公开(公告)号：US20050101980A1

公开(公告)日：2005-05-12

申请号：US10363509

申请日：2002-06-12

申请人： Don Alden ,  Dominique Freeman ,  Paul Lum ,  Vladimir Drbal ,  Dirk Boecker ,  Edward Verdonk

发明人： Don Alden ,  Dominique Freeman ,  Paul Lum ,  Vladimir Drbal ,  Dirk Boecker ,  Edward Verdonk

IPC分类号： A61B5/15 ,  A61B17/32

CPC分类号： A61B5/150022 ,  A61B5/150061 ,  A61B5/150068 ,  A61B5/150083 ,  A61B5/150099 ,  A61B5/150167 ,  A61B5/150427 ,  A61B5/150503

摘要： Blood samples can be collected without substantial contamination from ambient air, such that the blood sample may be analysed accurately for gaseous components such as oxygen and carbon dioxide. An embodiment of the device has integrated actuation, lancing, and sample acquisition components, which in some embodiments are miniatuized and/or disposable.

摘要翻译： 可以收集血液样本而没有来自环境空气的实质污染，使得可以准确地分析血液样品用于气体组分如氧气和二氧化碳。 该装置的一个实施例具有集成的致动，采血和采样部件，其在一些实施例中是微型化和/或一次性的。

公开(公告)号：US5647367A

公开(公告)日：1997-07-15

申请号：US657742

申请日：1996-05-31

申请人： Paul Lum ,  Edward Verdonk

发明人： Paul Lum ,  Edward Verdonk

IPC分类号： A61B8/12 ,  G10K11/35 ,  A61B8/00

CPC分类号： A61B8/12 ,  A61B8/445 ,  A61B8/4461 ,  A61B8/4483 ,  G10K11/355

摘要： An ultrasonic probe for imaging tissues from inside a patient's body cavity is disclosed. The ultrasonic probe includes a housing near to the probe's distal end, an ultrasonic beam emitting assembly having a pivotable part, and a driver for producing a pivotal motion on the pivotable part. The housing has a portion that is acoustically transparent. The pivotable part is movable and is operatively connected to the housing. The pivotable part can either have mounted on it a transducer for emitting ultrasound or a reflector for reflecting ultrasound. In either case, when the pivotable part pivots it sweeps ultrasonic energy over a selected angle. The driver is located near to the transducer such that all driving motions for driving the pivotal motion occur near the distal end of the ultrasonic probe.

摘要翻译： 公开了一种用于从患者体腔内部组织成像的超声波探头。 超声波探头包括靠近探头远端的壳体，具有可枢转部分的超声波束发射组件和用于在可枢转部件上产生枢转运动的驱动器。 外壳具有声透明部分。 可枢转部分是可移动的并且可操作地连接到壳体。 可枢转部件可以安装在其上用于发射超声的换能器或用于反射超声的反射器。 在任一种情况下，当可枢转部件枢转时，其在超过选定的角度上扫掠超声波能量。 驱动器位于传感器附近，使得用于驱动枢转运动的所有驱动运动发生在超声波探头的远端附近。

公开(公告)号：US5509418A

公开(公告)日：1996-04-23

申请号：US373682

申请日：1995-01-17

申请人： Paul Lum ,  Michael Greenstein ,  Edward Verdonk

发明人： Paul Lum ,  Michael Greenstein ,  Edward Verdonk

IPC分类号： A61B8/12

CPC分类号： A61B8/12 ,  A61B8/445 ,  A61B8/4461

摘要： A catheter apparatus for obtaining an image of internal surface characteristics of a vascular vessel is provided. The catheter apparatus comprises an tubular element adapted for insertion into the vascular vessel, a non-rotating acoustic waveguide disposed within the tubular element and coupled to a source of an ultrasonic signal located external to the vascular vessel, and an acoustically driven turbine. The turbine is responsive to the ultrasonic signal for directing the ultrasonic signal in a rotating pattern from a distal end of the acoustic waveguide through the tubular element at an angle relative to an axis of the vascular vessel. The ultrasonic signal includes a low frequency ultrasonic signal and a high frequency ultrasonic signal. The low frequency ultrasonic signal drives the acoustically driven turbine to direct the high frequency ultrasonic signal in the rotating pattern. The acoustically driven turbine comprises a plurality of turbine blades, and either an acoustic reflecting surface or an acoustic refracting lens. At least one transducer disposed external to the vascular vessel provides the source of the high and the low frequency ultrasonic signals. The tubular element may further be provided with a lumen for carrying a guidewire.

