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1.Process for preparing quinazoline Rho-kinase inhibitors and intermediates thereof 失效
标题翻译: 制备喹唑啉Rho激酶抑制剂及其中间体的方法公开(公告)号:US07645878B2
公开(公告)日:2010-01-12
申请号:US10252369
申请日:2002-09-24
申请人: Donald Bankston , Dhanaphalan Nagarathnam , Davoud Asgari , Jianxing Shao , Xiao-Gao Liu , Uday Khire , Chunguang Wang , Barry Hart , Stephen Boyer , Olaf Weber , Mark Lynch
发明人: Donald Bankston , Dhanaphalan Nagarathnam , Davoud Asgari , Jianxing Shao , Xiao-Gao Liu , Uday Khire , Chunguang Wang , Barry Hart , Stephen Boyer , Olaf Weber , Mark Lynch
IPC分类号: C07D239/94
CPC分类号: C07D307/79 , C07D239/86 , C07D239/91 , C07D239/93 , C07D403/12 , C07D403/14 , C07D405/04 , C07D405/14
摘要: A process for the preparation of various quinazoline compounds which are useful as Rho-Kinase inhibitors, and thus having utility in the treatment of hypertension and other indications.
摘要翻译: 用于制备可用作Rho-激酶抑制剂的各种喹唑啉化合物的方法,因此可用于治疗高血压和其他适应症。
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2.PROCESS FOR PREPARING QUINAZOLINE RHO-KINASE INHIBITORS AND INTERMEDIATES THEREOF 审中-公开
标题翻译: 制备喹唑啉RHO-激酶抑制剂及其中间体的方法公开(公告)号:US20100125139A1
公开(公告)日:2010-05-20
申请号:US12619884
申请日:2009-11-17
申请人: Donald BANKSTON , Dhanaphalan Nagarathnam , Davoud Asgari , Jianxing Shao , Xiao-Gao Liu , Uday Khire , Chunguang Wang , Barry Hart , Stephen Boyer , Olaf Weber , Mark Lynch
发明人: Donald BANKSTON , Dhanaphalan Nagarathnam , Davoud Asgari , Jianxing Shao , Xiao-Gao Liu , Uday Khire , Chunguang Wang , Barry Hart , Stephen Boyer , Olaf Weber , Mark Lynch
IPC分类号: C07D403/12 , C07D239/91 , C07D405/14 , C07D239/93
CPC分类号: C07D307/79 , C07D239/86 , C07D239/91 , C07D239/93 , C07D403/12 , C07D403/14 , C07D405/04 , C07D405/14
摘要: A process for the preparation of various quinazoline compounds which are useful as Rho-Kinase inhibitors, and thus having utility in the treatment of hypertension and other indications.
摘要翻译: 用于制备可用作Rho-激酶抑制剂的各种喹唑啉化合物的方法,因此可用于治疗高血压和其他适应症。
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公开(公告)号:US20060142313A1
公开(公告)日:2006-06-29
申请号:US11354977
申请日:2006-02-16
申请人: Dhanaphalan Nagarathnam , Davoud Asgari , Jianxing Shao , Xiao-Gao Liu , Uday Khire , Chunguang Wang , Barry Hart , Stephen Boyer , Olaf Weber , Mark Lynch
发明人: Dhanaphalan Nagarathnam , Davoud Asgari , Jianxing Shao , Xiao-Gao Liu , Uday Khire , Chunguang Wang , Barry Hart , Stephen Boyer , Olaf Weber , Mark Lynch
IPC分类号: A61K31/517 , A61K31/4709 , C07D403/02
CPC分类号: C07D401/14 , C07D403/04 , C07D403/12 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/14
摘要: Disclosed are compounds and derivatives thereof, their synthesis, and their use as Rho-kinase inhibitors. These compounds of the present invention are useful for inhibiting tumor growth, treating erectile dysfunction, and treating other indications mediated by Rho-kinase, e.g., coronary heart disease.
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公开(公告)号:US20100137324A1
公开(公告)日:2010-06-03
申请号:US12698386
申请日:2010-02-02
申请人: Dhanaphalan Nagarathnam , Davoud Asgari , Jianxing Shao , Xiao-Gao Liu , Uday Khire , Chunguang Wang , Barry Hart , Stephen Boyer , Olaf Weber , Mark Lynch
发明人: Dhanaphalan Nagarathnam , Davoud Asgari , Jianxing Shao , Xiao-Gao Liu , Uday Khire , Chunguang Wang , Barry Hart , Stephen Boyer , Olaf Weber , Mark Lynch
IPC分类号: A61K31/517 , C07D403/12 , C07D405/14 , C07D409/14 , C07D413/14 , C07D403/14 , A61P9/10 , A61P25/00 , A61P35/00
CPC分类号: C07D401/14 , C07D403/04 , C07D403/12 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/14
摘要: Disclosed are compounds and derivatives thereof, their synthesis, and their use as Rho-kinase inhibitors. These compounds of the present invention are useful for inhibiting tumor growth, treating erectile dysfunction, and treating other indications mediated by Rho-kinase, e.g., coronary heart disease.
