利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

14 条记录 (耗时 0.038 秒)

    HIGHLY PERMEATING TERBINAFINE FORMULATION
    9.
    发明申请
    HIGHLY PERMEATING TERBINAFINE FORMULATION 有权
    高效透皮贴剂配方

    公开(公告)号：US20120309843A1

    公开(公告)日：2012-12-06

    申请号：US13525108

    申请日：2012-06-15

    申请人： Servet Buyuktimkin ,  Nadir Buyuktimkin ,  Jagat Singh ,  John M. Newsam ,  Dominic King-Smith ,  Edward Kisak

    发明人： Servet Buyuktimkin ,  Nadir Buyuktimkin ,  Jagat Singh ,  John M. Newsam ,  Dominic King-Smith ,  Edward Kisak

    IPC分类号： A61K31/137 ,  A61P31/10

    CPC分类号： A61K31/137 ,  A61K9/0017 ,  A61K47/10 ,  A61K47/12 ,  A61K47/18 ,  A61K47/186 ,  A61K47/20 ,  A61K47/34 ,  A61K47/38

    摘要： The present invention provides topical compositions, methods of preparation, and methods of treatment for onychomychosis. In certain specific embodiments, the invention provides an anti-fungal pharmaceutical composition for topical application comprising an anti-fungal agent, a zwitterionic surfactant or charged derivative thereof; a carboxylic acid, a lower alcohol, and water. The acid is selected from a short-chain hydroxy acid, a short-chain fatty acid, and a mixture thereof. In certain other specific embodiments, the invention provides an anti-fungal pharmaceutical composition for topical application comprising an anti-fungal agent, a quarternary amino acid, a keratolytic agent; a lower alcohol; and water. In certain embodiments, the keratolytic agent is urea, ammonium thioglycolate, or a mixture thereof.

    摘要翻译： 本发明提供局部用组合物，制备方法和治疗甲真菌病的方法。 在某些具体实施方案中，本发明提供用于局部施用的抗真菌药物组合物，其包含抗真菌剂，两性离子表面活性剂或其带电衍生物; 羧酸，低级醇和水。 酸选自短链羟基酸，短链脂肪酸及其混合物。 在某些其他具体实施方案中，本发明提供了用于局部应用的抗真菌药物组合物，其包含抗真菌剂，季铵氨基酸，角质分解剂; 低级酒精; 和水。 在某些实施方案中，角质分解剂是尿素，巯基乙酸铵或其混合物。

    Topical formulation including diclofenac, or a pharmaceutically acceptable salt thereof
    10.
    发明授权
    Topical formulation including diclofenac, or a pharmaceutically acceptable salt thereof 有权
    包括双氯芬酸或其药学上可接受的盐的局部制剂

    公开(公告)号：US07795309B2

    公开(公告)日：2010-09-14

    申请号：US12281561

    申请日：2007-03-06

    申请人： Edward T. Kisak ,  John M. Newsam ,  Dominic King-Smith ,  Pankaj Karande ,  Samir Mitragotri

    发明人： Edward T. Kisak ,  John M. Newsam ,  Dominic King-Smith ,  Pankaj Karande ,  Samir Mitragotri

    IPC分类号： A61K31/195

    CPC分类号： A61K9/0014 ,  A61K31/196 ,  A61K45/06 ,  A61K2300/00

    摘要： There is described a topical formulation. The topical formulation comprises: (i) diclofenac or a pharmaceutically acceptable salt thereof, (ii) a first compound, and (iii) a second compound. The first compound and second compound are different, and each is selected from the group consisting essentially of N-lauroyl sarcosine, sodium octyl sulfate, methyl laurate, isopropyl myristate, oleic acid, glyceryl oleate and sodium lauryl sulfoacetate. It has been discovered that certain combination of compounds are excellent penetration enhancers and, as such, can be incorporated in a topical formulation to facilitate administration of diclofenac or a pharmaceutically acceptable salt thereof. The increased penetration enhancement can also lead to a reduction in the total concentration of skin irritants in the formulation.

    摘要翻译： 描述了一种局部制剂。 局部制剂包括：（i）双氯芬酸或其药学上可接受的盐，（ii）第一化合物和（iii）第二化合物。 第一化合物和第二化合物是不同的，并且各自选自基本上由N-月桂酰肌氨酸，辛基硫酸钠，月桂酸甲酯，肉豆蔻酸异丙酯，油酸，油酸甘油酯和月桂基磺基乙酸钠组成的组。 已经发现，化合物的某些组合是优异的渗透增强剂，因此，可以掺入局部制剂以促进双氯芬酸或其药学上可接受的盐的给药。 渗透增加的增加也可能导致制剂中皮肤刺激物的总浓度降低。