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公开(公告)号:US20120214788A1
公开(公告)日:2012-08-23
申请号:US13400491
申请日:2012-02-20
申请人: Dirk Heimbach , Susanne Röhrig , Dirk Schneider , Ulrich Rester , Eckhard Bender , Mark Meininghaus , Katja Zimmermann , Dmitry Zubov , Anja Buchmüller , Georges Von Degenfeld , Christoph Gerdes , Michael Gerisch , Mark Jean Gnoth , Yolanda Cancho Grande , Mario Jeske , Kersten Matthias Gericke
发明人: Dirk Heimbach , Susanne Röhrig , Dirk Schneider , Ulrich Rester , Eckhard Bender , Mark Meininghaus , Katja Zimmermann , Dmitry Zubov , Anja Buchmüller , Georges Von Degenfeld , Christoph Gerdes , Michael Gerisch , Mark Jean Gnoth , Yolanda Cancho Grande , Mario Jeske , Kersten Matthias Gericke
IPC分类号: A61K31/454 , A61P9/10 , A61P7/00 , A61K31/5377 , A61K31/4545
CPC分类号: C07D413/04 , C07D413/14 , C07D417/14
摘要: The invention relates to novel heteroaryl-substituted piperidines, to processes for their preparation, to their use for the treatment and/or prophylaxis of diseases and to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular of cardiovascular diseases and tumour diseases.
摘要翻译: 本发明涉及新颖的杂芳基取代的哌啶,其制备方法,其用于治疗和/或预防疾病及其用于制备用于治疗和/或预防疾病,特别是心血管疾病的药物的用途 和肿瘤疾病。
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公开(公告)号:US20120129831A1
公开(公告)日:2012-05-24
申请号:US13322602
申请日:2010-05-14
申请人: Dirk Heimbach , Susanne Röhrig , Yolanda Cancho Grande , Dirk Schneider , Ulrich Rester , Eckhard Bender , Mark Meininghaus , Katja Zimmermann , Dmitry Zubov , Anja Buchmüller , Georges Von Degenfeld , Christoph Gerdes , Michael Gerisch , Mark Jean Gnoth , Kersten Matthias Gericke , Mario Jeske
发明人: Dirk Heimbach , Susanne Röhrig , Yolanda Cancho Grande , Dirk Schneider , Ulrich Rester , Eckhard Bender , Mark Meininghaus , Katja Zimmermann , Dmitry Zubov , Anja Buchmüller , Georges Von Degenfeld , Christoph Gerdes , Michael Gerisch , Mark Jean Gnoth , Kersten Matthias Gericke , Mario Jeske
IPC分类号: A61K31/454 , A61K31/4545 , A01N1/02 , A61P9/00 , A61P35/00 , C07D413/14 , A61P7/02
CPC分类号: C07D413/14
摘要: The invention relates to novel substituted piperidines, to processes for preparation thereof, to the use thereof for treatment and/or prophylaxis of diseases and to the use thereof for production of medicaments for treatment and/or prophylaxis of diseases, especially of cardiovascular disorders and tumour disorders.
摘要翻译: 本发明涉及新型取代的哌啶,其制备方法,其用于治疗和/或预防疾病的用途及其用于生产用于治疗和/或预防疾病,特别是心血管疾病和肿瘤的药物的用途 疾病
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公开(公告)号:US08119663B2
公开(公告)日:2012-02-21
申请号:US12323454
申请日:2008-11-25
申请人: Dirk Heimbach , Susanne Röhrig , Dirk Schneider , Ulrich Rester , Eckhard Bender , Mark Meininghaus , Katja Zimmermann , Dmitry Zubov , Anja Buchmüller , Georges Von Degenfeld , Christoph Gerdes , Michael Gerisch , Mark Jean Gnoth , Yolanda Cancho Grande , Mario Jeske , Kersten Matthias Gericke
发明人: Dirk Heimbach , Susanne Röhrig , Dirk Schneider , Ulrich Rester , Eckhard Bender , Mark Meininghaus , Katja Zimmermann , Dmitry Zubov , Anja Buchmüller , Georges Von Degenfeld , Christoph Gerdes , Michael Gerisch , Mark Jean Gnoth , Yolanda Cancho Grande , Mario Jeske , Kersten Matthias Gericke
IPC分类号: A61K31/445 , C07D401/00
CPC分类号: C07D413/04 , C07D413/14 , C07D417/14
摘要: The invention relates to novel heteroaryl-substituted piperidines, to processes for their preparation, to their use for the treatment and/or prophylaxis of diseases and to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular of cardiovascular diseases and tumor diseases.