摘要翻译： 提供一种用于获得血管容器的内表面特征的图像的导管装置。 导管装置包括适于插入血管容器的管状元件，设置在管状元件内并连接到位于血管容器外部的超声信号源的非旋转声波导，以及声驱动涡轮。 涡轮机响应于超声波信号，以相对于血管容器轴线成一定角度的方式将超声波信号从声波导管的远端引导通过管状元件。 超声波信号包括低频超声信号和高频超声波信号。 低频超声波信号驱动声驱动涡轮以引导旋转图案中的高频超声波信号。 声驱动涡轮机包括多个涡轮叶片，以及声反射表面或声折射透镜。 设置在血管容器外部的至少一个换能器提供高频和低频超声波信号的源。 管状元件还可以设置有用于承载导丝的内腔。

公开(公告)号：US5507294A

公开(公告)日：1996-04-16

申请号：US373676

申请日：1995-01-17

申请人： Paul Lum ,  Michael Greenstein ,  Edward Verdonk

发明人： Paul Lum ,  Michael Greenstein ,  Edward Verdonk

IPC分类号： A61B8/00 ,  A61B8/06 ,  A61B8/12

CPC分类号： A61B8/06 ,  A61B8/12 ,  A61B8/445 ,  A61B8/4461

摘要： A catheter apparatus for obtaining an image of interior surface characteristics of a vascular vessel is provided. The catheter apparatus comprises an outer tubular element adapted for insertion into the vascular vessel, a rotatable inner tubular element disposed within the outer tubular element, and a non-rotating acoustic waveguide disposed within the inner tubular element and coupled to a source of an ultrasonic signal located external to the vascular vessel. The inner tubular element is rotated about an axis of the vascular vessel by use of an external driving member, such as a motor. The inner tubular element is provided with an acoustic reflecting or refracting element that directs the ultrasonic signal from a distal end of the acoustic waveguide through the outer tubular element at an angle relative to the axis of the vascular vessel. Sterile fluid disposed between the outer and inner tubular elements provides for acoustic coupling of the ultrasonic signal into the vessel, and further provides for lubrication of the rotating elements.

摘要翻译： 提供一种用于获得血管容器的内表面特征的图像的导管装置。 导管装置包括适于插入血管容器的外部管状元件，设置在外部管状元件内的可旋转内部管状元件，以及设置在内部管状元件内并耦合到超声波信号源的非旋转声波导 位于血管的外部。 内部管状元件通过使用诸如马达的外部驱动构件围绕血管的轴线旋转。 内部管状元件设置有声反射或折射元件，其将来自声波导的远端的超声波信号通过外部管状元件以相对于血管容器的轴线成一定角度引导。 设置在外部管状元件和内部管状元件之间的无菌流体提供超声波信号到容器中的声学耦合，并进一步提供旋转元件的润滑。

公开(公告)号：US5779643A

公开(公告)日：1998-07-14

申请号：US757040

申请日：1996-11-26

申请人： Paul Lum ,  Edward Verdonk

发明人： Paul Lum ,  Edward Verdonk

IPC分类号： A61B8/12

CPC分类号： A61B8/12 ,  A61B8/445 ,  A61B8/4461 ,  A61B8/4483 ,  Y10T29/42

摘要： An imaging guidewire for imaging tissues from inside a patient's body cavity. The imaging guidewire includes an elongated main body portion and an end portion. The end portion has a housing near to the guidewire's distal end, an ultrasonic beam emitting assembly having a pivotable part, and a driver for producing a pivotal motion on the pivotable part. The housing has a portion that is acoustically transparent. The pivotable part is movable and is operatively connected to the housing. The pivotable part can either have on it a transducer for emitting ultrasound or a reflector for reflecting ultrasound. In either case, when the pivotable part pivots it sweeps ultrasonic energy over a selected angle. The driver is located near to the transducer such that all driving motions for driving the pivotal motion occur near the distal end of the imaging guidewire.

摘要翻译： 一种用于从患者体腔内部组织成像的成像导丝。 成像导丝包括细长主体部分和端部部分。 端部具有靠近导丝的远端的壳体，具有可枢转部分的超声波束发射组件和用于在可枢转部件上产生枢转运动的驱动器。 外壳具有声透明部分。 可枢转部分是可移动的并且可操作地连接到壳体。 可枢转部件可以在其上具有用于发射超声的换能器或用于反射超声的反射器。 在任一种情况下，当可枢转部件枢转时，其在超过选定的角度上扫掠超声波能量。 驱动器位于换能器附近，使得用于驱动枢转运动的所有驱动运动发生在成像导丝的远端附近。