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5.Novel bicyclic urea derivatives useful in the treatment of cancer and other disorders 有权
标题翻译: 用于治疗癌症和其他疾病的新型双环脲衍生物公开(公告)号:US20050038031A1
公开(公告)日:2005-02-17
申请号:US10788426
申请日:2004-03-01
申请人: Jacques Dumas , Stephen Boyer , Sharad Verma , Lila Adnane , Yuanwei Chen , Wendy Lee , Barton Phillips , Roger Smith , William Scott , Jennifer Burke , Jianqing Chen , Zhi Chen , Jianmei Fan , Karl Miranda , Brian Raudenbush , Aniko Redman , Jianxing Shao , Ning Su , Gan Wang , Lin Yi , Qingming Zhu
发明人: Jacques Dumas , Stephen Boyer , Sharad Verma , Lila Adnane , Yuanwei Chen , Wendy Lee , Barton Phillips , Roger Smith , William Scott , Jennifer Burke , Jianqing Chen , Zhi Chen , Jianmei Fan , Karl Miranda , Brian Raudenbush , Aniko Redman , Jianxing Shao , Ning Su , Gan Wang , Lin Yi , Qingming Zhu
IPC分类号: A61K31/335 , A61K31/416 , A61K31/4184 , A61K31/4192 , A61K31/423 , A61K31/428 , A61K31/443 , A61K31/4433 , A61K31/4436 , A61K31/444 , A61K31/4709 , A61K31/498 , A61K31/53 , A61K31/538 , A61K31/5415 , A61P35/00 , C07D213/68 , C07D213/79 , C07D213/84 , C07D251/02 , C07D333/66 , C07D401/12 , C07D405/12 , C07D417/12
CPC分类号: C07D213/84 , C07D401/12 , C07D405/12 , C07D417/12
摘要: This invention relates to novel diaryl ureas, pharmaceutical compositions containing such compounds and the use of those compounds or compositions for treating hyper-proliferative and angiogenesis disorders, as a sole agent or in combination with cytotoxic therapies.
摘要翻译: 本发明涉及新的二芳基脲,含有这些化合物的药物组合物以及这些化合物或组合物用于治疗高增殖和血管生成障碍,作为唯一试剂或与细胞毒性疗法组合的用途。
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6.Bicyclic urea derivatives useful in the treatment of cancer and other disorders 有权
标题翻译: 用于治疗癌症和其他疾病的双环脲衍生物公开(公告)号:US08076488B2
公开(公告)日:2011-12-13
申请号:US10788426
申请日:2004-03-01
申请人: Jacques Dumas , Stephen Boyer , Sharad Verma , Lila Adnane , Yuanwei Chen , Wendy Lee , Barton Phillips , Roger A. Smith , William J. Scott , Jennifer Burke , Jianqing Chen , Zhi Chen , Jianmei Fan , Karl Miranda , Brian Raudenbush , Aniko Redman , Jianxing Shao , Ning Su , Gan Wang , Lin Yi , Qingming Zhu
发明人: Jacques Dumas , Stephen Boyer , Sharad Verma , Lila Adnane , Yuanwei Chen , Wendy Lee , Barton Phillips , Roger A. Smith , William J. Scott , Jennifer Burke , Jianqing Chen , Zhi Chen , Jianmei Fan , Karl Miranda , Brian Raudenbush , Aniko Redman , Jianxing Shao , Ning Su , Gan Wang , Lin Yi , Qingming Zhu
IPC分类号: C07D213/62 , C07D401/00 , C07D417/00
CPC分类号: C07D213/84 , C07D401/12 , C07D405/12 , C07D417/12
摘要: This invention relates to novel diaryl ureas, pharmaceutical compositions containing such compounds and the use of those compounds or compositions for treating hyper-proliferative and angiogenesis disorders, as a sole agent or in combination with cytotoxic therapies.
摘要翻译: 本发明涉及新的二芳基脲,含有这些化合物的药物组合物以及这些化合物或组合物用于治疗高增殖和血管生成障碍,作为唯一试剂或与细胞毒性疗法组合的用途。
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公开(公告)号:US20120053179A1
公开(公告)日:2012-03-01
申请号:US13289782
申请日:2011-11-04
申请人: Dhanapalan Nagarathnam , Jacques Dumas , Holia Hatoum-Mokdad , Stephen Boyer , Chunguang Wang , Hans Pluempe , Achim Feurer , Samir Bennabi
发明人: Dhanapalan Nagarathnam , Jacques Dumas , Holia Hatoum-Mokdad , Stephen Boyer , Chunguang Wang , Hans Pluempe , Achim Feurer , Samir Bennabi
IPC分类号: A61K31/5377 , C07D401/14 , C07D471/04 , C07D401/12 , C07D405/14 , C07D409/14 , C07D413/14 , A61K31/505 , A61K31/506 , A61K31/517 , A61K31/519 , A61P9/12 , A61P9/10 , A61P25/00 , A61P25/28 , A61P35/00 , A61P7/02 , A61P11/06 , A61P27/06 , A61P19/10 , A61P15/00 , C07D239/48
CPC分类号: C07D239/48 , A61K31/506 , C07D401/12 , C07D403/12 , C07D409/14 , C07D413/12 , C07D413/14 , C07D471/04
摘要: Disclosed are compounds and derivatives thereof, their synthesis, and their use as Rho-kinase inhibitors. These compounds are useful for inhibiting tumor growth, treating erectile dysfunction, and treating other indications mediated by Rho-kinase, e.g., coronary heart disease.