摘要翻译: 本发明涉及新颖的杂芳基取代的哌啶,其制备方法,其用于治疗和/或预防疾病及其用于制备用于治疗和/或预防疾病,特别是心血管疾病的药物的用途 和肿瘤疾病。
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公开(公告)号:US08987248B2
公开(公告)日:2015-03-24
申请号:US13202707
申请日:2010-03-12
申请人: Mario Jeske , Dirk Heimbach , Susanne Röhrig , Yolanda Cancho Grande , Dirk Schneider , Ulrich Rester , Eckhard Bender , Mark Meininghaus , Katja Zimmermann , Dmitry Zubov , Anja Buchmüller , Georges Von Degenfeld , Christoph Gerdes , Michael Gerisch , Mark Jean Gnoth , Kersten Matthias Gericke
发明人: Mario Jeske , Dirk Heimbach , Susanne Röhrig , Yolanda Cancho Grande , Dirk Schneider , Ulrich Rester , Eckhard Bender , Mark Meininghaus , Katja Zimmermann , Dmitry Zubov , Anja Buchmüller , Georges Von Degenfeld , Christoph Gerdes , Michael Gerisch , Mark Jean Gnoth , Kersten Matthias Gericke
IPC分类号: A61K31/5377 , C07D413/06 , C07D211/60 , C07D211/42 , C07D211/56 , C07D211/62 , C07D401/06 , C07D405/06 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/06
CPC分类号: C07D417/06 , A61K9/0019 , A61K9/10 , A61K9/2018 , A61K31/451 , A61K31/4523 , A61K31/4525 , A61K31/453 , A61K31/454 , A61K31/4545 , A61K31/496 , A61K31/5377 , A61K31/541 , A61K47/10 , A61K47/36 , C07D211/42 , C07D211/56 , C07D211/60 , C07D211/62 , C07D401/06 , C07D405/06 , C07D405/12 , C07D409/12 , C07D413/12
摘要: The invention relates to novel substituted piperidines, to processes for their preparation, to their use for the treatment and/or prophylaxis of diseases and to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular of cardiovascular disorders and tumor disorders.
摘要翻译: 本发明涉及新的取代的哌啶,其制备方法,其用于治疗和/或预防疾病及其用于制备用于治疗和/或预防疾病,特别是心血管疾病和肿瘤的药物的用途 疾病
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公开(公告)号:US20120046268A1
公开(公告)日:2012-02-23
申请号:US13202707
申请日:2010-03-12
申请人: Mario Jeske , Dirk Heimbach , Susanne Röhrig , Yolanda Cancho Grande , Dirk Schneider , Ulrich Rester , Eckhard Bender , Mark Meininghaus , Katja Zimmermann , Dmitry Zubov , Anja Buchmüller , Georges Von Degenfeld , Christoph Gerdes , Michael Gerisch , Mark Jean Gnoth , Kersten Matthias Gericke
发明人: Mario Jeske , Dirk Heimbach , Susanne Röhrig , Yolanda Cancho Grande , Dirk Schneider , Ulrich Rester , Eckhard Bender , Mark Meininghaus , Katja Zimmermann , Dmitry Zubov , Anja Buchmüller , Georges Von Degenfeld , Christoph Gerdes , Michael Gerisch , Mark Jean Gnoth , Kersten Matthias Gericke
IPC分类号: A61K31/4523 , C07D405/06 , C07D401/06 , C07D417/06 , C07D413/06 , A61K31/445 , A61K31/453 , A61K31/4525 , A61K31/454 , A61K31/4545 , A61K31/5377 , A61K31/496 , A61K31/541 , A61P7/02 , C12N5/078 , C07D211/60
CPC分类号: C07D417/06 , A61K9/0019 , A61K9/10 , A61K9/2018 , A61K31/451 , A61K31/4523 , A61K31/4525 , A61K31/453 , A61K31/454 , A61K31/4545 , A61K31/496 , A61K31/5377 , A61K31/541 , A61K47/10 , A61K47/36 , C07D211/42 , C07D211/56 , C07D211/60 , C07D211/62 , C07D401/06 , C07D405/06 , C07D405/12 , C07D409/12 , C07D413/12
摘要: The invention relates to novel substituted piperidines, to processes for their preparation, to their use for the treatment and/or prophylaxis of diseases and to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular of cardiovascular disorders and tumour disorders.
