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公开(公告)号：US06716962B2
公开(公告)日：2004-04-06
申请号：US09948374
申请日：2001-09-06
Applicant: Donald B Borders , Noreen D Francis , Amedeo A Fantini
Inventor： Donald B Borders , Noreen D Francis , Amedeo A Fantini
IPC: C07K114
Abstract: The present invention provides a rapid and inexpensive method for extractively isolating acidic lipopeptide antibiotics, such as those having a cyclic peptide or cyclic depsipeptide core, in high yield and purity. In particular, there is provided a method of extracting a variety of acidic lipopeptide antibiotics, directly or indirectly, into water immiscible organic solvents by using a divalent cation chelation procedure.
Abstract translation: 本发明提供了以高产率和纯度提取性分离酸性脂肽抗生素（例如具有环肽或环状多肽肽核心的那些）的快速且便宜的方法。 特别地，提供了通过使用二价阳离子螯合方法将各种酸性脂肽抗生素直接或间接地提取到与水不混溶的有机溶剂中的方法。
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公开(公告)号：US06737403B2
公开(公告)日：2004-05-18
申请号：US09904352
申请日：2001-07-13
Applicant: Donald B Borders , William V Curran , Amedeo A Fantini , Noreen D Francis , Howard Jarolmen , Richard A Leese
Inventor： Donald B Borders , William V Curran , Amedeo A Fantini , Noreen D Francis , Howard Jarolmen , Richard A Leese
IPC: A61K3812
CPC classification number: C07K1/14 , A61K38/00 , C07K7/08 , C07K7/56 , C07K9/00 , C07K11/02 , C08L23/08 , C08L23/0869 , C08L51/06 , C08L2203/14 , C09K3/10 , C09K2003/1037 , C09K2200/06 , C09K2200/062 , C09K2200/0622 , C08L2666/04 , C08L2666/02
Abstract: The present invention provides laspartomycin core peptides, laspartomycin core peptide derivatives, antimicrobial laspartomycin derivatives, methods for making laspartomycin core peptides, methods for making laspartomycin core peptide derivatives, methods for making antimicrobial laspartomycin derivatives, pharmaceutical compositions of antimicrobial laspartomycin derivatives, methods of inhibiting microbial growth and methods for treating and/or preventing microbial infections in a subject.
Abstract translation: 本发明提供了拉沙曲霉素核心肽，拉斯马霉素核心肽衍生物，抗菌蓝鲸霉素衍生物，制备拉沙曲霉素核心肽的方法，制备蓝鲸霉素核心肽衍生物的方法，制备抗菌蓝鲸霉素衍生物的方法，抗微生物蓝鲸霉素衍生物的药物组合物，抑制微生物的方法 用于治疗和/或预防受试者微生物感染的生长和方法。
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公开(公告)号：US06511962B1
公开(公告)日：2003-01-28
申请号：US09760328
申请日：2001-01-12
Applicant: Donald B Borders , William V Curran , Amedeo A Fantini , Noreen D Francis , Howard Jarolmen , Richard A Leese
Inventor： Donald B Borders , William V Curran , Amedeo A Fantini , Noreen D Francis , Howard Jarolmen , Richard A Leese
IPC: A61K3812
CPC classification number: C09K3/10 , A61K38/00 , C07K1/14 , C07K7/08 , C07K7/56 , C07K9/00 , C07K11/02 , C08L23/08 , C08L23/0869 , C08L51/06 , C08L2203/14 , C09K2003/1037 , C09K2200/06 , C09K2200/062 , C09K2200/0622 , C08L2666/04 , C08L2666/02
Abstract: The present invention provides a laspartomycin core peptide, a laspartomycin core peptide derivative, a antimicrobial laspartomycin derivative, a method for making laspartomycin core peptides, methods for making laspartomycin core peptide derivatives, methods for making antimicrobial laspartomycin derivatives, pharmaceutical compositions of antimicrobial laspartomycin derivatives, methods of inhibiting microbial growth and methods for treating and/or preventing microbial infections in a subject.
Abstract translation: 本发明提供了一种天蓝假单胞菌核心肽，一拉曲霉素核心肽衍生物，一种抗微生物蓝鲸霉素衍生物，一种制备蓝鲸霉素核心肽的方法，制备蓝鲸霉素核心肽衍生物的方法，制备抗菌蓝鲸霉素衍生物的方法，抗菌蓝鲸霉素衍生物的药物组合物， 抑制微生物生长的方法以及治疗和/或预防受试者微生物感染的方法。