公开(公告)号：US06642498B2

公开(公告)日：2003-11-04

申请号：US09990609

申请日：2001-11-21

申请人： Edward Verdonk ,  David A. King ,  Richard D. Pering ,  Richard J. Pittaro ,  Shahida Rana ,  Frederick A. Stawitcke

发明人： Edward Verdonk ,  David A. King ,  Richard D. Pering ,  Richard J. Pittaro ,  Shahida Rana ,  Frederick A. Stawitcke

IPC分类号： G01J142

CPC分类号： G01N21/6452 ,  G01N21/645 ,  G01N2021/6463 ,  G01N2021/6482

摘要： The present invention is directed to a micromirror optical multiplexer for directing light to an array of sensors. The micromirror optical multiplexer directs light from one or more sources onto multiple, coplanar sensors for the purpose of exciting fluorescence. The micromirror optical multiplexer includes at least one light source and a micromirror array having a top face and up to four side faces. Pivotable mirrors of the micromirror array are arranged in a multiple row, multiple column format on the top face. In addition, each of the side faces of the micromirror array has at least one row of pivotable mirrors. By pivoting one side face mirror and one top face mirror, a light source entering at one corner of the micromirror array can be directed to exit near normal incidence anywhere on the bottom of the device.

摘要翻译： 本发明涉及一种用于将光引导到传感器阵列的微镜光学多路复用器。 微镜光复用器将来自一个或多个源的光引导到多个共面传感器上，以激发荧光。 微镜光复用器包括至少一个光源和具有顶面和多达四个侧面的微镜阵列。 微镜阵列的透视镜在顶面以多列，多列格式排列。 此外，微镜阵列的每个侧面具有至少一排可枢转镜。 通过枢转一个侧面反射镜和一个顶面反射镜，进入微镜阵列的一个角落处的光源可被引导到设备底部的任何地方的正常入射附近。

公开(公告)号：US06657235B1

公开(公告)日：2003-12-02

申请号：US10153760

申请日：2002-05-22

申请人： Edward Verdonk ,  Richard J. Pittaro ,  Shahida Rana ,  David Andrew King ,  Frederick A. Stawitcke ,  Richard D. Pering

发明人： Edward Verdonk ,  Richard J. Pittaro ,  Shahida Rana ,  David Andrew King ,  Frederick A. Stawitcke ,  Richard D. Pering

IPC分类号： H01L2926

CPC分类号： H01L27/14643 ,  H01L25/0753 ,  H01L25/167 ,  H01L2924/0002 ,  H01L2924/00

摘要： The disclosure is directed toward an optical excitation/detection device that includes an arrayed plurality of photodetectors and discrete photoemitters, as well as a method for making such a device. A CMOS fabricated photodetector array includes an arrayed plurality of photoreceptor areas and photoemitter areas, wherein each photoreceptor area includes a CMOS integrated photoreceptor and each photoemitter area includes at least two buried electric contact pads. The CMOS array is selectively etched back at the locations of the photoemitter areas for regions to reveal the buried contact pads. A plurality of discrete semiconductor photoemitter devices (such as, for example, light emitting diodes) are inserted into, and mechanically retained within, the regions of the CMOS fabricated photodetector array. The inserted discrete semiconductor photoemitter devices make electrical contact with the buried electric contact pads that are revealed within each of the regions to form the optical excitation/detection device from an arrayed plurality of photodetectors and discrete semiconductor photoemitters.

摘要翻译： 本公开涉及包括阵列的多个光电探测器和分立光电发生器的光学激发/检测装置，以及用于制造这种装置的方法。 CMOS制造的光电检测器阵列包括阵列的多个感光体区域和光电发射器区域，其中每个感光体区域包括CMOS集成感光体，并且每个光电发射器区域包括至少两个埋入的电接触焊盘。 CMOS阵列在光电探测器区域的位置处被选择性地回蚀，用于区域以露出埋入的接触焊盘。 多个分立的半导体光电探测器装置（例如，发光二极管）被插入并机械地保持在CMOS制造的光电检测器阵列的区域内。 插入的分立半导体光电发生器装置与在每个区域内露出的掩埋电接触焊盘电接触，以从阵列的多个光电探测器和分立的半导体光电发生器形成光激发/检测装置。

公开(公告)号：US06640197B2

公开(公告)日：2003-10-28

申请号：US10072240

申请日：2002-02-08

申请人： Richard J. Pittaro ,  David Andrew King ,  Richard D. Pering ,  Shahida Rana ,  Frederick A. Stawitcke ,  Edward Verdonk

发明人： Richard J. Pittaro ,  David Andrew King ,  Richard D. Pering ,  Shahida Rana ,  Frederick A. Stawitcke ,  Edward Verdonk

IPC分类号： G01C2500

CPC分类号： G01N21/253

摘要： A sensor array is bonded to or molded together with a micro-lens array to form a sensor cartridge. The micro-lenses of the micro-lens array are configured to focus light incident on the sensors, into the sensors. An alignment structure has a mating profile that receives and engages one or more micro-lenses from the micro-lens array to laterally align the cartridge to enable repeatable precise positioning of the cartridge.