摘要翻译: 本发明涉及新的取代的哌啶,其制备方法,其用于治疗和/或预防疾病及其用于制备用于治疗和/或预防疾病,特别是心血管疾病和肿瘤的药物的用途 疾病
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公开(公告)号:US20090306139A1
公开(公告)日:2009-12-10
申请号:US12323454
申请日:2008-11-25
申请人: Dirk Heimbach , Susanne Rohrig , Dirk Schneider , Ulrich Rester , Eckhard Bender , Mark Meininghaus , Katja Zimmermann , Dmitry Zubov , Anja Buchmuller , Georges Von Degenfeld , Christoph Gerdes , Michael Gerisch , Mark Jean Gnoth , Yolanda Cancho Grande , Mario Jeske , Kersten Matthias Gericke
发明人: Dirk Heimbach , Susanne Rohrig , Dirk Schneider , Ulrich Rester , Eckhard Bender , Mark Meininghaus , Katja Zimmermann , Dmitry Zubov , Anja Buchmuller , Georges Von Degenfeld , Christoph Gerdes , Michael Gerisch , Mark Jean Gnoth , Yolanda Cancho Grande , Mario Jeske , Kersten Matthias Gericke
IPC分类号: A61K31/454 , C07D401/14 , A61P7/02
CPC分类号: C07D413/04 , C07D413/14 , C07D417/14
摘要: The invention relates to novel heteroaryl-substituted piperidines, to processes for their preparation, to their use for the treatment and/or prophylaxis of diseases and to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular of cardiovascular diseases and tumour diseases.
摘要翻译: 本发明涉及新颖的杂芳基取代的哌啶,其制备方法,其用于治疗和/或预防疾病及其用于制备用于治疗和/或预防疾病,特别是心血管疾病的药物的用途 和肿瘤疾病。
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公开(公告)号:US08476267B2
公开(公告)日:2013-07-02
申请号:US12668633
申请日:2008-06-28
申请人: Stephan Siegel , Andreas Wilmen , Susanne Röhrig , Niels Svenstrup , Mark Jean Gnoth , Stefan Heitmeier , Ulrich Rester , Adrian Tersteegen , Michael Gerisch
发明人: Stephan Siegel , Andreas Wilmen , Susanne Röhrig , Niels Svenstrup , Mark Jean Gnoth , Stefan Heitmeier , Ulrich Rester , Adrian Tersteegen , Michael Gerisch
IPC分类号: A61K31/535
CPC分类号: C07D487/04 , C12N5/0647
摘要: The invention relates to substituted imidazo-, pyrazolopyrazines and imidazotriazines and processes for their preparation, and their use for the manufacture of medicaments for the treatment and/or prophylaxis of diseases, in particular of hematological disorders, preferably of leukopenias and neutropenias.
