19/28
摘要： The invention is directed to methods and kits that allow for classification of colorectal cancer cells according to genomic profiles, and methods of diagnosing, predicting clinical outcomes, and stratifying patient populations for clinical testing and treatment using the same.
摘要翻译： 本发明涉及允许根据基因组谱分类结肠直肠癌细胞的方法和试剂盒，以及诊断，预测临床结果的方法，以及使用其进行临床测试和治疗的患者人群分层。
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6.发明授权Genomic classification of colorectal cancer based on patterns of gene copy number alterations 失效基于基因拷贝数变化模式的结直肠癌基因组分类公开(公告)号：US08498822B2
公开(公告)日：2013-07-30
申请号：US12607082
申请日：2009-10-28
申请人： Dimitri Semizarov , Xin Lu , Ke Zhang , Rick R. Lesniewski
发明人： Dimitri Semizarov , Xin Lu , Ke Zhang , Rick R. Lesniewski
CPC分类号： G06F19/34 , C12Q1/6886 , C12Q2600/106 , C12Q2600/112 , C12Q2600/156 , G06F19/12 , G06F19/18 , G06F19/24 , G06F19/28
摘要： The invention is directed to methods and kits that allow for classification of colorectal cancer cells according to genomic profiles, and methods of diagnosing, predicting clinical outcomes, and stratifying patient populations for clinical testing and treatment using the same.
摘要翻译： 本发明涉及允许根据基因组特征分类结肠直肠癌细胞的方法和试剂盒，以及诊断，预测临床结果的方法，以及使用其进行临床测试和治疗的患者人群分层。
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7.发明授权Genomic classification of malignant melanoma based on patterns of gene copy number alterations 失效基于基因拷贝数变化模式的恶性黑素瘤基因组分类公开(公告)号：US08498821B2
公开(公告)日：2013-07-30
申请号：US12607080
申请日：2009-10-28
申请人： Dimitri Semizarov , Xin Lu , Ke Zhang , Rick R. Lesniewski
发明人： Dimitri Semizarov , Xin Lu , Ke Zhang , Rick R. Lesniewski
CPC分类号： G06F19/34 , C12Q1/6886 , C12Q2600/106 , C12Q2600/112 , C12Q2600/156 , G06F19/18 , G06F19/24 , Y02A90/26
摘要： The invention is directed to methods and kits that allow for classification of malignant melanoma cells according to genomic profiles, and methods of diagnosing, predicting clinical outcomes, and stratifying patient populations for clinical testing and treatment using the same.
摘要翻译： 本发明涉及允许根据基因组分布对恶性黑素瘤细胞进行分类的方法和试剂盒，以及诊断，预测临床结果的方法以及使用其进行临床测试和治疗的患者群体分层。
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8.发明申请METHODS FOR ASSEMBLING PANELS OF CANCER CELL LINES FOR USE IN TESTING THE EFFICACY OF ONE OR MORE PHARMACEUTICAL COMPOSITIONS 有权用于组装用于测试一种或多种药物组合物的效果的癌细胞细胞系的方法公开(公告)号：US20100144554A1
公开(公告)日：2010-06-10
申请号：US12607077
申请日：2009-10-28
申请人： Dimitri Semizarov , Xin Lu , Ke Zhang , Rick R. Lesniewski
发明人： Dimitri Semizarov , Xin Lu , Ke Zhang , Rick R. Lesniewski
CPC分类号： G06F19/24 , G06F17/10 , G06F17/11 , G06F17/15 , G06F17/16 , G06F17/17 , G06F19/12 , G06F19/18 , G16H50/50 , G16H50/70
摘要： The present invention relates to algorithms for use in defining genomic subgroups of tumors and cancer cell lines. The present invention also relates to methods for assembling panels of tumors and cancer cell lines according to genomic subgroups for use in testing the efficacy of one or more pharmaceutical compounds in the treatment of subjects suffering from at least one cancer.
摘要翻译： 本发明涉及用于定义肿瘤和癌细胞系的基因组亚组的算法。 本发明还涉及根据基因组亚组装配肿瘤和癌细胞系的组的方法，用于测试一种或多种药物化合物治疗患有至少一种癌症的受试者的功效。
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9.发明授权公开(公告)号：US09297045B2
公开(公告)日：2016-03-29
申请号：US12910892
申请日：2010-10-25
申请人： Dimitri Semizarov , Xin Lu , Ke Zhang , Rick R. Lesniewski , John S. Coon
发明人： Dimitri Semizarov , Xin Lu , Ke Zhang , Rick R. Lesniewski , John S. Coon
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/112 , C12Q2600/118 , C12Q2600/156 , C12Q2600/158
摘要： Disclosed are methods for identifying early-stage non-small-cell lung cancer (NSCLC) patients who will have an unfavorable prognosis for the recurrence of lung cancer after surgical resection. The methods are based in part on the discovery that chromosomal copy number gains at Chr19, 34.7 Mb-35.6 Mb can be used for prognostic classification. The methods preferably use fluorescence in situ hybridization with fluorescently labeled nucleic acid probes to hybridize to patient samples to quantify the chromosomal copy number of this genetic locus.
摘要翻译： 公开了鉴定早期非小细胞肺癌（NSCLC）患者手术切除术后肺癌复发预后不良的方法。 这些方法部分基于发现Chr19,34.7Mb-35.6Mb的染色体拷贝数增加可用于预后分类。 所述方法优选使用与荧光标记的核酸探针的荧光原位杂交以与患者样品杂交以定量该遗传基因座的染色体拷贝数。
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10.发明授权公开(公告)号：US09291625B2
公开(公告)日：2016-03-22
申请号：US12910891
申请日：2010-10-25
申请人： Dimitri Semizarov , Xin Lu , Ke Zhang , Rick R. Lesniewski , John S. Coon
发明人： Dimitri Semizarov , Xin Lu , Ke Zhang , Rick R. Lesniewski , John S. Coon
IPC分类号： C12Q1/68 , G01N33/574
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/112 , C12Q2600/118 , C12Q2600/156 , C12Q2600/178 , G01N33/57423 , G01N2800/52 , G01N2800/54 , G01N2800/56 , G01N2800/60
摘要： The present disclosure provides methods for identifying early stage non-small-cell lung cancer (NSCLC) patients who will have an unfavorable prognosis for the recurrence of lung cancer after surgical resection. The methods are based in part on the discovery of chromosomal copy number abnormalities that can be used for prognostic classification. The methods preferably use fluorescence in situ hybridization with fluorescently labeled nucleic acid probes to hybridize to patient samples to quantify the chromosomal copy number of these genetic loci.
摘要翻译： 本公开提供了用于鉴定在手术切除后对肺癌复发有不利预后的早期非小细胞肺癌（NSCLC）患者的方法。 这些方法部分基于可用于预后分类的染色体拷贝数异常的发现。 方法优选使用与荧光标记的核酸探针的荧光原位杂交与患者样品杂交以定量这些遗传基因座的染色体拷贝数。
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