摘要翻译： 传感器阵列与微透镜阵列结合或模制在一起以形成传感器盒。 微透镜阵列的微透镜被配置为将入射到传感器上的光聚焦到传感器中。 对准结构具有匹配轮廓，该配合轮廓接收并接合来自微透镜阵列的一个或多个微透镜以横向对准盒，以使得盒的可重复的精确定位。

公开(公告)号：US07179654B2

公开(公告)日：2007-02-20

申请号：US10100346

申请日：2002-03-18

申请人： Edward Verdonk ,  David Andrew King ,  Richard J. Pittaro

发明人： Edward Verdonk ,  David Andrew King ,  Richard J. Pittaro

IPC分类号： G01N21/76 ,  B32B5/02 ,  B32B27/12 ,  B32B27/04

CPC分类号： G01N21/6454 ,  G01N21/6428 ,  Y10T436/10

摘要： A biochemical sensor apparatus having an optical radiation source, a sensor array, and a photodetector array is disclosed. Each sensor of the sensor array includes fluorophores for fluorescence (generating response radiation) when mixed with analytes of interest and exposed to stimulus radiation. An array of photodetectors, such as a CMOS imaging array is used to detect the response radiation. The detected response radiation is converted to digital values and the digital values used to analyze various properties of the analytes present in the sensors.

摘要翻译： 公开了一种具有光辐射源，传感器阵列和光电检测器阵列的生化传感器装置。 传感器阵列的每个传感器包括与感兴趣的分析物混合并暴露于刺激辐射时用于荧光的荧光团（产生响应辐射）。 使用诸如CMOS成像阵列的光电检测器阵列来检测响应辐射。 检测到的响应辐射被转换为数字值，数字值用于分析传感器中存在的分析物的各种性质。

公开(公告)号：US06821793B2

公开(公告)日：2004-11-23

申请号：US10668435

申请日：2003-09-22

申请人： Edward Verdonk ,  Richard J. Pittaro ,  Shahida Rana ,  David Andrew King ,  Frederick A. Stawitcke ,  Richard D. Pering

发明人： Edward Verdonk ,  Richard J. Pittaro ,  Shahida Rana ,  David Andrew King ,  Frederick A. Stawitcke ,  Richard D. Pering

IPC分类号： H01L2100

CPC分类号： H01L27/14643 ,  H01L25/0753 ,  H01L25/167 ,  H01L2924/0002 ,  H01L2924/00

摘要： The disclosure is directed toward an optical excitation/detection device that includes an arrayed plurality of photodetectors and discrete photoemitters, as well as a method for making such a device. A CMOS fabricated photodetector array includes an arrayed plurality of photoreceptor areas and photoemitter areas, wherein each photoreceptor area includes a CMOS integrated photoreceptor and each photoemitter area includes at least two buried electric contact pads. The CMOS array is selectively etched back at the locations of the photoemitter areas for regions to reveal the buried contact pads. A plurality of discrete semiconductor photoemitter devices (such as, for example, light emitting diodes) are inserted into, and mechanically retained within, the regions of the CMOS fabricated photodetector array. The inserted discrete semiconductor photoemitter devices make electrical contact with the buried electric contact pads that are revealed within each of the regions to form the optical excitation/detection device from an arrayed plurality of photodetectors and discrete semiconductor photoemitters.

摘要翻译： 本公开涉及包括阵列的多个光电探测器和分立光电发生器的光学激发/检测装置，以及用于制造这种装置的方法。 CMOS制造的光电检测器阵列包括阵列的多个感光体区域和光电发射器区域，其中每个感光体区域包括CMOS集成感光体，并且每个光电发射器区域包括至少两个埋入的电接触焊盘。 CMOS阵列在光电探测器区域的位置处被选择性地回蚀，用于区域以露出埋入的接触焊盘。 多个分立的半导体光电探测器装置（例如，发光二极管）被插入并机械地保持在CMOS制造的光电检测器阵列的区域内。 插入的分立半导体光电发生器装置与在每个区域内露出的掩埋电接触焊盘电接触，以从阵列的多个光电探测器和分立的半导体光电发生器形成光激发/检测装置。