摘要翻译: 本发明涉及取代的咪唑并,吡唑并吡嗪和咪唑并嗪及其制备方法,以及它们用于制备用于治疗和/或预防疾病,特别是血液病症,优选白细胞减少症和中性粒细胞减少症的药物的用途。
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公开(公告)号:US20110053929A1
公开(公告)日:2011-03-03
申请号:US12668633
申请日:2008-06-28
申请人: Stephan Siegel , Andreas Wilman , Susanne Röhrig , Niels Svenstrup , Mark Jean Gnoth , Stefan Heitmeier , Ulrich Rester , Adrian Tersteegen , Michael Gerisch
发明人: Stephan Siegel , Andreas Wilman , Susanne Röhrig , Niels Svenstrup , Mark Jean Gnoth , Stefan Heitmeier , Ulrich Rester , Adrian Tersteegen , Michael Gerisch
IPC分类号: A61K31/4985 , C07D487/04 , A61K31/5377 , A61P7/00 , C12N5/0789
CPC分类号: C07D487/04 , C12N5/0647
摘要: The invention relates to substituted imidazo-, pyrazolopyrazines and imidazotriazines and processes for their preparation, and their use for the manufacture of medicaments for the treatment and/or prophylaxis of diseases, in particular of hematological disorders, preferably of leukopenias and neutropenias.
摘要翻译: 本发明涉及取代的咪唑并,吡唑并吡嗪和咪唑并嗪及其制备方法,以及它们用于制备用于治疗和/或预防疾病,特别是血液病症,优选白细胞减少症和中性粒细胞减少症的药物的用途。
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公开(公告)号:US20090258877A1
公开(公告)日:2009-10-15
申请号:US12334131
申请日:2008-12-12
申请人: Stephan Siegel , Andreas Wilmen , Niels Svenstrup , Mark Jean Gnoth , Stefan Heitmeier , Ulrich Rester , Adrian Tersteegen , Michael Gerisch
发明人: Stephan Siegel , Andreas Wilmen , Niels Svenstrup , Mark Jean Gnoth , Stefan Heitmeier , Ulrich Rester , Adrian Tersteegen , Michael Gerisch
IPC分类号: A61K31/53 , C07D471/04 , C07D487/04 , A61K31/498 , A61P7/00
CPC分类号: C07D487/04
摘要: The invention relates to substituted triazolotriazines and triazolopyrazines and to processes for their preparation, and also to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular haematologic disorders, preferably of leukopenias and neutropenias.
摘要翻译: 本发明涉及取代的三氮代三嗪和三唑并吡嗪及其制备方法,以及它们用于制备用于治疗和/或预防疾病,特别是血液病,优选白细胞减少症和中性粒细胞减少症的药物的用途。
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公开(公告)号:US06649618B2
公开(公告)日:2003-11-18
申请号:US09906296
申请日:2001-07-16
申请人: Michael Härter , Barbara Albrecht , Michael Gerisch , Gabriele Handke , Joachim Hütter , Axel Jensen , Thomas Krahn , Joachim Mittendorf , Felix Oehme , Karl-Heinz Schlemmer , Henning Steinhagen
发明人: Michael Härter , Barbara Albrecht , Michael Gerisch , Gabriele Handke , Joachim Hütter , Axel Jensen , Thomas Krahn , Joachim Mittendorf , Felix Oehme , Karl-Heinz Schlemmer , Henning Steinhagen
IPC分类号: C07D491048
CPC分类号: C07D401/06 , C07D239/96 , C07D403/06 , C07D403/12 , C07D405/12 , C07D409/12 , C07D409/14 , C07D411/12 , C07D413/12 , C07D413/14 , C07D417/12 , C07D487/04 , C07D495/04 , C07D513/04
摘要: Novel amidoalkyl-uracil derivatives of the formula (I) in which A represents 1-3 ring atoms and X represents optionally substituted (C2-C10)alkylene or (C3-C8)cycloalkylene as defined in claim 1, a process for their preparation, and their use as medicaments for the prophylaxis and/or treatment of disorders are described.
摘要翻译: 式(I)的新型酰氨基烷基 - 尿嘧啶衍生物,其中A表示1-3个环原子,X表示如权利要求1所定义的任选取代的(C 2 -C 10)亚烷基或(C 3 -C 8)亚环烷基,其制备方法, 并描述其用作预防和/或治疗病症的药物。
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