摘要翻译: 公开了其化合物及其衍生物,其合成及其作为Rho-激酶抑制剂的用途。 这些化合物可用于抑制肿瘤生长,治疗勃起功能障碍和治疗由Rho-激酶介导的其它适应症,例如冠心病。
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公开(公告)号:US20050192304A1
公开(公告)日:2005-09-01
申请号:US11107793
申请日:2005-04-18
申请人: Dhanapalan Nagarathnam , Jacques Dumas , Holia Hatoum-Mokdad , Stephen Boyer , Chunguang Wang , Hans Pluempe , Achim Feurer , Samir Bennabi
发明人: Dhanapalan Nagarathnam , Jacques Dumas , Holia Hatoum-Mokdad , Stephen Boyer , Chunguang Wang , Hans Pluempe , Achim Feurer , Samir Bennabi
IPC分类号: A61K31/505 , A61K31/506 , A61K31/517 , A61K31/519 , A61P7/02 , A61P9/10 , A61P9/12 , A61P9/14 , A61P11/06 , A61P15/10 , A61P19/10 , A61P25/00 , A61P25/28 , A61P27/06 , A61P35/00 , A61P43/00 , C07B57/00 , C07D239/48 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/14 , C07D409/14 , C07D413/12 , C07D413/14 , C07D471/04 , C07D43/02
CPC分类号: C07D239/48 , A61K31/506 , C07D401/12 , C07D403/12 , C07D409/14 , C07D413/12 , C07D413/14 , C07D471/04
摘要: Disclosed are compounds and derivatives thereof, their synthesis, and their use as Rho-kinase inhibitors. These compounds are useful for inhibiting tumor growth, treating erectile dysfunction, and treating other indications mediated by Rho-kinase, e.g., coronary heart disease.
摘要翻译: 公开了其化合物及其衍生物,其合成及其作为Rho-激酶抑制剂的用途。 这些化合物可用于抑制肿瘤生长,治疗勃起功能障碍和治疗由Rho-激酶介导的其它适应症,例如冠心病。
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公开(公告)号:US06924290B2
公开(公告)日:2005-08-02
申请号:US10349177
申请日:2003-01-23
申请人: Dhanapalan Nagarathnam , Jacques Dumas , Holia Hatoum-Mokdad , Stephen Boyer , Chunguang Wang , Hans Pluempe , Achim Feurer , Samir Bennabi
发明人: Dhanapalan Nagarathnam , Jacques Dumas , Holia Hatoum-Mokdad , Stephen Boyer , Chunguang Wang , Hans Pluempe , Achim Feurer , Samir Bennabi
IPC分类号: A61K31/505 , A61K31/506 , A61K31/517 , A61K31/519 , A61P7/02 , A61P9/10 , A61P9/12 , A61P9/14 , A61P11/06 , A61P15/10 , A61P19/10 , A61P25/00 , A61P25/28 , A61P27/06 , A61P35/00 , A61P43/00 , C07B57/00 , C07D239/48 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/14 , C07D409/14 , C07D413/12 , C07D413/14 , C07D471/04
CPC分类号: C07D239/48 , A61K31/506 , C07D401/12 , C07D403/12 , C07D409/14 , C07D413/12 , C07D413/14 , C07D471/04
摘要: Disclosed are compounds and derivatives thereof, their synthesis, and their use as Rho-kinase inhibitors. These compounds are useful for inhibiting tumor growth, treating erectile dysfunction, and treating other indications mediated by Rho-kinase, e.g., coronary heart disease.
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10.PYRIDONECARBOXAMIDE DERIVATIVES USEFUL IN TREATING HYPER-PROLIFERATIVE AND ANGIOGENESIS DISORDERS 审中-公开
标题翻译: 用于治疗高血压和血管发生疾病的吡啶甲酰甲胆碱衍生物公开(公告)号:US20090306103A1
公开(公告)日:2009-12-10
申请号:US12300751
申请日:2007-05-18
申请人: Stephen Boyer , David Cantin , Sidney X. Liang
发明人: Stephen Boyer , David Cantin , Sidney X. Liang
IPC分类号: A61K31/4709 , C07D401/12 , A61K31/517 , A61K31/4545 , A61K31/4375 , A61P35/00
CPC分类号: C07D401/12
摘要: Pyridonecarboxamide derivatives, pharmaceutical compositions which contain the same and methods for treating hyper-proliferative disorders and angiogenesis disorders using the same.
摘要翻译: 吡啶并甲酰胺衍生物,含有该化合物的药物组合物以及使用该组合物治疗高增殖性疾病和血管生成障碍的方法。
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